2024
Safety and Pharmacokinetics of HRS-2261, a P2X3 Receptor Antagonist, in Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled Phase 1 Study
Fan Y, Zhang X, Zhang Q, Zheng L, Zhou R, Sun C, Wang X, Song K, He Z, Wang H, Zhang Q, Hu W. Safety and Pharmacokinetics of HRS-2261, a P2X3 Receptor Antagonist, in Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled Phase 1 Study. Clinical Pharmacokinetics 2024, 63: 293-302. PMID: 38198010, DOI: 10.1007/s40262-023-01330-7.Peer-Reviewed Original ResearchP2X3 receptor antagonistAdverse eventsReceptor antagonistHealthy subjectsChronic coughPlacebo-controlled phase 1 trialModerate adverse eventsMost adverse eventsTwice-daily dosingSelective P2X3 receptor antagonistPhase 1 studyPhase 1 trialUnexplained chronic coughSingle oral doseStudy phaseMedian tmaxPrimary endpointGood tolerabilityOral doseTherapeutic optionsResultsA totalDrug exposureMean t1/2Lower incidenceFood intake
2023
Efficacy and safety of rademikibart (CBP-201), a next-generation mAb targeting IL-4Rα, in adults with moderate to severe atopic dermatitis: A phase 2 randomized trial (CBP-201-WW001)
Silverberg J, Strober B, Feinstein B, Xu J, Guttman-Yassky E, Simpson E, Li P, Longphre M, Song J, Guo J, Yun J, Williams B, Pan W, Ho S, Collazo R, Wei Z. Efficacy and safety of rademikibart (CBP-201), a next-generation mAb targeting IL-4Rα, in adults with moderate to severe atopic dermatitis: A phase 2 randomized trial (CBP-201-WW001). Journal Of Allergy And Clinical Immunology 2023, 153: 1040-1049.e12. PMID: 38157942, DOI: 10.1016/j.jaci.2023.11.924.Peer-Reviewed Original ResearchTreatment-emergent adverse eventsEczema Area Severity IndexSevere atopic dermatitisSecondary endpointsAtopic dermatitisWeek 16Serious treatment-emergent adverse eventsNext-generation monoclonal antibodiesPhase 2 trialInjection site reactionsSignificant percent reductionQ4w dosingPrimary endpointTreatment discontinuationAdverse eventsCurrent therapiesLower incidenceQ2WIL-4RαUnspecified causesPandemic-related restrictionsQ4WTrial conductPlaceboMonoclonal antibodiesInvasive Pneumococcal Disease After 2 Decades of Pneumococcal Conjugate Vaccine Use.
Yildirim I, Lapidot R, Shaik-Dasthagirisaheb Y, Hinderstein S, Lee H, Klevens M, Grant L, Arguedas Mohs A, Cane A, Madoff L, Johnson H, Ivanof C, Burns M, Pelton S. Invasive Pneumococcal Disease After 2 Decades of Pneumococcal Conjugate Vaccine Use. 2023, 153 PMID: 38087952, DOI: 10.1542/peds.2023-063039.Peer-Reviewed Original ResearchConceptsInvasive pneumococcal diseaseIPD casesPCV13 eraPneumococcal diseaseCases of IPDIncidence of IPDRates of IPDPneumococcal conjugate vaccine useSerotype 15B/CImplementation of PCV13Non-PCV13 serotypesPneumococcal conjugate vaccineConfidence intervalsStatewide surveillance systemIPD incidence ratesIPD ratesPenicillin nonsusceptibilityConjugate vaccineVaccine serotypesSerotype 19ASterile sitesIncidence rateVaccine useLower incidenceVaccine formulations2737. Real World Evaluation of Antifungal Prophylaxis in Allogeneic Hematopoietic Stem Cell Transplant (aHSCT) Patients, Is Routine Antifungal Prophylaxis Needed?
Perreault S, Schiffer M, Roeder H, McManus D, Topal J. 2737. Real World Evaluation of Antifungal Prophylaxis in Allogeneic Hematopoietic Stem Cell Transplant (aHSCT) Patients, Is Routine Antifungal Prophylaxis Needed? Open Forum Infectious Diseases 2023, 10: ofad500.2348. PMCID: PMC10678736, DOI: 10.1093/ofid/ofad500.2348.Peer-Reviewed Original ResearchInvasive fungal infectionsBreakthrough invasive fungal infectionsAntifungal prophylaxisFluconazole prophylaxisRisk factorsDay 75Conditioning regimenRisk patientsLower incidenceAllogeneic hematopoietic stem cell transplant patientsHistory of IFIRate of IFIHematopoietic stem cell transplant patientsHigh-intensity conditioning regimensStem cell transplant patientsFungal infectionsAnti-mold prophylaxisHigh-dose steroidsRoutine antifungal prophylaxisTacrolimus/sirolimusIntensity conditioning regimensHigh-risk patientsLow-risk patientsCell transplant patientsBreakthrough fungal infectionsThree-year outcomes following transcatheter versus surgical aortic valve replacement in younger, low surgical risk patients with severe aortic stenosis
Modine T, Tchetche D, Van Mieghem N, Huang J, Forrest J, Reardon M. Three-year outcomes following transcatheter versus surgical aortic valve replacement in younger, low surgical risk patients with severe aortic stenosis. European Heart Journal 2023, 44: ehad655.1713. DOI: 10.1093/eurheartj/ehad655.1713.Peer-Reviewed Original ResearchTranscatheter aortic valve implantationSevere aortic stenosisSelf-expanding transcatheter aortic valve implantationLow-risk patientsAortic stenosisRisk patientsLower riskCause mortalityPrimary endpointYounger patientsLower incidenceLow surgical risk patientsSurgical aortic valve replacementGreater paravalvular regurgitationSurgical risk patientsAortic stenosis patientsAortic valve replacementIntermediate-term outcomesLow surgical riskAortic valve implantationThree-Year OutcomesEffective orifice areaYears of ageAortic gradientEchocardiographic outcomes1358-P: Disparities in Acute and Chronic Complications of Diabetes in Rural U.S.
STEIGER K, HERRIN J, SWARNA K, MCCOY R. 1358-P: Disparities in Acute and Chronic Complications of Diabetes in Rural U.S. Diabetes 2023, 72 DOI: 10.2337/db23-1358-p.Peer-Reviewed Original ResearchChronic diabetes complicationsDiabetes complicationsKidney diseaseMyocardial infarctionGreater incidenceEnd-stage kidney diseaseIncidence of strokeRate of complicationsLower extremity ulcersDiabetes-related complicationsHealth care utilizationOptumLabs Data WarehouseMedicare Advantage beneficiariesChronic complicationsCharcot jointExtremity ulcersHeart failureSevere hypoglycemiaCare utilizationSevere hyperglycemiaAtrial fibrillationLower incidenceComplicationsHigh incidenceDiabetesSingle-use versus reusable metallic laryngoscopes for non-emergent intubation: A retrospective review of 72,672 intubations
Chang D, Burnett G, Chiu S, Ouyang Y, Lin H, Hyman J. Single-use versus reusable metallic laryngoscopes for non-emergent intubation: A retrospective review of 72,672 intubations. Journal Of Clinical Anesthesia 2023, 89: 111187. PMID: 37339555, DOI: 10.1016/j.jclinane.2023.111187.Peer-Reviewed Original ResearchConceptsDifficult laryngeal viewRapid sequence inductionLaryngeal viewRescue intubationSequence inductionSubgroup analysisRisk factorsMacintosh bladeMiller bladeSingle-site retrospective cohort studyAlternate deviceRetrospective cohort studyGeneral anesthetic casesAcademic medical centerPoor laryngeal viewNon-emergent proceduresSecondary outcomesAdult patientsCohort studyPrimary outcomeRetrospective reviewTracheal intubationIntubation attemptsLower incidenceMedical CenterDeriving Schwann cells from hPSCs enables disease modeling and drug discovery for diabetic peripheral neuropathy
Majd H, Amin S, Ghazizadeh Z, Cesiulis A, Arroyo E, Lankford K, Majd A, Farahvashi S, Chemel A, Okoye M, Scantlen M, Tchieu J, Calder E, Le Rouzic V, Shibata B, Arab A, Goodarzi H, Pasternak G, Kocsis J, Chen S, Studer L, Fattahi F. Deriving Schwann cells from hPSCs enables disease modeling and drug discovery for diabetic peripheral neuropathy. Cell Stem Cell 2023, 30: 632-647.e10. PMID: 37146583, PMCID: PMC10249419, DOI: 10.1016/j.stem.2023.04.006.Peer-Reviewed Original ResearchConceptsDiabetic peripheral neuropathySchwann cellsPeripheral neuropathyPeripheral nervous systemPrimary Schwann cellsBupropion treatmentDiabetic patientsMyelin damageSensory dysfunctionPrimary gliaSelective vulnerabilityAntidepressant drugsHyperglycemic miceLower incidenceRetrospective analysisHuman pluripotent stem cellsSC deathNervous systemTherapeutic candidateHigh glucoseNeuropathyHealth recordsMolecular featuresStem cellsPluripotent stem cellsPredicting the Safety and Effectiveness of Inferior Vena Cava Filters (PRESERVE): Outcomes at 12 months
Johnson M, Spies J, Scott K, Kato B, Mu X, Rectenwald J, White R, Lewandowski R, Khaja M, Zuckerman D, Casciani T, Gillespie D. Predicting the Safety and Effectiveness of Inferior Vena Cava Filters (PRESERVE): Outcomes at 12 months. Journal Of Vascular And Interventional Radiology 2023, 34: 517-528.e6. PMID: 36841633, DOI: 10.1016/j.jvir.2022.12.009.Peer-Reviewed Original ResearchConceptsVena cava filtersEnd pointCava filtersPrimary effectiveness end pointPrimary safety end pointInferior vena cava filterEffectiveness end pointSafety end pointVenous thromboembolic eventsProphylactic placementAnticoagulation therapyThromboembolic eventsVenous thromboembolismThrombotic occlusionNonrandomized studyPrimary safetyTomography scanLower incidenceSignificant PESite investigatorsPatientsCore laboratoryStrut perforationMonthsDVTPredicting the Safety and Effectiveness of Inferior Vena Cava Filters (PRESERVE): Outcomes at 12 months
Johnson M, Spies J, Scott K, Kato B, Mu X, Rectenwald J, White R, Lewandowski R, Khaja M, Zuckerman D, Casciani T, Gillespie D. Predicting the Safety and Effectiveness of Inferior Vena Cava Filters (PRESERVE): Outcomes at 12 months. Journal Of Vascular Surgery Venous And Lymphatic Disorders 2023, 11: 573-585.e6. PMID: 36872169, DOI: 10.1016/j.jvsv.2022.11.002.Peer-Reviewed Original ResearchConceptsVena cava filtersEnd pointCava filtersPrimary effectiveness end pointPrimary safety end pointInferior vena cava filterEffectiveness end pointSafety end pointVenous thromboembolic eventsProphylactic placementAnticoagulation therapyThromboembolic eventsVenous thromboembolismThrombotic occlusionNonrandomized studyPrimary safetyTomography scanLower incidenceSignificant PESite investigatorsPatientsCore laboratoryStrut perforationMonthsDVTMalignant Melanoma in Older Adults: Different Patient or Different Disease?
Sasson D, Smetona J, Parsaei Y, Papageorge M, Ariyan S, Olino K, Clune J. Malignant Melanoma in Older Adults: Different Patient or Different Disease? Cureus 2023, 15: e34742. PMID: 36909026, PMCID: PMC9998075, DOI: 10.7759/cureus.34742.Peer-Reviewed Original ResearchMelanoma-specific survivalRecurrence-free survivalOlder patientsT2 tumorsNodal positivityMetastatic progressionOlder adultsConclusion Older adultsLog-rank testingKaplan-Meier analysisT4 tumorsYounger patientsT1 tumorsBreslow thicknessClinical outcomesTumor characteristicsTumor thicknessSingle institutionClinical behaviorMalignant melanomaLower incidenceHigh incidencePatientsConsecutive sampleAge groups
2022
Post-9/11 deployment history and the incidence of breast cancer among women veterans
Gaffey A, Han L, Ramsey C, Skanderson M, Dziura J, Driscoll M, Burg M, Brandt C, Bastian L, Haskell S. Post-9/11 deployment history and the incidence of breast cancer among women veterans. Annals Of Epidemiology 2022, 77: 98-102. PMID: 36470323, DOI: 10.1016/j.annepidem.2022.11.010.Peer-Reviewed Original ResearchConceptsOEF/OIF deploymentBreast cancerWomen veteransHealthcare utilizationHormone replacement therapy useRetrospective cohort studyVeterans Affairs (VA) careHealthy soldier effectOEF/OIFCohort studyTherapy useBC incidenceHormonal contraceptivesLifestyle factorsPrimary careBC diagnosisLower incidenceOperations Enduring Freedom/Iraqi FreedomWomenIncidenceGreater likelihoodIraqi FreedomVeteransCancerCareGenetic determinants for the racial disparities in the risk of prostate and testicular cancers
Uzamere I, Wang Y, Zheng T, Zhu Y. Genetic determinants for the racial disparities in the risk of prostate and testicular cancers. Communications Medicine 2022, 2: 138. PMID: 36352009, PMCID: PMC9630379, DOI: 10.1038/s43856-022-00205-5.Peer-Reviewed Original ResearchRisk of prostateTesticular cancerProstate cancerRisk allelesRacial disparitiesEuropean ancestryAfrican ancestryMethodsThe current studyLower incidenceIncidence disparitiesHigh incidenceRisk allele frequenciesCancerConclusionsOur findingsGenetic factorsMenT-testRegression analysisProstateIncidenceGenetic determinantsCurrent studyRiskAllele frequenciesDisparitiesMetabolic Syndrome and Liver Cancer
Jaffe A, Strazzabosco M. Metabolic Syndrome and Liver Cancer. 2022, 87-104. DOI: 10.1007/978-3-030-41683-6_51.Peer-Reviewed Original ResearchHepatitis B virusNonalcoholic fatty liver diseaseMetabolic syndromeRisk factorsHepatocellular carcinomaLiver diseaseLiver cancerParticular hepatitis B virusIncidence of HCCAdvanced liver diseaseIndependent risk factorFatty liver diseaseType 2 diabetesUnderlying pathogenic mechanismsHepatic manifestationHCC incidenceViral hepatitisAdvanced fibrosisSignificant morbidityDiabetes leadsTime patientsB virusHCC riskHigh prevalenceLower incidenceAdherence to the American Cancer Society Guidelines on nutrition and physical activity for cancer prevention and obesity‐related cancer risk and mortality in Black and Latina Women's Health Initiative participants
Pichardo MS, Esserman D, Ferrucci LM, Molina Y, Chlebowski RT, Pan K, Garcia DO, Lane DS, Shadyab AH, Lopez‐Pentecost M, Luo J, Kato I, Springfield S, Rosal MC, Bea JW, Feliciano E, Qi L, Nassir R, Snetselaar L, Manson J, Bird C, Irwin ML. Adherence to the American Cancer Society Guidelines on nutrition and physical activity for cancer prevention and obesity‐related cancer risk and mortality in Black and Latina Women's Health Initiative participants. Cancer 2022, 128: 3630-3640. PMID: 35996861, DOI: 10.1002/cncr.34428.Peer-Reviewed Original ResearchConceptsAmerican Cancer Society guidelinesObesity-related cancersWomen's Health InitiativeGuideline adherenceSociety guidelinesHealth initiativesPhysical activityLower riskEffect modificationCancer preventionObesity-related cancer incidenceObesity-related cancer riskWomen's Health Initiative participantsLatina womenPotential effect modificationPublic health interventionsNeighborhood socioeconomic statusCause deathCause mortalityLifestyle guidelinesPostmenopausal womenCancer incidenceLower incidenceACS guidelinesHigh adherenceAutomated versus conventional perioperative glycemic control in adult diabetic patients undergoing open heart surgery
Kaddoum R, Khalili A, Shebbo F, Ghanem N, Daher L, Ali A, Chehade N, Maroun P, Aouad M. Automated versus conventional perioperative glycemic control in adult diabetic patients undergoing open heart surgery. BMC Anesthesiology 2022, 22: 184. PMID: 35710339, PMCID: PMC9202201, DOI: 10.1186/s12871-022-01721-6.Peer-Reviewed Original ResearchConceptsOpen heart surgeryPercentage of patientsDiabetic patientsHeart surgeryControl groupGlucose controlHypoglycemic eventsGlucose control systemGlucose levelsPerioperative blood glucose levelsHyperglycemic eventsExperimental groupPerioperative glycemic controlAdult diabetic patientsIncidence of hyperglycemiaProportion of patientsRisk of mortalityTight glucose controlBlood glucose levelsCardiac surgeryGlycemic controlGlycemic variabilityLonger surgeryLower incidenceHigh riskBenefit of Extended Surveillance of Low-Risk Pancreatic Cysts After 5-Year Stability: A Systematic Review and Meta-Analysis
Chhoda A, Singh S, Sheth AH, Grimshaw AA, Gunderson C, Sharma P, Kunstman JW, Sharma A, Ahuja N, Gonda TA, Farrell JJ. Benefit of Extended Surveillance of Low-Risk Pancreatic Cysts After 5-Year Stability: A Systematic Review and Meta-Analysis. Clinical Gastroenterology And Hepatology 2022, 21: 1430-1446. PMID: 35568304, DOI: 10.1016/j.cgh.2022.04.025.Peer-Reviewed Original ResearchConceptsDisease-specific mortalityAdvanced neoplasiaBD-IPMNsExtended surveillancePooled incidenceWorrisome featuresSystematic reviewIntraductal papillary mucinous neoplasmHigh-grade dysplasiaPapillary mucinous neoplasmHigh-quality studiesRandom-effects modelWarrants further investigationWeb of ScienceNeoplasia incidenceWarrants further explorationSurvival benefitCochrane LibraryMucinous neoplasmsPancreatic cancerPancreatic cystsSurveillance periodEligible studiesOvid MEDLINELower incidencePercutaneous Coronary Intervention vs. Coronary Artery Bypass Grafting for Treating In-Stent Restenosis in Unprotected-Left Main: LM-DRAGON-Registry
Wańha W, Bil J, Kołodziejczak M, Kowalówka A, Kowalewski M, Hudziak D, Gocoł R, Januszek R, Figatowski T, Milewski M, Tomasiewicz B, Kübler P, Hrymniak B, Desperak P, Kuźma Ł, Milewski K, Góra B, Łoś A, Kulczycki J, Włodarczak A, Skorupski W, Grygier M, Lesiak M, D'Ascenzo F, Andres M, Kleczynski P, Litwinowicz R, Borin A, Smolka G, Reczuch K, Gruchała M, Gil RJ, Jaguszewski M, Bartuś K, Suwalski P, Dobrzycki S, Dudek D, Bartuś S, Ga̧sior M, Ochała A, Lansky AJ, Deja M, Legutko J, Kedhi E, Wojakowski W. Percutaneous Coronary Intervention vs. Coronary Artery Bypass Grafting for Treating In-Stent Restenosis in Unprotected-Left Main: LM-DRAGON-Registry. Frontiers In Cardiovascular Medicine 2022, 9: 849971. PMID: 35615559, PMCID: PMC9125786, DOI: 10.3389/fcvm.2022.849971.Peer-Reviewed Original ResearchPercutaneous coronary interventionTarget vessel revascularizationCoronary artery bypassCardiac deathMyocardial infarctionPCI groupArtery bypassCoronary interventionStent restenosisUnprotected left main coronary arteryLeft main coronary arteryMain coronary arteryManagement of patientsAnalysis of patientsCerebrovascular eventsPrimary endpointVessel revascularizationConsecutive patientsCoronary arteryCABGLower incidenceLower riskPatientsDeathMACCETracheostomy Is Associated With a Decrease in Delirium and Sedation for Intubated COVID-19 Patients
Morton C, Pisani M, Doyle M, Puchalski J. Tracheostomy Is Associated With a Decrease in Delirium and Sedation for Intubated COVID-19 Patients. Journal Of Bronchology & Interventional Pulmonology 2022, 30: 32-36. PMID: 35288526, DOI: 10.1097/lbr.0000000000000841.Peer-Reviewed Original ResearchConceptsProportion of daysCoronavirus disease 2019 acute respiratory distress syndromeIntubated COVID-19 patientsRichmond Agitation-Sedation Scale scoreUrban tertiary referral centerAcute respiratory distress syndromeAmount of opioidsConfusion Assessment MethodTertiary referral centerRespiratory distress syndromeSedation Scale scoreCOVID-19 patientsSignificant decreaseIntensive care unit dataBenzodiazepine dosingLorazepam equivalentsMorphine equivalentsOpioid dosingVentilator liberationRespiratory failureReferral centerDistress syndromeSedation needsSedation requirementsLower incidenceRespiratory Adverse Events After LMA® Mask Removal in Children: A Randomized Trial Comparing Propofol to Sevoflurane
Karam C, Zeeni C, Yazbeck-Karam V, Shebbo F, Khalili A, Raad S, Beresian J, Aouad M, Kaddoum R. Respiratory Adverse Events After LMA® Mask Removal in Children: A Randomized Trial Comparing Propofol to Sevoflurane. Anesthesia & Analgesia 2022, 136: 25-33. PMID: 35213484, DOI: 10.1213/ane.0000000000005945.Peer-Reviewed Original ResearchConceptsRespiratory adverse eventsTotal intravenous anesthesiaAdverse eventsEmergence agitationSecondary outcomesLower incidenceDouble-blind clinical trialPerioperative respiratory complicationsRemoval of LMALaryngeal mask airwayType of anesthesiaMinimal risk factorsQuality of anesthesiaLMA removalTIVA groupRespiratory complicationsHemodynamic stabilityLMA insertionMask airwaySevoflurane groupNatural airwayIntravenous anesthesiaPropofol inductionAdverse outcomesRespiratory events
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