Mycobacterium tuberculosis Gene Expression Associated With Fluoroquinolone Resistance and Efflux Pump Inhibition
van der Heijden Y, Maruri F, Blackman A, Morrison R, Guo Y, Sterling T. Mycobacterium tuberculosis Gene Expression Associated With Fluoroquinolone Resistance and Efflux Pump Inhibition. The Journal Of Infectious Diseases 2023, 228: 469-478. PMID: 37079382, PMCID: PMC10428193, DOI: 10.1093/infdis/jiad112.Peer-Reviewed Original ResearchMeSH KeywordsAntitubercular AgentsDrug Resistance, BacterialFluoroquinolonesGene ExpressionMicrobial Sensitivity TestsMycobacterium tuberculosisOfloxacinVerapamilConceptsExpression quantitative trait lociExpression quantitative trait loci analysisOfloxacin minimum inhibitory concentrationMinimum inhibitory concentrationWhole-genome sequencingRNA-seqEfflux pump inhibitionMTB isolatesGene expressionAllele frequency differencesQuantitative trait lociFluoroquinolone resistanceFold changePump inhibitionGenome sequenceFluoroquinolone-resistant Mycobacterium tuberculosisTrait lociRegulated genesAntituberculosis drug resistanceRNA sequencingEfflux pumpsEfflux pump inhibitor verapamilIncreased gene expressionGenesInhibitory concentration