2022
Brain–phenotype models fail for individuals who defy sample stereotypes
Greene AS, Shen X, Noble S, Horien C, Hahn CA, Arora J, Tokoglu F, Spann MN, Carrión CI, Barron DS, Sanacora G, Srihari VH, Woods SW, Scheinost D, Constable RT. Brain–phenotype models fail for individuals who defy sample stereotypes. Nature 2022, 609: 109-118. PMID: 36002572, PMCID: PMC9433326, DOI: 10.1038/s41586-022-05118-w.Peer-Reviewed Original ResearchConceptsBrain-phenotype relationshipsBrain functional organizationCognitive constructsIndividual differencesNeurocognitive measuresBrain activityNeurocognitive scoresStereotypical profileNeural targetsClinical interventionsNeural circuitsFunctional organizationIndividualsSuch relationshipsData-driven approachRelationshipStereotypesLarge-scale differences in functional organization of left- and right-handed individuals using whole-brain, data-driven analysis of connectivity
Tejavibulya L, Peterson H, Greene A, Gao S, Rolison M, Noble S, Scheinost D. Large-scale differences in functional organization of left- and right-handed individuals using whole-brain, data-driven analysis of connectivity. NeuroImage 2022, 252: 119040. PMID: 35272202, PMCID: PMC9013515, DOI: 10.1016/j.neuroimage.2022.119040.Peer-Reviewed Original ResearchConceptsHanded individualsFunctional connectivityLanguage areasWhole-brain functional connectivityRight-handed individualsFunctional organizationWhole-brain levelIndividual differencesHandedness differencesHandedness effectsFunctional connectomeBrain levelsSomatosensory cortexNetworks of interestWhole brainSex differencesBrainConnectomeIndividualsData-driven analysisConnectivityDistinct patternsLateralizationDifferencesSimilar amounts
2018
Task-induced brain state manipulation improves prediction of individual traits
Greene AS, Gao S, Scheinost D, Constable RT. Task-induced brain state manipulation improves prediction of individual traits. Nature Communications 2018, 9: 2807. PMID: 30022026, PMCID: PMC6052101, DOI: 10.1038/s41467-018-04920-3.Peer-Reviewed Original ResearchConceptsBrain statesIndividual differencesBrain-behavior relationshipsFluid intelligence scoresTask-based functional connectivity analysisResting-state fMRI dataBrain functional organizationFunctional connectivity analysisCognitive tasksFluid intelligenceIntelligence scoresFunctional connectivityFMRI dataConnectivity analysisHuman behaviorIndividual traitsTaskCertain tasksFunctional organizationOutperform modelsSuch relationshipsCognitionState manipulationIntelligenceVariance