1995
Modulation of systolic and diastolic function by endothelin‐1: relation to coronary flow
OFFSTAD J, TØNNESSEN T, KIRKEBØEN KA, ILEBEKK A, DOWNING SE. Modulation of systolic and diastolic function by endothelin‐1: relation to coronary flow. Acta Physiologica 1995, 154: 103-111. PMID: 7572206, DOI: 10.1111/j.1748-1716.1995.tb09892.x.Peer-Reviewed Original ResearchConceptsCoronary flowConstant perfusion pressureDiastolic stiffnessET-1Constant coronary flowDiastolic functionVentricular end-diastolic pressureVentricular systolic pressureEnd-diastolic pressureLeft ventricular functionEffects of endothelinPositive inotropic effectHaemodynamic alterationsSystolic functionPerfusion pressureSystolic pressureVentricular functionDiastolic pressureInotropic effectEndothelin-1Cardiac contractilityMmHg sCPP groupRat heartMmHg
1994
Endothelium-Dependent Regulation of Coronary Tone in the Neonatal Pig.
McGowan FX, Davis PJ, del Nido PJ, Sobek M, Allen JW, Downing SE. Endothelium-Dependent Regulation of Coronary Tone in the Neonatal Pig. Anesthesia & Analgesia 1994, 79: 1094. PMID: 7978431, DOI: 10.1213/00000539-199412000-00012.Peer-Reviewed Original ResearchConceptsCoronary perfusion pressureCoronary vasodilationCoronary toneEndothelin-1Baseline coronary perfusion pressureGuanylate cyclaseEndothelium-independent vasodilationNeonatal pig heartsEndothelium-dependent responsesSmooth muscle guanylate cyclaseL-arginine supplementationGlobal normothermic ischemiaMin of reperfusionBasal coronary toneEndothelium-dependent regulationCyclooxygenase inhibitor indomethacinNitric oxide synthaseSmooth muscle relaxationBasal NO productionNitric oxide synthesisCoronary vasoconstrictionVasoconstrictor responsesBasal toneVasodilatory responseL-NMMA