Nuclear expression of survivin portends a poor prognosis in Merkel cell carcinoma
Kim J, McNiff JM. Nuclear expression of survivin portends a poor prognosis in Merkel cell carcinoma. Modern Pathology 2008, 21: 764-769. PMID: 18425079, DOI: 10.1038/modpathol.2008.61.Peer-Reviewed Original ResearchConceptsMerkel cell carcinomaCell carcinomaPoor prognosisInhibition of apoptosisCutaneous Merkel cell carcinomaMedian patient ageAggressive clinical courseExpression of survivinNuclear staining patternClinical coursePatient ageNormal human tissuesPrimary lesionAggressive malignancyFemale ratioClinical managementDifferent human cancersFetal organsStrong immunoreactivityCarcinomaNuclear expressionSurvivin expressionStaining patternExact regulatory mechanismNuclear subcellular localizationCircumscribed palmar hypokeratosis: two cases and a review of the literature
Barry CI, Glusac EJ, Kashgarian M, Gwin K, McNiff JM. Circumscribed palmar hypokeratosis: two cases and a review of the literature. Journal Of Cutaneous Pathology 2008, 35: 484-487. PMID: 18399810, DOI: 10.1111/j.1600-0560.2007.00835.x.Peer-Reviewed Original ResearchCD8+ but not CD4+ T cells require cognate interactions with target tissues to mediate GVHD across only minor H antigens, whereas both CD4+ and CD8+ T cells require direct leukemic contact to mediate GVL
Matte-Martone C, Liu J, Jain D, McNiff J, Shlomchik WD. CD8+ but not CD4+ T cells require cognate interactions with target tissues to mediate GVHD across only minor H antigens, whereas both CD4+ and CD8+ T cells require direct leukemic contact to mediate GVL. Blood 2008, 111: 3884-3892. PMID: 18223170, PMCID: PMC2275040, DOI: 10.1182/blood-2007-11-125294.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesDisease Models, AnimalGraft vs Host DiseaseGraft vs Leukemia EffectHistocompatibility Antigens Class IHistocompatibility Antigens Class IIHumansLeukemia, Myelogenous, Chronic, BCR-ABL PositiveMiceMice, KnockoutMinor Histocompatibility AntigensReceptors, Antigen, T-CellStem Cell TransplantationTransplantation ChimeraTransplantation, HomologousConceptsCD4 cellsT cellsT cell antigen receptorAllogeneic stem cell transplantationMajor histocompatibility complex class IDirect cytolytic actionDistinct effector mechanismsDonor CD4 cellsDonor T cellsStem cell transplantationHistocompatibility complex class IMinor H antigensClass II moleculesComplex class IHost diseaseBCR-ABL cDNAGVHDEffector mechanismsMouse modelCML cellsBone marrowCognate interactionNoncytolytic pathwaysCD8Cytolytic action