Lindsay McAlpine, MD, BSc
she/her/hers
Assistant Professor
Research & Publications
Biography
News
Research Summary
My research interests are focused on understanding the neurological sequelae of COVID-19 using blood biomarkers, spinal fluid biomarkers, neuropsychological testing, and advanced MRI neuroimaging techniques, including vascular and functional imaging.
Contact: mcalpine.lab@yale.edu
Coauthors
Research Interests
Central Nervous System; Cerebrovascular Circulation; Endothelium, Vascular; Magnetic Resonance Imaging; Magnetic Resonance Angiography; Diffusion Magnetic Resonance Imaging; Cognitive Neuroscience; Post-Acute COVID-19 Syndrome
Public Health Interests
Chronic Diseases; Emerging Infectious Diseases; Infectious Diseases; COVID-19
Selected Publications
- Ischemic Stroke, Inflammation, and Endotheliopathy in COVID-19 PatientsMcAlpine LS, Zubair AS, Maran I, Chojecka P, Lleva P, Jasne AS, Navaratnam D, Matouk C, Schindler J, Sheth KN, Chun H, Lee AI, Spudich S, Sharma R, Sansing LH. Ischemic Stroke, Inflammation, and Endotheliopathy in COVID-19 Patients. Stroke 2021, 52: e233-e238. PMID: 33966492, PMCID: PMC8140646, DOI: 10.1161/strokeaha.120.031971.
- Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptomsSong E, Bartley CM, Chow RD, Ngo TT, Jiang R, Zamecnik CR, Dandekar R, Loudermilk RP, Dai Y, Liu F, Sunshine S, Liu J, Wu W, Hawes IA, Alvarenga BD, Huynh T, McAlpine L, Rahman NT, Geng B, Chiarella J, Goldman-Israelow B, Vogels CBF, Grubaugh ND, Casanovas-Massana A, Phinney BS, Salemi M, Alexander JR, Gallego JA, Lencz T, Walsh H, Wapniarski AE, Mohanty S, Lucas C, Klein J, Mao T, Oh J, Ring A, Spudich S, Ko AI, Kleinstein SH, Pak J, DeRisi JL, Iwasaki A, Pleasure SJ, Wilson MR, Farhadian SF. Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms. Cell Reports Medicine 2021, 2: 100288. PMID: 33969321, PMCID: PMC8091032, DOI: 10.1016/j.xcrm.2021.100288.
- Isolated Encephalopathy Without Severe Disease in a COVID-19 Patient: Case Presentation and Workup StrategiesMcAlpine LS, Barden M, Zubair AS, Sanamandra S. Isolated Encephalopathy Without Severe Disease in a COVID-19 Patient: Case Presentation and Workup Strategies. Cureus 2021, 13: e13277. PMID: 33728212, PMCID: PMC7955529, DOI: 10.7759/cureus.13277.
- Coronavirus disease 2019 and neurodegenerative disease: what will the future bring?McAlpine LS, Fesharaki-Zadeh A, Spudich S. Coronavirus disease 2019 and neurodegenerative disease: what will the future bring? Current Opinion In Psychiatry 2020, 34: 177-185. PMID: 33395100, PMCID: PMC7924921, DOI: 10.1097/yco.0000000000000688.
- Lessons from a neurology consult service for patients with COVID-19McAlpine LS, Zubair AS, Moeller J, Baehring J, Spudich S. Lessons from a neurology consult service for patients with COVID-19. The Lancet Neurology 2020, 19: 806-807. PMID: 32949536, PMCID: PMC7494315, DOI: 10.1016/s1474-4422(20)30316-1.
- Neuropathogenesis and Neurologic Manifestations of the Coronaviruses in the Age of Coronavirus Disease 2019Zubair AS, McAlpine LS, Gardin T, Farhadian S, Kuruvilla DE, Spudich S. Neuropathogenesis and Neurologic Manifestations of the Coronaviruses in the Age of Coronavirus Disease 2019. JAMA Neurology 2020, 77: 1018-1027. PMID: 32469387, PMCID: PMC7484225, DOI: 10.1001/jamaneurol.2020.2065.
Clinical Trials
Conditions | Study Title |
---|---|
COVID-19 Outpatient | Are you are currently experiencing brain fog from Long COVID? |
Diseases of the Nervous System | The Brain Shuttle Study |