The Role of microRNA Expression in Cortical Development During Conversion to Psychosis
Zheutlin AB, Jeffries CD, Perkins DO, Chung Y, Chekroud AM, Addington J, Bearden CE, Cadenhead KS, Cornblatt BA, Mathalon DH, McGlashan TH, Seidman LJ, Walker EF, Woods SW, Tsuang M, Cannon TD. The Role of microRNA Expression in Cortical Development During Conversion to Psychosis. Neuropsychopharmacology 2017, 42: 2188-2195. PMID: 28186095, PMCID: PMC5603810, DOI: 10.1038/npp.2017.34.Peer-Reviewed Original ResearchConceptsNorth American Prodrome Longitudinal StudyCortical thinningDisease onsetClinical high-risk individualsProinflammatory cytokine levelsHigh-risk individualsGray matter reductionsOnset of psychosisCortical gray matter reductionMicroRNA expressionMicroglial actionCytokine levelsProinflammatory cytokinesCortical maturationImmune cellsHealthy controlsInflammatory responsePeripheral leukocytesCortical developmentHigh riskImmune functionSynaptic plasticityImmune systemConversion statusResident macrophages