Endothelium-Dependent Regulation of Coronary Tone in the Neonatal Pig.
McGowan FX, Davis PJ, del Nido PJ, Sobek M, Allen JW, Downing SE. Endothelium-Dependent Regulation of Coronary Tone in the Neonatal Pig. Anesthesia & Analgesia 1994, 79: 1094. PMID: 7978431, DOI: 10.1213/00000539-199412000-00012.Peer-Reviewed Original ResearchConceptsCoronary perfusion pressureCoronary vasodilationCoronary toneEndothelin-1Baseline coronary perfusion pressureGuanylate cyclaseEndothelium-independent vasodilationNeonatal pig heartsEndothelium-dependent responsesSmooth muscle guanylate cyclaseL-arginine supplementationGlobal normothermic ischemiaMin of reperfusionBasal coronary toneEndothelium-dependent regulationCyclooxygenase inhibitor indomethacinNitric oxide synthaseSmooth muscle relaxationBasal NO productionNitric oxide synthesisCoronary vasoconstrictionVasoconstrictor responsesBasal toneVasodilatory responseL-NMMA