2023
The International Association for the Study of Lung Cancer Lung Cancer Staging Project: Proposals for the Revisions of the T-Descriptors in the Forthcoming Ninth Edition of the TNM Classification for Lung Cancer
Van Schil P, Asamura H, Nishimura K, Rami-Porta R, Kim Y, Bertoglio P, Cangir A, Donington J, Fang W, Giroux D, Lievens Y, Liu H, Lyons G, Sakai S, Travis W, Ugalde P, Yang C, Yotsukura M, Detterbeck F, Committee A. The International Association for the Study of Lung Cancer Lung Cancer Staging Project: Proposals for the Revisions of the T-Descriptors in the Forthcoming Ninth Edition of the TNM Classification for Lung Cancer. Journal Of Thoracic Oncology 2023, 19: 749-765. PMID: 38070600, PMCID: PMC11081813, DOI: 10.1016/j.jtho.2023.12.006.Peer-Reviewed Original ResearchLung cancerT descriptorChest wallTNM classificationInternational Association for the Study of Lung CancerInternational Association for the Study of Lung Cancer databaseMultivariate Cox regression analysisLung Cancer Staging ProjectInclusion criteriaPathologically staged tumorsCox regression analysisTNM classification of lung cancerClassification of lung cancerDate of diagnosisStudy of Lung CancerLung cancer databaseNinth EditionPleura involvementT3 descriptorsT4 tumorsWorse survivalCancer DatabaseComprehensive survival analysisPathological typeUnivariate analysisMalignant Melanoma in Older Adults: Different Patient or Different Disease?
Sasson D, Smetona J, Parsaei Y, Papageorge M, Ariyan S, Olino K, Clune J. Malignant Melanoma in Older Adults: Different Patient or Different Disease? Cureus 2023, 15: e34742. PMID: 36909026, PMCID: PMC9998075, DOI: 10.7759/cureus.34742.Peer-Reviewed Original ResearchMelanoma-specific survivalRecurrence-free survivalOlder patientsT2 tumorsNodal positivityMetastatic progressionOlder adultsConclusion Older adultsLog-rank testingKaplan-Meier analysisT4 tumorsYounger patientsT1 tumorsBreslow thicknessClinical outcomesTumor characteristicsTumor thicknessSingle institutionClinical behaviorMalignant melanomaLower incidenceHigh incidencePatientsConsecutive sampleAge groupsPredictive accuracy of elevated mitotic rate on lymph node positivity and recurrence in thin melanomas
Ly C, Blaha O, Wei W, Galan A, Kluger H, Ariyan S, Olino K, Clune J. Predictive accuracy of elevated mitotic rate on lymph node positivity and recurrence in thin melanomas. Frontiers In Oncology 2023, 12: 1077226. PMID: 36686728, PMCID: PMC9853390, DOI: 10.3389/fonc.2022.1077226.Peer-Reviewed Original ResearchMelanoma-specific mortalityElevated mitotic rateLymph node positivityMitoses/Mitotic rateT2 tumorsNode positivityThin melanomasSentinel lymph node positivityImportant prognostic factorSingle academic centerPrimary cutaneous melanomaLow mitotic ratePositive SLNNon-ulcerated lesionsSLN biopsyT4 tumorsPatient demographicsPrognostic factorsSLN positivityRetrospective reviewTumor characteristicsBreslow thicknessCutaneous melanomaT category
2021
Adjuvant Chemotherapy for T4 Non-Small Cell Lung Cancer with Additional Ipsilateral Lung Nodules
Li AX, Flores K, Canavan ME, Boffa DJ, Blasberg JD. Adjuvant Chemotherapy for T4 Non-Small Cell Lung Cancer with Additional Ipsilateral Lung Nodules. The Annals Of Thoracic Surgery 2021, 113: 421-428. PMID: 33684345, DOI: 10.1016/j.athoracsur.2021.02.042.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerDifferent ipsilateral lobeCell lung cancerAdditional tumor nodulesT4 non-small cell lung cancerAdjuvant chemotherapyIpsilateral lobeT4 diseaseTumor nodulesLung cancerT4 tumorsOverall survivalSurgical resectionIIIA non-small cell lung cancerAdjuvant multiagent chemotherapyResectable stage IINational Cancer DatabaseFurther prospective studiesLymph node metastasisMultiagent chemotherapyNode metastasisPrimary outcomeProspective studyPatient populationCancer Database
2016
The IASLC Lung Cancer Staging Project: Background Data and Proposals for the Classification of Lung Cancer with Separate Tumor Nodules in the Forthcoming Eighth Edition of the TNM Classification for Lung Cancer
Detterbeck FC, Bolejack V, Arenberg DA, Crowley J, Donington JS, Franklin WA, Girard N, Marom EM, Mazzone PJ, Nicholson AG, Rusch VW, Tanoue LT, Travis WD, Asamura H, Rami-Porta R, Committee I, Goldstraw P, Rami-Porta R, Asamura H, Ball D, Beer D, Beyruti R, Bolejack V, Chansky K, Crowley J, Detterbeck F, Eberhardt W, Edwards J, Galateau-Sallé F, Giroux D, Gleeson F, Groome P, Huang J, Kennedy C, Kim J, Kim Y, Kingsbury L, Kondo H, Krasnik M, Kubota K, Lerut A, Lyons G, Marino M, Marom E, van Meerbeeck J, Mitchell A, Nakano T, Nicholson A, Nowak A, Peake M, Rice T, Rosenzweig K, Ruffini E, Rusch V, Saijo N, Van Schil P, Sculier J, Shemanski L, Stratton K, Suzuki K, Tachimori Y, Thomas C, Travis W, Tsao M, Turrisi A, Vansteenkiste J, Watanabe H, Wu Y, Boards A, Baas P, Erasmus J, Hasegawa S, Inai K, Kernstine K, Kindler H, Krug L, Nackaerts K, Pass H, Rice D, Falkson C, Filosso P, Giaccone G, Kondo K, Lucchi M, Okumura M, Blackstone E, Workgroup M, Flieder D, Godoy M, Goo J, Goodman L, Jett J, de Leyn P, Marchevsky A, MacMahon H, Naidich D, Okada M, Perlman M, Powell C, van Schil P, Warth A, Institutions P, Cavaco F, Barrera E, Arca J, Lamelas I, Obrer A, Jorge R, Ball D, Bascom G, Orozco A, Castro M, Blum M, Chimondeguy D, Cvijanovic V, Defranchi S, de Olaiz Navarro B, Campuzano I, Vidueira I, Araujo E, García F, Fong K, Corral G, González S, Gilart J, Arangüena L, Barajas S, Girard P, Goksel T, Budiño M, Casaurrán G, Blanco J, Hernández J, Rodríguez H, Collantes J, Heras M, Elena J, Jakobsen E, Kostas S, Atance P, Ares A, Liao M, Losanovscky M, Lyons G, Magaroles R, De Esteban Júlvez L, Gorospe M, McCaughan B, Kennedy C, Íñiguez R, Sorribes L, Gozalo S, de Arriba C, Delgado M, Alarcón J, Cuesta J, Park J, Pass H, Fernández M, Rosenberg M, Ruffini E, Rusch V, de Cos Escuín J, Vinuesa A, Mitjans M, Strand T, Subotic D, Swisher S, Terra R, Thomas C, Tournoy K, Van Schil P, Velasquez M, Wu Y, Yokoi K. The IASLC Lung Cancer Staging Project: Background Data and Proposals for the Classification of Lung Cancer with Separate Tumor Nodules in the Forthcoming Eighth Edition of the TNM Classification for Lung Cancer. Journal Of Thoracic Oncology 2016, 11: 681-692. PMID: 26940530, DOI: 10.1016/j.jtho.2015.12.114.Peer-Reviewed Original ResearchConceptsSeparate tumor nodulesPrimary lung cancerLung cancerTumor nodulesEighth editionTNM classificationSurvival differencesSecond primary lung cancerIASLC Lung Cancer Staging ProjectLung Cancer Staging ProjectForthcoming Eighth EditionSame histologic appearanceProportion of patientsSurvival of patientsLung cancer databaseT3 tumorsT4 tumorsIndex tumorCancer DatabaseSuch tumorsHistologic appearanceAnatomic classificationPatientsTumorsCancer
2015
Neoadjuvant Chemotherapy for Breast Cancer Increases the Rate of Breast Conservation: Results from the National Cancer Database
Killelea BK, Yang VQ, Mougalian S, Horowitz NR, Pusztai L, Chagpar AB, Lannin DR. Neoadjuvant Chemotherapy for Breast Cancer Increases the Rate of Breast Conservation: Results from the National Cancer Database. Journal Of The American College Of Surgeons 2015, 220: 1063-1069. PMID: 25868410, DOI: 10.1016/j.jamcollsurg.2015.02.011.Peer-Reviewed Original ResearchConceptsNational Cancer DatabaseNeoadjuvant chemotherapyBreast preservationBreast conservationTumor sizeCancer DatabaseDefinitive breast surgerySmall institutional seriesBreast cancer increasesAdvanced nodal diseaseInvasive breast cancerYounger patient ageBreast tumor sizeLarger tumor sizeMultivariate logistic regressionHigh tumor gradeAmerican Cancer SocietyAdjuvant chemotherapyNodal diseasePrimary surgeryT4 tumorsInstitutional seriesPatient ageRetrospective reviewDistant metastasis
2014
Staging accuracy of ampullary tumors by endoscopic ultrasound: Meta‐analysis and systematic review
Trikudanathan G, Njei B, Attam R, Arain M, Shaukat A. Staging accuracy of ampullary tumors by endoscopic ultrasound: Meta‐analysis and systematic review. Digestive Endoscopy 2014, 26: 617-626. PMID: 24533918, DOI: 10.1111/den.12234.Peer-Reviewed Original ResearchConceptsEndoscopic ultrasoundAmpullary neoplasmsPooled sensitivityStaging accuracyTumor invasionMeta-analysisRegional lymph node statusAccuracy of endoscopic ultrasoundSpecificity of endoscopic ultrasoundDiagnosing nodal statusEndoscopic ultrasound studiesAccurate preoperative stagingLymph node involvementLymph node statusT1 stage tumorsModerate strength of agreementDiagnostic odds ratioNegative likelihood ratioPositive likelihood ratioPredicting tumor invasionMantel-Haenszel methodLikelihood ratioNodal statusT4 tumorsNode involvement
2012
The Prognostic Importance of Midline Involvement in Oral Tongue Cancer
Lloyd S, Yu JB, Wilson LD, Judson BL, Decker RH. The Prognostic Importance of Midline Involvement in Oral Tongue Cancer. American Journal Of Clinical Oncology 2012, 35: 468-473. PMID: 21701377, PMCID: PMC3755371, DOI: 10.1097/coc.0b013e3182195619.Peer-Reviewed Original ResearchConceptsContralateral lymph node metastasisLymph node metastasisOral tongue squamous cell carcinomaTongue squamous cell carcinomaT2-3 diseaseSquamous cell carcinomaNode metastasisClinicopathologic factorsCell carcinomaMidline involvementEnd Results (SEER) dataLymph node statusOral tongue cancerDifferent prognostic classesLateral tumorsT4 tumorsT1 tumorsT3 tumorsT4 lesionsHistologic subtypeT3 lesionsNode statusPrognostic importanceT classificationTongue cancer
2011
P3-07-26: How Generalizable Is the Patient Population Enrolled in ACOSOG Z11?
Lannin D, Killelea B, Grube B, Horowitz N, Chagpar A. P3-07-26: How Generalizable Is the Patient Population Enrolled in ACOSOG Z11? Cancer Research 2011, 71: p3-07-26-p3-07-26. DOI: 10.1158/0008-5472.sabcs11-p3-07-26.Peer-Reviewed Original ResearchPositive sentinel nodesSentinel node biopsySentinel nodesPositive nodesAxillary dissectionNode biopsyLower axillary recurrence ratePositive sentinel lymph nodesAxillary recurrence rateNode-positive patientsNeo-adjuvant chemotherapyPercentage of patientsNegative sentinel nodesBreast cancer patientsSentinel lymph nodesEligibility requirementsLumpectomy patientsZ11 trialT4 tumorsPositive patientsLymph nodesRecurrence ratePatient populationCancer patientsInstitutional database
2010
Coping with the unexpected at surgery
Detterbeck FC, Terrien CM. Coping with the unexpected at surgery. Expert Review Of Respiratory Medicine 2010, 4: 115-122. PMID: 20387297, DOI: 10.1586/ers.09.59.Peer-Reviewed Original ResearchConceptsLung cancer surgeryMultidisciplinary tumor boardN2 node involvementPN2 diseaseNode involvementT4 tumorsExperienced centersSuch patientsCancer surgeryPreoperative assessmentTumor boardChest wallBetter outcomesIntraoperative surprisesSurgeryResectionMediastinalPatientsTumorsCareful planningDisease
2006
Expression of estrogen receptors‐α and ‐β in bladder cancer cell lines and human bladder tumor tissue
Shen S, Smith C, Hsieh J, Yu J, Kim I, Jian W, Sonpavde, Ayala G, Younes M, Lerner S. Expression of estrogen receptors‐α and ‐β in bladder cancer cell lines and human bladder tumor tissue. Cancer 2006, 106: 2610-2616. PMID: 16700038, DOI: 10.1002/cncr.21945.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic AgentsBlotting, WesternCarcinoma, Transitional CellCell Line, TumorCell ProliferationEstradiolEstrogen Receptor alphaEstrogen Receptor betaFulvestrantGene Expression ProfilingGene Expression Regulation, NeoplasticHumansImmunohistochemistryMicroarray AnalysisNeoplasm StagingRaloxifene HydrochlorideReverse Transcriptase Polymerase Chain ReactionRNA, MessengerTamoxifenUrinary Bladder NeoplasmsConceptsBladder cancer cell linesExpression of ERbetaCancer cell linesERbeta expressionHuman bladder cancerBladder cancer cellsBladder cancerEstrogen receptorWestern blot analysisT4 tumorsCell linesMetastatic transitional cell carcinomaMuscle-invasive bladder cancerER-alpha mRNA levelsT3/T4 tumorsHuman bladder tumor tissuesRT4 cellsBladder cancer cell growthLevels of ERalphaGrade 3 tumorsCancer cellsInvasive bladder cancerTa/T1Transitional cell carcinomaEffects of estradiol
2003
Special Treatment Issues*
Detterbeck FC, Jones DR, Kernstine KH, Naunheim KS. Special Treatment Issues*. CHEST Journal 2003, 123: 244s-258s. PMID: 12527583, DOI: 10.1378/chest.123.1_suppl.244s.Peer-Reviewed Original ResearchConceptsMetachronous multiple primary lung cancerPrimary lung cancerSecond primary lung cancerLung cancerPancoast tumorPrimary tumorSame lobeNon-small cell lung cancerMultiple primary lung cancersLung cancer guidelinesMediastinal node involvementCell lung cancerNode involvementT4 tumorsMetachronous presentationMetastatic diseasePulmonary metastasesSolitary metastasisSurgical resectionCancer guidelinesSuch patientsBetter prognosisSatellite nodulesMultimodality approachAdrenal gland
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