2025
Sex Differences in Cardiovascular Outcomes of Intravascular Imaging-Guided PCI A Meta-Analysis of Randomized Controlled Trials
Ezenna C, Ibrahim S, Ramesh P, Ismayl M, Krishna M, Joseph M, Chi K, Altin S, Nanna M, Goldsweig A. Sex Differences in Cardiovascular Outcomes of Intravascular Imaging-Guided PCI A Meta-Analysis of Randomized Controlled Trials. JACC Advances 2025, 4: 102076. PMID: 40829371, PMCID: PMC12391688, DOI: 10.1016/j.jacadv.2025.102076.Peer-Reviewed Original ResearchPercutaneous coronary interventionRandomized Controlled TrialsCardiovascular outcomesRisk ratioControlled TrialsCoronary artery disease patientsIntravascular ultrasound-guided percutaneous coronary interventionAngiography-guided percutaneous coronary interventionSystematic review of PubMedAdverse cardiovascular eventsCoronary artery diseaseArtery disease patientsReview of PubMedIntravascular imaging guidanceSystematic reviewIntravascular imagingRandom-effects modelCardiovascular disease presentationCardiovascular eventsDisease presentationArtery diseaseAngiographySex differencesCoronary interventionCochrane DatabaseTowards a dynamic model to estimate evolving risk of major bleeding after percutaneous coronary intervention
Hurley N, Desai N, Dhruva S, Khera R, Schulz W, Huang C, Curtis J, Masoudi F, Rumsfeld J, Negahban S, Krumholz H, Mortazavi B. Towards a dynamic model to estimate evolving risk of major bleeding after percutaneous coronary intervention. PLOS Digital Health 2025, 4: e0000906. PMID: 40560847, PMCID: PMC12193038, DOI: 10.1371/journal.pdig.0000906.Peer-Reviewed Original ResearchNational Cardiovascular Data RegistryPercutaneous coronary interventionPrescription of medicationsRisk predictionArea under the receiver operating characteristic curveRisk prediction modelTreatment decision makingIndividualized carePatient dischargeData registryRisk estimatesRisk modelPrimary outcomeIndex admissionRisk informationModerate riskCoronary interventionPercutaneous coronary intervention proceduresRisk factorsPatient characteristicsIn-hospital bleeding eventsHigh riskLow riskMedical historyRegistryNovel risk score for patients undergoing Impella-assisted high-risk percutaneous coronary intervention
Lemor A, Shah T, Thompson J, Protty M, Mamas M, Kinnaird T, Bharadwaj A, Truesdell A, Schonning M, Zhang Y, Hussain Y, Falah B, Cohen D, Redfors B, Baron S, Witzke C, Dixon S, Basir M, Lansky A, O'Neill W. Novel risk score for patients undergoing Impella-assisted high-risk percutaneous coronary intervention. Cardiovascular Revascularization Medicine 2025 PMID: 40541479, DOI: 10.1016/j.carrev.2025.05.031.Peer-Reviewed Original ResearchNational Cardiovascular Data RegistryHigh-risk percutaneous coronary interventionRisk scoreBedside risk scoreIn-Hospital MortalityPercutaneous coronary interventionC-indexPercutaneous left ventricular assist deviceCoronary interventionLeft ventricular ejection fractionPredictors of in-hospital mortalityVentricular ejection fractionPre-procedural variablesPoor goodness of fitNovel risk scoreIn-hospital eventsAcute myocardial infarctionLeft main diseaseData registryComplex high-riskClinical decisionsEjection fractionMultivariate regressionLeft ventricular assist deviceHigh riskContemporary Use and Clinical Significance of Initial Triple Versus Double Therapy After Percutaneous Coronary Intervention for Myocardial Infarction in Patients With Atrial Fibrillation
Park D, McLean B, Akman Z, Li D, Babapour G, Nanna M. Contemporary Use and Clinical Significance of Initial Triple Versus Double Therapy After Percutaneous Coronary Intervention for Myocardial Infarction in Patients With Atrial Fibrillation. Journal Of The American Heart Association 2025, 14: e038589. PMID: 40401606, PMCID: PMC12229217, DOI: 10.1161/jaha.124.038589.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnticoagulantsAspirinAtrial FibrillationClinical RelevanceDrug Therapy, CombinationDual Anti-Platelet TherapyFemaleHemorrhageHospital MortalityHumansMaleMiddle AgedMyocardial InfarctionPercutaneous Coronary InterventionPlatelet Aggregation InhibitorsRetrospective StudiesTime FactorsTreatment OutcomeConceptsPercutaneous coronary interventionST-segment elevation myocardial infarctionDouble therapyTriple therapyClinical adverse eventsIn-Hospital MortalityAtrial fibrillationPost-PCIMyocardial infarctionIntracranial hemorrhageAdverse eventsCourse of triple therapyCoronary interventionStent thrombosisInverse probability of treatment weightingProbability of treatment weightingHigh-risk subgroupsMultivariate logistic regressionAssociated with higher oddsRandomized trial evidenceNo significant differenceVizient clinical databaseClinical significancePrescribing patternsCompare outcomesImpact of Mean Blood Pressure Profiles in Percutaneous Left Ventricular Assist Device‐Supported High‐Risk Percutaneous Coronary Intervention: The PROTECT III Study
Bonnet G, Rommel K, Falah B, Lansky A, Zhang Y, Schonning M, Redfors B, Burkhoff D, Cohen D, Basir M, O'Neill W, Granada J. Impact of Mean Blood Pressure Profiles in Percutaneous Left Ventricular Assist Device‐Supported High‐Risk Percutaneous Coronary Intervention: The PROTECT III Study. Journal Of The American Heart Association 2025, 14: e036367. PMID: 40371603, PMCID: PMC12184586, DOI: 10.1161/jaha.124.036367.Peer-Reviewed Original ResearchConceptsIn-Hospital OutcomesBP categoriesPercutaneous coronary interventionHigh-risk percutaneous coronary interventionMean blood pressureBaseline BP levelsCoronary interventionIn-Hospital DeathAssociated with higher ratesVentricular assist device supportStroke/transient ischemic attackLeft ventricular assist device supportCerebrovascular eventsAssist device supportPercutaneous left ventricular assist device supportHistory of heart failureIn-HospitalInterventionHemodynamic profileAdverse outcomesBP levelsPrevent hypotensionPercutaneous left ventricular assist deviceMyocardial infarctionBlood pressureRobotic-Assisted Percutaneous Coronary Intervention: Final Results of the PRECISION and PRECISION GRX Studies
Mahmud E, Madder R, Wohns D, Schussler J, Salisbury A, Campbell P, Patel T, Lombardi W, Nicholson W, Parikh M, Kelm N, Waksman R, Lansky A, Weisz G. Robotic-Assisted Percutaneous Coronary Intervention: Final Results of the PRECISION and PRECISION GRX Studies. Journal Of The Society For Cardiovascular Angiography & Interventions 2025, 4: 103655. PMID: 40933108, PMCID: PMC12418459, DOI: 10.1016/j.jscai.2025.103655.Peer-Reviewed Original ResearchTechnical success rateR-PCIPercutaneous coronary interventionTechnical successClinical successSuccess rateCoronary interventionCalcific lesionsLack of clinical dataSymptomatic coronary artery diseaseClinical success rateSingle-arm studyAdverse cardiovascular eventsCoronary artery diseaseBifurcation lesionsManual PCIMulticenter experienceComplex lesion typePatient cohortCardiovascular eventsResidual stenosisClinical dataRobotic percutaneous coronary interventionArtery diseaseLesionsCharacteristics and Outcomes of Older Patients Undergoing Protected Percutaneous Coronary Intervention With Impella
Jakob P, Lansky A, Basir M, Schonning M, Falah B, Zhou Z, Batchelor W, Abu‐Much A, Grines C, O'Neill W, Stähli B. Characteristics and Outcomes of Older Patients Undergoing Protected Percutaneous Coronary Intervention With Impella. Journal Of The American Heart Association 2025, 14: e038509. PMID: 40240978, PMCID: PMC12184249, DOI: 10.1161/jaha.124.038509.Peer-Reviewed Original ResearchConceptsHigh-risk percutaneous coronary interventionOutcomes of patientsPercutaneous coronary interventionOlder patientsCoronary interventionYears of ageCerebral eventsHigher left ventricular ejection fractionRates of respiratory failureSevere valvular heart diseaseRates of all-cause deathOutcomes of older patientsIn-hospital vascular complicationsVentricular ejection fractionCardiac Surgery scoreAll-cause deathValvular heart diseaseLeft main percutaneous coronary interventionEjection fractionRespiratory failureRenal functionPericardial tamponadeBaseline characteristicsSafety profileYounger patientsOptical Coherence Tomography Versus Angiography Alone to Guide PCI for Complex Lesions: A Meta-Analysis of Randomized Controlled Trials
Ezenna C, Krishna M, Joseph M, Ibrahim S, Pereira V, Jenil-Franco A, Nanna M, Bangalore S, Goldsweig A. Optical Coherence Tomography Versus Angiography Alone to Guide PCI for Complex Lesions: A Meta-Analysis of Randomized Controlled Trials. Circulation Cardiovascular Interventions 2025, 18: e015141. PMID: 40159113, DOI: 10.1161/circinterventions.125.015141.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionAdverse cardiovascular eventsRandomized Controlled TrialsOptical coherence tomographyMyocardial infarctionControlled TrialsCardiac deathCardiovascular eventsComplex lesionsRisk ratioMeta-analysis of randomized controlled trialsOCT-guided percutaneous coronary interventionHigh-resolution intracoronary imagingMajor adverse cardiovascular eventsAssociated with lower major adverse cardiovascular eventsMedian Follow-UpTarget vessel revascularizationPeriprocedural myocardial infarctionRandom-effects modelClinical outcomesCoherence tomographyFollow-upCochrane DatabaseCoronary interventionStent thrombosisDrug-Coated Balloons for Coronary Artery Disease: From Theory to Practice
Moumneh M, Jamil Y, Nanna M, Damluji A. Drug-Coated Balloons for Coronary Artery Disease: From Theory to Practice. Current Treatment Options In Cardiovascular Medicine 2025, 27: 28. PMID: 40893483, PMCID: PMC12392985, DOI: 10.1007/s11936-025-01084-4.Peer-Reviewed Original ResearchDrug-Coated BalloonCoronary artery diseasePercutaneous coronary interventionArtery diseaseIn-stent stenosisAcute coronary syndromeNovel DCBEffective drug deliveryIn-stent restenosisBleeding riskDrug-eluting stentsIncreased bleedingPatient selectionLarge-vessel diseaseStandard treatmentCoronary syndromeClinical indicationsDiabetes mellitusReduce complicationsReviewThe purposeCoronary interventionDe-novo small vessel diseaseClinical casesLesion preparationConsensus groupCardiovascular Event Prevalence in Type 1 Versus Type 2 Diabetes: Veradigm Metabolic Registry Insights
Goldsweig A, Knee A, Tak H, Desai N, Bradley S, Lotfi A, Spertus J, Goldsweig B. Cardiovascular Event Prevalence in Type 1 Versus Type 2 Diabetes: Veradigm Metabolic Registry Insights. Journal Of The Society For Cardiovascular Angiography & Interventions 2025, 4: 102502. PMID: 40231053, PMCID: PMC11993881, DOI: 10.1016/j.jscai.2024.102502.Peer-Reviewed Original ResearchIncident cardiovascular eventsPrevalence ratiosDiabetes mellitus type 1Risk of incident cardiovascular eventsCardiovascular diseaseCardiovascular eventsPrimary carePercutaneous coronary interventionMyocardial infarctionType 2 diabetesOutpatient facilitiesEvent prevalenceLimb ischemiaCoronary interventionAge categoriesStudy populationDM2 patientsRisk factorsHemoglobin A1cCarePrevalencePeripheral revascularizationInterventionComorbiditiesDM2Charting the Course for Careers in Interventional Heart Failure: Training, Challenges, and Future Directions
Cheng R, Villela M, Masoumi A, Esposito M, Baran D, Rommel K, Fudim M, Mahfoud F, Lansky A, Burkhoff D, Kapur N. Charting the Course for Careers in Interventional Heart Failure: Training, Challenges, and Future Directions. Journal Of The Society For Cardiovascular Angiography & Interventions 2025, 4: 102569. PMID: 40231064, PMCID: PMC11993878, DOI: 10.1016/j.jscai.2025.102569.Peer-Reviewed Original ResearchTranscatheter valve therapiesHeart failureValve therapyCardiogenic shockCoronary interventionLow ejection fractionDevice-based therapiesTraining pathwaysComplexity of therapeutic optionsEndomyocardial biopsyEjection fractionImplantable pressure sensorTherapeutic optionsHeart transplantationAdvanced HFAtrial pressureImprove outcomesCardiology trainingMechanical Circulatory Support in Patients Without Cardiogenic Shock Undergoing Percutaneous Coronary Intervention
Miller P, Gordon A, Liu Y, Ahmad T, Bromfield S, Girotra S, Davila C, Crawford G, Whitney J, Desai N. Mechanical Circulatory Support in Patients Without Cardiogenic Shock Undergoing Percutaneous Coronary Intervention. Journal Of The American Heart Association 2025, 14: e037424. PMID: 39791394, PMCID: PMC12054512, DOI: 10.1161/jaha.124.037424.Peer-Reviewed Original ResearchConceptsMicroaxial left ventricular assist deviceIntra-aortic balloon pump usePercutaneous coronary interventionIntra-aortic balloon pumpBalloon pump useCardiogenic shockLeft ventricular assist deviceTotal health care costsIndex admissionBalloon pumpIncident dialysisHealth care costsCoronary interventionAssociated with lower mortalityPump useLVAD useHigh-risk percutaneous coronary interventionAssociated with higher costsInverse probability treatmentCare costsMechanical circulatory supportInsured populationSecondary outcomesPrimary outcomeRetrospective studySex Differences in the Safety and Efficacy of Different Durations of DAPT After PCI
Park D, Mahajan S, Fishman E, Ambrosini A, Acero L, Hu J, Campbell G, Babapour G, Kelsey M, Douglas P, Gupta A, Frampton J, Nanna M. Sex Differences in the Safety and Efficacy of Different Durations of DAPT After PCI. JACC Advances 2025, 4: 101543. PMID: 39886301, PMCID: PMC11780104, DOI: 10.1016/j.jacadv.2024.101543.Peer-Reviewed Original ResearchMonths of DAPTDuration of dual antiplatelet therapyNet adverse clinical eventsDuration of DAPTRandomized Controlled TrialsPercutaneous coronary interventionShorter duration of dual antiplatelet therapyRisk of bleedingBleeding riskLow risk of bleedingSex-based differencesAssociated with lower riskAdverse clinical eventsDual antiplatelet therapyAdverse cardiovascular eventsNetwork Meta-AnalysisWeb of Science databasesAntiplatelet therapyClinical impactCardiovascular eventsClinical eventsSystematic reviewSignificant sex-based differencesControlled TrialsCoronary intervention
2024
Fractional flow reserve-guided complete revascularization versus culprit-only percutaneous coronary intervention in patients with myocardial infarction: A meta-analysis of randomized controlled trials
Ezenna C, Krishna M, Joseph M, Pereira V, Ramesh P, Ismayl M, Nanna M, Goldsweig A. Fractional flow reserve-guided complete revascularization versus culprit-only percutaneous coronary intervention in patients with myocardial infarction: A meta-analysis of randomized controlled trials. Cardiovascular Revascularization Medicine 2024, 78: 31-40. PMID: 39721936, DOI: 10.1016/j.carrev.2024.12.004.Peer-Reviewed Original ResearchContrast-induced acute kidney injuryMultivessel coronary artery diseaseFFR-guided CRCoronary artery diseaseComposite adverse eventsPercutaneous coronary interventionRandomized Controlled TrialsCardiac deathAdverse eventsMyocardial infarctionComplete revascularizationRecurrent myocardial infarction ratesMedian follow-up durationRisk ratioCoronary interventionStent thrombosisMeta-analysis of randomized controlled trialsControlled TrialsFFR-guided complete revascularizationFollow-up durationMeta-analysisAcute kidney injuryAll-cause deathCochrane CENTRAL databasesCulprit-only percutaneous coronary interventionShort Versus One-Year Dual Antiplatelet Therapy After Percutaneous Coronary Intervention: an Updated Meta-Analysis
Joseph M, Krishna M, Ezenna C, Pereira V, Ismayl M, Nanna M, Bangalore S, Goldsweig A. Short Versus One-Year Dual Antiplatelet Therapy After Percutaneous Coronary Intervention: an Updated Meta-Analysis. The American Journal Of Cardiology 2024, 237: 17-28. PMID: 39577682, DOI: 10.1016/j.amjcard.2024.10.038.Peer-Reviewed Original ResearchPost-percutaneous coronary interventionAcute coronary syndromeDrug-eluting stentsPercutaneous coronary interventionCoronary interventionAcute coronary syndrome cohortCochrane CENTRAL databasesShortening DAPT durationMonths post-percutaneous coronary interventionClopidogrel subgroupRandomized Controlled TrialsNo significant differenceCoronary syndromeMonotherapyTicagrelor monotherapyDAPT durationShorter DAPTBleedingStent thrombosisP2Y12iMyocardial infarctionControlled TrialsSubgroup interactionsDAPTMeta-analysisEffect of apixaban versus vitamin K antagonist and aspirin versus placebo on days alive and out of hospital: An analysis from AUGUSTUS
Fanaroff A, Vora A, Wojdyla D, Mehran R, Granger C, Goodman S, Aronson R, Windecker S, Alexander J, Lopes R. Effect of apixaban versus vitamin K antagonist and aspirin versus placebo on days alive and out of hospital: An analysis from AUGUSTUS. American Heart Journal 2024, 280: 60-69. PMID: 39557109, DOI: 10.1016/j.ahj.2024.11.005.Peer-Reviewed Original ResearchConceptsAcute coronary syndromeTime-to-event analysisAtrial fibrillationCoronary syndromeClinical trialsEffect of antithrombotic therapyVitamin K antagonistsProportion of patientsRobust variance estimationRandomized clinical trialsClinical trial endpointsPercutaneous coronary interventionK antagonistsAntithrombotic therapyPoisson regressionTreatment armsFollow-upIschemic eventsPlaceboRate ratiosAntithrombotic agentsTrial endpointsWarfarinCoronary interventionIntervention methodsImpact of Time to Initiation of Targeted Temperature Management Among Patients with Out-of-Hospital Cardiac Arrest Undergoing Percutaneous Coronary Intervention
Kovach C, Leonard J, Messenger J, Waldo S, Perman S. Impact of Time to Initiation of Targeted Temperature Management Among Patients with Out-of-Hospital Cardiac Arrest Undergoing Percutaneous Coronary Intervention. Therapeutic Hypothermia And Temperature Management 2024, 15: 74-81. PMID: 39311798, DOI: 10.1089/ther.2024.0030.Peer-Reviewed Original ResearchOdds of neurologically favorable survivalOut-of-hospital cardiac arrestST-elevation myocardial infarctionNeurologically favorable survivalPercutaneous coronary interventionInitiation of targeted temperature managementTemperature management initiationFavorable survivalOverall survivalHospital dischargeVentricular tachycardiaTemperature managementSurvivors of ventricular tachycardiaVentricular fibrillationCoronary interventionAssociated with adverse clinical outcomesDelayed coronary angiographyProportion of patientsAdverse clinical outcomesPropensity-weighted analysisAssociated with decreased oddsAssociated with delayWithdrawal of life-sustaining careLife-sustaining careCoronary angiographyMachine learning prediction of one-year mortality after percutaneous coronary intervention in acute coronary syndrome patients
Hosseini K, Behnoush A, Khalaji A, Etemadi A, Soleimani H, Pasebani Y, Jenab Y, Masoudkabir F, Tajdini M, Mehrani M, Nanna M. Machine learning prediction of one-year mortality after percutaneous coronary intervention in acute coronary syndrome patients. International Journal Of Cardiology 2024, 409: 132191. PMID: 38777044, DOI: 10.1016/j.ijcard.2024.132191.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionLogistic regressionPost-PCI mortalityPrediction of one-year mortalityCoronary interventionPrediction of 1-year mortalityBody mass indexAcute coronary syndrome patientsOne-year mortalityIndividual-level assessmentsReceiver operating characteristic curveAcute coronary syndromeCoronary syndrome patientsTehran Heart CenterRates of comorbiditiesMass indexHigher ageSyndrome patientsCoronary syndromeHeart CenterFollow-upLipid profileU-shaped correlationPatientsCharacteristic curveIllusion of revascularization: does anyone achieve optimal revascularization during percutaneous coronary intervention?
Fezzi S, Ding D, Mahfoud F, Huang J, Lansky A, Tu S, Wijns W. Illusion of revascularization: does anyone achieve optimal revascularization during percutaneous coronary intervention? Nature Reviews Cardiology 2024, 21: 652-662. PMID: 38710772, DOI: 10.1038/s41569-024-01014-0.Peer-Reviewed Original ResearchPercutaneous coronary interventionOptimal revascularizationRisk of periprocedural myocardial infarctionCoronary interventionMyocardial infarctionStent-related eventsEfficacy of percutaneous coronary interventionCoronary artery diseasePeriprocedural myocardial infarctionAcute myocardial infarctionReperfusion of acute myocardial infarctionClinical successRevascularization outcomesArtery diseaseIncreased riskAngiographic guidancePercutaneous revascularizationRevascularizationPatientsIntracoronary imagingLincoffDiagnostic toolPhysiological assessmentAngiographic Characteristics and Clinical Outcomes in Patients With Chronic Kidney Disease Undergoing Impella-Supported High-Risk Percutaneous Coronary Intervention: Insights From the cVAD PROTECT III Study
Bharadwaj A, Abu-Much A, Maini A, Zhou Z, Li Y, Batchelor W, Grines C, Baron S, Redfors B, Lansky A, Basir M, O’Neill W. Angiographic Characteristics and Clinical Outcomes in Patients With Chronic Kidney Disease Undergoing Impella-Supported High-Risk Percutaneous Coronary Intervention: Insights From the cVAD PROTECT III Study. Circulation Cardiovascular Interventions 2024, 17: e013503. PMID: 38708609, PMCID: PMC11239095, DOI: 10.1161/circinterventions.123.013503.Peer-Reviewed Original ResearchChronic kidney diseaseHigh-risk percutaneous coronary interventionPercutaneous coronary interventionAdvanced chronic kidney diseaseIII studiesCerebrovascular eventsAngiographic characteristicsClinical outcomesCoronary calcificationCoronary interventionSevere coronary calcificationCardiac Surgery scoreHigh-risk patientsLong-term outcomesPercutaneous coronary intervention complicationsPCI-related complicationsPrevalence of hypertensionPeripheral arterial diseaseCoronary complicationsBaseline comorbiditiesSurgery scoreArtery diseasePrimary outcomeEGFRKidney disease
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