Symptom clusters in adolescent depression and differential response to treatment: a secondary analysis of the Treatment for Adolescents with Depression Study randomised trial
Bondar J, Caye A, Chekroud A, Kieling C. Symptom clusters in adolescent depression and differential response to treatment: a secondary analysis of the Treatment for Adolescents with Depression Study randomised trial. The Lancet Psychiatry 2020, 7: 337-343. PMID: 32199509, DOI: 10.1016/s2215-0366(20)30060-2.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBayes TheoremChildCognitive Behavioral TherapyCombined Modality TherapyDepressive Disorder, MajorDiagnostic and Statistical Manual of Mental DisordersFemaleFluoxetineHumansMalePsychiatric Status Rating ScalesSelective Serotonin Reuptake InhibitorsTreatment OutcomeUnited StatesConceptsChildren's Depression Rating Scale-RevisedCognitive behavioral therapyCDRS-R scoresSymptom clustersDepression StudyTreatment efficacySecondary analysisMajor depressive disorderDSM-IV diagnosisCo-occurring symptomsSpecific symptom clustersPlacebo groupAcute phaseClinical profileActive treatmentSymptom scoresSleep disturbancesClinical trialsDepressive disorderPill placeboTreatment responseTherapeutic modalitiesSpecific symptomsNew therapiesPhysical complaints