2013
Endothelin-1 Induced Middle Cerebral Artery Occlusion Model for Ischemic Stroke with Laser Doppler Flowmetry Guidance in Rat
Ansari S, Azari H, Caldwell K, Regenhardt R, Hedna V, Waters M, Hoh B, Mecca A. Endothelin-1 Induced Middle Cerebral Artery Occlusion Model for Ischemic Stroke with Laser Doppler Flowmetry Guidance in Rat. Journal Of Visualized Experiments 2013 DOI: 10.3791/50014-v.Peer-Reviewed Original Research
2011
Angiotensin(1–7) increases survival of stroke‐prone spontaneously hypertensive rats
Regenhardt R, Ritucci‐Chinni P, Desland F, Mecca A, Sumners C. Angiotensin(1–7) increases survival of stroke‐prone spontaneously hypertensive rats. The FASEB Journal 2011, 25: 650.10-650.10. DOI: 10.1096/fasebj.25.1_supplement.650.10.Peer-Reviewed Original ResearchHemorrhagic strokeCerebroprotective actionHypertensive ratsSystemic arterial pressureNovel therapeutic targetArtificial cerebrospinal fluidWeeks of ageAngiotensin systemIschemic strokeSalt dietArterial pressureSpontaneous hypertensionTherapeutic optionsAngiotensin IIINOS expressionStroke occurrenceCerebrospinal fluidTherapeutic targetOsmotic pumpHemorrhagic stroke occurrenceStrokeRatsSignificant increaseWeeksSurvival
2006
Effects of central and peripheral injections of apelin on fluid intake and cardiovascular parameters in rats
Mitra A, Katovich MJ, Mecca A, Rowland NE. Effects of central and peripheral injections of apelin on fluid intake and cardiovascular parameters in rats. Physiology & Behavior 2006, 89: 221-225. PMID: 16839572, DOI: 10.1016/j.physbeh.2006.06.006.Peer-Reviewed Original ResearchConceptsBlood pressureFluid intakeRole of apelinHypotensive actionPeripheral administrationAntidipsogenic effectPeripheral injectionSodium appetiteCardiovascular parametersSated ratsAngiotensin peptidesSprague-DawleyUnrestrained ratsApelinFluid homeostasisRatsDisparate effectsIntakeNovel peptideConsistent effectRobust effectPrevious studiesPeptidesAdministrationAppetite
2005
Protection from angiotensin II‐induced cardiac hypertrophy and fibrosis by systemic lentiviral delivery of ACE2 in rats
Huentelman MJ, Grobe JL, Vazquez J, Stewart JM, Mecca AP, Katovich MJ, Ferrario CM, Raizada MK. Protection from angiotensin II‐induced cardiac hypertrophy and fibrosis by systemic lentiviral delivery of ACE2 in rats. Quarterly Journal Of Experimental Physiology And Cognate Medical Sciences 2005, 90: 783-790. PMID: 16049057, DOI: 10.1113/expphysiol.2005.031096.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin IIAngiotensin-Converting Enzyme 2AnimalsAnimals, NewbornBlood PressureBody WeightCarboxypeptidasesCardiomyopathy, HypertrophicEndomyocardial FibrosisGene ExpressionGenetic VectorsHeartLentivirusMiceMyocardiumOrgan SizePeptidyl-Dipeptidase ARatsRats, Sprague-DawleyTransduction, GeneticConceptsRenin-angiotensin systemAngiotensin IIMyocardial fibrosisCardiac hypertrophyAngiotensin II infusionSystolic blood pressureBody weight ratioOverexpression of ACE2Potential therapeutic targetII infusionMmHg increaseBlood pressureHeart weightControl ratsDawley ratsCardiovascular diseaseEnzyme 2Protective effectTherapeutic targetMouse ACE2FibrosisHypertrophyRatsACE2Significant attenuation