2024
Association of personalized and tumor-informed ctDNA with patient survival outcomes in pancreatic adenocarcinoma
Botta G, Abdelrahim M, Drengler R, Aushev V, Esmail A, Laliotis G, Brewer C, George G, Abbate S, Chandana S, Tejani M, Malla M, Bansal D, Rivero-Hinojosa S, Spickard E, McCormick N, Cecchini M, Lacy J, Fei N, Kasi P, Kasi A, Dayyani F, Hanna D, Sharma S, Malhotra M, Aleshin A, Liu M, Jurdi A. Association of personalized and tumor-informed ctDNA with patient survival outcomes in pancreatic adenocarcinoma. The Oncologist 2024, 29: 859-869. PMID: 39022993, PMCID: PMC11449101, DOI: 10.1093/oncolo/oyae155.Peer-Reviewed Original ResearchMolecular residual diseasePancreatic ductal adenocarcinomaPatient survival outcomesCtDNA detectionSurvival outcomesStage I–III pancreatic ductal adenocarcinomaAssociated with shorter DFSMedian follow-up timeFollow-up timeCtDNA levelsResidual diseaseShorter DFSPrognostic factorsPancreatic adenocarcinomaAssociated with patient survival outcomesDuctal adenocarcinomaRetrospective analysisDiagnosed patientsMultivariate analysisSurveillance periodPatientsPlasma samplesTumor informationWhole exomeSurveillance window
2022
Benefit of Extended Surveillance of Low-Risk Pancreatic Cysts After 5-Year Stability: A Systematic Review and Meta-Analysis
Chhoda A, Singh S, Sheth AH, Grimshaw AA, Gunderson C, Sharma P, Kunstman JW, Sharma A, Ahuja N, Gonda TA, Farrell JJ. Benefit of Extended Surveillance of Low-Risk Pancreatic Cysts After 5-Year Stability: A Systematic Review and Meta-Analysis. Clinical Gastroenterology And Hepatology 2022, 21: 1430-1446. PMID: 35568304, DOI: 10.1016/j.cgh.2022.04.025.Peer-Reviewed Original ResearchConceptsDisease-specific mortalityAdvanced neoplasiaBD-IPMNsExtended surveillancePooled incidenceWorrisome featuresSystematic reviewIntraductal papillary mucinous neoplasmHigh-grade dysplasiaPapillary mucinous neoplasmHigh-quality studiesRandom-effects modelWarrants further investigationWeb of ScienceNeoplasia incidenceWarrants further explorationSurvival benefitCochrane LibraryMucinous neoplasmsPancreatic cancerPancreatic cystsSurveillance periodEligible studiesOvid MEDLINELower incidence
2018
Risk of Radiation-Induced Cancer From Computed Tomography Angiography Use in Imaging Surveillance for Unruptured Cerebral Aneurysms
Malhotra A, Wu X, Chugh A, Mustafa A, Matouk CC, Gandhi D, Sanelli P. Risk of Radiation-Induced Cancer From Computed Tomography Angiography Use in Imaging Surveillance for Unruptured Cerebral Aneurysms. Stroke 2018, 50: 76-82. PMID: 30580703, DOI: 10.1161/strokeaha.118.022454.Peer-Reviewed Original ResearchSurveillance imagingExcess lifetime riskCancer riskAneurysmal ruptureLifetime riskCancer incidenceRadiation Risk Assessment ToolIntracranial aneurysmsLonger surveillance periodsRadiation-induced cancer riskBrain cancer incidenceHigh-risk groupUnruptured cerebral aneurysmsCost-effectiveness/utility analysesBEIR VII reportRisk of radiationNoninvasive imaging modalityRisk assessment toolExcess cancer riskAngiography useImaging surveillanceTomography angiographySurveillance periodRisk groupsCerebral aneurysms
2017
Declines in Human Papillomavirus (HPV)–Associated High-Grade Cervical Lesions After Introduction of HPV Vaccines in Connecticut, United States, 2008–2015
Niccolai LM, Meek JI, Brackney M, Hadler JL, Sosa LE, Weinberger DM. Declines in Human Papillomavirus (HPV)–Associated High-Grade Cervical Lesions After Introduction of HPV Vaccines in Connecticut, United States, 2008–2015. Clinical Infectious Diseases 2017, 65: 884-889. PMID: 28520854, DOI: 10.1093/cid/cix455.Peer-Reviewed Original ResearchConceptsCervical cancer screeningCervical lesionsRisk behaviorsHPV vaccinationVaccination coverageHuman papillomavirusCancer screeningBirth cohortHigh-grade cervical lesionsHPV vaccination coverageRates of CIN2Cervical intraepithelial neoplasiaHigh-grade lesionsSexual risk behaviorsSignificant declineHPV vaccineVaccine impactIntraepithelial neoplasiaCervical cancerRisk factorsSurveillance periodSimilar epidemiologyChlamydia trachomatisCohort patternsNegative binomial regression
2015
Increase of serotypes 15A and 23B in IPD in Germany in the PCV13 vaccination era
van der Linden M, Perniciaro S, Imöhl M. Increase of serotypes 15A and 23B in IPD in Germany in the PCV13 vaccination era. BMC Infectious Diseases 2015, 15: 207. PMID: 25940580, PMCID: PMC4424534, DOI: 10.1186/s12879-015-0941-9.Peer-Reviewed Original ResearchConceptsInvasive pneumococcal diseasePenicillin non-susceptible isolatesNon-PCV13 serotypesNon-susceptible isolatesSerotype 15AVaccination periodSurveillance of IPDClonal complexesChildhood pneumococcal conjugate vaccinationGerman National Reference CenterEarly vaccination periodHigher-valent vaccinesPneumococcal conjugate vaccinationNational Reference CenterConclusionsThe prevalenceConjugate vaccinationSerotype 23BPneumococcal diseaseChildhood vaccinationVaccination eraSurveillance periodSerogroups 23BackgroundThis studyReference centerVaccination formulations
2010
Barrett's Surveillance Identifies Patients with Early Esophageal Adenocarcinoma
Wong T, Tian J, Nagar AB. Barrett's Surveillance Identifies Patients with Early Esophageal Adenocarcinoma. The American Journal Of Medicine 2010, 123: 462-467. PMID: 20399324, DOI: 10.1016/j.amjmed.2009.10.013.Peer-Reviewed Original ResearchConceptsGastroesophageal reflux diseaseEsophageal adenocarcinomaBarrett's esophagusSurveillance programReflux diseaseBarrett's surveillanceBarrett's surveillance programEarly esophageal adenocarcinomaHigh-grade dysplasiaDevelopment of dysplasiaRetrospective study designProgression of metaplasiaRisk of cancerUpper endoscopic proceduresInstitutional review boardBarrett's cohortSurveillance endoscopyMore patientsRetrospective reviewEndoscopic surveillanceBarrett's segmentSurveillance groupSurveillance periodEndoscopic proceduresNew diagnosisA cluster-randomized trial of enhanced labor ward-based PMTCT services to increase nevirapine coverage in Lusaka, Zambia
Megazzini KM, Sinkala M, Vermund SH, Redden DT, Krebs DW, Acosta EP, Mwanza J, Goldenberg RL, Chintu N, Bulterys M, Stringer JS. A cluster-randomized trial of enhanced labor ward-based PMTCT services to increase nevirapine coverage in Lusaka, Zambia. AIDS 2010, 24: 447-455. PMID: 19926959, DOI: 10.1097/qad.0b013e328334b285.Peer-Reviewed Original ResearchConceptsWomen/infant pairsCluster-randomized trialNevirapine coverageInfant pairsLabour wardClinic coverageProbability of HIVProportion of HIVPrevention of motherStandard of carePMTCT programmePMTCT servicesChild transmissionHIV testingUnknown serostatusSurveillance periodIntervention periodControl clinicsRelative riskTreatment clinicsUmbilical cordHIVClinicGEE modelOdds of coverage
2005
Effectiveness of a city-wide program to prevent mother-to-child HIV transmission in Lusaka, Zambia
Stringer JS, Sinkala M, Maclean CC, Levy J, Kankasa C, DeGroot A, Stringer EM, Acosta EP, Goldenberg RL, Vermund SH. Effectiveness of a city-wide program to prevent mother-to-child HIV transmission in Lusaka, Zambia. AIDS 2005, 19: 1309-1315. PMID: 16052086, PMCID: PMC2745046, DOI: 10.1097/01.aids.0000180102.88511.7d.Peer-Reviewed Original ResearchConceptsMother-infant pairsHIV testingCord bloodSurveillance populationAntenatal HIV testingPerinatal HIV preventionProportion of HIVChild HIV transmissionHIV test resultsMain outcome measuresNewborn cord bloodHIV prevention programsHIV serologyInfant dosePublic sector facilitiesSeropositive womenAntenatal careHIV transmissionPrescribed regimenCascade of eventsLabor onsetPopulation effectivenessSurveillance periodHIV preventionOutcome measures
2004
Modifiable Risk Factors for Nursing Home-Acquired Pneumonia
Quagliarello V, Ginter S, Han L, Van Ness P, Allore H, Tinetti M. Modifiable Risk Factors for Nursing Home-Acquired Pneumonia. Clinical Infectious Diseases 2004, 40: 1-6. PMID: 15614684, DOI: 10.1086/426023.Peer-Reviewed Original ResearchConceptsModifiable risk factorsElderly nursing home residentsInadequate oral careNursing home residentsCox proportional hazards modelCases of pneumoniaRisk factorsProportional hazards modelOral careHome residentsSurveillance periodHazards modelCandidate modifiable risk factorNursing home-acquired pneumoniaPneumonia prevention strategiesRisk of pneumoniaPrimary outcomeSwallowing difficultiesIndependent associationAttributable fractionPneumoniaNursing homesPrevention strategiesElderly residentsSame covariates
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