2025
Consensus Guideline for the Management of Patients with Appendiceal Tumors, Part 1: Appendiceal Tumors Without Peritoneal Involvement
Godfrey E, Mahoney F, Bansal V, Su D, Hanna D, Lopez-Ramirez F, Baron E, Turaga K, Benson A, Cusack J, Winer J, Gunderson C, Misdraji J, Shah R, Magge D, Solsky I, Eng C, Eng O, Shergill A, Shen J, Foote M. Consensus Guideline for the Management of Patients with Appendiceal Tumors, Part 1: Appendiceal Tumors Without Peritoneal Involvement. Annals Of Surgical Oncology 2025, 1-34. PMID: 40560498, DOI: 10.1245/s10434-025-17359-w.Peer-Reviewed Original ResearchAppendiceal tumorsPeritoneal involvementConsensus guidelinesHeterogeneous group of tumorsSystemic therapy recommendationsGroup of tumorsManagement of patientsAppendiceal malignancyAppendiceal adenocarcinomaIntraperitoneal chemotherapyMucinous neoplasmsMargin statusModified Delphi consensusPathological findingsClinical dataPathological classificationColorectal cancerPathway blockTherapy recommendationsTumorConsensus recommendationsObservational studyTherapy conceptsHeterogeneous groupStandard careConsensus guideline for the management of patients with appendiceal tumors, part 1: Appendiceal tumors without peritoneal involvement
Godfrey E, Mahoney F, Bansal V, Su D, Hanna D, Lopez‐Ramirez F, Baron E, Turaga K, Benson A, Cusack J, Winer J, Gunderson C, Misdraji J, Shah R, Magge D, Solsky I, Eng C, Eng O, Shergill A, Shen J, Foote M, Group P. Consensus guideline for the management of patients with appendiceal tumors, part 1: Appendiceal tumors without peritoneal involvement. Cancer 2025, 131: e35867. PMID: 40558045, DOI: 10.1002/cncr.35867.Peer-Reviewed Original ResearchConceptsAppendiceal tumorsPeritoneal involvementConsensus guidelinesHeterogeneous group of tumorsSystemic therapy recommendationsGroup of tumorsManagement of patientsAppendiceal malignancyAppendiceal adenocarcinomaIntraperitoneal chemotherapyMucinous neoplasmsMargin statusModified Delphi consensusPathological findingsClinical dataColorectal cancerPathological classificationPathway blockTherapy recommendationsTumorConsensus recommendationsObservational studyTherapy conceptsHeterogeneous groupStandard careIdentification of differential epigenetic landscapes in subtypes of appendiceal cancer.
Ladel L, Tan W, Sailo B, Das P, Tyagi A, Nalbantoglu I, Sharma A, Ahuja N. Identification of differential epigenetic landscapes in subtypes of appendiceal cancer. Journal Of Clinical Oncology 2025, 43: 4199-4199. DOI: 10.1200/jco.2025.43.16_suppl.4199.Peer-Reviewed Original ResearchDifferentially Methylated RegionsAppendiceal cancerAdvanced neoplasiaColorectal cancerCpG islandsAppendiceal neoplasmsNormal tissuesMalignant subtypeGenomic dataLow-grade appendiceal mucinous neoplasmEpigenetic landscapeHeterogeneous group of malignanciesPromoter regionAnalysis of CpG islandsAppendiceal mucinous neoplasmGroup of malignanciesNon-neoplastic controlsEnzymatic methyl-seqHypermethylated CpG islandsSingle-base resolutionHypomethylated CpG islandsRare malignancyQ-value cutoffMucinous neoplasmsEpigenetic clusteringTowards automating risk stratification of intraductal papillary mucinous Neoplasms: Artificial intelligence advances beyond human expertise with confocal laser endomicroscopy
Krishna S, Abdelbaki A, Li Z, Culp S, Xiong X, Napoleon B, Mok S, Bertani H, Feng Y, Kongkam P, Luthra A, Machicado J, El-Dika S, Leblanc S, Tan D, Burlen J, Keane M, Keihanian T, Ladd A, Muniraj T, Visrodia K, Chen W, Esnakula A, Hart P, Chao W. Towards automating risk stratification of intraductal papillary mucinous Neoplasms: Artificial intelligence advances beyond human expertise with confocal laser endomicroscopy. Pancreatology 2025, 25: 658-666. PMID: 40447463, PMCID: PMC12354341, DOI: 10.1016/j.pan.2025.05.011.Peer-Reviewed Original ResearchNeedle-based confocal laser endomicroscopyIntraductal papillary mucinous neoplasmBD-IPMNInterobserver agreementArtificial intelligenceConfocal laser endomicroscopyLaser endomicroscopyBranch ductPapillary mucinous neoplasmPerformance of expertsHuman expertiseAI modelsPost Hoc AnalysisMucinous neoplasmsDysplasia gradeEndoscopic ultrasoundClinical criteriaInterobserver variabilityCyst epitheliumSuperior accuracyDysplasiaAUCPost-hocArtificialDiagnostic parametersSystemic chemotherapy in patients with unresectable pseudomyxoma peritonei from low-grade appendiceal mucinous neoplasms: a case series
Vierra M, Morgan R, Ostowari A, Turaga K, Shergill A, Eng O. Systemic chemotherapy in patients with unresectable pseudomyxoma peritonei from low-grade appendiceal mucinous neoplasms: a case series. Journal Of Gastrointestinal Oncology 2025, 16: 757-765. PMID: 40386613, PMCID: PMC12078827, DOI: 10.21037/jgo-24-440.Peer-Reviewed Original ResearchLow-grade appendiceal mucinous neoplasmProgression-free survivalSystemic chemotherapyAppendiceal mucinous neoplasmPseudomyxoma peritoneiCase seriesCarcinoembryonic antigenMucinous neoplasmsFolinic acidAnti-vascular endothelial growth factorMedian progression-free survivalCEA responseMetastatic peritoneal diseaseElevated carcinoembryonic antigenPeritoneal cancer indexMedian Follow-UpBenefit of chemotherapyResponse to chemotherapyCycles of chemotherapyOutcomes of patientsTreated 5 patientsUniversity of Chicago Medical CenterEndothelial growth factorUnresectable diseasePeritoneal disease
2023
Surveillance of Pancreatic Cystic Neoplasms
Chhoda A, Schmidt J, Farrell J. Surveillance of Pancreatic Cystic Neoplasms. Gastrointestinal Endoscopy Clinics Of North America 2023, 33: 613-640. PMID: 37245939, DOI: 10.1016/j.giec.2023.03.010.Peer-Reviewed Original ResearchConceptsPancreatic cystic neoplasmsAdvanced neoplasiaCystic neoplasmsIntraductal papillary mucinous neoplasmClinical surveillance guidelinesHigh-risk morphologyConsensus clinical guidelinesPapillary mucinous neoplasmAccurate preoperative diagnosisCross-sectional imagingSurgical resectionSurgical indicationsPreoperative diagnosisSurveillance guidelinesSurveillance intervalsMucinous neoplasmsMalignant potentialClinical evaluationClinical guidelinesPancreatic cystsClinical challengeSurveillance strategiesNeoplasmsNeoplasiaCurrent conceptsUtility of promoter hypermethylation in malignant risk stratification of intraductal papillary mucinous neoplasms
Chhoda A, Sharma A, Sailo B, Tang H, Ruzgar N, Tan W, Ying L, Khatri R, Narayanan A, Mane S, De Kumar B, Wood L, Iacobuzio-Donahue C, Wolfgang C, Kunstman J, Salem R, Farrell J, Ahuja N. Utility of promoter hypermethylation in malignant risk stratification of intraductal papillary mucinous neoplasms. Clinical Epigenetics 2023, 15: 28. PMID: 36803844, PMCID: PMC9942382, DOI: 10.1186/s13148-023-01429-5.Peer-Reviewed Original ResearchConceptsPapillary mucinous neoplasmMalignant risk stratificationCACNA1G geneRisk stratificationMucinous neoplasmsBiomarker panelBackgroundIntraductal papillary mucinous neoplasmIntraductal papillary mucinous neoplasmEarly detectionPrevious case-control studyHigh-grade dysplasiaCase-control studyPancreatic cancer precursorsReceiver Operating Characteristic (ROC) curve analysisSignificant diagnostic challengeCross-sectional imagingCharacteristic curve analysisOperating Characteristic curve analysisG geneHigh diagnostic specificityPrior validation studiesSignificant procedural riskIPMN tissuesSurgical resectionAdvanced neoplasia
2022
Benefit of Extended Surveillance of Low-Risk Pancreatic Cysts After 5-Year Stability: A Systematic Review and Meta-Analysis
Chhoda A, Singh S, Sheth AH, Grimshaw AA, Gunderson C, Sharma P, Kunstman JW, Sharma A, Ahuja N, Gonda TA, Farrell JJ. Benefit of Extended Surveillance of Low-Risk Pancreatic Cysts After 5-Year Stability: A Systematic Review and Meta-Analysis. Clinical Gastroenterology And Hepatology 2022, 21: 1430-1446. PMID: 35568304, DOI: 10.1016/j.cgh.2022.04.025.Peer-Reviewed Original ResearchConceptsDisease-specific mortalityAdvanced neoplasiaBD-IPMNsExtended surveillancePooled incidenceWorrisome featuresSystematic reviewIntraductal papillary mucinous neoplasmHigh-grade dysplasiaPapillary mucinous neoplasmHigh-quality studiesRandom-effects modelWarrants further investigationWeb of ScienceNeoplasia incidenceWarrants further explorationSurvival benefitCochrane LibraryMucinous neoplasmsPancreatic cancerPancreatic cystsSurveillance periodEligible studiesOvid MEDLINELower incidenceA Review of Mucinous Cystic and Intraductal Neoplasms of the Pancreatobiliary Tract.
Ozcan K, Klimstra D. A Review of Mucinous Cystic and Intraductal Neoplasms of the Pancreatobiliary Tract. Archives Of Pathology & Laboratory Medicine 2022, 146: 298-311. PMID: 35192699, DOI: 10.5858/arpa.2021-0399-ra.Peer-Reviewed Original ResearchConceptsMucinous cystic neoplasmsIntraductal neoplasmsPancreatobiliary tractCystic neoplasmsPancreatic neoplasmsIntraductal papillary mucinous neoplasmPancreatic intraductal neoplasmsIntraductal oncocytic papillary neoplasmBile duct neoplasmsPapillary mucinous neoplasmCystic pancreatic neoplasmsMass-forming neoplasmIntraductal tubulopapillary neoplasmIntraductal papillary neoplasmIntraductal papillary neoplasm of bile ductSensitive imaging techniqueMucinous neoplasmsPapillary neoplasmPancreatobiliary neoplasmsPrognostic variationsGenomic alterationsTubulopapillary neoplasmNeoplasmsBile ductPathological features
2021
Celecoxib and Myrtol
Vierra M, Dhiman A, Witmer H, Ulrich L, Hindi E, Fenton E, Shergill A, Polite B, Eng O, Turaga K. Celecoxib and Myrtol. American Journal Of Clinical Oncology 2021, 45: 9-13. PMID: 34857698, DOI: 10.1097/coc.0000000000000878.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAgedAntineoplastic Combined Chemotherapy ProtocolsAppendiceal NeoplasmsCarcinoembryonic AntigenCelecoxibCytoreduction Surgical ProceduresDrug CombinationsFemaleGPI-Linked ProteinsHumansMaleMiddle AgedMonoterpenesNeoplasm Recurrence, LocalPeritoneal NeoplasmsRetrospective StudiesTreatment OutcomeConceptsAppendiceal mucinous neoplasmProgression-free survivalOverall survivalCarcinoembryonic antigenCycles of systemic chemotherapyExtensive peritoneal disseminationMedian Follow-UpCombination of celecoxibValues 3 monthsLimited treatment optionsCEA trendsCytoreductive surgerySystemic chemotherapyPeritoneal diseasePeritoneal disseminationRecurrent diseaseMedian ageMucinous neoplasmsTreatment optionsFollow-upPatientsMyrtolMonthsCelecoxibSurvivalSa302 IS MULTIFOCALITY IN INTRADUCTAL PAPILLARY MUCINOUS NEOPLASMS A RISK FACTOR FOR PANCREATIC MALIGNANCY?: A SYSTEMATIC REVIEW AND META-ANALYSIS
Chhoda A, Singh S, Grimshaw A, Sheth A, Sharma A, Kunstman J, Ahuja N, Farrell J. Sa302 IS MULTIFOCALITY IN INTRADUCTAL PAPILLARY MUCINOUS NEOPLASMS A RISK FACTOR FOR PANCREATIC MALIGNANCY?: A SYSTEMATIC REVIEW AND META-ANALYSIS. Gastroenterology 2021, 160: s-477. DOI: 10.1016/s0016-5085(21)01845-x.Peer-Reviewed Original ResearchResection of pancreatic cystic neoplasms in recurrent acute pancreatitis prevents recurrent pancreatitis but does not identify more malignancies
Muniraj T, Aslanian HR, Laine L, Jamidar PA, Farrell JF, Mitchell KA, Salem RR. Resection of pancreatic cystic neoplasms in recurrent acute pancreatitis prevents recurrent pancreatitis but does not identify more malignancies. World Journal Of Gastroenterology 2021, 27: 1630-1642. PMID: 33958848, PMCID: PMC8058652, DOI: 10.3748/wjg.v27.i15.1630.Peer-Reviewed Original ResearchConceptsIntra-ductal papillary mucinous neoplasmRecurrent acute pancreatitisPancreatic cystic neoplasmsCystic neoplasmsBD-IPMNAcute pancreatitisCause of pancreatitisRole of resectionMucinous cystic neoplasmPrevalence of malignancyPapillary mucinous neoplasmSerous cystic neoplasmsCross-sectional imagingMean episodesRAP patientsSurgical resectionCyst resectionMD-IPMNPrimary outcomeIPMN patientsRecurrent pancreatitisRetrospective studyCyst featuresGallstone aetiologyMucinous neoplasmsCystic Tumors Other than IPMN
Kunstman J, Farrell J. Cystic Tumors Other than IPMN. 2021, 608-623. DOI: 10.1002/9781119570097.ch74.Peer-Reviewed Original ResearchIntraductal papillary mucinous neoplasmMucinous cystic neoplasmCystic lesionsCystic neoplasmsCystic pancreatic endocrine neoplasmsNeoplastic cystic lesionsPapillary mucinous neoplasmSolid pseudopapillary neoplasmPancreatic endocrine neoplasmsPancreatic specialistsCystic tumorSurgical interventionMucinous neoplasmsCommon lesionsSerous cystadenomaPseudopapillary neoplasmEndocrine neoplasmsNeoplasmsClinical issuesLesionsNatural historyPancreasSuccessful managementLongitudinal seriesCystadenomaA Multi-institutional Study of Peritoneal Recurrence Following Resection of Low-grade Appendiceal Mucinous Neoplasms
Baumgartner J, Srivastava A, Melnitchouk N, Drage M, Huber A, Gonzalez R, Bell P, Wu E, Resnick M, Turaga K, Poli E, Esquivel J, Deneve J, Kelly K, Veerapong J, Lowy A. A Multi-institutional Study of Peritoneal Recurrence Following Resection of Low-grade Appendiceal Mucinous Neoplasms. Annals Of Surgical Oncology 2021, 28: 4685-4694. PMID: 33415564, DOI: 10.1245/s10434-020-09499-y.Peer-Reviewed Original ResearchConceptsLow-grade appendiceal mucinous neoplasmAppendiceal mucinous neoplasmPeritoneal recurrenceMulti-institutional studyMucinous neoplasmsFollow-upConclusionsThis multi-institutional studyRate of peritoneal recurrenceRisk of peritoneal recurrenceMedian time to recurrenceMulti-institutional retrospective reviewMedian Follow-UpTime to recurrenceSeries of patientsEvidence of perforationExtra-appendiceal mucinFollow-up dataAbsence of perforationAcellular mucinPseudomyxoma peritoneiMedian agePartial cecectomyPrimary endpointRetrospective reviewBackgroundPeritoneal dissemination
2020
S0106 Imaging Resource Utilization in the Surveillance of Presumed Branched Duct Intraductal Papillary Mucinous Neoplasm (BD-IPMN)
Yousaf M, Zhang Z, Chhoda A, Madhani K, Chaudhary F, Suarez A, Muniraj T, Kunstman J, Jamidar P, Aslanian H, Salem R, Farrell J. S0106 Imaging Resource Utilization in the Surveillance of Presumed Branched Duct Intraductal Papillary Mucinous Neoplasm (BD-IPMN). The American Journal Of Gastroenterology 2020, 115: s51-s51. DOI: 10.14309/01.ajg.0000702472.90174.1c.Peer-Reviewed Original ResearchAppendiceal Mucinous Neoplasm: Nurse Education About a Rare and Complex Disease.
Kamm A, Turaga K. Appendiceal Mucinous Neoplasm: Nurse Education About a Rare and Complex Disease. Clinical Journal Of Oncology Nursing 2020, 24: 409-414. PMID: 32678367, DOI: 10.1188/20.cjon.409-414.Peer-Reviewed Original ResearchConceptsAppendiceal mucinous neoplasmMucinous tumorsComplexity of surgical managementNursing literatureNursing educationCare providersNursesUnique needsMucinous neoplasmsSurgical managementSurgical treatmentPostoperative needComplex diseasesLow incidenceSurgeryTumorPatientsDiseaseDiagnosisNeedsMinimal informationEndoscopic Ultrasound-Guided Fine Needle Aspiration Cytologic Evaluation of Intraductal Papillary Mucinous Neoplasm and Mucinous Cystic Neoplasms of Pancreas
Gilani SM, Adeniran AJ, Cai G. Endoscopic Ultrasound-Guided Fine Needle Aspiration Cytologic Evaluation of Intraductal Papillary Mucinous Neoplasm and Mucinous Cystic Neoplasms of Pancreas. American Journal Of Clinical Pathology 2020, 154: 559-570. PMID: 32589187, DOI: 10.1093/ajcp/aqaa079.Peer-Reviewed Original ResearchConceptsIntraductal papillary mucinous neoplasmMucinous cystic neoplasmMucinous cystic lesionsHigh-grade dysplasiaPapillary mucinous neoplasmCystic neoplasmsMucinous neoplasmsAncillary testingFine-needle aspiration cytologic evaluationUltrasound-guided fine-needle aspiration cytologyEndoscopic ultrasound-guided fine-needle aspiration cytologyFine needle aspiration cytologyRisk of malignancyNeedle aspiration cytologyUse of cytologyPositive cytologic diagnosisCytologic categoriesModerate dysplasiaCystic lesionsCytopathology guidelinesInvasive malignancyMalignancy rateHistologic diagnosisCytologic evaluationEndoscopic ultrasoundSimple mucinous cysts of the pancreas have heterogeneous somatic mutations
Attiyeh M, Zhang L, Iacobuzio-Donahue C, Allen P, Imam R, Basturk O, Klimstra D, Sigel C. Simple mucinous cysts of the pancreas have heterogeneous somatic mutations. Human Pathology 2020, 101: 1-9. PMID: 32380013, PMCID: PMC7321854, DOI: 10.1016/j.humpath.2020.04.006.Peer-Reviewed Original ResearchConceptsIntraductal papillary mucinous neoplasmPapillary mucinous neoplasmMucinous neoplasmsMucinous cystsGenomic alterationsSpectrum of genomic alterationsPancreatic intraepithelial neoplasiaHeterogeneous somatic mutationsSimple mucinous cystTargeted sequencing analysisPancreatic cancer genesIntraepithelial neoplasiaMucinous neoplasiaGNAS mutationsNeoplasmsSomatic mutationsEpithelial liningMutated genesCancer genesPreinvasive neoplasmsCystsPancreasNeoplasiaMutationsAlterationsIntraoperative pancreatoscopy for surgical planning in a patient with ansa pancreatica and mixed-type intraductal pancreatic mucinous neoplasm
Magulick JP, Salem R, Jamidar P. Intraoperative pancreatoscopy for surgical planning in a patient with ansa pancreatica and mixed-type intraductal pancreatic mucinous neoplasm. Gastrointestinal Endoscopy 2020, 92: 968-970. PMID: 32360408, DOI: 10.1016/j.gie.2020.04.052.Peer-Reviewed Original Research
2019
Pancreatic Intraductal Papillary Mucinous Neoplasm With Elevated Pre-Operative Cystic Carcinoembryonic Antigen Level: A Histopathologic Correlation
Beech C, Freedman-Weiss M, Salem R, Jain D, Zhang X. Pancreatic Intraductal Papillary Mucinous Neoplasm With Elevated Pre-Operative Cystic Carcinoembryonic Antigen Level: A Histopathologic Correlation. Gastroenterology Research 2019, 12: 185-190. PMID: 31523327, PMCID: PMC6731045, DOI: 10.14740/gr1201.Peer-Reviewed Original ResearchCarcinoembryonic antigen levelCEA levelsInvasive carcinomaAntigen levelsCEA stainingIntraductal papillary mucinous neoplasm subtypesPancreatic intraductal papillary mucinous neoplasmsIntraductal papillary mucinous neoplasmPresence of dysplasiaPapillary mucinous neoplasmGrade of dysplasiaRisk of malignancySize of lesionsDuct involvementPathologic variablesCystic lesionsIPMN casesMucinous neoplasmsMucinous secretionHistopathologic correlationNeoplasm subtypesCarcinomaGlycoprotein expressionSignificant correlationDysplasia
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