2025
An update on botulinum toxin treatment of painful diabetic neuropathy, post-traumatic painful neuropathy/neuralgia, post-herpetic neuralgia and occipital neuralgia
Jabbari B, Tohidian A. An update on botulinum toxin treatment of painful diabetic neuropathy, post-traumatic painful neuropathy/neuralgia, post-herpetic neuralgia and occipital neuralgia. Toxicon 2025, 255: 108237. PMID: 39798899, DOI: 10.1016/j.toxicon.2025.108237.Peer-Reviewed Original ResearchConceptsPainful diabetic neuropathyPost-traumatic neuralgiaOccipital neuralgiaPostherpetic neuralgiaMode of treatmentBotulinum toxin treatmentDiabetic neuropathyTreatment of painful diabetic neuropathyPost-herpetic neuralgiaCohort of patientsPain disordersEfficacy criteriaNeuralgiaAmerican Academy of NeurologyLevel of efficacyToxin treatmentAmerican AcademyNeuropathyBotulinum therapyEfficacyPatientsTreatment
2024
Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
Collaborators G, Steinmetz J, Seeher K, Schiess N, Nichols E, Cao B, Servili C, Cavallera V, Cousin E, Hagins H, Moberg M, Mehlman M, Abate Y, Abbas J, Abbasi M, Abbasian M, Abbastabar H, Abdelmasseh M, Abdollahi M, Abdollahi M, Abdollahifar M, Abd-Rabu R, Abdulah D, Abdullahi A, Abedi A, Abedi V, Zuñiga R, Abidi H, Abiodun O, Aboagye R, Abolhassani H, Aboyans V, Abrha W, Abualhasan A, Abu-Gharbieh E, Aburuz S, Adamu L, Addo I, Adebayo O, Adekanmbi V, Adekiya T, Adikusuma W, Adnani Q, Adra S, Afework T, Afolabi A, Afraz A, Afzal S, Aghamiri S, Agodi A, Agyemang-Duah W, Ahinkorah B, Ahmad A, Ahmad D, Ahmad S, Ahmadzade A, Ahmed A, Ahmed A, Ahmed H, Ahmed J, Ahmed L, Ahmed M, Ahmed S, Ajami M, Aji B, Ajumobi O, Akade S, Akbari M, Akbarialiabad H, Akhlaghi S, Akinosoglou K, Akinyemi R, Akonde M, Al Hasan S, Alahdab F, AL-Ahdal T, Al-amer R, Albashtawy M, AlBataineh M, Aldawsari K, Alemi H, Alemi S, Algammal A, Al-Gheethi A, Alhalaiqa F, Alhassan R, Ali A, Ali E, Ali L, Ali M, Ali M, Ali R, Ali S, Ali S, Ali Z, Alif M, Alimohamadi Y, Aliyi A, Aljofan M, Aljunid S, Alladi S, Almazan J, Almustanyir S, Al-Omari B, Alqahtani J, Alqasmi I, Alqutaibi A, Salman R, Altaany Z, Al-Tawfiq J, Altirkawi K, Alvis-Guzman N, Al-Worafi Y, Aly H, Aly S, Alzoubi K, Amani R, Amindarolzarbi A, Amiri S, Amirzade-Iranaq M, Amu H, Amugsi D, Amusa G, Amzat J, Ancuceanu R, Anderlini D, Anderson D, Andrei C, Androudi S, Angappan D, Angesom T, Anil A, Ansari-Moghaddam A, Anwer R, Arafat M, Aravkin A, Areda D, Ariffin H, Arifin H, Arkew M, Ärnlöv J, Arooj M, Artamonov A, Artanti K, Aruleba R, Asadi-Pooya A, Asena T, Asghari-Jafarabadi M, Ashraf M, Ashraf T, Atalell K, Athari S, Atinafu B, Atorkey, Atout M, Atreya A, Aujayeb A, Avan A, Quintanilla B, Ayatollahi H, Ayinde O, Ayyoubzadeh S, Azadnajafabad S, Azizi Z, Azizian K, Azzam A, Babaei M, Badar M, Badiye A, Baghdadi S, Bagherieh S, Bai R, Baig A, Balakrishnan S, Balalla S, Baltatu O, Banach M, Bandyopadhyay S, Banerjee I, Baran M, Barboza M, Barchitta M, Bardhan M, Barker-Collo S, Bärnighausen T, Barrow A, Bashash D, Bashiri H, Bashiru H, Basiru A, Basso J, Basu S, Batiha A, Batra K, Baune B, Bedi N, Begde A, Begum T, Behnam B, Behnoush A, Beiranvand M, Béjot Y, Bekele A, Belete M, Belgaumi U, Bemanalizadeh M, Bender R, Benfor B, Bennett D, Bensenor I, Berice B, Bettencourt P, Beyene K, Bhadra A, Bhagat D, Bhangdia K, Bhardwaj N, Bhardwaj P, Bhargava A, Bhaskar S, Bhat A, Bhat V, Bhatti G, Bhatti J, Bhatti R, Bijani A, Bikbov B, Bilalaga M, Biswas A, Bitaraf S, Bitra V, Bjørge T, Bodolica V, Bodunrin A, Boloor A, Braithwaite D, Brayne C, Brenner H, Briko A, Vega M, Brown J, Budke C, Buonsenso D, Burkart K, Burns R, Bustanji Y, Butt M, Butt N, Butt Z, Cabral L, dos Santos F, Calina D, Campos-Nonato I, Cao C, Carabin H, Cárdenas R, Carreras G, Carvalho A, Castañeda-Orjuela C, Casulli A, Catalá-López F, Catapano A, Caye A, Cegolon L, Cenderadewi M, Cerin E, Chacón-Uscamaita P, Chan J, Chanie G, Charan J, Chattu V, Abebe E, Chen H, Chen J, Chi G, Chichagi F, Chidambaram S, Chimoriya R, Ching P, Chitheer A, Chong Y, Chopra H, Choudhari S, Chowdhury E, Chowdhury R, Christensen H, Chu D, Chukwu I, Chung E, Coberly K, Columbus A, Comachio J, Conde J, Cortesi P, Costa V, Couto R, Criqui M, Cruz-Martins N, Ohadi M, Dadana S, Dadras O, Dai X, Dai Z, D'Amico E, Danawi H, Dandona L, Dandona R, Darwish A, Das S, Das S, Dascalu A, Dash N, Dashti M, De la Hoz F, de la Torre-Luque A, De Leo D, Dean F, Dehghan A, Dehghan A, Dejene H, Demant D, Demetriades A, Demissie S, Deng X, Desai H, Devanbu V, Dhama K, Dharmaratne S, Dhimal M, da Silva D, Diaz D, Dibas M, Ding D, Dinu M, Dirac M, Diress M, Chi T, Phuong T, Doan K, Dodangeh M, Doheim M, Dokova K, Dongarwar D, Dsouza H, Dube J, Duraisamy S, Durojaiye O, Dutta S, Dziedzic A, Edinur H, Eissazade N, Ekholuenetale M, Ekundayo T, Nahas N, Sayed I, Najafi M, Elbarazi I, Elemam N, Elgar F, Elgendy I, Elhabashy H, Elhadi M, Elilo L, Ellenbogen R, Elmeligy O, Elmonem M, Elshaer M, Elsohaby I, Emamverdi M, Emeto T, Endres M, Esezobor C, Eskandarieh S, Fadaei A, Fagbamigbe A, Fahim A, Faramarzi A, Fares J, Kouhanjani M, Faro A, Farzadfar F, Fatehizadeh A, Fathi M, Fathi S, Fatima S, Feizkhah A, Fereshtehnejad S, Ferrari A, Ferreira N, Fetensa G, Firouraghi N, Fischer F, Fonseca A, Force L, Fornari A, Foroutan B, Fukumoto T, Gadanya M, Gaidhane A, Galali Y, Galehdar N, Gan Q, Gandhi A, Ganesan B, Gardner W, Garg N, Gau S, Gautam R, Gebre T, Gebrehiwot M, Gebremeskel G, Gebreslassie H, Getacher L, Yazdi B, Ghadirian F, Ghaffarpasand F, Ghanbari R, Ghasemi M, Ghazy R, Ghimire S, Gholami A, Gholamrezanezhad A, Ghotbi E, Ghozy S, Gialluisi A, Gill P, Glasstetter L, Gnedovskaya E, Golchin A, Golechha M, Goleij P, Golinelli D, Gomes-Neto M, Goulart A, Goyal A, Gray R, Grivna M, Guadie H, Guan B, Guarducci G, Guicciardi S, Gunawardane D, Guo H, Gupta B, Gupta R, Gupta S, Gupta V, Gupta V, Gutiérrez R, Habibzadeh F, Hachinski V, Haddadi R, Hadei M, Hadi N, Haep N, Haile T, Haj-Mirzaian A, Hall B, Halwani R, Hameed S, Hamiduzzaman M, Hammoud A, Han H, Hanifi N, Hankey G, Hannan A, Hao J, Harapan H, Hareru H, Hargono A, Harlianto N, Haro J, Hartman N, Hasaballah A, Hasan F, Hasani H, Hasanian M, Hassan A, Hassan S, Hassanipour S, Hassankhani H, Hassen M, Haubold J, Hay S, Hayat K, Hegazy M, Heidari G, Heidari M, Heidari-Soureshjani R, Hesami H, Hezam K, Hiraike Y, Hoffman H, Holla R, Hopf K, Horita N, Hossain M, Hossain B, Hossain S, Hosseinzadeh H, Hosseinzadeh M, Hostiuc S, Hu C, Huang J, Huda N, Hussain J, Hussein N, Huynh H, Hwang B, Ibitoye S, Ilaghi M, Ilesanmi O, Ilic I, Ilic M, Immurana M, Iravanpour F, Islam M, Ismail F, Iso H, Isola G, Iwagami M, Iwu C, Iyer M, Jaan A, Jacob L, Jadidi-Niaragh F, Jafari M, Jafarinia M, Jafarzadeh A, Jahankhani K, Jahanmehr N, Jahrami H, Jaiswal A, Jakovljevic M, Jamora R, Jana S, Javadi N, Javed S, Javeed S, Jayapal S, Jayaram S, Jiang H, Johnson C, Johnson W, Jokar M, Jonas J, Joseph A, Joseph N, Joshua C, Jürisson M, Kabir A, Kabir Z, Kabito G, Kadashetti V, Kafi F, Kalani R, Kalantar F, Kaliyadan F, Kamath A, Kamath S, Kanchan T, Kandel A, Kandel H, Kanmodi K, Karajizadeh M, Karami J, Karanth S, Karaye I, Karch A, Karimi A, Karimi H, Behnagh A, Kasraei H, Kassebaum N, Kauppila J, Kaur H, Kaur N, Kayode G, Kazemi F, Keikavoosi-Arani L, Keller C, Keykhaei M, Khadembashiri M, Khader Y, Khafaie M, Khajuria H, Khalaji A, Khamesipour F, Khammarnia M, Khan M, Khan M, Khan Y, Suheb M, Khanmohammadi S, Khanna T, Khatab K, Khatatbeh H, Khatatbeh M, Khateri S, Khatib M, Kashani H, Khonji M, khorashadizadeh F, Khormali M, Khubchandani J, Kian S, Kim G, Kim J, Kim M, Kim Y, Kimokoti R, Kisa A, Kisa S, Kivimäki M, Kochhar S, Kolahi A, Koly K, Kompani F, Koroshetz W, Kosen S, Arami M, Koyanagi A, Kravchenko M, Krishan K, Krishnamoorthy V, Defo B, Kuddus A, Kumar A, Kumar G, Kumar M, Kumar N, Kumsa N, Kundu S, Kurniasari M, Kusuma D, Kuttikkattu A, Kyu H, La Vecchia C, Ladan M, Lahariya C, Laksono T, Lal D, Lallukka T, Lám J, Lami F, Landires I, Langguth B, Lasrado S, Latief K, Latifinaibin K, Lau K, Laurens M, Lawal B, Le L, Le T, Ledda C, Lee M, Lee S, Lee S, Lee W, Lee Y, Leonardi M, Lerango T, Li M, Li W, Ligade V, Lim S, Linehan C, Liu C, Liu J, Liu W, Lo C, Lo W, Lobo S, Logroscino G, Lopes G, Lopukhov P, Lorenzovici L, Lorkowski S, Loureiro J, Lubinda J, Lucchetti G, Saute R, Feei Z, Mabrok M, Machoy M, Madadizadeh F, Razek M, Maghazachi A, Maghbouli N, Mahjoub S, Mahmoudi M, Majeed A, Malagón-Rojas J, Rad E, Malhotra K, Malik A, Malik I, Mallhi T, Malta D, Manilal A, Mansouri V, Mansournia M, Marasini B, Marateb H, Maroufi S, Martinez-Raga J, Martini S, Martins-Melo F, Martorell M, März W, Marzo R, Massano J, Mathangasinghe Y, Mathews E, Maude R, Maugeri A, Maulik P, Mayeli M, Mazaheri M, McAlinden C, McGrath J, Meena J, Mehndiratta M, Mendez-Lopez M, Mendoza W, Mendoza-Cano O, Menezes R, Merati M, Meretoja A, Merkin A, Mersha A, Mestrovic T, Mi T, Miazgowski T, Michalek I, Mihretie E, Minh L, Mirfakhraie R, Mirica A, Mirrakhimov E, Mirzaei M, Misganaw A, Misra S, Mithra P, Mizana B, Mohamadkhani A, Mohamed N, Mohammadi E, Mohammadi H, Mohammadi S, Mohammadi S, Mohammadshahi M, Mohammed M, Mohammed S, Mohammed S, Mohan S, Mojiri-forushani H, Moka N, Mokdad A, Molinaro S, Möller H, Monasta L, Moniruzzaman, Montazeri F, Moradi M, Moradi Y, Moradi-Lakeh M, Moraga P, Morovatdar N, Morrison S, Mosapour A, Mosser J, Mossialos E, Motaghinejad M, Mousavi P, Mousavi S, Mubarik S, Muccioli L, Mughal F, Mukoro G, Mulita A, Mulita F, Musaigwa F, Mustafa A, Mustafa G, Muthu S, Nagarajan A, Naghavi P, Naik G, Nainu F, Nair T, Najmuldeen H, Ansari N, Nambi G, Areshtanab H, Nargus S, Nascimento B, Naser A, Nashwan A, Nasoori H, Nasreldein A, Natto Z, Nauman J, Nayak B, Nazri-Panjaki A, Negaresh M, Negash H, Negoi I, Negoi R, Negru S, Nejadghaderi S, Nematollahi M, Nesbit O, Newton C, Nguyen D, Nguyen H, Nguyen H, Nguyen N, Nguyen P, Nguyen V, Niazi R, Nikolouzakis T, Niranjan V, Nnyanzi L, Noman E, Noroozi N, Norrving B, Noubiap J, Nri-Ezedi C, Ntaios G, Nuñez-Samudio V, Nurrika D, Oancea B, Odetokun I, O'Donnell M, Ogunsakin R, Oguta J, Oh I, Okati-Aliabad H, Okeke S, Okekunle A, Okonji O, Okwute P, Olagunju A, Olaiya M, Olana M, Olatubi M, Oliveira G, Olufadewa I, Olusanya B, Bali A, Ong S, Onwujekwe O, Ordak M, Orji A, Ortega-Altamirano D, Osuagwu U, Otstavnov N, Otstavnov S, Ouyahia A, Owolabi M, A M, Pacheco-Barrios K, Padubidri J, Pal P, Palange P, Palladino C, Palladino R, Palma-Alvarez R, Pan F, Panagiotakos D, Panda-Jonas S, Pandey A, Pandey A, Pandian J, Pangaribuan H, Pantazopoulos I, Pardhan S, Parija P, Parikh R, Park S, Parthasarathi A, Pashaei A, Patel J, Patil S, Patoulias D, Pawar S, Pedersini P, Pensato U, Pereira D, Pereira J, Pereira M, Peres M, Perico N, Perna S, Petcu I, Petermann-Rocha F, Pham H, Phillips M, Pinilla-Monsalve G, Piradov M, Plotnikov E, Poddighe D, Polat B, Poluru R, Pond C, Poudel G, Pouramini A, Pourbagher-Shahri A, Pourfridoni M, Pourtaheri N, Prakash P, Prakash S, Prakash V, Prates E, Pritchett N, Purnobasuki H, Qasim N, Qattea I, Qian G, Radhakrishnan V, Raee P, Shahraki H, Rafique I, Raggi A, Raghav P, Rahati M, Rahim F, Rahimi Z, Rahimifard M, Rahman O, Rahman M, Rahman M, Rahman M, Rahmani A, Rahmani S, Youshanlouei H, Rahmati M, Moolambally S, Rajabpour-Sanati A, Ramadan H, Ramasamy S, Ramasubramani P, Ramazanu S, Rancic N, Rao I, Rao S, Rapaka D, Rashedi V, Rashid A, Rashidi M, Alavijeh M, Rasouli-Saravani A, Rawaf S, Razo C, Redwan E, Bana A, Remuzzi G, Rezaei N, Rezaei N, Rezaei N, Rezaeian M, Rhee T, Riad A, Robinson S, Rodrigues M, Rodriguez J, Roever L, Rogowski E, Romoli M, Ronfani L, Roy P, Pramanik K, Rubagotti E, Ruiz M, Russ T, Sunnerhagen K, Saad A, Saadatian Z, Saber K, SaberiKamarposhti M, Sacco S, Saddik B, Sadeghi E, Sadeghian S, Saeed U, Saeed U, Safdarian, Safi S, Sagar R, Sagoe D, Sharif-Askari F, Sharif-Askari N, Sahebkar A, Sahoo S, Sahraian M, Sajedi S, Sakshaug J, Saleh M, Omran H, Salem M, Salimi S, Kafil H, Samadzadeh S, Samargandy S, Samodra Y, Samuel V, Samy A, Sanadgol N, Sanjeev R, Sanmarchi F, Santomauro D, Santri I, Santric-Milicevic M, Saravanan A, Sarveazad A, Satpathy M, Saylan M, Sayyah M, Scarmeas N, Schlaich M, Schuermans A, Schwarzinger M, Schwebel D, Selvaraj S, Sendekie A, Sengupta P, Senthilkumaran S, Serban D, Sergindo M, Sethi Y, SeyedAlinaghi S, Seylani A, Shabani M, Shabany M, Shafie M, Shahabi S, Shahbandi A, Shahid S, Shahraki-Sanavi F, Shahsavari H, Shahwan M, Shaikh M, Shaji K, Sham S, Shama A, Shamim M, Shams-Beyranvand M, Shamsi M, Shanawaz M, Sharath M, Sharfaei S, Sharifan A, Sharma M, Sharma R, Shashamo B, Shayan M, Sheikhi R, Shekhar S, Shen J, Shenoy S, Shetty P, Shiferaw D, Shigematsu M, Shiri R, Shittu A, Shivakumar K, Shokri F, Shool S, Shorofi S, Shrestha S, Tankwanchi A, Siddig E, Sigfusdottir I, Silva J, Silva L, Sinaei E, Singh B, Singh G, Singh P, Singh S, Sirota S, Sivakumar S, Al Mamun Sohag A, Solanki R, Soleimani H, Solikhah S, Solomon Y, Solomon Y, Song S, Song Y, Sotoudeh H, Spartalis M, Stark B, Starnes J, Starodubova A, Stein D, Steiner T, Stovner L, Suleman M, Abdulkader R, Sultana A, Sun J, Sunkersing D, Sunny A, Susianti H, Swain C, Szeto M, Tabarés-Seisdedos R, Tabatabaei S, Tabatabai S, Tabish M, Taheri M, Tahvildari A, Tajbakhsh A, Tampa M, Tamuzi J, Tan K, Tang H, Tareke M, Tarigan I, Tat N, Tat V, Oliaee R, Tavangar S, Tavasol A, Tefera Y, Tehrani-Banihashemi A, Temesgen W, Temsah M, Teramoto M, Tesfaye A, Tesfaye E, Tesler R, Thakali O, Thangaraju P, Thapa R, Thapar R, Thomas N, Thrift A, Ticoalu J, Tillawi T, Toghroli R, Tonelli M, Tovani-Palone M, Traini E, Tran N, Tran N, Van Tran P, Tromans S, Truelsen T, Truyen T, Tsatsakis A, Tsegay G, Tsermpini E, Tualeka A, Tufa D, Ubah C, Udoakang A, Ulhaq I, Umair M, Umakanthan S, Umapathi K, Unim B, Unnikrishnan B, Vaithinathan A, Vakilian A, Tahbaz S, Valizadeh R, Van den Eynde J, Vart P, Varthya S, Vasankari T, Vaziri S, Vellingiri B, Venketasubramanian N, Verras G, Vervoort D, Villafañe J, Villani L, Veloz A, Viskadourou M, Vladimirov S, Vlassov V, Volovat S, Vu L, Vujcic I, Wagaye B, Waheed Y, Wahood W, Walde M, Wang F, Wang S, Wang Y, Wang Y, Waqas M, Waris A, Weerakoon K, Weintraub R, Weldemariam A, Westerman R, Whisnant J, Wickramasinghe D, Wickramasinghe N, Willekens B, Wilner L, Winkler A, Wolfe C, Wu A, Hanson S, Xu S, Xu X, Yadollahpour A, Yaghoubi S, Yahya G, Yamagishi K, Yang L, Yano Y, Yao Y, Yehualashet S, Yeshaneh A, Yesiltepe M, Yi S, Yiğit A, Yiğit V, Yon D, Yonemoto N, You Y, Younis M, Yu C, Yusuf H, Zadey S, Zahedi M, Zakham F, Zaki N, Zali A, Zamagni G, Zand R, Zandieh G, Zangiabadian M, Zarghami A, Zastrozhin M, Zeariya M, Zegeye Z, Zeukeng F, Zhai C, Zhang C, Zhang H, Zhang Y, Zhang Z, Zhao H, Zhao Y, Zheng P, Zhou H, Zhu B, Zhumagaliuly A, Zielińska M, Zikarg Y, Zoladl M, Murray C, Ong K, Feigin V, Vos T, Dua T. Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021. The Lancet Neurology 2024, 23: 344-381. PMID: 38493795, PMCID: PMC10949203, DOI: 10.1016/s1474-4422(24)00038-3.Peer-Reviewed Original ResearchConceptsDisability-adjusted life yearsAge-standardised ratesNervous systemHealth lossDiabetic neuropathyAge-standardised rates of deathGlobal burdenGlobal Burden of Disease StudyAge-standardised DALYsAge-standardised rate of DALYsRates of disability-adjusted life yearsNervous system morbidityBurden of Disease StudyGlobal Burden of DiseaseCause of disability-adjusted life yearsAge-standardised prevalenceBurden of disordersRisk Factors StudyNeurodevelopmental disordersNeurological conditionsBurden of diseasePeripheral nervous systemRate of deathYears of lifeNervous system damage
2023
Genetic Profiling of Sodium Channels in Diabetic Painful and Painless and Idiopathic Painful and Painless Neuropathies
Almomani R, Sopacua M, Marchi M, Ślęczkowska M, Lindsey P, de Greef B, Hoeijmakers J, Salvi E, Merkies I, Ferdousi M, Malik R, Ziegler D, Derks K, Boenhof G, Martinelli-Boneschi F, Cazzato D, Lombardi R, Dib-Hajj S, Waxman S, Smeets H, Gerrits M, Faber C, Lauria G, Group O. Genetic Profiling of Sodium Channels in Diabetic Painful and Painless and Idiopathic Painful and Painless Neuropathies. International Journal Of Molecular Sciences 2023, 24: 8278. PMID: 37175987, PMCID: PMC10179245, DOI: 10.3390/ijms24098278.Peer-Reviewed Original ResearchMeSH KeywordsDiabetes MellitusDiabetic NeuropathiesHumansNAV1.7 Voltage-Gated Sodium ChannelNeuralgiaSmall Fiber NeuropathySodium ChannelsConceptsDiabetic peripheral neuropathySmall fiber neuropathyPainless neuropathySFN patientsPainful neuropathyPeripheral neuropathyNeuropathy patientsPainless diabetic peripheral neuropathyPathogenic variantsPersonalized pain treatmentPainful peripheral neuropathyDifferent pathogenic variantsGenetic profilingSodium channel genePotential pathogenic variantsDPN patientsNeuropathic painNociceptive pathwaysPain treatmentNeuropathyPatientsSodium channelsFrequent featureDifferent centersSCN7ADeriving Schwann cells from hPSCs enables disease modeling and drug discovery for diabetic peripheral neuropathy
Majd H, Amin S, Ghazizadeh Z, Cesiulis A, Arroyo E, Lankford K, Majd A, Farahvashi S, Chemel A, Okoye M, Scantlen M, Tchieu J, Calder E, Le Rouzic V, Shibata B, Arab A, Goodarzi H, Pasternak G, Kocsis J, Chen S, Studer L, Fattahi F. Deriving Schwann cells from hPSCs enables disease modeling and drug discovery for diabetic peripheral neuropathy. Cell Stem Cell 2023, 30: 632-647.e10. PMID: 37146583, PMCID: PMC10249419, DOI: 10.1016/j.stem.2023.04.006.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBupropionDiabetes MellitusDiabetic NeuropathiesDrug DiscoveryHumansMiceRetrospective StudiesSchwann CellsSciatic NerveConceptsDiabetic peripheral neuropathySchwann cellsPeripheral neuropathyPeripheral nervous systemPrimary Schwann cellsBupropion treatmentDiabetic patientsMyelin damageSensory dysfunctionPrimary gliaSelective vulnerabilityAntidepressant drugsHyperglycemic miceLower incidenceRetrospective analysisHuman pluripotent stem cellsSC deathNervous systemTherapeutic candidateHigh glucoseNeuropathyHealth recordsMolecular featuresStem cellsPluripotent stem cells
2022
Peripheral Ion Channel Genes Screening in Painful Small Fiber Neuropathy
Ślęczkowska M, Almomani R, Marchi M, Salvi E, de Greef B, Sopacua M, Hoeijmakers J, Lindsey P, Waxman S, Lauria G, Faber C, Smeets H, Gerrits M. Peripheral Ion Channel Genes Screening in Painful Small Fiber Neuropathy. International Journal Of Molecular Sciences 2022, 23: 14095. PMID: 36430572, PMCID: PMC9696564, DOI: 10.3390/ijms232214095.Peer-Reviewed Original ResearchMeSH KeywordsAnoctaminsCohort StudiesDiabetic NeuropathiesHumansIon ChannelsNeuralgiaPotassium ChannelsSmall Fiber NeuropathyConceptsSmall fiber neuropathyNeuropathic painIon channel genesPainful small fiber neuropathyPain score VASPathogenic heterozygous variantGenetic variantsIon channelsCohort studyDiabetic neuropathySevere painDifferent etiologiesPainPatientsVoltage-gated sodium ion channelsHeterozygous variantsNeuropathySodium ion channelsGene screeningGeneration sequencingPrevious findingsSuch variantsEtiologySCN1BVariants
2021
Should You Recommend Cannabinoids for This Patient With Painful Neuropathy? : Grand Rounds Discussion From Beth Israel Deaconess Medical Center.
Smetana GW, Tetrault JM, Hill KP, Burns RB. Should You Recommend Cannabinoids for This Patient With Painful Neuropathy? : Grand Rounds Discussion From Beth Israel Deaconess Medical Center. Annals Of Internal Medicine 2021, 174: 237-246. PMID: 33556279, DOI: 10.7326/m20-7945.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnalgesicsCannabinoidsChronic PainDiabetic NeuropathiesFemaleHumansPractice Guidelines as TopicTreatment OutcomeConceptsNeuropathic painChronic painBeth Israel Deaconess Medical CenterPlacebo-treated patientsChronic neuropathic painPainful diabetic neuropathyPotential therapeutic effectsPrimary care practicesEvidence Review GroupEffects of cannabisNoncancer painPainful neuropathyDiabetic neuropathyTherapeutic effectMedical CenterGeneral internistsPainMedical cannabisReview GroupPatientsCare practicesSystematic reviewAddiction medicineCBD productsPatient interest
2020
Alcohol Use and Clinical Outcomes in Adults in the Type 1 Diabetes Exchange
Alessi SM, Foster NC, Rash CJ, Van Name MA, Tamborlane WV, Cengiz E, Polsky S, Wagner J. Alcohol Use and Clinical Outcomes in Adults in the Type 1 Diabetes Exchange. Canadian Journal Of Diabetes 2020, 44: 501-506. PMID: 32792103, DOI: 10.1016/j.jcjd.2020.06.005.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcohol DrinkingBiomarkersCross-Sectional StudiesDiabetes Mellitus, Type 1Diabetic NeuropathiesFemaleFollow-Up StudiesHumansHypoglycemiaMalePrognosisConceptsBody mass indexSevere hypoglycemiaFormer drinkersLower oddsAlcohol consumptionNonbinge drinkersType 1Current binge drinkersPresence of neuropathyDiabetes-related distressDiabetes-related outcomesType 1 diabetesCross-sectional studyYears of ageNon-Hispanic whitesDiabetic ketoacidosisRecent severe hypoglycemiaMedical chartsClinical outcomesMass indexProspective studyDiabetes distressBlood glucoseBinge drinkersDrinking status
2019
A gain-of-function sodium channel β2-subunit mutation in painful diabetic neuropathy
Alsaloum M, Estacion M, Almomani R, Gerrits MM, Bönhof GJ, Ziegler D, Malik R, Ferdousi M, Lauria G, Merkies IS, Faber CG, Dib-Hajj S, Waxman S. A gain-of-function sodium channel β2-subunit mutation in painful diabetic neuropathy. Molecular Pain 2019, 15: 1744806919849802. PMID: 31041876, PMCID: PMC6510061, DOI: 10.1177/1744806919849802.Peer-Reviewed Original ResearchConceptsDiabetic peripheral neuropathyPeripheral neuropathyNeuropathic painDiabetic peripheral neuropathy patientsPainful diabetic peripheral neuropathyDorsal root ganglion neuronsPainful diabetic neuropathyPeripheral neuropathy patientsSodium channel β subunitsSpectrum of patientsUse-dependent inhibitionCardiac conducting systemSodium channel α subunitVoltage-gated sodium channelsChannel α-subunitsSCN11A geneDiabetic neuropathyDiabetes mellitusChronic painNeuropathy patientsGanglion neuronsNegative genetic screeningChannel β subunitHealth sequelaeRepetitive stimulation
2016
Pain intensity rating training
Smith SM, Amtmann D, Askew RL, Gewandter JS, Hunsinger M, Jensen MP, McDermott MP, Patel KV, Williams M, Bacci ED, Burke LB, Chambers CT, Cooper SA, Cowan P, Desjardins P, Etropolski M, Farrar JT, Gilron I, Huang IZ, Katz M, Kerns RD, Kopecky EA, Rappaport BA, Resnick M, Strand V, Vanhove GF, Veasley C, Versavel M, Wasan AD, Turk DC, Dworkin RH. Pain intensity rating training. Pain 2016, 157: 1056-1064. PMID: 27058680, DOI: 10.1097/j.pain.0000000000000502.Peer-Reviewed Original ResearchConceptsPain intensity ratingsAverage pain intensity ratingsPain assessmentPainful diabetic peripheral neuropathyAddiction Clinical Trial TranslationsNetworks (ACTTION) public-private partnershipDiabetic peripheral neuropathyIntensity ratingsLow back painPatient-reported outcomesClinical trial participantsPeripheral neuropathyPain fluctuationsTreatment trialsTrial participantsSignificant differencesStandardized guidanceDiscriminant validityParticipantsGroupMost measuresNeuropathyAnalgesicsPainAssessmentBotulinum Toxin Treatment of Neuropathic Pain
Mittal SO, Safarpour D, Jabbari B. Botulinum Toxin Treatment of Neuropathic Pain. Seminars In Neurology 2016, 36: 073-083. PMID: 26866499, DOI: 10.1055/s-0036-1571953.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholine Release InhibitorsAnalgesicsBotulinum ToxinsBotulinum Toxins, Type ADiabetic NeuropathiesFemaleHumansMiddle AgedNeuralgiaTreatment OutcomeConceptsNeuropathic painBoNT treatmentComplex regional pain syndromeBotulinum toxin treatmentPainful diabetic neuropathyRegional pain syndromeCarpal tunnel syndromePhantom limb painEvidence-based statementsForm of painTechnique of injectionPosttraumatic neuralgiaAnalgesic medicationPain syndromePostherpetic neuralgiaDiabetic neuropathyOccipital neuralgiaLevel of efficacyLimb painTrigeminal neuralgiaTunnel syndromeClinical trialsToxin treatmentPainNeuralgia
2015
Serial casting for reconstruction of a deformed Charcot foot: a case report.
Rosenblum JI, Weiss S, Gazes M, Amit-Kohn M. Serial casting for reconstruction of a deformed Charcot foot: a case report. WOUNDS A Compendium Of Clinical Research And Practice 2015, 27: e7-11. PMID: 25974962.Peer-Reviewed Original ResearchConceptsCharcot foot deformitySerial castingReconstructive surgical interventionsLife-threatening infectionsCharcot footCharcot neuroarthropathyFull ambulationMale patientsPeripheral neuropathySurgical interventionFoot deformityCase reportEpithelial breakdownPediatric deformitySevere deformityCurrent treatmentFoot reconstructionEffective modalityBody weightLess deformityPatientsDeformityUlcerationBoneFoot
2014
Effect of variability in the 7‐day baseline pain diary on the assay sensitivity of neuropathic pain randomized clinical trials: An ACTTION study
Farrar JT, Troxel AB, Haynes K, Gilron I, Kerns RD, Katz NP, Rappaport BA, Rowbotham MC, Tierney AM, Turk DC, Dworkin RH. Effect of variability in the 7‐day baseline pain diary on the assay sensitivity of neuropathic pain randomized clinical trials: An ACTTION study. Pain 2014, 155: 1622-1631. PMID: 24831421, DOI: 10.1016/j.pain.2014.05.009.Peer-Reviewed Original ResearchConceptsDiabetic peripheral neuropathyLikelihood of responseClinical trialsPostherpetic neuralgiaPainful diabetic peripheral neuropathyAddiction Clinical Trial TranslationsNetworks (ACTTION) public-private partnershipBaseline pain levelsPlacebo-treated groupRandomized clinical trialsAnalgesic clinical trialsPatient-level dataClinical trial dataExploratory logistic regressionAvailable baseline factorsNeuropathic painPain diaryPain levelsBaseline factorsPain therapyPeripheral neuropathyPatient sexPatients' baselinePain ratingsStudy protocolAntinociceptive Effect of Chlorogenic Acid in Rats with Painful Diabetic Neuropathy
Bagdas D, Ozboluk H, Cinkilic N, Gurun M. Antinociceptive Effect of Chlorogenic Acid in Rats with Painful Diabetic Neuropathy. Journal Of Medicinal Food 2014, 17: 730-732. PMID: 24611441, DOI: 10.1089/jmf.2013.2966.Peer-Reviewed Original ResearchConceptsDiabetic neuropathic painAntinociceptive effectNeuropathic painChronic treatmentPainful diabetic neuropathyPossible antinociceptive effectSignificant antinociceptive effectChlorogenic acid treatmentChlorogenic acidDiabetic neuropathyNondiabetic ratsDiabetic ratsSingle doseAntinociceptive potentialRatsBeneficial effectsPainTreatmentPresent studyNeuropathyStreptozotocinHyperglycemiaDiabetesDose
2012
Maladaptive Dendritic Spine Remodeling Contributes to Diabetic Neuropathic Pain
Tan AM, Samad OA, Fischer TZ, Zhao P, Persson AK, Waxman SG. Maladaptive Dendritic Spine Remodeling Contributes to Diabetic Neuropathic Pain. Journal Of Neuroscience 2012, 32: 6795-6807. PMID: 22593049, PMCID: PMC6622192, DOI: 10.1523/jneurosci.1017-12.2012.Peer-Reviewed Original ResearchConceptsDiabetic neuropathic painNeuropathic painDendritic spinesSpine plasticitySpine morphologyMajor public health problemDiabetes-induced changesDevelopment of painDendritic spine remodelingDendritic spine plasticitySpontaneous firing activityPublic health problemAvailable clinical treatmentsEvidence of painDendritic spine morphologyDendritic spine shapeNeuronal hyperresponsivenessRange neuronsWDR neuronsNeuron hyperexcitabilitySTZ injectionDorsal hornMechanical painChronic painDiabetic ratsDiabetic Neuropathy
Inzucchi S, Rosenstock J, Umpierrez G. Diabetic Neuropathy. The Journal Of Clinical Endocrinology & Metabolism 2012, 97: 35a-35a. PMID: 22563114, DOI: 10.1210/jcem.97.5.zeg35a.Peer-Reviewed Original ResearchDiabetic NeuropathiesHumans
2009
The Semmes Weinstein monofilament examination as a screening tool for diabetic peripheral neuropathy
Feng Y, Schlösser FJ, Sumpio BE. The Semmes Weinstein monofilament examination as a screening tool for diabetic peripheral neuropathy. Journal Of Vascular Surgery 2009, 50: 675-682.e1. PMID: 19595541, DOI: 10.1016/j.jvs.2009.05.017.Peer-Reviewed Original ResearchConceptsSemmes-Weinstein monofilament examinationDiabetic peripheral neuropathyNerve conduction studiesNegative predictive valuePositive predictive valueDiagnostic valueMonofilament examinationPeripheral neuropathyDiabetes mellitusPredictive valueLower extremity amputationRisk of ulcerationPublication date restrictionsCurrent literatureReference testConduction studiesExtremity amputationPlantar aspectDate restrictionsCurrent evidenceFifth metatarsalGreat toePubMed databaseEarly interventionIndependent investigators
2007
Screening for Coronary Artery Disease in Patients With Diabetes
Bax JJ, Young LH, Frye RL, Bonow RO, Steinberg HO, Barrett EJ. Screening for Coronary Artery Disease in Patients With Diabetes. Diabetes Care 2007, 30: 2729-2736. PMID: 17901530, DOI: 10.2337/dc07-9927.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAtherosclerosisCoronary DiseaseDiabetic AngiopathiesDiabetic NeuropathiesDiabetic RetinopathyHumansHyperglycemiaMass ScreeningRisk AssessmentConceptsCoronary artery diseaseArtery diseaseCardiovascular diseaseHigh-risk coronary artery diseaseStable coronary artery diseaseCoronary artery calcium scoringAdditive survival benefitIntensive medical managementRecognition of diabetesCVD risk reductionPercutaneous coronary revascularizationStrong clinical suspicionAmerican Diabetes AssociationType 2 diabetesClinical trial resultsCost of diabetesAsymptomatic patientsAtherosclerotic burdenCoronary revascularizationCardiac eventsClinical suspicionCoronary atherosclerosisDiabetic populationSurvival benefitAsymptomatic atherosclerosis
2006
The Association of Psychological Factors, Physical Activity, Neuropathy, and Quality of Life in Type 2 Diabetes
Chyun DA, Melkus GD, Katten DM, Price WJ, Davey JA, Grey N, Heller G, Wackers FJ. The Association of Psychological Factors, Physical Activity, Neuropathy, and Quality of Life in Type 2 Diabetes. Biological Research For Nursing 2006, 7: 279-288. PMID: 16581898, DOI: 10.1177/1099800405285748.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnxietyAttitude to HealthConnecticutCoronary DiseaseCross-Sectional StudiesDepressionDiabetes Mellitus, Type 2Diabetic NeuropathiesFemaleHostilityHumansLinear ModelsMaleMiddle AgedMotor ActivityMultivariate AnalysisQuality of LifeRisk FactorsSocioeconomic FactorsSurveys and QuestionnairesVirginiaConceptsQuality of lifeBody mass indexDepressive symptomsMass indexPhysical inactivityMedical Outcomes Study Short Form-36Diabetes-related microvascular complicationsHigher Body Mass IndexPoor QOLAsymptomatic Diabetics (DIAD) studyCardiac risk factorsDiabetes-related factorsShort Form-36Type 2 diabetesPsychological factorsDetection of ischemiaMicrovascular complicationsForm-36Diabetes QualityFemale sexRisk factorsAncillary studiesDiabetic studyPhysical activityType 2
2004
Cardiac Abnormalities in Diabetic Patients With Neuropathy
Johnson BF, Nesto RW, Pfeifer MA, Slater WR, Vinik AI, Chyun DA, Law G, Wackers FJ, Young LH. Cardiac Abnormalities in Diabetic Patients With Neuropathy. Diabetes Care 2004, 27: 448-454. PMID: 14747227, DOI: 10.2337/diacare.27.2.448.Peer-Reviewed Original ResearchMeSH KeywordsAldehyde ReductaseBenzothiazolesCardiac OutputDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2Diabetic NeuropathiesDouble-Blind MethodEnzyme InhibitorsExercise TestFemaleHeartHeart Conduction SystemHeart RateHumansMaleMiddle AgedPhthalazinesPlacebosStroke VolumeThiazolesVentricular Function, LeftConceptsLeft ventricular ejection fractionDiabetic patientsARI treatmentCardiac outputStroke volumeCardiac abnormalitiesAldose reductase inhibitorExercise left ventricular ejection fractionAbnormal heart rate variabilityDiastolic peak filling rateAsymptomatic cardiac abnormalitiesGated radionuclide ventriculographyMaximal bicycle exercisePlacebo-treated subjectsDiastolic filling rateVentricular ejection fractionCoronary artery diseaseValvular heart diseasePeak filling rateExercise cardiac outputLV stroke volumeHeart rate variabilityBlinded treatmentInsulin useArtery disease
2001
The frequency of undiagnosed diabetes and impaired glucose tolerance in patients with idiopathic sensory neuropathy
Novella S, Inzucchi S, Goldstein J. The frequency of undiagnosed diabetes and impaired glucose tolerance in patients with idiopathic sensory neuropathy. Muscle & Nerve 2001, 24: 1229-1231. PMID: 11494278, DOI: 10.1002/mus.1137.Peer-Reviewed Original ResearchConceptsIdiopathic sensory neuropathyAbnormal glucose metabolismUndiagnosed abnormal glucose metabolismPainful symptomsSensory neuropathyGlucose metabolismOral glucose tolerance testComparison of patientsGlucose tolerance testUndiagnosed diabetesGlucose toleranceTolerance testPatientsNeuropathySymptomsP-valueMetabolismDiabetesHigh frequency
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