2024
Structural neural plasticity evoked by rapid-acting antidepressant interventions
Liao C, Dua A, Wojtasiewicz C, Liston C, Kwan A. Structural neural plasticity evoked by rapid-acting antidepressant interventions. Nature Reviews Neuroscience 2024, 26: 101-114. PMID: 39558048, PMCID: PMC11892022, DOI: 10.1038/s41583-024-00876-0.Peer-Reviewed Original ResearchAntidepressant interventionsStructural neural plasticityNeural plasticityPsychoactive drugsRapid-acting antidepressant drugsAction of psychoactive drugsRepetitive transcranial magnetic stimulationExcitatory synaptic functionAntidepressant effectsPrefrontal cortexDepressive disorderNon-invasive neurostimulationAntidepressant drugsMood disordersNeurobiological actionsTranscranial magnetic stimulationElectroconvulsive therapyPsychedelic drugsCortical pyramidal neuronsMechanisms of plasticityLongitudinal effectsGrowth of dendritic spinesPyramidal neuronsStructural plasticitySynaptic function
2023
Deriving Schwann cells from hPSCs enables disease modeling and drug discovery for diabetic peripheral neuropathy
Majd H, Amin S, Ghazizadeh Z, Cesiulis A, Arroyo E, Lankford K, Majd A, Farahvashi S, Chemel A, Okoye M, Scantlen M, Tchieu J, Calder E, Le Rouzic V, Shibata B, Arab A, Goodarzi H, Pasternak G, Kocsis J, Chen S, Studer L, Fattahi F. Deriving Schwann cells from hPSCs enables disease modeling and drug discovery for diabetic peripheral neuropathy. Cell Stem Cell 2023, 30: 632-647.e10. PMID: 37146583, PMCID: PMC10249419, DOI: 10.1016/j.stem.2023.04.006.Peer-Reviewed Original ResearchConceptsDiabetic peripheral neuropathySchwann cellsPeripheral neuropathyPeripheral nervous systemPrimary Schwann cellsBupropion treatmentDiabetic patientsMyelin damageSensory dysfunctionPrimary gliaSelective vulnerabilityAntidepressant drugsHyperglycemic miceLower incidenceRetrospective analysisHuman pluripotent stem cellsSC deathNervous systemTherapeutic candidateHigh glucoseNeuropathyHealth recordsMolecular featuresStem cellsPluripotent stem cells
2016
Ketamine’s Mechanisms of Rapid Antidepressant Activity: Evidence from Preclinical Studies
Hermes G, Sanacora G. Ketamine’s Mechanisms of Rapid Antidepressant Activity: Evidence from Preclinical Studies. 2016, 73-98. DOI: 10.1007/978-3-319-42925-0_6.Peer-Reviewed Original ResearchAntidepressant activityPreclinical studiesAntidepressant actionKetamine's mechanismPreclinical literatureRodent modelsRapid onsetBrain-derived neurotrophic factor (BDNF) expressionBehavioral effectsClassic antidepressant drugsRapid antidepressant activityNeurotrophic factor expressionChronic stressor exposureReceptor-targeted drugsNovel drug developmentAntidepressant propertiesKetamine effectsClinical trialsAntidepressant drugsSynaptic plasticityReceptor activationClinical settingFactor expressionStressor exposureDurable effects
2012
Antidepressants
Bhagwagar Z, Heninger G. Antidepressants. 2012, 1185-1198. DOI: 10.1093/med/9780199696758.003.0153.Peer-Reviewed Original ResearchWorld Health Organization Global BurdenMajor public health problemPharmacology of antidepressantsLargest causeTreatment of depressionMajor depressive disorderPublic health problemAbstract Major depressive disorderImportance of depressionRecurrent illnessDepressive disorderPrimary treatmentAntidepressant drugsGlobal burdenHigh riskHealth problemsDepressionAntidepressantsDrugsPatientsDepressed individualsSelective useCliniciansBurdenDisease
2009
Melanin-concentrating hormone directly inhibits GnRH neurons and blocks kisspeptin activation, linking energy balance to reproduction
Wu M, Dumalska I, Morozova E, van den Pol A, Alreja M. Melanin-concentrating hormone directly inhibits GnRH neurons and blocks kisspeptin activation, linking energy balance to reproduction. Proceedings Of The National Academy Of Sciences Of The United States Of America 2009, 106: 17217-17222. PMID: 19805188, PMCID: PMC2761345, DOI: 10.1073/pnas.0908200106.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainEnergy MetabolismFemaleGonadotropin-Releasing HormoneGreen Fluorescent ProteinsHypothalamic HormonesImmunohistochemistryKisspeptinsMaleMelaninsMembrane PotentialsMiceMice, TransgenicMicroscopy, FluorescenceNeuronsPatch-Clamp TechniquesPeptide FragmentsPituitary HormonesReceptors, SomatostatinReproductionTime FactorsTumor Suppressor ProteinsVesicular Glutamate Transport Protein 2ConceptsInhibitory effectDirect postsynaptic effectGnRH-GFP neuronsMCH knockout miceMCH-immunoreactive fibersRole of MCHMelanin-concentrating hormone (MCH) systemMCH receptor antagonistsPatch-clamp recordingsMelanin-concentrating hormoneNegative energy balanceKisspeptin activationDrug abuse behaviorGnRH neuronsPostsynaptic effectsExcitatory effectsGABAergic neuronsTransgenic GFP miceImmunoreactive fibersReceptor antagonistCNS neuronsAntidepressant drugsBrain slicesFood restrictionKnockout mice
2007
Cytisine, a partial agonist of high-affinity nicotinic acetylcholine receptors, has antidepressant-like properties in male C57BL/6J mice
Mineur YS, Somenzi O, Picciotto MR. Cytisine, a partial agonist of high-affinity nicotinic acetylcholine receptors, has antidepressant-like properties in male C57BL/6J mice. Neuropharmacology 2007, 52: 1256-1262. PMID: 17320916, PMCID: PMC1959230, DOI: 10.1016/j.neuropharm.2007.01.006.Peer-Reviewed Original ResearchConceptsAntidepressant-like effectsAntidepressant-like propertiesAntidepressant efficacyNicotinic acetylcholine receptorsPartial agonistBasolateral amygdalaAcetylcholine receptorsHigh-affinity nicotinic acetylcholine receptorsC-Fos immunoreactivityNovel antidepressant drugsC-fos expressionPotential neurobiological correlatesAlpha3/Classical antidepressantsAntidepressant drugsRodent modelsImmunohistochemical analysisNeuronal activityAnimal modelsFull agonistAgonistsNeuronal systemsEfficacyNeurobiological correlatesCytisine
2006
A Role for MAP Kinase Signaling in Behavioral Models of Depression and Antidepressant Treatment
Duman CH, Schlesinger L, Kodama M, Russell DS, Duman RS. A Role for MAP Kinase Signaling in Behavioral Models of Depression and Antidepressant Treatment. Biological Psychiatry 2006, 61: 661-670. PMID: 16945347, DOI: 10.1016/j.biopsych.2006.05.047.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAniline CompoundsAnimalsAntidepressive AgentsBehavior, AnimalBenzamidesBrain-Derived Neurotrophic FactorDepressionDisease Models, AnimalDose-Response Relationship, DrugDrug InteractionsEnzyme InhibitorsHelplessness, LearnedHindlimb SuspensionMaleMiceMice, Inbred C57BLMice, KnockoutMitogen-Activated Protein Kinase KinasesMotor ActivitySignal TransductionSwimmingConceptsBrain-derived neurotrophic factorAntidepressant-like effectsAntidepressant treatmentSwim testBDNF heterozygous knockout miceDepressive-like behaviorDepressive-like phenotypeTail suspension testEffects of desipramineHeterozygous knockout miceDepressive behavioral phenotypeEffect of inhibitionRodent behavioral modelsMouse behavioral modelsHeterozygous gene deletionAntidepressant mechanismAcute administrationAcute blockadeNeurotrophic factorAntidepressant drugsSuspension testDepressive phenotypeKnockout miceMEK inhibitionMEK inhibitors
2002
Norepinephrine but not Serotonin Reuptake Inhibitors Enhance Theta and Gamma Activity of the Septo-Hippocampal System
Hajós M, Hoffmann W, Robinson D, Yu J, Hajós-Korcsok É. Norepinephrine but not Serotonin Reuptake Inhibitors Enhance Theta and Gamma Activity of the Septo-Hippocampal System. Neuropsychopharmacology 2002, 28: 857-864. PMID: 12637957, DOI: 10.1038/sj.npp.1300116.Peer-Reviewed Original ResearchConceptsSerotonin reuptake inhibitor fluvoxamineReuptake inhibitorsSepto-hippocampal systemAntidepressant drugsSelective serotonin reuptake inhibitor fluvoxamineMedial septum/diagonal bandExtracellular single-unit recordingsOscillatory activitySelective NE reuptake inhibitorNorepinephrine reuptake inhibitorsEffective antidepressant drugsTheta frequencyExtracellular NE levelsHippocampal EEG recordingsNE reuptake inhibitorSingle-unit recordingsHippocampal oscillatory activityGamma wave activityNE levelsSystemic administrationAcute effectsDiagonal bandHuman depressionHippocampal formationHippocampal EEGGlutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatments
Krystal JH, Sanacora G, Blumberg H, Anand A, Charney DS, Marek G, Epperson CN, Goddard A, Mason GF. Glutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatments. Molecular Psychiatry 2002, 7: s71-s80. PMID: 11986998, DOI: 10.1038/sj.mp.4001021.Peer-Reviewed Original ResearchConceptsCortical GABA levelsMood-stabilizing treatmentMood disordersGABA levelsΓ-amino-butyric acid (GABA) systemMood-stabilizing agentsGlutamate receptor functionDevelopment of medicationsGABA deficitAvailable antidepressantsGABAergic modulationAntimanic effectsGlutamatergic activityClinical evidenceNovel antidepressantsGABA systemAntidepressant drugsNew agentsReceptor functionAvailable evidenceReceptor targetsAntidepressantsDisordersGlutamateTreatment
2001
Antidepressant-associated mania and psychosis resulting in psychiatric admissions.
Preda A, MacLean RW, Mazure CM, Bowers MB. Antidepressant-associated mania and psychosis resulting in psychiatric admissions. The Journal Of Clinical Psychiatry 2001, 62: 30-3. PMID: 11235925, DOI: 10.4088/jcp.v62n0107.Peer-Reviewed Original ResearchConceptsSelective serotonin reuptake inhibitorsGeneral hospital psychiatric unitAntidepressant-associated maniaNewer atypical agentsSide effect profileSerotonin reuptake inhibitorsHospital psychiatric unitRate of admissionAdverse behavioral effectsAntidepressant useReuptake inhibitorsEffect profileAtypical agentsPsychiatric admissionsAntidepressant drugsPsychiatric unitBehavioral effectsAdverse behavioral reactionsAdmissionSignificant increasePsychosisManiaDrugsTolerabilityAntidepressants
2000
Differential effects of tricyclic antidepressant drugs on membrane dynamics—a fluorescence spectroscopic study
Sanganahalli B, Joshi P, Joshi N. Differential effects of tricyclic antidepressant drugs on membrane dynamics—a fluorescence spectroscopic study. Life Sciences 2000, 68: 81-90. PMID: 11132248, DOI: 10.1016/s0024-3205(00)00918-8.Peer-Reviewed Original ResearchConceptsDimyristoyl phosphatidyl cholineSteady state anisotropyAntidepressant drugsTime-dependent anisotropyDecay of anisotropyFluorescence decay timeSynaptosomal membranesActivity of Na+-K+-ATPaseTricyclic antidepressant drugsNa+-K+-ATPaseDecay timeAntidepressant drug amitriptylineNortriptyline treatmentLimiting anisotropyRat brain synaptosomesTricyclic antidepressant drug amitriptylineDesipramineAmitriptylineCase of amitriptylineImipramineNortriptylineRat brainAnisotropyBrain synaptosomesTime-dependent fluorescence spectroscopyImpairment of GABAergic Transmission in Depression: New Insights from Neuroimaging Studies
Sanacora G, Mason G, Krystal J. Impairment of GABAergic Transmission in Depression: New Insights from Neuroimaging Studies. Critical Reviews In Neurobiology 2000, 14: 23. PMID: 11253954, DOI: 10.1615/critrevneurobiol.v14.i1.20.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsNeurobiology of depressionGABAergic functionTechnique of PETCSF GABA concentrationsGABA-mimetic agentsNovel neuroimaging techniquesNondepressed comparison subjectsMood stabilizingChronic administrationGABAergic transmissionGABAergic neurotransmissionAntidepressant propertiesGABAergic abnormalitiesDepressed patientsAntidepressant drugsDisorder pathophysiologyLower plasmaComparison subjectsAnimal studiesGABAergic contributionGABA concentrationNovel imaging techniqueNeuroimaging studiesNeuroimaging techniquesDepression
1996
Comments on "Effectiveness of Pindolol With Selected Antidepressant Drugs in the Treatment of Major Depression"
Anderson G. Comments on "Effectiveness of Pindolol With Selected Antidepressant Drugs in the Treatment of Major Depression". Journal Of Clinical Psychopharmacology 1996, 16: 256.. PMID: 8784661, DOI: 10.1097/00004714-199606000-00013.Peer-Reviewed Original ResearchClinical and Biochemical Effects of Catecholamine Depletion on Antidepressant-Induced Remission of Depression
Miller HL, Delgado PL, Salomon RM, Berman R, Krystal JH, Heninger GR, Charney DS. Clinical and Biochemical Effects of Catecholamine Depletion on Antidepressant-Induced Remission of Depression. JAMA Psychiatry 1996, 53: 117-128. PMID: 8629887, DOI: 10.1001/archpsyc.1996.01830020031005.Peer-Reviewed Original ResearchConceptsNorepinephrine reuptake inhibitorsReuptake inhibitorsCatecholamine depletionAlpha-methylparatyrosineTreatment groupsHamilton Depression Rating ScaleHomovanillic acid levelsSerotonin reuptake inhibitorsDepression Rating ScaleSimilar significant decreaseAntihistamine diphenhydramine hydrochlorideSeparate test sessionsFeelings of worthlessnessConsiderable sedationLoss of interestDepressed patientsDepressive relapseAntidepressant drugsInactive placeboTherapeutic effectTherapeutic mechanismDepressive symptomsCatecholamine metabolitesPlasma 3RemissionChapter 17 Biogenic amine transporters of the plasma membrane
Rudnick G. Chapter 17 Biogenic amine transporters of the plasma membrane. Handbook Of Biological Physics 1996, 2: 381-404. DOI: 10.1016/s1383-8121(96)80058-3.ChaptersPlasma membraneSpecific transportersSmall neurotransmittersNerve terminalsBiogenic amine transportersMain inactivation mechanismNeurotransmitter transportersExtracellular transmitterAmine transportersTransportersBiogenic amine neurotransmittersInactivation mechanismAntidepressant drugsNervous systemNeurotransmitter activityCases of ACHNeurotransmittersAmine neurotransmittersProducts of hydrolysisMembraneCellsNorepinephrineAChDopamineHydrolysisEffects of Rapid Tryptophan Depletion in Patients With Seasonal Affective Disorder in Remission After Light Therapy
Lam RW, Zis AP, Grewal A, Delgado PL, Charney DS, Krystal JH. Effects of Rapid Tryptophan Depletion in Patients With Seasonal Affective Disorder in Remission After Light Therapy. JAMA Psychiatry 1996, 53: 41-44. PMID: 8540776, DOI: 10.1001/archpsyc.1996.01830010043007.Peer-Reviewed Original ResearchConceptsRapid tryptophan depletionSeasonal affective disorderTryptophan depletionLight therapyClinical remissionAffective disordersTryptophan levelsDouble-blind crossover studyRecurrent major depressive episodesMajor depressive episodeBright light therapyEffect of therapyFree tryptophan levelsAntidepressant effectsCrossover studySerotonergic mechanismsDepressive episodeAntidepressant drugsTherapeutic effectSignificant relapseDepression scoresPatientsTherapyRemissionNonseasonal depression
1992
Inadequate Treatment of Depressed Nursing Home Elderly
Heston L, Garrard J, Makris L, Kane R, Cooper S, Dunham T, Zelterman D. Inadequate Treatment of Depressed Nursing Home Elderly. Journal Of The American Geriatrics Society 1992, 40: 1117-1122. PMID: 1401696, DOI: 10.1111/j.1532-5415.1992.tb01800.x.Peer-Reviewed Original ResearchConceptsDiagnosis of depressionAntidepressant drug treatmentMajor depressionDrug treatmentNursing homesNursing Home ElderlyPrimary care physiciansNursing home stayNursing home residentsSkilled nursing homesEnd of studyChart reviewCare physiciansPhysician diagnosisResidents age 65Medical recordsHome residentsAntidepressant drugsPrevalence ratesAge 65Admission cohortDSM-IIIInadequate treatmentDiagnosisHome stay
1990
Value of the DST for predicting response of patients with major depression to hospitalization and desipramine
Nelson JC, Mazure CM, Jatlow PI. Value of the DST for predicting response of patients with major depression to hospitalization and desipramine. American Journal Of Psychiatry 1990, 147: 1488-1492. PMID: 2221161, DOI: 10.1176/ajp.147.11.1488.Peer-Reviewed Original ResearchConceptsDexamethasone suppression testResponse of patientsMajor depressionNegative dexamethasone suppression testPositive dexamethasone suppression testWeeks of hospitalizationNonpsychotic major depressionPlasma levelsSuppression testRate of responseAntidepressant drugsDrug treatmentPatientsHospitalizationDesipraminePrior reportsDepressionResponsePrior studiesPlaceboFindingsTrialsWeeksClinical data on the role of serotonin in the mechanism(s) of action of antidepressant drugs.
Price LH, Charney DS, Delgado PL, Goodman WK, Krystal JH, Woods SW, Heninger GR. Clinical data on the role of serotonin in the mechanism(s) of action of antidepressant drugs. The Journal Of Clinical Psychiatry 1990, 51 Suppl: 44-50; discussion 51-2. PMID: 2182616.Peer-Reviewed Original ResearchConceptsIntravenous L-tryptophanBrain serotonin functionAntidepressant drug actionRole of serotoninL-tryptophanThymoleptic drugsPlasma TrpView of evidencePRL responseNeuroendocrine effectsSerum prolactinSerotonin functionAntidepressant drugsClinical dataTherapeutic effectPreclinical studiesReceptor sensitivityClinical settingChallenge paradigmDrug actionRecent evidenceAntidepressantsProlactinDrugsDepressionDoes melancholia predict response in major depression?
Nelson J, Mazure C, Jatlow P. Does melancholia predict response in major depression? Journal Of Affective Disorders 1990, 18: 157-165. PMID: 2139060, DOI: 10.1016/0165-0327(90)90032-4.Peer-Reviewed Original Research
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