A phase 3 randomized trial of sulopenem vs. ertapenem in patients with complicated intraabdominal infections
Dunne M, Aronin S, Das A, Akinapelli K, Breen J, Zelasky M, Puttagunta S. A phase 3 randomized trial of sulopenem vs. ertapenem in patients with complicated intraabdominal infections. Clinical Microbiology And Infection 2024 PMID: 39491784, DOI: 10.1016/j.cmi.2024.10.025.Peer-Reviewed Original ResearchComplicated intraabdominal infectionsIntraabdominal infectionsPhase 3 randomized trialErtapenem-treated patientsClinical success rateRandomized to 5Confidence intervalsNon-inferiority marginOral regimensAmoxicillin-clavulanateClinical responsePrimary endpointTreatment armsIsolated pathogensTreatment durationHospitalized adultsErtapenemB. fragilisPatientsSuccess rateSulopenemInfectionEndpointTreatment differencesDays