Endothelium-Dependent Regulation of Coronary Tone in the Neonatal Pig.
McGowan FX, Davis PJ, del Nido PJ, Sobek M, Allen JW, Downing SE. Endothelium-Dependent Regulation of Coronary Tone in the Neonatal Pig. Anesthesia & Analgesia 1994, 79: 1094. PMID: 7978431, DOI: 10.1213/00000539-199412000-00012.Peer-Reviewed Original ResearchConceptsCoronary perfusion pressureCoronary vasodilationCoronary toneEndothelin-1Baseline coronary perfusion pressureGuanylate cyclaseEndothelium-independent vasodilationNeonatal pig heartsEndothelium-dependent responsesSmooth muscle guanylate cyclaseL-arginine supplementationGlobal normothermic ischemiaMin of reperfusionBasal coronary toneEndothelium-dependent regulationCyclooxygenase inhibitor indomethacinNitric oxide synthaseSmooth muscle relaxationBasal NO productionNitric oxide synthesisCoronary vasoconstrictionVasoconstrictor responsesBasal toneVasodilatory responseL-NMMAATP gated potassium channels in acute myocardial hibernation and reperfusion
Offstad J, Kirkebøen K, Ilebekk A, Downing S. ATP gated potassium channels in acute myocardial hibernation and reperfusion. Cardiovascular Research 1994, 28: 872-880. PMID: 7923294, DOI: 10.1093/cvr/28.6.872.Peer-Reviewed Original ResearchConceptsVentricular systolic pressureLeft ventricular systolic pressurePerfusion-contraction matchingLow-flow ischaemiaSystolic pressurePiglet heartsPerfusion pressureIsolated rabbit heartRabbit heartsKATP channelsFlow ischaemiaRed blood cellsH reperfusionCoronary flowAcute hibernationKATP channel antagonist glibenclamideCoronary blood flow regulationBlood cellsPotassium channelsChannel antagonist glibenclamideEffects of aprikalimKATP channel modulationCoronary vascular toneAdenosine receptor blockadeAdenosine receptor antagonism