2024
Neuroprotective effect of neuron‐specific deletion of the C16 ceramide synthetic enzymes in an animal model of multiple sclerosis
Amatruda M, Marechal D, Gacias M, Wentling M, Turpin‐Nolan S, Morstein J, Moniruzzaman M, Brüning J, Haughey N, Trauner D, Casaccia P. Neuroprotective effect of neuron‐specific deletion of the C16 ceramide synthetic enzymes in an animal model of multiple sclerosis. Glia 2024, 73: 271-290. PMID: 39489703, PMCID: PMC11662985, DOI: 10.1002/glia.24631.Peer-Reviewed Original ResearchExperimental autoimmune encephalomyelitisNeuron-specific deletionMultiple sclerosisDemyelinating disordersCourse of EAESalvage pathwayAnimal model of multiple sclerosisModel of multiple sclerosisDisease severityRecycling of sphingosineWild type miceCeramide synthase 6Central nervous systemPalmitic acidAutoimmune encephalomyelitisExposure to oxidative stressType miceInflammatory demyelinationMyelin damageSaturated fatAnimal modelsMitochondrial dysfunctionCerS5Nervous systemNeuroprotective effects
2023
Deriving Schwann cells from hPSCs enables disease modeling and drug discovery for diabetic peripheral neuropathy
Majd H, Amin S, Ghazizadeh Z, Cesiulis A, Arroyo E, Lankford K, Majd A, Farahvashi S, Chemel A, Okoye M, Scantlen M, Tchieu J, Calder E, Le Rouzic V, Shibata B, Arab A, Goodarzi H, Pasternak G, Kocsis J, Chen S, Studer L, Fattahi F. Deriving Schwann cells from hPSCs enables disease modeling and drug discovery for diabetic peripheral neuropathy. Cell Stem Cell 2023, 30: 632-647.e10. PMID: 37146583, PMCID: PMC10249419, DOI: 10.1016/j.stem.2023.04.006.Peer-Reviewed Original ResearchConceptsDiabetic peripheral neuropathySchwann cellsPeripheral neuropathyPeripheral nervous systemPrimary Schwann cellsBupropion treatmentDiabetic patientsMyelin damageSensory dysfunctionPrimary gliaSelective vulnerabilityAntidepressant drugsHyperglycemic miceLower incidenceRetrospective analysisHuman pluripotent stem cellsSC deathNervous systemTherapeutic candidateHigh glucoseNeuropathyHealth recordsMolecular featuresStem cellsPluripotent stem cells
2021
Posterior Reversible Encephalopathy Syndrome (PRES) in a Patient with Opioid Use Disorder
Tumenta T, Adeyemo S, Oladeji O, Jegede O, Laurent B, Olupona T. Posterior Reversible Encephalopathy Syndrome (PRES) in a Patient with Opioid Use Disorder. Case Reports In Psychiatry 2021, 2021: 9999481. PMID: 34221530, PMCID: PMC8225411, DOI: 10.1155/2021/9999481.Peer-Reviewed Original ResearchPosterior reversible encephalopathy syndromeReversible encephalopathy syndromeHeroin use disorderEncephalopathy syndromeUse disordersSignificant white matter diseaseClinical-radiographic syndromeOpioid use disorderCerebral white matterWhite matter diseaseOpioid withdrawalNeurology teamEndothelial injuryMyelin damageCerebral autoregulationClinical symptomsCT headMedical floorChronic headacheMental statusRisk factorsRadiographic syndromeMultifactorial etiologyCerebral hemispheresWhite matter
2016
Myelin phagocytosis by astrocytes after myelin damage promotes lesion pathology
Ponath G, Ramanan S, Mubarak M, Housley W, Lee S, Sahinkaya FR, Vortmeyer A, Raine CS, Pitt D. Myelin phagocytosis by astrocytes after myelin damage promotes lesion pathology. Brain 2016, 140: 399-413. PMID: 28007993, PMCID: PMC5841057, DOI: 10.1093/brain/aww298.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnimalsAnimals, NewbornAstrocytesCell ProliferationCells, CulturedChild, PreschoolCultureCytokinesDemyelinating Autoimmune Diseases, CNSEndocytosisFemaleHumansHydrazonesMacrophagesMaleMiddle AgedMyelin SheathPhagocytosisRatsRats, Sprague-DawleyStrokeTime FactorsTransforming Growth Factor betaConceptsMyelin injuryMyelin phagocytosisMyelin debrisMultiple sclerosis lesionsMultiple sclerosisLesion pathologySclerosis lesionsAcute multiple sclerosis lesionsCentral nervous system pathologyProgressive multifocal leukoencephalopathyNervous system pathologySecretion of chemokinesNF-κB activationElevated chemokine expressionHypertrophic astrocytesMost astrocytesMyelin uptakeMultifocal leukoencephalopathyFirst-line responseAcute lesionsMyelin damageReactive astrocytesChemokine expressionAstroglial responseImmune cells
2014
Modulation of oligodendrocyte generation during a critical temporal window after NG2 cell division
Hill RA, Patel KD, Goncalves CM, Grutzendler J, Nishiyama A. Modulation of oligodendrocyte generation during a critical temporal window after NG2 cell division. Nature Neuroscience 2014, 17: 1518-1527. PMID: 25262495, PMCID: PMC4275302, DOI: 10.1038/nn.3815.Peer-Reviewed Original Research
1997
Functional Repair of Myelinated Fibers in the Spinal Cord by Transplantation of Glial Cells
Waxman S, Kocsis J. Functional Repair of Myelinated Fibers in the Spinal Cord by Transplantation of Glial Cells. Altschul Symposia Series 1997, 283-298. DOI: 10.1007/978-1-4615-5949-8_28.Peer-Reviewed Original ResearchConduction velocityMyelinated axonsMyelin sheathNon-myelinated fibresClinical deficitsMyelin damageConduction abnormalitiesDemyelinated axonsSpinal cordGlial cellsMyelinated fibersConduction blockSynaptic terminalsAction potentialsRefractory periodCell bodiesDemyelinated fibersAxonsFunctional repair
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