2018
Reading the (functional) writing on the (structural) wall: Multimodal fusion of brain structure and function via a deep neural network based translation approach reveals novel impairments in schizophrenia
Plis SM, Amin MF, Chekroud A, Hjelm D, Damaraju E, Lee HJ, Bustillo JR, Cho K, Pearlson GD, Calhoun VD. Reading the (functional) writing on the (structural) wall: Multimodal fusion of brain structure and function via a deep neural network based translation approach reveals novel impairments in schizophrenia. NeuroImage 2018, 181: 734-747. PMID: 30055372, PMCID: PMC6321628, DOI: 10.1016/j.neuroimage.2018.07.047.Peer-Reviewed Original ResearchConceptsGray matter patternsIntrinsic connectivity networksPosterior cingulate cortexHealthy controlsDynamic functional connectivityStructural MRIFunctional MRIDFNC statesGray matter densitySignificant group differencesTemporal lobeTemporal cortexCingulate cortexSame brainFunctional connectivityBrain structuresCognitive scoresStrong associationLinkage/associationMultimodal brain imaging dataImaging dataGroup differencesSignificant correlationSMRI dataCortex
2017
The Role of microRNA Expression in Cortical Development During Conversion to Psychosis
Zheutlin AB, Jeffries CD, Perkins DO, Chung Y, Chekroud AM, Addington J, Bearden CE, Cadenhead KS, Cornblatt BA, Mathalon DH, McGlashan TH, Seidman LJ, Walker EF, Woods SW, Tsuang M, Cannon TD. The Role of microRNA Expression in Cortical Development During Conversion to Psychosis. Neuropsychopharmacology 2017, 42: 2188-2195. PMID: 28186095, PMCID: PMC5603810, DOI: 10.1038/npp.2017.34.Peer-Reviewed Original ResearchConceptsNorth American Prodrome Longitudinal StudyCortical thinningDisease onsetClinical high-risk individualsProinflammatory cytokine levelsHigh-risk individualsGray matter reductionsOnset of psychosisCortical gray matter reductionMicroRNA expressionMicroglial actionCytokine levelsProinflammatory cytokinesCortical maturationImmune cellsHealthy controlsInflammatory responsePeripheral leukocytesCortical developmentHigh riskImmune functionSynaptic plasticityImmune systemConversion statusResident macrophages