Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes
Hundal RS, Petersen KF, Mayerson AB, Randhawa PS, Inzucchi S, Shoelson SE, Shulman GI. Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes. Journal Of Clinical Investigation 2002, 109: 1321-1326. PMID: 12021247, PMCID: PMC150979, DOI: 10.1172/jci14955.Peer-Reviewed Original ResearchConceptsAspirin treatmentInsulin resistanceTolerance testPlasma glucoseInsulin-stimulated peripheral glucose uptakeHigh-dose aspirin treatmentMixed meal tolerance testType 2 diabetic subjectsMixed-meal tolerance testType 2 diabetes mellitusHigh-dose aspirinWeeks of treatmentC-reactive proteinPeripheral glucose uptakeHyperinsulinemic-euglycemic clampType 2 diabetesPlasma insulin concentrationHepatic glucose productionFatty acid levelsDiabetes mellitusDiabetic subjectsTotal cholesterolGlucose toleranceInsulin clearanceTissue inflammationThe Effects of Rosiglitazone on Insulin Sensitivity, Lipolysis, and Hepatic and Skeletal Muscle Triglyceride Content in Patients With Type 2 Diabetes
Mayerson AB, Hundal RS, Dufour S, Lebon V, Befroy D, Cline GW, Enocksson S, Inzucchi SE, Shulman GI, Petersen KF. The Effects of Rosiglitazone on Insulin Sensitivity, Lipolysis, and Hepatic and Skeletal Muscle Triglyceride Content in Patients With Type 2 Diabetes. Diabetes 2002, 51: 797-802. PMID: 11872682, PMCID: PMC2995527, DOI: 10.2337/diabetes.51.3.797.Peer-Reviewed Original ResearchMeSH KeywordsAdipocytesAdipose TissueBlood GlucoseBody CompositionCalorimetry, IndirectDiabetes Mellitus, Type 2Fatty AcidsGlucose Clamp TechniqueGlycated HemoglobinGlycerolHumansHyperinsulinismInsulinKineticsLipidsLipolysisLiverMagnetic Resonance SpectroscopyMicrodialysisMiddle AgedMuscle, SkeletalOxidation-ReductionRosiglitazoneThiazolesThiazolidinedionesTriglyceridesConceptsPlasma fatty acid concentrationsMuscle triglyceride contentEffects of rosiglitazoneType 2 diabetesInsulin sensitivityPeripheral adipocytesTriglyceride contentRosiglitazone treatmentFatty acid concentrationsTwo-step hyperinsulinemic-euglycemic clampSkeletal muscle triglyceride contentType 2 diabetic subjectsInsulin-stimulated glucose metabolismWhole-body insulin sensitivityExtramyocellular lipid contentInsulin-responsive organHepatic triglyceride contentHyperinsulinemic-euglycemic clampAdipocyte insulin sensitivityDiabetic subjectsInsulin clampGlucose metabolismGlycerol releaseResponsive organSubcutaneous fat