2021
Role of inflammation in benign gynecologic disorders: from pathogenesis to novel therapies†
AlAshqar A, Reschke L, Kirschen GW, Borahay MA. Role of inflammation in benign gynecologic disorders: from pathogenesis to novel therapies†. Biology Of Reproduction 2021, 105: 7-31. PMID: 33739368, PMCID: PMC8256101, DOI: 10.1093/biolre/ioab054.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsBenign gynecologic disordersRole of inflammationGynecologic disordersClinical sequelaeCardiometabolic risk factorsNF-κB inhibitorCardiometabolic medicationsInflammatory markersSystemic complicationsGynecologic malignanciesVitamin DInflammatory pathwaysLesion progressionRisk factorsCardiovascular diseaseCyclooxygenase-2Uterine leiomyomaPathophysiological perspectiveSex steroidsHormonal treatmentDiagnostic adjunctTherapeutic implicationsNumerous cytokinesImmune systemInflammation
2019
Cardiometabolic Risk Factors and Benign Gynecologic Disorders.
AlAshqar A, Patzkowsky K, Afrin S, Wild R, Taylor HS, Borahay MA. Cardiometabolic Risk Factors and Benign Gynecologic Disorders. Obstetrical & Gynecological Survey 2019, 74: 661-673. PMID: 31755543, PMCID: PMC6986276, DOI: 10.1097/ogx.0000000000000718.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCardiometabolic risk factorsBenign gynecologic disordersRisk factorsUterine leiomyomaGynecologic disordersUterine leiomyoma pathogenesisBenign gynecologic conditionsPolycystic ovarian syndromeExtracellular matrix depositionCardiometabolic riskOvarian syndromeSystemic inflammationAtherosclerotic changesChronic inflammationGynecologic conditionsHyperestrogenic stateVitamin DInsulin resistanceDietary factorsCardiovascular diseasePreventive strategiesTherapeutic interventionsLeiomyoma pathogenesisClinical implicationsEndometriosis