2025
Consensus guideline for the management of peritoneal mesothelioma
Brown L, Wilkins S, Bansal V, Su D, Gomez‐Mayorga J, Turaga K, Gunderson C, Lee B, Nash G, Hays J, Raghav K, Husain A, Kluger M, Zauderer M, Kindler H, Alexander H, Group P. Consensus guideline for the management of peritoneal mesothelioma. Cancer 2025, 131: e35868. PMID: 40558081, DOI: 10.1002/cncr.35868.Peer-Reviewed Original ResearchConceptsPeritoneal mesotheliomaConsensus guidelinesManagement of peritoneal mesotheliomaTreatment of peritoneal mesotheliomaPathway blockAssessment of patient characteristicsHigh-risk patientsClinical trial enrollmentPresence of symptomsDisease histologyIntermediate-riskMultimodal therapyHigh quality evidenceMalignant pathologyClinicopathological featuresBenign neoplasmsSurgical interventionRare incidenceClinical evidencePatient characteristicsTrial enrollmentQuality evidenceMultidisciplinary assessmentTherapy timeMesotheliomaConsensus Guideline for the Management of Peritoneal Mesothelioma
Brown L, Wilkins S, Bansal V, Su D, Gomez-Mayorga J, Turaga K, Gunderson C, Lee B, Nash G, Hays J, Raghav K, Husain A, Kluger M, Zauderer M, Kindler H, Alexander H. Consensus Guideline for the Management of Peritoneal Mesothelioma. Annals Of Surgical Oncology 2025, 1-17. PMID: 40560500, DOI: 10.1245/s10434-025-17358-x.Peer-Reviewed Original ResearchPeritoneal mesotheliomaConsensus guidelinesManagement of peritoneal mesotheliomaAssessment of patient characteristicsHigh-risk patientsClinical trial enrollmentPresence of symptomsDisease histologyIntermediate-riskMultimodal therapyMalignant pathologyClinicopathological featuresBenign neoplasmsSurgical interventionRare incidenceClinical evidencePatient characteristicsPathway blockTrial enrollmentHigh riskMultidisciplinary assessmentTherapy timeLimited evidenceMesotheliomaClinical careContemporary Bypass Techniques in Hybrid Revascularization
Olutola O, Vega P, Pelletier M. Contemporary Bypass Techniques in Hybrid Revascularization. 2025, 127-138. DOI: 10.1007/978-3-031-87302-7_12.Peer-Reviewed Original ResearchCoronary Artery Bypass GraftingLeft internal mammary arteryMinimally invasive direct coronary artery bypassPercutaneous coronary interventionHybrid coronary revascularizationCardiac surgeonsBypass GraftingAssociated with lower perioperative mortalitySimultaneous coronary artery bypass graftingLeft internal mammary artery bypassHybrid operating suiteLIMA-LAD bypassInterventional cardiologistsLeft anterior descending (LAD) arteryRobotic-assisted approachOff-pump surgeryLow perioperative mortalityHigh-risk patientsInternal mammary artery graftsMinimally invasive techniquesCoronary artery bypassArtery Bypass GraftingInternal mammary arteryMammary artery graftsSingle-vessel diseaseFluoroquinolones for Dermatologists: A Practical Guide to Clinical Use and Risk Management
Wahood S, Alani O, Draw I, Shqair L, Wang D, Bunick C, Damiani G, Ho J, Obagi S, Akbarialiabad H, Galimberti F, Ghannoum M, Grada A. Fluoroquinolones for Dermatologists: A Practical Guide to Clinical Use and Risk Management. Pharmaceuticals 2025, 18: 800. PMID: 40573197, PMCID: PMC12196204, DOI: 10.3390/ph18060800.Peer-Reviewed Original ResearchSoft tissue infectionsTissue infectionsMultidrug-resistant Gram-negative organismsRisk of torsade de pointesClinical useLiterature search of PubMedResistant to ciprofloxacinComplicated skin infectionsHigh-risk patientsQT interval prolongationCorrected QT IntervalShort treatment courseGram-negative organismsPatient risk factorsSearch of PubMedBacterial skinOral fluoroquinolonesInterval prolongationTreatment courseOral formulationResistance patternsCure rateQT intervalTopical treatmentSkin infectionsOutcomes of medical and surgical management in infectious intracranial aneurysms: a multicenter cohort analysis
Alawieh A, Dimisko L, Zohdy Y, Koo A, Saad H, Baba B, Newman S, Grossberg J, Matouk C, Cawley C, Pradilla G, Reisner A, Fox W, Perez-Vega C, Burkhardt J, Salem M, Jabbour P, Naamani K, Schmidt R, Gooch M, Starke R, Abdelsalam A, Lu V, Levitt M, Chalhoub R, Kobeissy F, Spiotta A, Barrow D, Howard B. Outcomes of medical and surgical management in infectious intracranial aneurysms: a multicenter cohort analysis. Journal Of NeuroInterventional Surgery 2025, jnis-2025-023421. PMID: 40409986, DOI: 10.1136/jnis-2025-023421.Peer-Reviewed Original ResearchInfectious intracranial aneurysmsModified Rankin ScaleOutcome predictorsManagement of infectious intracranial aneurysmsEndovascular interventionIntracranial aneurysmsMedical managementComplication of systemic infectionRetrospective registry-based cohort studyHigh-risk patientsRegistry-based cohort studyStandardized management guidelinesTertiary care centerLimitations of medical managementPredictors of failureMultivariate logistic regressionDays of initiationMulticenter cohort analysisInfective endocarditisTreatment failureSurgical managementMulticenter cohortAneurysm sizeCase seriesClinical decision-makingThe Five-Item Modified Frailty Index Predicts Adverse Surgical Outcomes in Patients Undergoing Mastectomy
Chiarella L, Huelsboemer L, Diatta F, Klimitz F, Kammien A, Kochen A, Boroumand S, Allam O, Kauke-Navarro M, Pomahac B. The Five-Item Modified Frailty Index Predicts Adverse Surgical Outcomes in Patients Undergoing Mastectomy. Annals Of Surgical Oncology 2025, 32: 4829-4837. PMID: 40342005, DOI: 10.1245/s10434-025-17105-2.Peer-Reviewed Original ResearchConceptsHigh-risk patientsMFI-5Surgical complicationsFrail patientsPredicting adverse surgical outcomesNational Surgical Quality Improvement Program dataIncreased risk of complicationsQuality Improvement Program dataMethodsThis retrospective cohort studyPredicting surgical complicationsDependent functional statusHigher Body Mass IndexAdverse surgical outcomesOdds of complicationsRetrospective cohort studyAcute kidney failureRisk of complicationsAdult female patientsCongestive heart failurePostoperative complication riskAdjusted multivariable logistic regressionBody mass indexChronic obstructive pulmonary diseaseHigh-risk groupMultivariate logistic regressionTissue-based gene expression testing in localized prostate cancer
Sivanesan N, Diaz G, Sprenkle P. Tissue-based gene expression testing in localized prostate cancer. Current Opinion In Urology 2025, 35: 432-438. PMID: 40314067, DOI: 10.1097/mou.0000000000001289.Peer-Reviewed Original ResearchConceptsLocalized prostate cancerTissue-based genomic testingProstate cancerRisk stratificationGenomic testingManagement of localized prostate cancerProstate cancer risk stratificationIdentified high-risk patientsClinically significant cancerProstate cancer outcomesImpact of genomic testingHigh-risk patientsAssess tumor aggressivenessLow-risk casesGenomic assaysGene expression testsTreatment decision-makingPSA levelsGleason scoreSignificant cancerOncotype DXTumor aggressivenessTherapeutic choiceReduce overtreatmentProspective studyCharacterization and Clinical Implications of p53 Dysfunction in Patients With Myelodysplastic Syndromes
Zampini M, Riva E, Lanino L, Sauta E, Dos Reis R, Ejarque R, Maggioni G, Termanini A, Merlotti A, Campagna A, Dall’Olio L, Kulasekararaj A, Calvi M, Di Vito C, Bonometti A, Rahal D, Croci G, Boveri E, Gianelli U, Ponzoni M, Caselli R, Albertazzi S, Todisco G, Ubezio M, Crisafulli L, Frigo A, Lugli E, Mosca E, Acha P, Ghisletti S, Nicassio F, Santoro A, Diez-Campelo M, Solé F, Ades L, Platzbecker U, Santini V, Fenaux P, Haferlach T, Sallman D, Garcia-Manero G, Mavilio D, Remondini D, Castellani G, D'Amico S, Zeidan A, Komrokji R, Kordasti S, Ficara F, Della Porta M, Consortium C, Russo A, Travaglino E, Delleani M, Asti G, Ventura D, Tentori C, Buizza A, Brindisi M, Pinocchio N, Pesce F. Characterization and Clinical Implications of p53 Dysfunction in Patients With Myelodysplastic Syndromes. Journal Of Clinical Oncology 2025, 43: 2069-2083. PMID: 40315418, PMCID: PMC12169866, DOI: 10.1200/jco-24-02394.Peer-Reviewed Original ResearchConceptsMyelodysplastic syndromeP53 dysfunctionPhenotype of immune cellsClassification of myeloid neoplasmsIdentified high-risk patientsImpaired antigen presentationOptimal timing of therapeutic interventionsAbnormal p53 proteinHigh-risk patientsSubsets of patientsBone marrow progenitorsTiming of therapeutic interventionDesign of clinical trialsRecognition of patientsTumor protein 53Variant allele frequencyNF-kB pathwayInnovative immunotherapyMyeloid neoplasmsDismal outcomeMarrow progenitorsImmune dysregulationBiallelic inactivationImmune cellsPoor prognosisCoronary Computed Angiography and Coronary Artery Calcium Score for Preoperative Cardiovascular Risk Stratification in Patients Undergoing Noncardiac Surgery
Kyriakoulis I, Kumar S, Lianos G, Schizas D, Kokkinidis D. Coronary Computed Angiography and Coronary Artery Calcium Score for Preoperative Cardiovascular Risk Stratification in Patients Undergoing Noncardiac Surgery. Journal Of Cardiovascular Development And Disease 2025, 12: 159. PMID: 40278217, PMCID: PMC12027494, DOI: 10.3390/jcdd12040159.Peer-Reviewed Original ResearchCoronary artery calcium scoreMajor adverse cardiovascular eventsPostoperative major adverse cardiovascular eventsArtery calcium scoreNoncardiac surgeryCalcium scoreRisk stratificationComputed angiographySeverity of coronary artery diseasePreoperative imaging protocolRisk evaluation of patientsPreoperative risk stratificationHigh-risk patientsEvaluation of patientsInfluence surgical decisionsAdverse cardiovascular eventsCoronary artery diseaseCardiovascular risk stratificationPerioperative risk predictionSuperior prognostic performanceStratify patientsAnatomical assessmentSurgical decisionCardiovascular eventsPrognostic performanceStroke risk prediction in symptomatic anterior circulation ICAD: Analysis of regional QMRA flow from the MYRIAD study
Amin-Hanjani S, Elder T, Du X, Romano J, Liebeskind D, De Havenon A, Chatterjee A, Prabhakaran S. Stroke risk prediction in symptomatic anterior circulation ICAD: Analysis of regional QMRA flow from the MYRIAD study. Journal Of Stroke And Cerebrovascular Diseases 2025, 34: 108322. PMID: 40246039, PMCID: PMC12101060, DOI: 10.1016/j.jstrokecerebrovasdis.2025.108322.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlgorithmsBlood Flow VelocityCerebral AngiographyCerebrovascular CirculationCollateral CirculationFemaleHumansIntracranial ArteriosclerosisIschemic StrokeMagnetic Resonance AngiographyMaleMiddle AgedMiddle Cerebral ArteryPerfusion ImagingPredictive Value of TestsPrognosisProspective StudiesRecurrenceRisk AssessmentRisk FactorsStrokeTime FactorsConceptsMiddle cerebral arteryIntracranial atherosclerotic diseaseQuantitative MRAStroke riskRecurrent strokeFlow patientsIdentification of high-risk patientsIntracranial arteriesLow-flow patientsProximal intracranial arteriesHigh-risk patientsStroke risk predictionInvestigation of therapeutic interventionsRecurrent stroke riskRisk predictionRecurrence riskZ-score thresholdRegional hypoperfusionArtery territoryPrimary outcomeCerebral arteryLow flowsPatientsZ-scoreAtherosclerotic diseaseNeuroprotective Strategies in Coronary Artery Disease Interventions
Fatima M, Bazarbaev A, Rana A, Khurshid R, Effiom V, Bajwa N, Nasir A, Candelario K, Tabraiz S, Colon S, Lee C, Dankwa S, Hameed I. Neuroprotective Strategies in Coronary Artery Disease Interventions. Journal Of Cardiovascular Development And Disease 2025, 12: 143. PMID: 40278202, PMCID: PMC12027976, DOI: 10.3390/jcdd12040143.Peer-Reviewed Original ResearchCoronary Artery Bypass GraftingDeep hypothermic circulatory arrestNeurological complicationsNerve injuryNeuroprotective strategiesOff-pump coronary artery bypass graftingHybrid revascularizationHypothermic circulatory arrestCranial nerve injuryNMDA receptor antagonistHigh-risk patientsEndoscopic coronary artery bypassCoronary artery bypassPeripheral nerve injuryArtery Bypass GraftingCerebral perfusion monitoringBloodless surgical fieldCoronary artery interventionRisk of strokeEmbolic protection devicesAntiplatelet administrationAortic manipulationReceptor antagonistCirculatory arrestTherapeutic hypothermiaRisk Stratification for Venous Thromboembolism Prophylaxis
Mansour E, Ganz M, Scuderi G. Risk Stratification for Venous Thromboembolism Prophylaxis. Orthopedic Clinics Of North America 2025, 56: 155-163. PMID: 40044349, DOI: 10.1016/j.ocl.2024.09.003.Peer-Reviewed Original ResearchConceptsHigh-risk patientsVenous thromboembolismReduction of venous thromboembolismTotal joint arthroplastyLow-risk patientsLow-dose aspirinVenous thromboembolism prophylaxisRisk stratification scoresIntermittent mechanical compressionRisk stratificationThromboembolism prophylaxisThromboprophylaxis agentsStratification scoresEarly mobilizationLow riskOrthopedic surgeryPatientsTotal knee arthroplastyRevision total hip arthroplastyTJA patientsJoint arthroplastyTotal hip arthroplastyKnee arthroplastyMechanical compressionMaking Progress in Clinical Trials for Suicide Prevention
Wilkinson S, Bryan C, Alphs L, Canuso C, Ostacher M, Price R, Bloch M, Zarate C, Rhee T. Making Progress in Clinical Trials for Suicide Prevention. JAMA Psychiatry 2025, 82: 420-426. PMID: 39937491, DOI: 10.1001/jamapsychiatry.2024.4810.Peer-Reviewed Original ResearchSuicide preventionSelf-reports of suicidal ideationRisk of suicideAt-risk populationsClinical trialsHigh-risk populationUsual carePublic health crisisMental illnessSuicide-related eventsSelf-ReportElevated riskTime-to-event designsHigh-risk patientsCriterion standardStudy outcomesSuicide ratesClinical populationsHealth crisisLiability concernsSuicidal ideationCompare groupsClinical experienceTreatment developmentSuicideThe Five-Item Modified Frailty Index (mFI-5) Predicts Adverse Short-term Outcomes in Patients Undergoing Mastectomy: A Propensity Score-matched Analysis of 252,054 Cases
Klimitz F, Diatta F, Freeman J, Schaschinger T, Brown S, Knoedler S, Hundeshagen G, Kauke-Navarro M, Pomahac B, Panayi A. The Five-Item Modified Frailty Index (mFI-5) Predicts Adverse Short-term Outcomes in Patients Undergoing Mastectomy: A Propensity Score-matched Analysis of 252,054 Cases. Clinical Breast Cancer 2025 PMID: 40253274, DOI: 10.1016/j.clbc.2025.03.015.Peer-Reviewed Original ResearchHigh-risk patientsModified Frailty IndexPropensity score matchingMFI-5Mastectomy patientsHigh riskPostoperative complicationsPostoperative outcomesRisk stratificationFive-item modified frailty indexMedical complicationsHigh risk of postoperative complicationsAmerican College of Surgeons National Surgical Quality Improvement ProgramSurgeons National Surgical Quality Improvement ProgramAdverse short-term outcomesNational Surgical Quality Improvement ProgramRisk of postoperative complicationsFrailty indexPredictor of postoperative outcomesSurgical Quality Improvement ProgramLow-risk patientsPreoperative risk stratificationPropensity Score Matching AnalysisIncorporating frailty assessmentImprove risk stratificationComparison of High-Flow Nasal Cannula and Conventional Oxygen Therapy for High Risk Patients During Bronchoscopy Examination: A Multicenter Randomized Controlled Trial.
Qin H, Li J, Wang J, Yang Y, Jing G, Chen R, Tan W, Zhang Y, Li T, Yang J, Dai B, Wang Q, Jiao Y, Xia Y, Huang H, Li Q, Dong Y, Bai C, Zhang W. Comparison of High-Flow Nasal Cannula and Conventional Oxygen Therapy for High Risk Patients During Bronchoscopy Examination: A Multicenter Randomized Controlled Trial. Annals Of The American Thoracic Society 2025, 22: 1018-1026. PMID: 40106752, DOI: 10.1513/annalsats.202410-1109oc.Peer-Reviewed Original ResearchConceptsHigh-flow nasal cannulaConventional oxygen therapyHigh-risk patientsMulticenter randomized controlled trialTreatment escalationTranscutaneous carbon dioxideOxygen therapyBronchoscopy examinationRandomized Controlled TrialsRisk patientsAirway stenosisNasal cannulaCompare high-flow nasal cannulaConventional oxygen therapy groupControlled TrialsDuration of desaturationOccurrence of desaturationHigh-risk factorsHigh-risk populationNo significant differenceEndoscopy examinationAdverse eventsBronchoscopyClinical trialsPatientsRisk of Atherosclerotic Cardiovascular Disease After Chronic Obstructive Pulmonary Disease Hospitalization among Primary and Secondary Prevention Older Adults
Mosher C, Osazuwa‐Peters O, Nanna M, MacIntyre N, Que L, Palmer S, Jones W, O'Brien E. Risk of Atherosclerotic Cardiovascular Disease After Chronic Obstructive Pulmonary Disease Hospitalization among Primary and Secondary Prevention Older Adults. Journal Of The American Heart Association 2025, 14: e035010. PMID: 39791395, PMCID: PMC12054414, DOI: 10.1161/jaha.124.035010.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary disease hospitalizationsChronic obstructive pulmonary diseaseAtherosclerotic cardiovascular diseaseSecondary prevention cohortPrevention cohortASCVD hospitalizationRisk of atherosclerotic cardiovascular diseaseHazard ratioHospital outcomesHigh riskRisk factorsCardiovascular disease eventsCardiovascular diseasePrimary prevention cohortIdentified multiple risk factorsRisk of cardiovascular disease eventsMultiple risk factorsPulmonary disease hospitalizationsObstructive pulmonary diseaseOlder adultsHigh-risk patient cohortASCVD eventsDisease eventsHigh-risk patientsMeta-analyses
2024
Perioperative Pain Management: An Update on Pharmacology with a Special Focus on the Opioid Tolerant Elderly
Chow R, Rajput K. Perioperative Pain Management: An Update on Pharmacology with a Special Focus on the Opioid Tolerant Elderly. Current Anesthesiology Reports 2024, 15: 6. DOI: 10.1007/s40140-024-00656-7.Peer-Reviewed Original ResearchElderly patientsOpioid toleranceChronic painPain managementModerate to high-risk patientsIncreasing use of opioidsOpioid-tolerant patientsSide effects of sedationOpioid sparing effectDoses of opioidsHigh-risk patientsUse of opioidsDrug-drug interactionsChronic opioidsOpioid requirementsTolerant patientsMultimodal analgesicsEffects of sedationPerioperative painRespiratory depressionHome dosePreexisting comorbiditiesPain surgeryRegional anestheticsPerioperative periodCardiovascular Events in Adults with Type 2 Diabetes and ASCVD Initiating Once-Weekly Semaglutide vs DPP-4is in the USA
Inzucchi S, Tan X, Liang Y, Yedigarova L, Xie L, de Havenon A. Cardiovascular Events in Adults with Type 2 Diabetes and ASCVD Initiating Once-Weekly Semaglutide vs DPP-4is in the USA. Diabetes Therapy 2024, 16: 187-203. PMID: 39688779, PMCID: PMC11794941, DOI: 10.1007/s13300-024-01678-4.Peer-Reviewed Original ResearchHealth care resource utilizationAtherosclerotic cardiovascular diseaseDPP-4i usersDPP-4isGLP-1 RAsOnce-weekly semaglutideMedical costsType 2 diabetesDPP-4iDecreased risk of strokeRisk of cardiovascular outcomesCardiovascular eventsOnce-weekly GLP-1 RAsPeptide 1 receptor agonistsTotal medical costsDipeptidyl peptidase 4 inhibitorsOccurrence of cardiovascular eventsHigh-risk patientsRisk of strokeObservational cohort analysisData Mart DatabaseOutpatient visitsDecreased riskSemaglutide treatmentBaseline characteristicsGastric Cancer at a Nigerian Tertiary Referral Center: Experiences With Establishing an Institutional Cancer Registry
Yibrehu B, Mohammed T, Murthy S, Aderibigbe A, Daramola O, Arije O, Owoade I, Wuraola F, Olasehinde O, Betiku O, Folorunso S, Omoyiola O, Aderounmu A, Adisa A, Kingham P, Alatise O. Gastric Cancer at a Nigerian Tertiary Referral Center: Experiences With Establishing an Institutional Cancer Registry. Journal Of Surgical Oncology 2024, 131: 630-636. PMID: 39558548, DOI: 10.1002/jso.27993.Peer-Reviewed Original ResearchInstitutional cancer registryGastric cancerCancer RegistryTreatment modalitiesSuspected gastric cancerManagement of gastric cancerQuality of registry dataTertiary referral centerGastric cancer registryHigh-risk patientsDatabase of patientsGastric cancer databasePeriodic chart reviewMetastatic diseaseAdvanced diseaseReferral centerCancer DatabaseAvailability of robust dataMedian timeChart reviewFollow-upDeadly malignancyBlood workPatientsRegistry dataPrimary Prevention of Stroke: Identifying High-Risk Patients
Kaslow J, Kernan W. Primary Prevention of Stroke: Identifying High-Risk Patients. 2024, 431-443. DOI: 10.1007/978-3-031-66289-8_36.Peer-Reviewed Original ResearchRisk factorsPrimary careHealthy behaviorsPatient-centeredCoronary artery diseaseRisk of strokeChronic diseasesPreventable deathsMedical practicePublic healthUnhealthy onesIncreased riskRisk reductionHigh riskHigh-risk patientsStrokeRiskArtery diseaseCareHealthDisabilityPatientsMedicationFactorsGuidelines
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