A novel locus in CSMD1 gene is associated with increased susceptibility to severe malaria in Malian children
Damena D, Barry A, Morrison R, Gaoussou S, Mahamar A, Attaher O, Issiaka D, Dicko Y, Dicko A, Duffy P, Fried M. A novel locus in CSMD1 gene is associated with increased susceptibility to severe malaria in Malian children. Frontiers In Genetics 2024, 15: 1390786. PMID: 38854427, PMCID: PMC11157005, DOI: 10.3389/fgene.2024.1390786.Peer-Reviewed Original ResearchGenome-wide association studiesSingle nucleotide polymorphismsMinor allele frequencySevere malariaMalian childrenLinkage disequilibriumAssociated with increased susceptibility to malariaCSMD1 geneSusceptibility to severe malariaMalaria disease severityPlasmodium falciparum malariaSusceptibility to malariaHost genetic factorsAssociated with protectionAssociated with increased oddsRecessive mode of inheritanceLogistic regression analysisFalciparum malariaMalaria pathogenesisMode of inheritanceGWA studiesClinical presentationOdds of SMAssociation studiesCandidate genes