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John Rose, PhD

Professor Emeritus of Pathology and Senior Research Scientist
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Additional Titles

Director, Molecular Virology Program

About

Titles

Professor Emeritus of Pathology and Senior Research Scientist

Director, Molecular Virology Program

Biography

Dr. Rose earned his Ph.D. at Stanford University in 1973 in the laboratory of Dr. Charles Yanofsky. His thesis research focused on regulation of the tryptophan operon of E. coli. He then did postdoctoral research at MIT in the laboratories of Drs. David Baltimore and Harvey Lodish, where he began work on eucaryotic RNA viruses. In 1978, Dr. Rose took a faculty position at the Salk Institute, where he continued work on RNA virus transcription, as well as structure, function, and transport of the vesicular stomatitis virus (VSV) glycoprotein. In 1986, he moved to become Professor of Pathology and Cell Biology at Yale University School of Medicine. In 1994, his laboratory developed a system for recovering non-segmented, negative-strand RNA viruses from DNA plasmids. His work at Yale during the past fifteen years has focused largely on new approaches to vaccine development using vectors based on recombinant VSV and other viral replicons. This work has led to development of robust vaccine platforms that can protect animals against numerous viral and bacterial pathogens, typically after a single dose. A VSV-based HIV vaccine advanced from the Rose laboratory has recently completed a successful Phase I clinical trial.

Appointments

Education & Training

Fellow
Massachusetts Institute of Technology (1978)
PhD
Stanford University (1973)
BS
Brandeis University (1969)

Research

Overview

Vaccine development employing vectors based on recombinant negative-strand RNA viruses. Assembly of enveloped viruses. Specific targeting of viral vectors. Intracellular transport and targeting of viral and cellular membrane proteins.

Medical Subject Headings (MeSH)

Pathology; Virology

Research at a Glance

Yale Co-Authors

Frequent collaborators of John Rose's published research.

Publications

2014

2008

2003

2001

2000

Academic Achievements & Community Involvement

  • honor

    National Institutes of Health MERIT award, 2003-2012

  • honor

    National Institutes of Health MERIT award, 1986-1996

Get In Touch

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