Disruption of the D2 Dopamine Receptor Alters GH and IGF-I Secretion and Causes Dwarfism in Male Mice
Díaz-Torga G, Feierstein C, Libertun C, Gelman D, Kelly M, Low M, Rubinstein M, Becú-Villalobos D. Disruption of the D2 Dopamine Receptor Alters GH and IGF-I Secretion and Causes Dwarfism in Male Mice. Endocrinology 2002, 143: 1270-1279. DOI: 10.1210/en.143.4.1270.Peer-Reviewed Original ResearchKnockout miceMale miceD2 receptorsIGF-IGHRH-GH-IGF-I axisIGF-binding protein-3 levelsLoss of D2 receptorsGH-IGF-I axisD2R antagonist sulpirideD2R-/- miceBasal GH releaseKnockout male miceDopamine D2 receptorsIGF-I secretionSerum GH concentrationsWild-type miceAdult knockout miceImpaired body growthRate of skeletal maturationMonths of lifeMonths of ageD2R-/-Somatotrope populationAntagonist sulpirideGH release