Dhruva Biswas, MA, PhD, MBBS
Associate Research ScientistCards
Contact Info
Cardiovascular Medicine
300 George St
New Haven, Connecticut 06510
United States
Publications Overview
- 33 Publications
- 1,999 Citations
- 1 Yale Co-Author
Cardiovascular Data Science laboratory
Contact Info
Cardiovascular Medicine
300 George St
New Haven, Connecticut 06510
United States
Publications Overview
- 33 Publications
- 1,999 Citations
- 1 Yale Co-Author
Cardiovascular Data Science laboratory
Contact Info
Cardiovascular Medicine
300 George St
New Haven, Connecticut 06510
United States
Publications Overview
- 33 Publications
- 1,999 Citations
- 1 Yale Co-Author
Cardiovascular Data Science laboratory
About
Titles
Associate Research Scientist
Biography
Introduction
Dr. Biswas is a Clinician-Data Scientist at the Cardiovascular Data Science (CarDS) Lab and an Associate Research Scientist at the Yale School of Medicine.
His research aims to integrate AI-driven insights into clinical practice. This includes developing digital and molecular biomarkers to identify high-risk patients who are currently overlooked, evaluating the clinical contexts in which algorithm performance may be improved, and depicting the underlying pathophysiological mechanisms.
Dr. Biswas has authored publications in several peer-reviewed journals, including first author articles in Nature Medicine, Nature Cancer, and JACC Advances. His work has been featured in media outlets including The Times, the Independent, and Yahoo News UK. He has been recognized as ‘at the forefront of medical research’ Nature Medicine ’19.
Background
Dr. Biswas started his medical training at the University of Cambridge in 2012, taking a MA in Neuroscience in 2015. His undergraduate research was recognized with the international Rob Clarke Presentation Gold award.
Next, he joined the MB/PhD programme at University College London. As a Jean Shanks Foundation MB-PhD grant awardee, he undertook PhD research between UCL Cancer Institute and the Francis Crick Institute. His thesis work was recognized with international prizes including the F1000 Outstanding Presentation Prize and the Clinical & Experimental Metastasis Poster Prize. He was also recognized with the Sir David Cooksey Translation Prize for exceptional contribution to the Francis Crick Institute’s COVID-19 diagnostic testing pipeline, and as a Francis Crick Institute Translation Fellow for acting as a role model in the translational medicine community. He graduated with PhD and MBBS degrees in 2022.
Dr. Biswas then secured an Academic Foundation training position in the Cardiology stream at King’s College London. During his two-year medical internship, he received a Medical Leadership Award for outstanding contributions and the Isaac Schapera Award for research at University of London medical schools, as well as working part-time as a Postdoctoral Fellow at University College London.
Mentorship and community engagement
In addition to his research and clinical duties, Dr. Biswas is passionate about mentoring the next generation of scientists. He has supervised several MSc projects, with all achieving distinction grades, and three nominated for the Dean's Research Prize for the top project mark in their respective cohorts. He is also committed to patient and public involvement, including helping to host Meet a Scientist events at the Francis Crick Institute, and being involved with the South London structural heart team looking at equity of access to life-prolonging procedures.
Appointments
Departments & Organizations
Education & Training
- Postdoctoral Fellow
- University College London
- Translation Fellow
- The Francis Crick Institute
- Academic Foundation Doctor
- King's College London
- MBBS
- University College London (2022)
- PhD
- UCL Cancer Institute & The Francis Crick Institute, Molecular Portraits of Cancer Evolution and Ecology (2020)
- MA
- University of Cambridge, Medical Sciences Tripos (Specialization in Physiology, Development & Neuroscience) (2015)
Research
Overview
Medical Subject Headings (MeSH)
ORCID
0000-0001-9141-5188- View Lab Website
Cardiovascular Data Science laboratory
Research at a Glance
Publications Timeline
Research Interests
Artificial Intelligence
Publications
Featured Publications
A clonal expression biomarker associates with lung cancer mortality
Biswas D, Birkbak N, Rosenthal R, Hiley C, Lim E, Papp K, Boeing S, Krzystanek M, Djureinovic D, La Fleur L, Greco M, Döme B, Fillinger J, Brunnström H, Wu Y, Moore D, Skrzypski M, Abbosh C, Litchfield K, Al Bakir M, Watkins T, Veeriah S, Wilson G, Jamal-Hanjani M, Moldvay J, Botling J, Chinnaiyan A, Micke P, Hackshaw A, Bartek J, Csabai I, Szallasi Z, Herrero J, McGranahan N, Swanton C. A clonal expression biomarker associates with lung cancer mortality. Nature Medicine 2019, 25: 1540-1548. PMID: 31591602, PMCID: PMC6984959, DOI: 10.1038/s41591-019-0595-z.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsNon-small cell lung cancerClinicopathological risk factorsCell lung cancerLung cancer mortalityPrognostic gene expression signaturesCancer cell proliferationGene expression signaturesCancer mortalityLung cancerRisk factorsExpression-based biomarkersCopy number gainsDisease subtypesClinical descriptorsTranscriptomic biomarkersIndividual tumorsCancer typesDiagnostic precisionMolecular biomarkersExpression signaturesCell proliferationDNA copy number gainsBiomarkersPatientsIntratumor heterogeneityA local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer
Wu Y, Biswas D, Usaite I, Angelova M, Boeing S, Karasaki T, Veeriah S, Czyzewska-Khan J, Morton C, Joseph M, Hessey S, Reading J, Georgiou A, Al-Bakir M, McGranahan N, Jamal-Hanjani M, Hackshaw A, Quezada S, Hayday A, Swanton C. A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer. Nature Cancer 2022, 3: 696-709. PMID: 35637401, PMCID: PMC9236901, DOI: 10.1038/s43018-022-00376-z.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsT cell populationsT cellsLung tissueLung cancerCD8+ T cellsNonsmall-cell lung cancerNonsmall cell lung cancerEffector memory phenotypeT cell compartmentCell lung cancerAssociated with survivalNonmalignant lung tissuesStem-like featuresNontumor lung tissuesT cell biologyHuman lung tissueImmunotherapeutic strategiesMemory phenotypeNatural killerLung tumorsTissue-residentPost-surgeryResident memoryMurine tissuesTumorRace- and Ethnicity-Related Differences in Heart Failure With Preserved Ejection Fraction Using Natural Language Processing
Brown S, Biswas D, Wu J, Ryan M, Bernstein B, Fairhurst N, Kaye G, Baral R, Cannata A, Searle T, Melikian N, Sado D, Lüscher T, Teo J, Dobson R, Bromage D, McDonagh T, Vazir A, Shah A, O’Gallagher K. Race- and Ethnicity-Related Differences in Heart Failure With Preserved Ejection Fraction Using Natural Language Processing. JACC Advances 2024, 3: 101064. PMID: 39050815, PMCID: PMC11268103, DOI: 10.1016/j.jacadv.2024.101064.Peer-Reviewed Original ResearchCitationsAltmetricConceptsBlack patientsPro-B-type natriuretic peptide levelsN-terminal pro-B-type natriuretic peptide levelsEuropean Society of Cardiology criteriaDiagnosis of HFpEFNatriuretic peptide levelsHeterogeneous clinical syndromeEuropean SocietyCardiology criteriaHFpEF diagnosisClinical presentationFPEF scoreAsian patientsPatient demographicsEthnicity-related differencesMetabolic comorbiditiesAtrial fibrillationHeart failureHFpEFDiagnostic performancePeptide levelsWhite patientsClinical syndromePatientsQuantify health inequalitiesThe future of liquid biopsy
Biswas D, Ganeshalingam J, Wan J. The future of liquid biopsy. The Lancet Oncology 2020, 21: e550. PMID: 33271107, DOI: 10.1016/s1470-2045(20)30687-2.Peer-Reviewed Original ResearchCitationsAltmetric
2024
Cancer cell – Fibroblast crosstalk via HB-EGF, EGFR, and MAPK signaling promotes the expression of macrophage chemo-attractants in squamous cell carcinoma
Giangreco G, Rullan A, Naito Y, Biswas D, Liu Y, Hooper S, Nenclares P, Bhide S, Chon U Cheang M, Chakravarty P, Hirata E, Swanton C, Melcher A, Harrington K, Sahai E. Cancer cell – Fibroblast crosstalk via HB-EGF, EGFR, and MAPK signaling promotes the expression of macrophage chemo-attractants in squamous cell carcinoma. IScience 2024, 27: 110635. PMID: 39262776, PMCID: PMC11387794, DOI: 10.1016/j.isci.2024.110635.Peer-Reviewed Original ResearchConceptsTumor microenvironmentSquamous cell carcinoma cohortCancer cellsMacrophage chemo-attractantsSquamous cell carcinomaTumor-stroma crosstalkRecruitment of macrophagesExpression of CSF2Prognostic significanceCarcinoma cohortCell carcinomaPatient prognosisHB-EGFStromal fibroblastsCancer outcomesCancer progressionCancerMAPK signalingIndicator of signalingChemo-attractantsCellsFibroblastsCarcinomaExpressionEGFR134 Race and ethnicity-related differences in the diagnosis of heart failure with preserved ejection fraction using natural language processing
Brown S, Biswas D, Wu H, Ryan M, Bernstein B, Fairhurst N, Kaye G, Baral R, Cannata A, Searle T, Melikian N, Sado D, Lüscher T, Teo J, Dobson R, Bromage D, McDonagh T, Vazir A, Shah A, O’Gallagher K. 134 Race and ethnicity-related differences in the diagnosis of heart failure with preserved ejection fraction using natural language processing. 2024, a140-a141. DOI: 10.1136/heartjnl-2024-bcs.132.Peer-Reviewed Original ResearchConceptsArtificial intelligence methods for improved detection of undiagnosed heart failure with preserved ejection fraction
Wu J, Biswas D, Ryan M, Bernstein B, Rizvi M, Fairhurst N, Kaye G, Baral R, Searle T, Melikian N, Sado D, Lüscher T, Grocott‐Mason R, Carr‐White G, Teo J, Dobson R, Bromage D, McDonagh T, Shah A, O'Gallagher K. Artificial intelligence methods for improved detection of undiagnosed heart failure with preserved ejection fraction. European Journal Of Heart Failure 2024, 26: 302-310. PMID: 38152863, DOI: 10.1002/ejhf.3115.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsLeft ventricular ejection fractionDiagnosis of HFpEFEuropean Society of CardiologyHeart failureNatural language processingElectronic health recordsEuropean Society of Cardiology criteriaClinical diagnosis of HFEuropean Society of Cardiology diagnostic criteriaDiagnostic criteriaVentricular ejection fractionRetrospective cohort studyDiagnosis of HFSociety of CardiologyClinician-assigned diagnosisConsecutive patientsHFpEF patientsEjection fractionElectronic health record dataAcute cardiovascular eventsExpert clinical reviewNatural language processing methodsNatural language processing pipelineHFpEFCardiovascular eventsPD-1 defines a distinct, functional, tissue-adapted state in Vδ1+ T cells with implications for cancer immunotherapy
Davies D, Kamdar S, Woolf R, Zlatareva I, Iannitto M, Morton C, Haque Y, Martin H, Biswas D, Ndagire S, Munonyara M, Gillett C, O’Neill O, Nussbaumer O, Hayday A, Wu Y. PD-1 defines a distinct, functional, tissue-adapted state in Vδ1+ T cells with implications for cancer immunotherapy. Nature Cancer 2024, 5: 420-432. PMID: 38172341, PMCID: PMC10965442, DOI: 10.1038/s43018-023-00690-0.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCheckpoint inhibitionPD-1T cellsProgrammed cell death protein 1Cell death protein 1PD-1 expressionResponse to TCR signalingPD-1 engagementT cell recognitionCancer immunotherapyTCR signalingTranscriptomic programsProtein 1CancerFunctional relevanceCellsImmunotherapyNeoantigensMelanomaPatientsOncology
2023
Using natural language processing to generate a large-scale database of aortic stenosis with long-term follow-up: the CASPER (cogstack aortic stenosis patient electronic registry) database
Wu J, Biswas D, Seale T, Bean D, Fairhurst N, Kaye G, Dobson R, Chowienczyk P, Shah A, O'gallagher K. Using natural language processing to generate a large-scale database of aortic stenosis with long-term follow-up: the CASPER (cogstack aortic stenosis patient electronic registry) database. European Heart Journal 2023, 44: ehad655.2952. DOI: 10.1093/eurheartj/ehad655.2952.Peer-Reviewed Original ResearchAltmetricConceptsNatural language processingElectronic heath recordsLanguage processingData pipelineNatural language processing toolkitRetrieval systemProcessing toolkitSNOMED termsClinical notesAutomated detectionRandomised controlled trialsManual validationLong-term mortality dataCohort of AS patientsMortality dataData sourcesSocial deprivationPatient trajectoriesInfluence of ethnicityControlled trialsPatient demographic dataRandomised trialsExtract dataDatabaseDemographic dataAbstract 18205: Ethnicity and Aortic Stenosis: Presentation, Management and Outcomes
Biswas D, Wu J, Bharucha A, Fairhurst N, Kaye G, Baghai M, Dworakowski R, Byrne J, MacCarthy P, Shah A, Eskandari M, O'Gallagher K. Abstract 18205: Ethnicity and Aortic Stenosis: Presentation, Management and Outcomes. Circulation 2023, 148: a18205-a18205. DOI: 10.1161/circ.148.suppl_1.18205.Peer-Reviewed Original ResearchConceptsAortic valve replacementTranscatheter aortic valve implantationAsian patientsWhite patientsBlack patientsSevere ASAortic stenosisBenefit of transcatheter aortic valve implantationSurgical aortic valve replacementManagement of aortic stenosisCox multivariate analysisSocial deprivationManagement of ASAortic valve implantationTAVI interventionKing's College HospitalEthnicity-based differencesValve replacementCardiac symptomsCollege HospitalElectronic health recordsMortality benefitValve implantationMultivariate analysisAS diagnosis
Academic Achievements & Community Involvement
honor Medical Leadership Award for outstanding contribution
Regional AwardKing’s College HospitalDetails07/01/2024United Kingdomhonor Isaac Schapera Award for research into problems relating to the causes and cures of diseases
Regional AwardUniversity of London medical schoolsDetails05/01/2024United Kingdomhonor Translation Fellow for helping to create an outstanding translation community and acting as a role model for others
Regional AwardThe Francis Crick InstituteDetails12/01/2021United Kingdomhonor Sir David Cooksey Translation Prize Winner for exceptional contribution to the COVID-19 diagnostic testing pipeline
Regional AwardThe Francis Crick InstituteDetails11/01/2020United Kingdomhonor Astor Foundation travel bursary
Regional AwardUniversity College LondonDetails08/01/2019United Kingdom
News & Links
News
- November 05, 2024
Yale Researchers at American Heart Association Scientific Session 2024
- September 12, 2024
Welcome New Staff, Faculty, Fellows & Postdocs (September 2024)
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Cardiovascular Medicine
300 George St
New Haven, Connecticut 06510
United States
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195 Church Street
Lab
New Haven, CT 06510