2024
Humanized dopamine D4.7 receptor male mice display risk‐taking behavior and deficits of social recognition and working memory in light/dark‐dependent manner
Alachkar A, Phan A, Dabbous T, Alhassen S, Alhassen W, Reynolds B, Rubinstein M, Ferré S, Civelli O. Humanized dopamine D4.7 receptor male mice display risk‐taking behavior and deficits of social recognition and working memory in light/dark‐dependent manner. Journal Of Neuroscience Research 2024, 102: e25299. PMID: 38361407, PMCID: PMC11503891, DOI: 10.1002/jnr.25299.Peer-Reviewed Original ResearchConceptsPsychiatric disordersBehavioral phenotypesImpaired social recognition memoryEtiology of psychiatric disordersAttention-deficit hyperactivity disorderDopamine D<sub>4</sub> receptor (DWorking memory deficitsSocial recognition memoryDark phaseRisk-taking behaviorRecognition memoryWorking memoryMemory deficitsR miceIncreased risk behaviorSocial recognitionSpecific behaviorsBehavioral featuresDisordersMale miceDopaminePotential causal relationshipRisk behaviorsLight phaseDeficits
2002
Disruption of the D2 Dopamine Receptor Alters GH and IGF-I Secretion and Causes Dwarfism in Male Mice
Díaz-Torga G, Feierstein C, Libertun C, Gelman D, Kelly M, Low M, Rubinstein M, Becú-Villalobos D. Disruption of the D2 Dopamine Receptor Alters GH and IGF-I Secretion and Causes Dwarfism in Male Mice. Endocrinology 2002, 143: 1270-1279. DOI: 10.1210/en.143.4.1270.Peer-Reviewed Original ResearchKnockout miceMale miceD2 receptorsIGF-IGHRH-GH-IGF-I axisIGF-binding protein-3 levelsLoss of D2 receptorsGH-IGF-I axisD2R antagonist sulpirideD2R-/- miceBasal GH releaseKnockout male miceDopamine D2 receptorsIGF-I secretionSerum GH concentrationsWild-type miceAdult knockout miceImpaired body growthRate of skeletal maturationMonths of lifeMonths of ageD2R-/-Somatotrope populationAntagonist sulpirideGH release