About
Titles
Biostatistician
Biography
After earning my Bachelors of Science degree in Biostatistics from Emmanuel College in 2019, I earned my Masters of Science degree in Applied Statistics and Research Methods from the University of Northern Colorado in 2020. During my time as a student, I presented and completed many research works, including multiple presentations at the Biophysical Society Meeting and a Master's Thesis.
Within the Yale Center for Analytical Sciences, I now work as a Biostatistician to support both internal analytical projects, as well as clinical trial studies that often involve investigators outside of Yale.
I conduct analyses implementing statistics, biostatistics, and epidemiology on health research projects. I also provide consultation on the research design, data management, statistical programming, analysis, and reporting portions of each assignment.
A large portion of my work results in publications in peer-reviewed journals or presentations at conferences. Examples of work published in scientific journals include Blood, Menopause, Journal of Vascular Surgery, and more.
Education & Training
- MSc
- The University of Northern Colorado, Applied Statistics and Research Methods (2020)
- BSc
- Emmanuel College, Biostatistics (2019)
Research
Overview
Presentations
- Parziale, S. "Evaluating Player Performance Within the 50 Largest Contracts in MLB History". UCONN Sports Analytics Symposium, Storrs, CT, 2024
- Patki, R., Carpenter, T., Murari, K., Parziale, S., Deng, Y., Humbert, L., Lopez, M., Picazo, Insogna, K. "3D-DXA reveals dramatic effects of burosumab on trabecular and cortical envelopes in symptomatic adults with X-linked Hypophosphatemia". The American Society for Bone and Mineral Research, Vancouver, BC, Canada, 2023
- Parziale, S. "Implementing Biostatistical Methods within Sports Analytics using Propensity Score Matching". Colorado/Wyoming Chapter - American Statistical Association, Aurora, CO, 2023
- Adenu-Mensah, N., Antonios, J., Parziale ,S., Deng, Y., Sujijantarat, N., Koo, A., Nowicki, K., MD, Gilmore, E., Sheth, K., Matouk, C., Hebert, R. “Post-Operative Complications after Decompressive Hemicraniectomies for Large Hemispheric Strokes: An Institutional Analysis and Review”. Annual Northeast Cerebrovascular Summit, Boston, MA, 2023
- Insogna, K., Sullivan, R., Parziale, S., Deng, Y. “Effect of burosumab on muscle function and ATP muscle flux in young, treatment-naïve subjects with XLH”. Yale Phosphate Club, New Haven, CT, 2023
- Guarente, J., Hendrickson, J., Parziale, S., Li F., Tormey, C., Siddon, A. “SRSF2 or TET2 mutations in patients with MDS predict increased red blood cell alloimmunization”. American Society of Hematology, 2022
- Brahmandam, A., Kim, T., Parziale, S., Deng, Y., Setia, O., Tonnessen, B., Chaar, C., Guzman, R., Aboian , E. “Intravascular Ultrasound is Associated with Improved Patency in Peripheral Arterial Interventions”. Eastern Vascular Society, Philadelphia, PA, 2022
- Parziale, S. “Analyzing Home-Ice Efficacy in the National Hockey League”. UCONN Sports Analytics Symposium, Storrs, CT, 2022
- Parziale, S. “Introducing Common Techniques to Address Issues within Multiple Logistic Regression Analysis: A National Football League Case Study”. UCONN Sports Analytics Symposium, Storrs, CT, 2021
- Parziale, S. “Introducing Common Techniques to Address Issues within Multiple Logistic Regression Analysis: A National Football League Case Study”. University of Northern Colorado Research Evening, Greeley, CO, 2020
- Huang, Z., Parziale, S., Tocco A., Yu, Z.; Larkins, R. “The Dynamics of Ursus americanus Migration in Response to Colorado Forest Fires”. University of Northern Colorado Research Evening, Greeley, CO, 2019
- Parziale, S., Mehrtens, K., Ware, A., Matozel, E., Dale, N.; Price, A. “Using Single Molecule Methods to Study Mechanisms of Site Specific DNA Cleavage” Emmanuel College Summer Research Poster Session, Boston, MA, 2018
- Parziale, S., Mehrtens, K., Ware, A., Matozel, E., Dale, N.; Price, A. “Using Single Molecule Methods to Study Mechanisms of Site Specific DNA Cleavage” Biophysical Society Meeting, Baltimore, MD, 2019
- Ferreira, R., Piatt, S., Parziale, S.; Price, A. “Measuring the Kinetics of DNA Cleavage with Single- Molecule Resolution” Emmanuel College Summer Research Poster Session, Boston, MA, 2017
- Ferreira, R., Piatt, S., Parziale, S.; Price, A. “Measuring the Kinetics of DNA Cleavage with Single- Molecule Resolution” Biophysical Society Meeting, San Francisco, CA, 2018
Research at a Glance
Yale Co-Authors
Frequent collaborators of Stephen Parziale's published research.
Karl Insogna, MD, FACP
Anna Maria Santoro
Thomas Carpenter, MD
Britt Tonnessen, MD
Cassius Iyad Ochoa Chaar, MD, MPH, MS, RPVI
Edouard Aboian, MD
Publications
2024
Intravascular Ultrasound Use is Associated with Improved Patency in Lower Extremity Peripheral Arterial Interventions
Brahmandam A, Kim T, Parziale S, Deng Y, Setia O, Tonnessen B, Ochoa Chaar C, Guzman R, Aboian E. Intravascular Ultrasound Use is Associated with Improved Patency in Lower Extremity Peripheral Arterial Interventions. Annals Of Vascular Surgery 2024, 106: 410-418. PMID: 38810722, DOI: 10.1016/j.avsg.2024.03.008.Peer-Reviewed Original ResearchConceptsChronic limb-threatening ischemiaChronic limb threatening ischemia patientsGeneralized estimating equationsPeripheral vascular interventionsPeripheral arterial diseaseAssociated with improved patencyPredictors of 1-year outcomeIntravascular ultrasound useVascular Quality InitiativeSubgroup analysisAdjunctive useD lesionsTASC CPropensity matchingTreatment modalitiesTrans-Atlantic Inter-Society Consensus (TASC) classificationMajor amputationLimb-threatening ischemiaBalloon angioplastyIntravascular ultrasoundImproved patencyUltrasound useOne-year followQuality InitiativePredictors of patency
2023
Effect of Burosumab on Muscle Function and Strength, and Rates of ATP Synthesis in Skeletal Muscle in Adults With XLH
Insogna K, Sullivan R, Parziale S, Deng Y, Carrano D, Simpson C, Dufour S, Carpenter T, Petersen K. Effect of Burosumab on Muscle Function and Strength, and Rates of ATP Synthesis in Skeletal Muscle in Adults With XLH. The Journal Of Clinical Endocrinology & Metabolism 2023, 109: e1061-e1071. PMID: 37930769, DOI: 10.1210/clinem/dgad642.Peer-Reviewed Original ResearchConceptsSymptoms of painMuscle function testsFunction testsMuscle strengthMuscle functionSkeletal muscleLower extremity joint painSTS testMuscle function studiesImproved muscle functionTreatment-naïve adultsSynthesis rateMonths of studyJoint painThird doseSymptomatic adultsClinical trialsRight calfATP synthesis rateBurosumabPainMuscle concentrationsXLHSymptomsMuscleCirculating Levels of Leptin and Lipocalin-2 in Patients With X-Linked Hypophosphatemia
Simpson C, Santoro A, Carpenter T, Deng Y, Parziale S, Insogna K. Circulating Levels of Leptin and Lipocalin-2 in Patients With X-Linked Hypophosphatemia. Journal Of The Endocrine Society 2023, 7: bvad116. PMID: 37860221, PMCID: PMC10583534, DOI: 10.1210/jendso/bvad116.Peer-Reviewed Original ResearchCitationsAltmetricConceptsLipocalin-2Control subjectsGreater riskLevels of LCN2Excessive weight gainLevels of leptinSerum leptin levelsCirculating LevelsLCN2 levelsSerum levelsYear age cohortLeptin levelsMetabolic abnormalitiesRetrospective studyAge cohortsInsulin sensitivityHigh prevalencePatientsWeight gainXLHLeptinAge 2HypophosphatemiaObesityChildren
2022
Differing effects of oral conjugated equine estrogen and transdermal estradiol on vitamin D metabolism in postmenopausal women: a 4-year longitudinal study
Santoro AM, Simpson CA, Cong E, Haas A, Sullivan RR, Parziale S, Deng Y, Insogna KL. Differing effects of oral conjugated equine estrogen and transdermal estradiol on vitamin D metabolism in postmenopausal women: a 4-year longitudinal study. Menopause The Journal Of The North American Menopause Society 2022, 29: 1200-1203. PMID: 35969885, DOI: 10.1097/gme.0000000000002045.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsTransdermal estradiol groupConjugated equine estrogensVitamin D metabolismTransdermal estradiolEquine estrogensPostmenopausal womenEstradiol groupTreatment armsD metabolismVitamin DD levelsKronos Early Estrogen Prevention StudyConjugated equine estrogen groupOral conjugated equine estrogenVitamin D insufficientLeast square mean valuesEstrogen groupMicronized progesteroneEstrogen replacementPrevention StudySignificant treatment effectStudy groupTreatment groupsShort-term benefitsTreatment assignmentA programmable DNA roadblock system using dCas9 and multivalent target sites.
Matozel EK, Parziale S, Price AC. A programmable DNA roadblock system using dCas9 and multivalent target sites. PLoS One 2022, 17: e0268099. PMID: 35522691, DOI: 10.1371/journal.pone.0268099.Peer-Reviewed Original ResearchIntravascular Ultrasound Examination Is Associated With Improved Patency in Peripheral Arterial Interventions
Brahmandam, A., Kim, T.I., Parziale, S., Deng, Y., Setia, O., Tonnessen, B.H., Ochoa Chaar, C.I., Guzman, R.J., & Aboian, E. (2022). Intravascular Ultrasound Examination Is Associated With Improved Patency in Peripheral Arterial Interventions. Journal of Vascular Surgery.Peer-Reviewed Original ResearchSRSF2 or TET2 Mutations in Patients with MDS Predict Increased Red Blood Cell Alloimmunization
Guarente, J., Hendrickson, J.E., Li, F., Parziale, S., Tormey, C.A., & Siddon, A.J. (2022). SRSF2 or TET2 Mutations in Patients with MDS Predict Increased Red Blood Cell Alloimmunization. Blood.Peer-Reviewed Original Research