2025
Long-Term Outcomes and Risk Factors of Mortality After Reoperation on the Aortic Root: A Single-Center 20-Year Experience
Bozini N, Piber N, Vitanova K, Sideris K, Herold U, Guenzinger R, Georgescu T, Amabile A, Krane M, Prinzing A. Long-Term Outcomes and Risk Factors of Mortality After Reoperation on the Aortic Root: A Single-Center 20-Year Experience. Journal Of Clinical Medicine 2025, 14: 3727. PMID: 40507487, PMCID: PMC12155750, DOI: 10.3390/jcm14113727.Peer-Reviewed Original ResearchAortic root reoperationNon-elective surgeryTemporary mechanical circulatory supportAortic rootMechanical circulatory supportRoot reoperationConcomitant proceduresProlonged cardiopulmonary bypass timeAssociated with worse survivalRisk factorsCirculatory supportCardiopulmonary bypass timeRisk factors of mortalityBaseline patient riskHigh-volume centersTranscatheter aortic valve implantationReceiver operating characteristic curveLong-term outcomesPredictors of mortalityFactors of mortalityHigh-risk procedureAortic valve implantationYears of ageBypass timeEuroSCORE IIRacial and ethnic disparities in aortic stenosis within a universal healthcare system characterized by natural language processing for targeted intervention
Biswas D, Wu J, Brown S, Bharucha A, Fairhurst N, Kaye G, Jones K, Copeland F, O’Donnell B, Kyle D, Searle T, Pareek N, Dworakowski R, Papachristidis A, Melikian N, Wendler O, Deshpande R, Baghai M, Galloway J, Teo J, Dobson R, Byrne J, MacCarthy P, Shah A, Eskandari M, O’Gallagher K. Racial and ethnic disparities in aortic stenosis within a universal healthcare system characterized by natural language processing for targeted intervention. European Heart Journal - Digital Health 2025, 6: 392-403. PMID: 40395418, PMCID: PMC12088714, DOI: 10.1093/ehjdh/ztaf018.Peer-Reviewed Original ResearchSurgical aortic valve replacementTranscatheter aortic valve implantationAortic stenosisBlack patientsWhite patientsSevere ASEthnic disparitiesSurgical aortic valve replacement proceduresAS managementAortic valve replacementRetrospective cohort studySocioeconomic statusAll-Cause MortalityAortic valve implantationHealthcare systemAS severityValve replacementUniversal healthcare systemValvular interventionsSelf-reported raceCohort studyValve implantationSymptomatic casesMultivariate analysisPrimary outcomeOutcomes of transcatheter aortic valve implantation in Africa: A systematic review and meta-analysis
Ahmed A, Safiriyu I, Kaddoura R, Mohyeldin M, Nwokeocha N, Sandeep N, Khalil H, Alhusain R, Zarich S. Outcomes of transcatheter aortic valve implantation in Africa: A systematic review and meta-analysis. International Journal Of Cardiology 2025, 429: 133139. PMID: 40074042, DOI: 10.1016/j.ijcard.2025.133139.Peer-Reviewed Original ResearchTranscatheter aortic valve implantationOutcomes of transcatheter aortic valve implantationAll-Cause MortalityAortic valve implantationAdverse eventsValve implantationIn-hospital all-cause mortalitySevere aortic stenosisMeta-analysisProcedural success rateTranscatheter aortic valve implantation outcomesStandard of careSurgical riskAortic stenosisPooled proportionProcedural successFollow-upObservational studyInterquartile rangeNational registryMortality rateGrey literatureHealthcare systemSuccess rateConfidence intervals
2024
Sex disparities in outcomes of transcatheter aortic valve implantation- a multi-year propensity-matched nationwide study
Kumar M, Hu J, Ali S, Khlidj Y, Upreti P, Ati L, Kumar S, Shaka H, Zheng S, Bae J, Alraies M, Mba B, Yadav N, Vora A, Davila C. Sex disparities in outcomes of transcatheter aortic valve implantation- a multi-year propensity-matched nationwide study. International Journal Of Cardiology 2024, 418: 132619. PMID: 39370048, DOI: 10.1016/j.ijcard.2024.132619.Peer-Reviewed Original ResearchTranscatheter aortic valve implantationAcute kidney injuryProcedure-related mortalityAcute respiratory failureMechanical circulatory supportTranscatheter aortic valve implantation outcomesSudden cardiac arrestPropensity score matchingAortic stenosisReadmission ratesCardiogenic shockIncidence of acute kidney injuryOutcomes of transcatheter aortic valve implantationManagement of severe aortic stenosisCirculatory supportPost-procedural complication ratesSevere aortic stenosisPost-procedural bleedingSignificant disparitiesPost-procedural outcomesIn-Hospital MortalityAortic valve implantationPearson chi-square testNationwide Readmissions DatabaseWomenComparative Analysis of PCI Strategies in Aortic Stenosis Patients Undergoing TAVI: A Systematic Review and Network Meta‐Analysis
Fallahtafti P, Soleimani H, Ebrahimi P, Ghaseminejad‐Raeini A, Karimi E, Shirinezhad A, Sabri M, Mehrani M, Taheri H, Siegel R, Shah N, Nanna M, Hakim D, Hosseini K. Comparative Analysis of PCI Strategies in Aortic Stenosis Patients Undergoing TAVI: A Systematic Review and Network Meta‐Analysis. Clinical Cardiology 2024, 47: e24324. PMID: 39054901, PMCID: PMC11272956, DOI: 10.1002/clc.24324.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve implantationCoronary artery diseasePercutaneous coronary interventionIn-Hospital MortalityNetwork Meta-AnalysisMyocardial infarctionAortic stenosisAssociated with worse 30-day outcomeMeta-analysisIncreased risk of 1-year mortalityAssociated with higher 1-year mortalityRisk of 1-year mortalitySevere aortic stenosisFrequentist network meta-analysisRates of myocardial infarctionPercutaneous coronary intervention timeTime of revascularizationAortic valve implantationSevere ASNo significant differencePacemaker implantationPost-TAVIValve implantationPatient characteristicsArtery diseaseThe Predictive Value of Aortic Calcification on Computed Tomography for Major Cardiovascular Events
Chlorogiannis D, Pargaonkar S, Apostolos A, Vythoulkas-Biotis N, Kokkinidis D, Nagraj S. The Predictive Value of Aortic Calcification on Computed Tomography for Major Cardiovascular Events. Journal Of Clinical Medicine 2024, 13: 4019. PMID: 39064058, PMCID: PMC11277087, DOI: 10.3390/jcm13144019.Peer-Reviewed Original ResearchTranscatheter aortic valve implantationPrediction of MACEAortic calcificationComputed tomographyPredictive valueCardiovascular diseaseAbdominal aortic calcificationTranscatheter aortic valve implantation proceduresDescending Thoracic AortaAdverse cardiovascular eventsIdentification of patientsPrevalence of cardiovascular diseaseExtra-coronary calcificationAortic valve implantationAtherosclerotic cardiovascular diseaseMinimally invasive percutaneous proceduresInvasive percutaneous proceduresThoracic calcificationDiagnostic modalitiesAortic archRisk stratificationAortic valveCardiovascular eventsCoronary calcificationThoracic aorta
2023
Stroke reduction by cerebral embolic protection devices in transcatheter aortic valve implantation: a systematic review and Bayesian meta-analysis
Heuts S, Gabrio A, Veenstra L, Maesen B, Kats S, Maessen J, Walton A, Nanayakkara S, Lansky A, van 't Hof A, Vriesendorp P. Stroke reduction by cerebral embolic protection devices in transcatheter aortic valve implantation: a systematic review and Bayesian meta-analysis. Heart 2023, 110: 757-765. PMID: 37996242, DOI: 10.1136/heartjnl-2023-323359.Peer-Reviewed Original ResearchTranscatheter aortic valve implantationCerebral embolic protectionAbsolute risk differenceAortic valve implantationRelative riskTAVI patientsValve implantationSystematic reviewCerebral embolic protection devicesMedian relative riskEmbolic protection devicesMultiple sensitivity analysesEmbolic protectionPrimary outcomeFuture trialsStandard treatmentStroke reductionBaseline riskRisk differenceElectronic databasesExpert consensusNew-generation devicesSecondary analysisStrokeRelevant reductionThree-year outcomes following transcatheter versus surgical aortic valve replacement in younger, low surgical risk patients with severe aortic stenosis
Modine T, Tchetche D, Van Mieghem N, Huang J, Forrest J, Reardon M. Three-year outcomes following transcatheter versus surgical aortic valve replacement in younger, low surgical risk patients with severe aortic stenosis. European Heart Journal 2023, 44: ehad655.1713. DOI: 10.1093/eurheartj/ehad655.1713.Peer-Reviewed Original ResearchTranscatheter aortic valve implantationSevere aortic stenosisSelf-expanding transcatheter aortic valve implantationLow-risk patientsAortic stenosisRisk patientsLower riskCause mortalityPrimary endpointYounger patientsLower incidenceLow surgical risk patientsSurgical aortic valve replacementGreater paravalvular regurgitationSurgical risk patientsAortic stenosis patientsAortic valve replacementIntermediate-term outcomesLow surgical riskAortic valve implantationThree-Year OutcomesEffective orifice areaYears of ageAortic gradientEchocardiographic outcomesAbstract 18205: Ethnicity and Aortic Stenosis: Presentation, Management and Outcomes
Biswas D, Wu J, Bharucha A, Fairhurst N, Kaye G, Baghai M, Dworakowski R, Byrne J, MacCarthy P, Shah A, Eskandari M, O'Gallagher K. Abstract 18205: Ethnicity and Aortic Stenosis: Presentation, Management and Outcomes. Circulation 2023, 148: a18205-a18205. DOI: 10.1161/circ.148.suppl_1.18205.Peer-Reviewed Original ResearchAortic valve replacementTranscatheter aortic valve implantationAsian patientsWhite patientsBlack patientsSevere ASAortic stenosisBenefit of transcatheter aortic valve implantationSurgical aortic valve replacementManagement of aortic stenosisCox multivariate analysisSocial deprivationManagement of ASAortic valve implantationTAVI interventionKing's College HospitalEthnicity-based differencesValve replacementCardiac symptomsCollege HospitalElectronic health recordsMortality benefitValve implantationMultivariate analysisAS diagnosisFeasibility of redo-TAVI in self-expanding Evolut valves: a CT analysis from the Evolut Low Risk Trial substudy.
Grubb K, Shekiladze N, Spencer J, Perdoncin E, Tang G, Xie J, Lisko J, Sanchez J, Lucas L, Sathananthan J, Rogers T, Deeb G, Fukuhara S, Blanke P, Leipsic J, Forrest J, Reardon M, Gleason P. Feasibility of redo-TAVI in self-expanding Evolut valves: a CT analysis from the Evolut Low Risk Trial substudy. EuroIntervention 2023, 19: e330-e339. PMID: 37067193, PMCID: PMC10333920, DOI: 10.4244/eij-d-22-01125.Peer-Reviewed Original ResearchConceptsRedo-TAVIFlow compromiseEvolut valvesBalloon-expandable SAPIEN 3Transcatheter aortic valve implantationHigher Body Mass IndexAortic valve implantationAortic root dimensionsBody mass indexSinotubular junction diameterSmaller annulus diameterSAPIEN 3Clinical characteristicsValve implantationTranscatheter valveMass indexAnatomical feasibilityCoronary accessFemale sexCoronary heightsAnnulus diameterHigh riskEvolutLower sinusProcedural variablesTranscatheter versus surgical aortic valve replacement in lower-risk and higher-risk patients: a meta-analysis of randomized trials
Ahmad Y, Howard J, Arnold A, Madhavan M, Cook C, Alu M, Mack M, Reardon M, Thourani V, Kapadia S, Thyregod H, Sondergaard L, Jørgensen T, Toff W, Van Mieghem N, Makkar R, Forrest J, Leon M. Transcatheter versus surgical aortic valve replacement in lower-risk and higher-risk patients: a meta-analysis of randomized trials. European Heart Journal 2023, 44: 836-852. PMID: 36660821, DOI: 10.1093/eurheartj/ehac642.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementTranscatheter aortic valve implantationHigh-risk patientsLow-risk patientsComposite of deathAortic valve replacementValve replacementMAIN OUTCOMENew-onset atrial fibrillationSignificant differencesRandomized clinical trial dataAcute kidney injuryAortic valve implantationMain clinical outcomesRisk of deathClinical trial dataMajor bleedingKidney injurySecondary endpointsVascular complicationsValve implantationClinical outcomesParavalvular leakRandomized trialsAtrial fibrillation
2022
Safety and performance of a novel cerebral embolic protection device for transcatheter aortic valve implantation: the PROTEMBO C Trial.
Jagielak D, Targonski R, Frerker C, Abdel-Wahab M, Wilde J, Werner N, Lauterbach M, Leick J, Grygier M, Misterski M, Erglis A, Narbute I, Witkowski AR, Adam M, Frank D, Gatto F, Schmidt T, Lansky AJ. Safety and performance of a novel cerebral embolic protection device for transcatheter aortic valve implantation: the PROTEMBO C Trial. EuroIntervention 2022, 18: 590-597. PMID: 35608032, PMCID: PMC10241272, DOI: 10.4244/eij-d-22-00238.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve implantationAortic valve implantationLesion volumeValve implantationTechnical successC trialSingle lesionCerebral embolic protection devicesPerformance endpointBrain diffusion-weighted magnetic resonance imagingLarge single lesionsPrimary safety endpointBrain lesion volumeDiffusion-weighted magnetic resonance imagingCerebral protection systemSingle-arm studyEmbolic protection devicesPrimary performance endpointRate of deathMagnetic resonance imagingTAVI casesTAVI patientsVARC-2Cerebrovascular eventsPrimary endpointRisk Stratification of New Persistent Left Bundle Branch Block After Transcatheter Aortic Valve Implantation
Tsushima T, Main A, Al-Kindi S, Dallan L, Wheat H, Baeza C, Pelletier M, Arruda M, Mackall J, Thal S, Ohno Y, Lee K, Siqueira D, Kaneko T, Harloff M, Costa G, Barbanti M, Attizzani G. Risk Stratification of New Persistent Left Bundle Branch Block After Transcatheter Aortic Valve Implantation. The American Journal Of Cardiology 2022, 175: 80-87. PMID: 35597627, DOI: 10.1016/j.amjcard.2022.03.053.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionTranscatheter aortic valve implantationPersistent left bundle branch blockAssociated with cardiac mortalityNOP-LBBBLeft bundle branch blockLong-term outcomesBundle branch blockAortic valve implantationCardiac mortalityRisk stratificationComposite outcomeNew-onset persistent left bundle branch blockBranch blockValve implantationRetrospective study of patientsVentricular ejection fractionStudy of patientsHeart failure readmissionEjection fractionPermanent pacemakerRetrospective studyHeart failurePost-TAVIPatients
2021
Transfemoral versus transapical approach for transcatheter aortic valve implantation: a systematic review and meta-analysis of adjusted studies
Hage F, Harris A, Clerc O, Altibi A, Hage A, Hamaya R, Papatheodorou S. Transfemoral versus transapical approach for transcatheter aortic valve implantation: a systematic review and meta-analysis of adjusted studies. European Heart Journal 2021, 42: ehab724.1624. DOI: 10.1093/eurheartj/ehab724.1624.Peer-Reviewed Original ResearchTranscatheter aortic valve implantationMid-term mortalityAcute kidney injuryAortic valve implantationTA-TAVIMeta-analysisKidney injuryVascular complicationsValve implantationPacemaker requirementHazard ratioOdds ratioMyocardial infarctionStandard surgical replacementHigher postoperative mortalityPostoperative aortic regurgitationAssociated with reduced vascular complicationsPerioperative surgical complicationsFollow-up durationSevere aortic stenosisKaplan-Meier curvesLong follow-upLong-term outcomesComorbidities of patientsMeta-analysis of studiesA randomized evaluation of the TriGuard™ HDH cerebral embolic protection device to Reduce the Impact of Cerebral Embolic LEsions after TransCatheter Aortic Valve ImplanTation: the REFLECT I trial
Lansky AJ, Makkar R, Nazif T, Messé S, Forrest J, Sharma R, Schofer J, Linke A, Brown D, Dhoble A, Horwitz P, Zang M, DeMarco F, Rajagopal V, Dwyer MG, Zivadinov R, Stella P, Rovin J, Parise H, Kodali S, Baumbach A, Moses J. A randomized evaluation of the TriGuard™ HDH cerebral embolic protection device to Reduce the Impact of Cerebral Embolic LEsions after TransCatheter Aortic Valve ImplanTation: the REFLECT I trial. European Heart Journal 2021, 42: 2670-2679. PMID: 34000004, DOI: 10.1093/eurheartj/ehab213.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementEfficacy endpointCerebral embolic protection devicesTranscatheter aortic valve implantationCentral nervous system injuryCerebral embolic lesionsCerebral ischemic lesionsHealth Stroke ScalePrimary efficacy endpointPrimary safety outcomeAortic valve replacementAortic valve implantationEmbolic protection devicesNervous system injuryDiffusion-weighted magnetic resonanceMontreal Cognitive AssessmentEffectiveness endpointCause mortalityCerebral protectionSafety endpointStroke ScaleValve implantationValve replacementI trialIschemic lesions
2020
Cochrane corner: transcatheter aortic valve implantation versus surgical aortic valve replacement for severe aortic stenosis in people with low surgical risk
Kolkailah A, Doukky R, Pelletier M, Volgman A, Kaneko T, Nabhan A. Cochrane corner: transcatheter aortic valve implantation versus surgical aortic valve replacement for severe aortic stenosis in people with low surgical risk. Heart 2020, 106: 1043-1045. PMID: 32482670, DOI: 10.1136/heartjnl-2020-316661.Peer-Reviewed Original ResearchQuantifying the Impact of Care Fragmentation on Outcomes After Transcatheter Aortic Valve Implantation
Hirji SA, Zogg CK, Vaduganathan M, Kiehm S, Percy ED, Yazdchi F, Pelletier M, Shah PB, Bhatt DL, O'Gara P, Kaneko T. Quantifying the Impact of Care Fragmentation on Outcomes After Transcatheter Aortic Valve Implantation. The American Journal Of Cardiology 2020, 128: 113-119. PMID: 32650903, DOI: 10.1016/j.amjcard.2020.05.005.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCardiac CatheterizationCenters for Medicare and Medicaid Services, U.S.ComorbidityContinuity of Patient CareCoronary AngiographyDiabetes MellitusFemaleHospital CostsHospital MortalityHospitalsHumansHypertensionLength of StayLung DiseasesMaleMultivariate AnalysisPacemaker, ArtificialPatient ReadmissionPericardiocentesisPostoperative ComplicationsProsthesis ImplantationStrokeTranscatheter Aortic Valve ReplacementUnited StatesConceptsNonindex hospitalNonindex readmissionsCare fragmentationTranscatheter aortic valve implantation outcomesTranscatheter aortic valve implantationHigher co-morbidity burdenNational Readmission DatabaseAortic valve implantationCo-morbidity burdenTotal hospital costsMajor cardiac proceduresUS adult patientsFuture health policyValue of careIndex readmissionTAVI patientsCause mortalityIndex hospitalNoncardiac causesAdult patientsPatient characteristicsReadmission ratesValve implantationReadmission lengthCardiac proceduresAortic Valve Replacement for Severe Aortic Stenosis Before and During the Era of Transcatheter Aortic Valve Implantation
Akintoye E, Ando T, Sandio A, Adegbala O, Salih M, Zubairu J, Oseni A, Sistla P, Alqasrawi M, Egbe A, Mentias A, Afonso L, Briasoulis A, Panaich S, Desai M. Aortic Valve Replacement for Severe Aortic Stenosis Before and During the Era of Transcatheter Aortic Valve Implantation. The American Journal Of Cardiology 2020, 126: 73-81. PMID: 32336533, DOI: 10.1016/j.amjcard.2020.03.038.Peer-Reviewed Original ResearchConceptsSevere aortic stenosisAortic valve replacementNational Inpatient SampleTAVI eraAortic stenosisMean annual changeValve replacementFavorable short-term outcomesTranscatheter aortic valve replacementTranscatheter aortic valve implantationRate of AVRAcute kidney injuryRate of strokeAortic valve implantationShort-term outcomesRisk-adjusted ratesHospital mortalityPre-TAVIHospital outcomesKidney injuryHome dischargeHospital dischargePacemaker implantationValve implantationMedian lengthChapter 41 Embolic protection devices for stroke prevention during cardiac interventions
Ghare M, Zhou S, Tirziu D, Lansky A. Chapter 41 Embolic protection devices for stroke prevention during cardiac interventions. 2020, 941-960. DOI: 10.1016/b978-0-12-813704-8.00041-3.Peer-Reviewed Original ResearchTranscatheter aortic valve implantationAortic stenosisSevere symptomatic aortic stenosisSurgical aortic valve replacementSymptomatic aortic stenosisAortic valve replacementHigh-risk patientsPrevention of strokeAortic valve implantationEmbolic protection devicesNeurologic eventsStroke preventionDevastating complicationIntermediate riskNeurologic injuryValve implantationValve replacementAdjunctive pharmacotherapyStroke rateCurrent evidenceTranscatheter proceduresCardiac interventionsPatientsStrokePrevention
2019
Transcatheter aortic valve implantation versus surgical aortic valve replacement for severe aortic stenosis in people with low surgical risk
Kolkailah A, Doukky R, Pelletier M, Volgman A, Kaneko T, Nabhan A. Transcatheter aortic valve implantation versus surgical aortic valve replacement for severe aortic stenosis in people with low surgical risk. Cochrane Database Of Systematic Reviews 2019, 12: cd013319. PMID: 31860123, PMCID: PMC6984621, DOI: 10.1002/14651858.cd013319.pub2.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementLength of hospital stayLow surgical riskAortic valve replacementTranscatheter aortic valve implantationAcute kidney injuryRisk of PPM implantationRisk of atrial fibrillationSurgical riskAortic valve stenosisRandomised controlled trialsValve replacementAortic valve implantationAtrial fibrillationCardiac deathCertainty of evidenceMyocardial infarctionPPM implantationPermanent pacemakerValve implantationAssociated with shorter lengths of hospital stayNew-onset atrial fibrillationRisk ratioLong-term follow-up dataShorter length of hospital stay
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