Nuclear expression of survivin portends a poor prognosis in Merkel cell carcinoma
Kim J, McNiff JM. Nuclear expression of survivin portends a poor prognosis in Merkel cell carcinoma. Modern Pathology 2008, 21: 764-769. PMID: 18425079, DOI: 10.1038/modpathol.2008.61.Peer-Reviewed Original ResearchConceptsMerkel cell carcinomaCell carcinomaPoor prognosisInhibition of apoptosisCutaneous Merkel cell carcinomaMedian patient ageAggressive clinical courseExpression of survivinNuclear staining patternClinical coursePatient ageNormal human tissuesPrimary lesionAggressive malignancyFemale ratioClinical managementDifferent human cancersFetal organsStrong immunoreactivityCarcinomaNuclear expressionSurvivin expressionStaining patternExact regulatory mechanismNuclear subcellular localization