2024
Validation of biomarkers of aging
Moqri M, Herzog C, Poganik J, Ying K, Justice J, Belsky D, Higgins-Chen A, Chen B, Cohen A, Fuellen G, Hägg S, Marioni R, Widschwendter M, Fortney K, Fedichev P, Zhavoronkov A, Barzilai N, Lasky-Su J, Kiel D, Kennedy B, Cummings S, Slagboom P, Verdin E, Maier A, Sebastiano V, Snyder M, Gladyshev V, Horvath S, Ferrucci L. Validation of biomarkers of aging. Nature Medicine 2024, 30: 360-372. PMID: 38355974, PMCID: PMC11090477, DOI: 10.1038/s41591-023-02784-9.Peer-Reviewed Original Research
2023
Biomarkers of aging for the identification and evaluation of longevity interventions
Moqri, Herzog C, Poganik J, Consortium B, Justice J, Belsky D, Higgins-Chen A, Moskalev A, Fuellen G, Cohen A, Bautmans I, Widschwendter M, Ding J, Fleming A, Mannick J, Han J, Zhavoronkov A, Barzilai N, Kaeberlein M, Cummings S, Kennedy B, Ferrucci L, Horvath S, Verdin E, Maier A, Snyder M, Sebastiano V, Gladyshev V. Biomarkers of aging for the identification and evaluation of longevity interventions. Cell 2023, 186: 3758-3775. PMID: 37657418, PMCID: PMC11088934, DOI: 10.1016/j.cell.2023.08.003.Peer-Reviewed Original Research
2021
Aging biomarkers and the brain
Higgins-Chen AT, Thrush KL, Levine ME. Aging biomarkers and the brain. Seminars In Cell And Developmental Biology 2021, 116: 180-193. PMID: 33509689, PMCID: PMC8292153, DOI: 10.1016/j.semcdb.2021.01.003.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2020
Schizophrenia and Epigenetic Aging Biomarkers: Increased Mortality, Reduced Cancer Risk, and Unique Clozapine Effects
Higgins-Chen AT, Boks MP, Vinkers CH, Kahn RS, Levine ME. Schizophrenia and Epigenetic Aging Biomarkers: Increased Mortality, Reduced Cancer Risk, and Unique Clozapine Effects. Biological Psychiatry 2020, 88: 224-235. PMID: 32199607, PMCID: PMC7368835, DOI: 10.1016/j.biopsych.2020.01.025.Peer-Reviewed Original ResearchMeSH KeywordsAgingBiomarkersClozapineDNA MethylationEpigenesis, GeneticHumansMaleNeoplasmsSchizophreniaConceptsAge-associated proteinsEpigenetic clocksDNA methylation data setsMethylation data setsEpigenetic ageing biomarkersReduced cancer riskCD8 T cellsBody mass indexLong-term outcomesHorvath's epigenetic clockLower cancer ratesDNA methylationDNA methylation predictorsBiological age differencesMitotic clockMitotic divisionAge clocksCause mortalityNatural killerMass indexEarly mortalityMedication dataSZ casesClozapine's effectIncreased Mortality