Structure-guided design of VAR2CSA-based immunogens and a cocktail strategy for a placental malaria vaccine
Ma R, Salinas N, Orr-Gonzalez S, Richardson B, Ouahes T, Torano H, Jenkins B, Dickey T, Neal J, Duan J, Morrison R, Gittis A, Doritchamou J, Zaidi I, Lambert L, Duffy P, Tolia N. Structure-guided design of VAR2CSA-based immunogens and a cocktail strategy for a placental malaria vaccine. PLOS Pathogens 2024, 20: e1011879. PMID: 38437239, PMCID: PMC10939253, DOI: 10.1371/journal.ppat.1011879.Peer-Reviewed Original ResearchConceptsPlacental malaria vaccinesMalaria vaccineAccumulation of Plasmodium falciparum-infected erythrocytesInfected erythrocytesAccumulation of infected erythrocytesPlasmodium falciparum-infected erythrocytesChondroitin sulfate AMalaria vaccine antigensFalciparum-infected erythrocytesLow birth weightPlacental malariaMaternal anemiaPlacental accumulationVAR2CSABirth weightDesign immunogensPregnancy lossVaccination strategiesVaccine antigensStable immunogensImmunogenicityCocktail strategyPrevent adhesionStructure-guided designAntibodies