2023
Cellular allostatic load is linked to increased energy expenditure and accelerated biological aging
Bobba-Alves N, Sturm G, Lin J, Ware S, Karan K, Monzel A, Bris C, Procaccio V, Lenaers G, Higgins-Chen A, Levine M, Horvath S, Santhanam B, Kaufman B, Hirano M, Epel E, Picard M. Cellular allostatic load is linked to increased energy expenditure and accelerated biological aging. Psychoneuroendocrinology 2023, 155: 106322. PMID: 37423094, PMCID: PMC10528419, DOI: 10.1016/j.psyneuen.2023.106322.Peer-Reviewed Original ResearchConceptsCellular agingCellular energy expenditureDNA methylation clockMitochondrial oxidative phosphorylationStress adaptationMtDNA instabilityOXPHOS activityMethylation clockOxidative phosphorylationMetabolic shiftEnergetic costHuman fibroblast lineCellular basisPhysiological responsesFibroblast linesStress triggersPotential driversBiological agingEnergy expenditureChronic activationLifespanDamaging effectsPrimary human fibroblast linesCytokine secretionPhosphorylation
2022
PCBrainAge: A Brain‐Specific AD‐Associated DNA Methylation Clock
Thrush K, Markov Y, Higgins‐Chen A, Morgan L. PCBrainAge: A Brain‐Specific AD‐Associated DNA Methylation Clock. Alzheimer's & Dementia 2022, 18 DOI: 10.1002/alz.069230.Peer-Reviewed Original ResearchΕ4 carrier statusAlzheimer's diseasePathogenesis of ADCarrier statusAPOE ε4 carrier statusAD diagnostic criteriaNeuropathological changesNeuropathological criteriaAD developmentBlood measuresDiagnostic criteriaAD riskBrain samplesBrain tissueClinical diagnosisNovel predictorCortical measuresDiseaseMolecular changesRecent evidenceSignificant differencesBlood tissueBloodDNA methylation agingDNA methylation clock