2024
Atypical Interpersonal Problem-Solving and Resting-state Functional Connectivity in Adolescents with Maltreatment Experience
Gerin M, Viding E, Puetz V, Armbruster-Genc D, Rankin G, McCrory E. Atypical Interpersonal Problem-Solving and Resting-state Functional Connectivity in Adolescents with Maltreatment Experience. Current Neuropharmacology 2024, 22: 290-301. PMID: 37818587, PMCID: PMC10788892, DOI: 10.2174/1570159x22666231002145440.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBrainChildGyrus CinguliHumansMagnetic Resonance ImagingMental DisordersMental HealthNeural PathwaysConceptsResting-state functional connectivityPosterior cingulate cortexMedial prefrontal cortexMental health symptomsMaltreatment experiencesSocial functioningLingual gyrusFunctional connectivityHealth symptomsInterpersonal problem-solving skillsRetrosplenial cortexElevated mental health symptomsDefault mode network hubInterpersonal problem solvingPoor social functioningAdverse environmental experiencesProblem-solving performanceNon-maltreated peersProblem-solving skillsExperiences of abuseSeed-based analysisNeurocognitive processingNeurocognitive functioningMental health disordersEarly adversity
2022
A genetically informed Registered Report on adverse childhood experiences and mental health
Baldwin J, Sallis H, Schoeler T, Taylor M, Kwong A, Tielbeek J, Barkhuizen W, Warrier V, Howe L, Danese A, McCrory E, Rijsdijk F, Larsson H, Lundström S, Karlsson R, Lichtenstein P, Munafò M, Pingault J. A genetically informed Registered Report on adverse childhood experiences and mental health. Nature Human Behaviour 2022, 7: 269-290. PMID: 36482079, PMCID: PMC7614239, DOI: 10.1038/s41562-022-01482-9.Peer-Reviewed Original ResearchMeSH KeywordsAdverse Childhood ExperiencesChildHumansMental DisordersMental HealthParentsRisk FactorsUnited StatesConceptsMental health problemsAdverse childhood experiencesHealth problemsElevated riskMental healthGenetic confoundingChildhood experiencesPsychiatric vulnerabilityGenetic riskHigher polygenic scoresConfoundingChildrenPrevious associationsRiskGene-environment correlationSmall increaseAssociationHealthReportPolygenic scoresSocial thinning and stress generation after childhood maltreatment: a neurocognitive social transactional model of psychiatric vulnerability
McCrory E, Foulkes L, Viding E. Social thinning and stress generation after childhood maltreatment: a neurocognitive social transactional model of psychiatric vulnerability. The Lancet Psychiatry 2022, 9: 828-837. PMID: 35926524, DOI: 10.1016/s2215-0366(22)00202-4.Peer-Reviewed Original ResearchConceptsTransactional modelChildhood maltreatmentNeurocognitive alterationsPsychiatric disordersQuantity of relationshipsIndividual's social networkSocial functioningSocial architecturePsychiatric vulnerabilityMaltreatmentSocial environmentExtant evidencePsychiatric riskNeurocognitive sequelaeSocial processesStress generationSocial networksDisorders
2019
Neurocognitive Adaptation and Mental Health Vulnerability Following Maltreatment: The Role of Social Functioning
McCrory E, Ogle J, Gerin M, Viding E. Neurocognitive Adaptation and Mental Health Vulnerability Following Maltreatment: The Role of Social Functioning. Child Maltreatment 2019, 24: 435-451. PMID: 30897955, DOI: 10.1177/1077559519830524.Peer-Reviewed Original ResearchConceptsSocial functioningEarly maltreatment experiencesMental health vulnerabilitiesMental health problemsNeurocognitive adaptationsEmotion regulationThreat processingStudy of childrenReward processingComputational psychiatryMental health disordersMaltreatment experiencesLatent vulnerabilityChildhood maltreatmentSocial supportFunctioningHealth disordersNeural functionMaltreatmentHealth vulnerabilityProcessingHealth problemsVulnerabilityKey findingsAdolescents
2017
Annual Research Review: Childhood maltreatment, latent vulnerability and the shift to preventative psychiatry – the contribution of functional brain imaging
McCrory E, Gerin M, Viding E. Annual Research Review: Childhood maltreatment, latent vulnerability and the shift to preventative psychiatry – the contribution of functional brain imaging. Journal Of Child Psychology And Psychiatry 2017, 58: 338-357. PMID: 28295339, PMCID: PMC6849838, DOI: 10.1111/jcpp.12713.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdolescent PsychiatryChildChild AbuseChild PsychiatryFunctional NeuroimagingHumansMental DisordersNeurocognitive DisordersConceptsAnterior cingulate cortexLatent vulnerabilityEmotion regulationThreat processingReward processingChildhood maltreatmentActive emotion regulationDorsal ACC activityReceipt of rewardAdverse caregiving environmentsFuture psychiatric disordersPsychiatric disordersFunctional brain imagingEffective preventative approachesEffortful processingExecutive controlStudy of childrenError monitoringPoor mental healthNeurocognitive domainsNeurocognitive functioningCaregiving environmentNeural responsesEarly neglectNeural responsiveness
2016
Disentangling the mental health impact of childhood abuse and neglect
Cecil C, Viding E, Fearon P, Glaser D, McCrory E. Disentangling the mental health impact of childhood abuse and neglect. Child Abuse & Neglect 2016, 63: 106-119. PMID: 27914236, DOI: 10.1016/j.chiabu.2016.11.024.Peer-Reviewed Original ResearchConceptsMental healthMaltreatment typesMain independent predictorsMental health impactMental health outcomesCommunity violence exposureIndependent predictorsTrauma-related symptomsOutcome measuresPsychiatric symptomsHigh-risk youthHealth outcomesPsychiatric symptomatologySocio-demographic variablesSymptom severityNeighbourhood deprivationViolence exposureChildhood abuseHealth impactsCommunity sampleSymptomsIndividual responsesSpecific effectsCurrent studyEmotional abuseEpigenetic signatures of childhood abuse and neglect: Implications for psychiatric vulnerability
Cecil C, Smith R, Walton E, Mill J, McCrory E, Viding E. Epigenetic signatures of childhood abuse and neglect: Implications for psychiatric vulnerability. Journal Of Psychiatric Research 2016, 83: 184-194. PMID: 27643477, DOI: 10.1016/j.jpsychires.2016.09.010.Peer-Reviewed Original ResearchConceptsEpigenetic signaturesDNA methylationBiological processesMethylomic variationUnique epigenetic signatureGene ontology analysisSpecific biological processesHigh-confidence associationsUnique methylation patternOrganismal growthOntology analysisEpigenetic processesMethylation patternsMolecular linkEpithelial cell samplesNeural developmentNovel insightsNovel potential biomarkersMethylationCell samplesStringent setPotential pathwaysGenomePotential biomarkersBuccal epithelial cell samples
2015
The theory of latent vulnerability: Reconceptualizing the link between childhood maltreatment and psychiatric disorder
McCrory E, Viding E. The theory of latent vulnerability: Reconceptualizing the link between childhood maltreatment and psychiatric disorder. Development And Psychopathology 2015, 27: 493-505. PMID: 25997767, DOI: 10.1017/s0954579415000115.Peer-Reviewed Original ResearchConceptsPsychiatric disordersMental health problemsLatent vulnerabilityPsychiatric riskHealth problemsClinical interventionsDisordersNeurocognitive domainsPrevention approachesChildhood maltreatmentIntervention opportunitiesRisk trajectoriesPsychiatry approachMemory processingInterventionThreat processingChildrenRiskVulnerable childrenMaltreatmentLong termLife spanRisk environmentMaltreating environment
2010
Heritable Variations in Gray Matter Concentration as a Potential Endophenotype for Psychopathic Traits
Rijsdijsk F, Viding E, De Brito S, Forgiarini M, Mechelli A, Jones AP, McCrory E. Heritable Variations in Gray Matter Concentration as a Potential Endophenotype for Psychopathic Traits. JAMA Psychiatry 2010, 67: 406-413. PMID: 20368516, DOI: 10.1001/archgenpsychiatry.2010.20.Peer-Reviewed Original Research