2025
Comparison of High-Flow Nasal Cannula and Conventional Oxygen Therapy for High Risk Patients During Bronchoscopy Examination: A Multicenter Randomized Controlled Trial.
Qin H, Li J, Wang J, Yang Y, Jing G, Chen R, Tan W, Zhang Y, Li T, Yang J, Dai B, Wang Q, Jiao Y, Xia Y, Huang H, Li Q, Dong Y, Bai C, Zhang W. Comparison of High-Flow Nasal Cannula and Conventional Oxygen Therapy for High Risk Patients During Bronchoscopy Examination: A Multicenter Randomized Controlled Trial. Annals Of The American Thoracic Society 2025, 22: 1018-1026. PMID: 40106752, DOI: 10.1513/annalsats.202410-1109oc.Peer-Reviewed Original ResearchConceptsHigh-flow nasal cannulaConventional oxygen therapyHigh-risk patientsMulticenter randomized controlled trialTreatment escalationTranscutaneous carbon dioxideOxygen therapyBronchoscopy examinationRandomized Controlled TrialsRisk patientsAirway stenosisNasal cannulaCompare high-flow nasal cannulaConventional oxygen therapy groupControlled TrialsDuration of desaturationOccurrence of desaturationHigh-risk factorsHigh-risk populationNo significant differenceEndoscopy examinationAdverse eventsBronchoscopyClinical trialsPatientsHypoxia-induced Wnt5a-secreting fibroblasts promote colon cancer progression
Harada A, Yasumizu Y, Harada T, Fumoto K, Sato A, Maehara N, Sada R, Matsumoto S, Nishina T, Takeda K, Morii E, Kayama H, Kikuchi A. Hypoxia-induced Wnt5a-secreting fibroblasts promote colon cancer progression. Nature Communications 2025, 16: 3653. PMID: 40246836, PMCID: PMC12006413, DOI: 10.1038/s41467-025-58748-9.Peer-Reviewed Original ResearchConceptsColon cancer progressionSingle-cell RNA-seq dataCancer progressionEndothelial cellsRNA-seq dataColon cancer aggressivenessSuppression of angiogenesisColon cancer growthColon cancer formationCancer aggressivenessInflammatory fibroblastsVEGF receptor1Cancer growthPromote tumorigenesisCancer formationWnt5aMeta-analysisWnt ligandsLuminal sideFibroblast subtypesColonHypoxic environmentFibroblastsCells
2024
Hypoxia is linked to acquired resistance to immune checkpoint inhibitors in lung cancer
Robles-Oteíza C, Hastings K, Choi J, Sirois I, Ravi A, Expósito F, de Miguel F, Knight J, López-Giráldez F, Choi H, Socci N, Merghoub T, Awad M, Getz G, Gainor J, Hellmann M, Caron É, Kaech S, Politi K. Hypoxia is linked to acquired resistance to immune checkpoint inhibitors in lung cancer. Journal Of Experimental Medicine 2024, 222: e20231106. PMID: 39585348, PMCID: PMC11602551, DOI: 10.1084/jem.20231106.Peer-Reviewed Original ResearchConceptsImmune checkpoint inhibitorsNon-small cell lung cancerAcquired ResistanceCheckpoint inhibitorsResistant tumorsPatients treated with anti-PD-1/PD-L1 therapyAnti-PD-1/PD-L1 therapyLung cancerResistance to immune checkpoint inhibitorsAssociated with decreased progression-free survivalHypoxia activated pro-drugsTargeting hypoxic tumor regionsTreat non-small cell lung cancerAnti-CTLA-4Anti-PD-1Immune checkpoint inhibitionTumor metabolic featuresProgression-free survivalCell lung cancerResistant cancer cellsHypoxic tumor regionsMHC-II levelsRegions of hypoxiaKnock-outCheckpoint inhibitionPerinatal Hypoxia and Immune System Activation in Schizophrenia Pathogenesis: Critical Considerations During COVID-19 Pandemic.
Kawikova I, Hakenova K, Lebedeva M, Kleteckova L, Jakob L, Spicka V, Wen L, Spaniel F, Vales K. Perinatal Hypoxia and Immune System Activation in Schizophrenia Pathogenesis: Critical Considerations During COVID-19 Pandemic. Physiological Research 2024, 73: s615-s639. PMID: 39589306, PMCID: PMC11627263, DOI: 10.33549/physiolres.935501.Peer-Reviewed Original ResearchConceptsPerinatal hypoxiaPerinatal factorsMaternal immune activationImmune system activationDevelopment of experimental modelsInteraction of genetic backgroundAssociated with hypoxiaNeurodevelopmental disordersMaternal infectionObstetric complicationsSchizophrenia pathogenesisImmune activationMetabolic disturbancesTherapeutic strategiesPerinatal periodSchizophrenia etiologyDisorganized thoughtsExperimental modelSchizophreniaSystem activityEmotional bluntingHypoxiaChronic stressGenetic backgroundCognitive impairmentTargeting hypoxia and thrombospondin‐2 in diabetic wound healing
Huang Y, Xing H, Naud S, Kyriakides T. Targeting hypoxia and thrombospondin‐2 in diabetic wound healing. The FASEB Journal 2024, 38: e70091. PMID: 39383062, PMCID: PMC11486302, DOI: 10.1096/fj.202302429rrr.Peer-Reviewed Original ResearchConceptsThrombospondin-2Diabetic miceWound healingHIF-1aMatricellular protein thrombospondin-2Diabetic woundsImpaired wound healingWounds of diabetic miceDimethyloxalylglycine treatmentTargeting hypoxiaSustained hypoxiaDiabetic patientsTSP2 expressionCell dysfunctionIncreased neovascularizationDiabetic wound healingGenetic ablationDiabetic fibroblastsElevated glucoseReduced hypoxiaImprove healingImmunofluorescence analysisHIF-1a activationHypoxiaWestern blottingProcoagulant phenotype of virus-infected pericytes is associated with portal thrombosis and intrapulmonary vascular dilations in fatal COVID-19
Cadamuro M, Lasagni A, Radu C, Calistri A, Pilan M, Valle C, Bonaffini P, Vitiello A, Toffanin S, Venturin C, Friòn-Herrera Y, Sironi S, Alessio M, Previtali G, Seghezzi M, Gianatti A, Strazzabosco M, Strain A, Campello E, Spiezia L, Palù G, Frigo A, Tosoni A, Nebuloni M, Parolin C, Sonzogni A, Simioni P, Fabris L. Procoagulant phenotype of virus-infected pericytes is associated with portal thrombosis and intrapulmonary vascular dilations in fatal COVID-19. Journal Of Hepatology 2024, 81: 872-885. PMID: 38908437, DOI: 10.1016/j.jhep.2024.06.014.Peer-Reviewed Original ResearchConceptsIntrapulmonary vascular dilatationWorsening respiratory failureSARS-CoV-2 infectionRespiratory failureFatal COVID-19Procoagulant phenotypeSARS-CoV-2Development of intrapulmonary vascular dilatationsVascular dilatationAssociated with portal thrombosisComplication of COVID-19 infectionTissue factorWork-up of patientsHuman pulmonary microvascular endothelial cellsEndothelial cellsObliterative portal venopathyPulmonary microvascular endothelial cellsAbsence of cirrhosisFatal respiratory failureAssociated with younger ageSevere liver diseaseDevelopment of hypoxemiaPathophysiology of thrombosisPortal vein branchesSevere COVID-19Identifying G6PC3 as a Potential Key Molecule in Hypoxic Glucose Metabolism of Glioblastoma Derived from the Depiction of 18F‐Fluoromisonidazole and 18F‐Fluorodeoxyglucose Positron Emission Tomography
Okamoto M, Yamaguchi S, Sawaya R, Echizenya S, Ishi Y, Kaneko S, Motegi H, Toyonaga T, Hirata K, Fujimura M. Identifying G6PC3 as a Potential Key Molecule in Hypoxic Glucose Metabolism of Glioblastoma Derived from the Depiction of 18F‐Fluoromisonidazole and 18F‐Fluorodeoxyglucose Positron Emission Tomography. BioMed Research International 2024, 2024: 2973407. PMID: 38449509, PMCID: PMC10917478, DOI: 10.1155/2024/2973407.Peer-Reviewed Original ResearchConceptsPositron emission tomographyF-FDGMRNA expressionOverall survivalGlucose metabolismF-FDG positron emission tomographyAssociated with poor overall survivalProtein expressionEmission tomographyGross total resectionPotential key moleculesFluorine-18 fluorodeoxyglucoseHypoxic conditionsDegree of glucose metabolismMolecular mechanisms of glucose metabolismAggressive primary brain tumorPoor overall survivalPrimary brain tumorKey moleculesTotal resectionPreoperative examinationIntratumoral hypoxiaPrognostic valuePoor prognosisBiomarkers of glioblastomaProteogenomic characterization of primary colorectal cancer and metastatic progression identifies proteome-based subtypes and signatures
Tanaka A, Ogawa M, Zhou Y, Namba K, Hendrickson R, Miele M, Li Z, Klimstra D, Buckley P, Gulcher J, Wang J, Roehrl M. Proteogenomic characterization of primary colorectal cancer and metastatic progression identifies proteome-based subtypes and signatures. Cell Reports 2024, 43: 113810. PMID: 38377004, PMCID: PMC11288375, DOI: 10.1016/j.celrep.2024.113810.Peer-Reviewed Original ResearchConceptsMetastatic colorectal adenocarcinomaModulation of major histocompatibility complexColorectal adenocarcinomaMetastatic progressionEpithelial-to-mesenchymal transition featuresPrimary colorectal adenocarcinomaTumor microenvironment analysisPrimary colorectal cancerCopy number alterationsProgression of colorectal adenocarcinomaAlternative telomere lengtheningTumor suppressor geneOncogenic pathway activationAntigen processing pathwayMajor histocompatibility complexProteomic subtypesLiver metastasesMetastatic lesionsImmune signaturesGenomic alterationsImmune evasionColorectal cancerMicroenvironment analysisSuppressor geneProteogenomic characterizationHypoxia-Directed Treatment of Human Papillomavirus–Related Oropharyngeal Carcinoma
Lee N, Sherman E, Schöder H, Wray R, Boyle J, Singh B, Grkovski M, Paudyal R, Cunningham L, Zhang Z, Hatzoglou V, Katabi N, Diplas B, Han J, Imber B, Pham K, Yu Y, Zakeri K, McBride S, Kang J, Tsai C, Chen L, Gelblum D, Shah J, Ganly I, Cohen M, Cracchiolo J, Morris L, Dunn L, Michel L, Fetten J, Kripani A, Pfister D, Ho A, Shukla-Dave A, Humm J, Powell S, Li B, Reis-Filho J, Diaz L, Wong R, Riaz N. Hypoxia-Directed Treatment of Human Papillomavirus–Related Oropharyngeal Carcinoma. Journal Of Clinical Oncology 2024, 42: 940-950. PMID: 38241600, PMCID: PMC10927322, DOI: 10.1200/jco.23.01308.Peer-Reviewed Original ResearchConceptsProgression-free survivalCurative-intent chemoradiotherapyLocoregional controlOropharyngeal carcinomaOverall survivalGrade 3Adverse eventsTumor hypoxiaHuman papillomavirus (HPV)-related oropharyngeal carcinomasHPV-related oropharyngeal carcinomaMedian follow-up timeHypoxic tumorsSurgical removal of diseaseAcute grade 3Late grade 3HPV-related carcinomasPhase II studyFollow-up timeMeasure tumor hypoxiaRemoval of diseaseDefinitive chemoradiotherapyStandard chemoradiotherapyGross diseaseLate dysphagiaOS ratesIn search of simplicity for a complicated matter—a creative step forward, but still falling short in the early prediction of the hypoxic-ischemic spiraling of death
Busl K, Maciel C. In search of simplicity for a complicated matter—a creative step forward, but still falling short in the early prediction of the hypoxic-ischemic spiraling of death. Resuscitation 2024, 195: 110118. PMID: 38220063, DOI: 10.1016/j.resuscitation.2024.110118.Peer-Reviewed Original Research
2023
SMC5 Plays Independent Roles in Congenital Heart Disease and Neurodevelopmental Disability
O'Brien M, Pryzhkova M, Lake E, Mandino F, Shen X, Karnik R, Atkins A, Xu M, Ji W, Konstantino M, Brueckner M, Ment L, Khokha M, Jordan P. SMC5 Plays Independent Roles in Congenital Heart Disease and Neurodevelopmental Disability. International Journal Of Molecular Sciences 2023, 25: 430. PMID: 38203602, PMCID: PMC10779392, DOI: 10.3390/ijms25010430.Peer-Reviewed Original ResearchA 56-Year-Old Man With Progressive Subacute Hypoxemia
Steinberg A, Zeba F, Rassias A, Mota P. A 56-Year-Old Man With Progressive Subacute Hypoxemia. CHEST Journal 2023, 164: e169-e172. PMID: 38070964, DOI: 10.1016/j.chest.2023.06.042.Peer-Reviewed Original ResearchSialylated Glycan Bindings from SARS-CoV-2 Spike Protein to Blood and Endothelial Cells Govern the Severe Morbidities of COVID-19
Scheim D, Vottero P, Santin A, Hirsh A. Sialylated Glycan Bindings from SARS-CoV-2 Spike Protein to Blood and Endothelial Cells Govern the Severe Morbidities of COVID-19. International Journal Of Molecular Sciences 2023, 24: 17039. PMID: 38069362, PMCID: PMC10871123, DOI: 10.3390/ijms242317039.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 spike proteinRed blood cellsCOVID-19Severe COVID-19 patientsSpike proteinSevere COVID-19COVID-19 correlatesCOVID-19 patientsCommon cold infectionsCOVID-19 morbidityLong-COVID patientsFuture therapeutic strategiesSARS-CoV-2Key risk factorsKey morbiditiesSurface of plateletsSevere morbidityClinical efficacyVascular damageViral loadMicrovascular occlusionRisk factorsCOVID patientsClinical studiesClinical susceptibilityHypoxemia in School-age Children Undergoing One-lung Ventilation: A Retrospective Cohort Study from the Multicenter Perioperative Outcomes Group
Templeton T, Krol B, Miller S, Lee L, Mathis M, Vishneski S, Chatterjee D, Gupta R, Shroeder R, Saha A, Schonberger R. Hypoxemia in School-age Children Undergoing One-lung Ventilation: A Retrospective Cohort Study from the Multicenter Perioperative Outcomes Group. Anesthesiology 2023, 140: 25-37. PMID: 37738432, DOI: 10.1097/aln.0000000000004781.Peer-Reviewed Original ResearchConceptsIncreased risk of hypoxemiaOne-lung ventilationRisk of hypoxemiaRight-sided casesIncreased riskSevere hypoxemiaDuration of one-lung ventilationVideo-assisted thoracoscopic surgeryRoom air oxygen saturationLow tidal volume ventilationRisk factorsOxygen saturationMulticenter Perioperative Outcomes Group databasePrevalence of hypoxemiaAssociated with hypoxemiaAssociated with increased riskTidal volume ventilationRetrospective cohort studySelection operator regression analysisChildren 4Nonmodifiable risk factorsMultivariate least absolute shrinkageSchool-aged childrenThoracoscopic surgeryThoracic surgeryMitochondrial leak metabolism induces the Spemann-Mangold Organizer via Hif-1α in Xenopus
MacColl Garfinkel A, Mnatsakanyan N, Patel J, Wills A, Shteyman A, Smith P, Alavian K, Jonas E, Khokha M. Mitochondrial leak metabolism induces the Spemann-Mangold Organizer via Hif-1α in Xenopus. Developmental Cell 2023, 58: 2597-2613.e4. PMID: 37673063, PMCID: PMC10840693, DOI: 10.1016/j.devcel.2023.08.015.Peer-Reviewed Original ResearchConceptsSpemann-Mangold organizerATP productionMitochondrial respirationC subunit ringHIF-1αMitochondrial oxidative metabolismEmbryonic patterningCell fateATP synthaseC subunitVentral mesodermHIF-1α activationInstructive roleHypoxia-inducible factor-1αΒ-cateninGeneral mechanismXenopusFactor-1αRespirationMembrane leakOxidative metabolismMetabolismMesodermActivationOxygen consumptionImproving pulse oximetry accuracy in dark-skinned patients: technical aspects and current regulations
Cabanas A, Martín-Escudero P, Shelley K. Improving pulse oximetry accuracy in dark-skinned patients: technical aspects and current regulations. British Journal Of Anaesthesia 2023, 131: 640-644. PMID: 37544838, DOI: 10.1016/j.bja.2023.07.005.Peer-Reviewed Original ResearchPostictal hypoxia involves reactive oxygen species and is ameliorated by chronic mitochondrial uncoupling
Villa B, George A, Shutt T, Sullivan P, Rho J, Teskey G. Postictal hypoxia involves reactive oxygen species and is ameliorated by chronic mitochondrial uncoupling. Neuropharmacology 2023, 238: 109653. PMID: 37422182, DOI: 10.1016/j.neuropharm.2023.109653.Peer-Reviewed Original ResearchConceptsPostictal hypoxiaNovel object recognition taskObject recognition taskHippocampus of ratsPostictal cognitive impairmentCognitive deficitsCognitive dysfunctionCognitive impairmentMetabolic componentsRecognition taskProlonged severe hypoxiaSeizure inductionMitochondrial uncouplingPotential therapeutic strategyArteriole vasoconstrictionHippocampusMild mitochondrial uncouplingEvoked seizuresSeizure controlTherapeutic strategiesPostictal stateTherapeutic benefitPathological sequelaeMitochondrial functionTissue oxygenationSingle-use versus reusable metallic laryngoscopes for non-emergent intubation: A retrospective review of 72,672 intubations
Chang D, Burnett G, Chiu S, Ouyang Y, Lin H, Hyman J. Single-use versus reusable metallic laryngoscopes for non-emergent intubation: A retrospective review of 72,672 intubations. Journal Of Clinical Anesthesia 2023, 89: 111187. PMID: 37339555, DOI: 10.1016/j.jclinane.2023.111187.Peer-Reviewed Original ResearchConceptsDifficult laryngeal viewRapid sequence inductionLaryngeal viewRescue intubationSequence inductionSubgroup analysisRisk factorsMacintosh bladeMiller bladeSingle-site retrospective cohort studyAlternate deviceRetrospective cohort studyGeneral anesthetic casesAcademic medical centerPoor laryngeal viewNon-emergent proceduresSecondary outcomesAdult patientsCohort studyPrimary outcomeRetrospective reviewTracheal intubationIntubation attemptsLower incidenceMedical CenterSurvivorship after post-anoxic cerebral hyperexcitability requires more than functional independence
Elmer J, Maciel C. Survivorship after post-anoxic cerebral hyperexcitability requires more than functional independence. Resuscitation 2023, 189: 109866. PMID: 37302685, DOI: 10.1016/j.resuscitation.2023.109866.Peer-Reviewed Original ResearchConceptsFunctional independencePersistent Hypoxemia in an Asymptomatic 4-year-old Boy.
Brumer E, de Ángel Solá D, Hogan M, Chen L. Persistent Hypoxemia in an Asymptomatic 4-year-old Boy. Pediatrics In Review 2023, 44: 290-293. PMID: 37122046, DOI: 10.1542/pir.2021-005293.Peer-Reviewed Case Reports and Technical Notes
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply