2023
A systematic review of childhood maltreatment and resting state functional connectivity
Gerin M, Viding E, Herringa R, Russell J, McCrory E. A systematic review of childhood maltreatment and resting state functional connectivity. Developmental Cognitive Neuroscience 2023, 64: 101322. PMID: 37952287, PMCID: PMC10665826, DOI: 10.1016/j.dcn.2023.101322.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityAnterior cingulate cortexFunctional connectivityCingulate cortexChildhood maltreatmentAltered functional connectivityState functional connectivityDorsal anterior cingulate cortexNegative psychiatric outcomesVentral anterior cingulate cortexDorsolateral prefrontal cortexRsFC alterationsAltered connectivityInclusion criteriaAmygdala connectivityNineteen studiesPsychiatric outcomesFuture symptomsSystematic reviewBrain regionsClinical disordersBrain circuitsAnterior insulaPrefrontal cortexMaltreatment exposure
2022
Altered reward and effort processing in children with maltreatment experience: a potential indicator of mental health vulnerability
Armbruster-Genç D, Valton V, Neil L, Vuong V, Freeman Z, Packer K, Kiffin M, Roiser J, Viding E, McCrory E. Altered reward and effort processing in children with maltreatment experience: a potential indicator of mental health vulnerability. Neuropsychopharmacology 2022, 47: 1063-1070. PMID: 35149765, PMCID: PMC8832084, DOI: 10.1038/s41386-022-01284-7.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingInternalizing symptomsHistory of maltreatmentAnterior cingulate cortexEffort processingEffort-based decision-making taskDecision-making taskEffort-based decisionElevated internalizing symptomsNon-maltreated childrenImpact of maltreatmentMental health vulnerabilitiesFuture internalizing symptomsNeural indicesACC activationAltered rewardBehavioral indicesMaltreatment experiencesLatent vulnerabilityCingulate cortexEffort sensitivityGroup differencesRewardMaltreatmentLongitudinal study
2018
Primary and Secondary Variants of Psychopathy in a Volunteer Sample Are Associated With Different Neurocognitive Mechanisms
Sethi A, McCrory E, Puetz V, Hoffmann F, Knodt A, Radtke S, Brigidi B, Hariri A, Viding E. Primary and Secondary Variants of Psychopathy in a Volunteer Sample Are Associated With Different Neurocognitive Mechanisms. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2018, 3: 1013-1021. PMID: 29752216, PMCID: PMC6185817, DOI: 10.1016/j.bpsc.2018.04.002.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexNeurocognitive mechanismsPsychopathic traitsPrimary psychopathySecondary psychopathyCingulate cortexEmotional face processing taskComparison groupDifferent neurocognitive mechanismsDistinct neural correlatesFace processing taskFunctional magnetic resonance imagingInferior parietal lobeVolunteer sampleAnger processingNeurocognitive correlatesInsula activityNeural correlatesNeural responsesAnxiety measuresNeural activationSecondary presentationLower anxietyPsychopathy groupHigh anxietyAn fMRI investigation of empathic processing in boys with conduct problems and varying levels of callous-unemotional traits
Sethi A, O'Nions E, McCrory E, Bird G, Viding E. An fMRI investigation of empathic processing in boys with conduct problems and varying levels of callous-unemotional traits. NeuroImage Clinical 2018, 18: 298-304. PMID: 29876250, PMCID: PMC5987797, DOI: 10.1016/j.nicl.2018.01.027.Peer-Reviewed Original ResearchConceptsCP/HCUMedial prefrontal cortexCallous-unemotional traitsConduct problemsOwn emotionsAnterior cingulate cortexAnterior insulaEmpathic processingAffective experienceConjunction analysisACC/medial prefrontal cortexBrain areasBayes factor analysisEmpathy deficitsFMRI investigationTD groupNeural responsesConjunction effectOne's feelingsLess empathyEmotionsPrefrontal cortexNeutral scenarioCingulate cortexOccipital cortex
2017
Annual Research Review: Childhood maltreatment, latent vulnerability and the shift to preventative psychiatry – the contribution of functional brain imaging
McCrory E, Gerin M, Viding E. Annual Research Review: Childhood maltreatment, latent vulnerability and the shift to preventative psychiatry – the contribution of functional brain imaging. Journal Of Child Psychology And Psychiatry 2017, 58: 338-357. PMID: 28295339, PMCID: PMC6849838, DOI: 10.1111/jcpp.12713.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexLatent vulnerabilityEmotion regulationThreat processingReward processingChildhood maltreatmentActive emotion regulationDorsal ACC activityReceipt of rewardAdverse caregiving environmentsFuture psychiatric disordersPsychiatric disordersFunctional brain imagingEffective preventative approachesEffortful processingExecutive controlStudy of childrenError monitoringPoor mental healthNeurocognitive domainsNeurocognitive functioningCaregiving environmentNeural responsesEarly neglectNeural responsiveness
2013
Association of Callous Traits with Reduced Neural Response to Others’ Pain in Children with Conduct Problems
Lockwood P, Sebastian C, McCrory E, Hyde Z, Gu X, De Brito S, Viding E. Association of Callous Traits with Reduced Neural Response to Others’ Pain in Children with Conduct Problems. Current Biology 2013, 23: 901-905. PMID: 23643836, PMCID: PMC3918856, DOI: 10.1016/j.cub.2013.04.018.Peer-Reviewed Original ResearchConceptsAnterior cingulate cortexFunctional magnetic resonance imagingConduct problemsNeural responsesAnterior insulaCallous traitsAdult psychopathyReduced blood oxygen level-dependent responsesAtypical neural responsesBlood oxygen level-dependent (BOLD) responseInferior frontal gyrusBilateral anterior insulaLevel-dependent responsesConsiderable societal costsEmpathic processingEmpathic deficitsEmpathic responsesFrontal gyrusAntisocial behaviorCingulate cortexACC responseEmpathyLarge samplePsychopathyNegative associationNeural responses to fearful eyes in children with conduct problems and varying levels of callous–unemotional traits
Sebastian C, McCrory E, Dadds M, Cecil C, Lockwood P, Hyde Z, De Brito S, Viding E. Neural responses to fearful eyes in children with conduct problems and varying levels of callous–unemotional traits. Psychological Medicine 2013, 44: 99-109. PMID: 23510564, DOI: 10.1017/s0033291713000482.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingSubgenual anterior cingulate cortexImportant translational implicationsNeural responsesAnterior cingulate cortexAmygdala responseMagnetic resonance imagingFearful eyesConduct problemsTrial participantsEye conditionsCingulate cortexCortex responsesResonance imagingEvidence baseAmygdala reactivityTranslational implicationsHeterogeneous groupTD controlsEyesChildrenFear recognition deficitsNeural levelParticipantsLow levels