Seth Herzon, PhD

2024

• Colibactin Exerts Androgen-dependent and -independent Effects on Prostate Cancer

  Agrawal R, Al-Hiyari S, Hugh-White R, Hromas R, Patel Y, Williamson E, Mootor M, Gonzalez A, Fu J, Haas R, Jordan M, Wickes B, Mohammed G, Tian M, Doris M, Jobin C, Wernke K, Pan Y, Yamaguchi T, Herzon S, Boutros P, Liss M. Colibactin Exerts Androgen-dependent and -independent Effects on Prostate Cancer. European Urology Oncology 2024 PMID: 39547899, DOI: 10.1016/j.euo.2024.10.015.

  Peer-Reviewed Original Research

  Concepts

• Intramolecular oxyalkylation of unactivated alkenes

  Xu Z, Airan Y, Tomanik M, Yang A, Bhak N, Herzon S. Intramolecular oxyalkylation of unactivated alkenes. Tetrahedron 2024, 161: 134070. PMID: 38911481, PMCID: PMC11192504, DOI: 10.1016/j.tet.2024.134070.

  Peer-Reviewed Original Research

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• Mechanism of Action of KL-50, a Candidate Imidazotetrazine for the Treatment of Drug-Resistant Brain Cancers

  Huseman E, Lo A, Fedorova O, Elia J, Gueble S, Lin K, Sundaram R, Oh J, Liu J, Menges F, Rees M, Ronan M, Roth J, Batista V, Crawford J, Pyle A, Bindra R, Herzon S. Mechanism of Action of KL-50, a Candidate Imidazotetrazine for the Treatment of Drug-Resistant Brain Cancers. Journal Of The American Chemical Society 2024, 146: 18241-18252. PMID: 38815248, PMCID: PMC11409917, DOI: 10.1021/jacs.3c06483.

  Peer-Reviewed Original Research

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• 1073 GENOME-SCALE CRISPR/CAS9 SCREENING REVEALS THE ROLE OF PSMD4 IN COLIBACTIN-MEDIATED CELL CYCLE ARREST

  Dougherty M, Hoffmann R, Airan Y, Gharaibeh R, Herzon S, Yang Y, Jobin C. 1073 GENOME-SCALE CRISPR/CAS9 SCREENING REVEALS THE ROLE OF PSMD4 IN COLIBACTIN-MEDIATED CELL CYCLE ARREST. Gastroenterology 2024, 166: s-253. DOI: 10.1016/s0016-5085(24)01066-7.

  Peer-Reviewed Original Research

  Concepts

• An oxidative photocyclization approach to the synthesis of Securiflustra securifrons alkaloids

  Alexander B, Bartfield N, Gupta V, Mercado B, Del Campo M, Herzon S. An oxidative photocyclization approach to the synthesis of Securiflustra securifrons alkaloids. Science 2024, 383: 849-854. PMID: 38386756, DOI: 10.1126/science.adl6163.

  Peer-Reviewed Original Research

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  MeSH Keywords and Concepts