1995
Modulation of systolic and diastolic function by endothelin‐1: relation to coronary flow
OFFSTAD J, TØNNESSEN T, KIRKEBØEN KA, ILEBEKK A, DOWNING SE. Modulation of systolic and diastolic function by endothelin‐1: relation to coronary flow. Acta Physiologica 1995, 154: 103-111. PMID: 7572206, DOI: 10.1111/j.1748-1716.1995.tb09892.x.Peer-Reviewed Original ResearchConceptsCoronary flowConstant perfusion pressureDiastolic stiffnessET-1Constant coronary flowDiastolic functionVentricular end-diastolic pressureVentricular systolic pressureEnd-diastolic pressureLeft ventricular functionEffects of endothelinPositive inotropic effectHaemodynamic alterationsSystolic functionPerfusion pressureSystolic pressureVentricular functionDiastolic pressureInotropic effectEndothelin-1Cardiac contractilityMmHg sCPP groupRat heartMmHg
1994
ATP gated potassium channels in acute myocardial hibernation and reperfusion
Offstad J, Kirkebøen K, Ilebekk A, Downing S. ATP gated potassium channels in acute myocardial hibernation and reperfusion. Cardiovascular Research 1994, 28: 872-880. PMID: 7923294, DOI: 10.1093/cvr/28.6.872.Peer-Reviewed Original ResearchConceptsVentricular systolic pressureLeft ventricular systolic pressurePerfusion-contraction matchingLow-flow ischaemiaSystolic pressurePiglet heartsPerfusion pressureIsolated rabbit heartRabbit heartsKATP channelsFlow ischaemiaRed blood cellsH reperfusionCoronary flowAcute hibernationKATP channel antagonist glibenclamideCoronary blood flow regulationBlood cellsPotassium channelsChannel antagonist glibenclamideEffects of aprikalimKATP channel modulationCoronary vascular toneAdenosine receptor blockadeAdenosine receptor antagonism