2023
Broadening the Use of Machine Learning in Psychiatry
Adkinson B, Chekroud A. Broadening the Use of Machine Learning in Psychiatry. Biological Psychiatry 2023, 93: 4-5. PMID: 36456077, DOI: 10.1016/j.biopsych.2022.10.006.Peer-Reviewed Original ResearchMachine LearningPsychiatry
2018
Multivariate Pattern Analysis of Genotype–Phenotype Relationships in Schizophrenia
Zheutlin AB, Chekroud AM, Polimanti R, Gelernter J, Sabb FW, Bilder RM, Freimer N, London ED, Hultman CM, Cannon TD. Multivariate Pattern Analysis of Genotype–Phenotype Relationships in Schizophrenia. Schizophrenia Bulletin 2018, 44: 1045-1052. PMID: 29534239, PMCID: PMC6101611, DOI: 10.1093/schbul/sby005.Peer-Reviewed Original ResearchConceptsMultivariate pattern analysisIndependent samplesVisual memoryCognitive endophenotypesPredictive strengthSchizophreniaMemoryIndividual variationPattern analysisSingle predictorCertain domainsDiscovery samplePsychiatric patientsPolygenic risk scoresPredictive powerScoresEndophenotypesPotential relationshipRelationshipRandom forestGenetic risk variantsLimited setPredictorsComprehensive setSamples
2016
Multisite prediction of 4-week and 52-week treatment outcomes in patients with first-episode psychosis: a machine learning approach
Koutsouleris N, Kahn R, Chekroud A, Leucht S, Falkai P, Wobrock T, Derks E, Fleischhacker W, Hasan A. Multisite prediction of 4-week and 52-week treatment outcomes in patients with first-episode psychosis: a machine learning approach. The Lancet Psychiatry 2016, 3: 935-946. PMID: 27569526, DOI: 10.1016/s2215-0366(16)30171-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultClinical Decision-MakingFemaleHumansMachine LearningMalePsychotic DisordersTreatment OutcomeConceptsFirst-episode psychosisTreatment outcomesEuropean First Episode Schizophrenia TrialKaplan-Meier log-rank analysisLog-rank analysisReal-world careWeeks of treatmentPrevious depressive episodesCommencement of treatmentPoor treatment outcomesFirst-episode sampleBetter treatment outcomesClinical trial designQuality of lifeMeaningful outcome indicatorsHospital eventsMale sexOutcome predictorsDepressive episodeTreatment adherenceFunctional deficitsSchizophrenia trialsSuperior efficacyNew patientsSymptom persistence