Parsing the antidepressant effects of non-invasive brain stimulation and pharmacotherapy: A symptom clustering approach on ELECT-TDCS
Goerigk S, Padberg F, Chekroud A, Kambeitz J, Bühner M, Brunoni A. Parsing the antidepressant effects of non-invasive brain stimulation and pharmacotherapy: A symptom clustering approach on ELECT-TDCS. Brain Stimulation 2021, 14: 906-912. PMID: 34048940, DOI: 10.1016/j.brs.2021.05.008.Peer-Reviewed Original ResearchConceptsTranscranial direct current stimulationNon-invasive brain stimulationDepressive symptomsBrain stimulationEfficacy of tDCSCore depressive symptomsLinear mixed regression modelsDepressive symptom clustersConsiderable inter-individual variabilityDirect current stimulationEscitalopram 20Antidepressant effectsAntidepressant efficacyInter-individual variabilityAtypical symptomsDepressed patientsMixed regression modelsInsomnia symptomsTDCS sessionsPharmacotherapyEscitalopramSymptomsPlaceboSymptom clustersCurrent stimulation