2025
Functional Correlates of Atypical Visuoperceptual Organization in a Multisite Clinical High-Risk Sample
Pokorny V, Tran T, Williams T, Kenney J, Silverstein S, Gold J, Waltz J, Schiffman J, Ellman L, Strauss G, Walker E, Woods S, Powers A, Corlett P, Mittal V. Functional Correlates of Atypical Visuoperceptual Organization in a Multisite Clinical High-Risk Sample. Journal Of Psychopathology And Clinical Science 2025, 134: 527-539. PMID: 40193439, PMCID: PMC12162206, DOI: 10.1037/abn0000992.Peer-Reviewed Original ResearchConceptsClinical high riskPsychotic-like Experiences groupClinical high-risk statusClinical high-risk samplesMeasures of cognitive abilityClinical high-risk groupHigh-risk sampleMeasuring perceptual organizationFaces taskPsychotic disordersPerceptual priorsCognitive abilitiesCognitive functionClinical groupsPerceptual organizationHealthy control groupContext-sensitiveSocial functioningTwo-tone imagesTarget circleSymbolic codeEbbinghausFunctional correlatesTaskParticipantsA Review of the Evidence Surrounding Popular Cognitive Enhancers
Draghmeh K, Elmarasi M, Fuehrlein B. A Review of the Evidence Surrounding Popular Cognitive Enhancers. Current Psychopharmacologye 2025, 13 DOI: 10.2174/0122115560363501250609121229.Peer-Reviewed Original ResearchPredicting cognitive functioning in early psychosis: factors supporting and limiting generalizability of connectome-based models
O’Neill A, Pax M, Parent J, Sepulcre J, Camprodon J, Noble S, Roffman J, Eryilmaz H. Predicting cognitive functioning in early psychosis: factors supporting and limiting generalizability of connectome-based models. NPP—Digital Psychiatry And Neuroscience 2025, 3: 11. PMID: 40475845, PMCID: PMC12133584, DOI: 10.1038/s44277-025-00032-1.Peer-Reviewed Original ResearchConnectome-based predictive modelingEarly psychosisCognitive functionGoal of precision psychiatryPredictors of cognitive functionPrediction of cognitive functionPredicting cognitive performancePredicting cognitive functionModels of cognitionConnectome-based modelsPersonalized treatment developmentBrain connectivity patternsImpact functional outcomesHuman Connectome ProjectFluid cognitionPsychotic disordersSomatomotor networkCognitive abilitiesCognitive performancePrecision psychiatryVirtual lesion analysisTreatment developmentPsychosisCognitive outcomesCognitive impairmentIncidence and predictors of immune checkpoint inhibitor treatment–related cognitive impairment in a racial and ethnic diverse population
Sayer M, Agrawal P, Ng D, Kagramanov D, Trudeau J, Othy S, Acharya M, Chan A. Incidence and predictors of immune checkpoint inhibitor treatment–related cognitive impairment in a racial and ethnic diverse population. Supportive Care In Cancer 2025, 33: 523. PMID: 40451933, PMCID: PMC12127230, DOI: 10.1007/s00520-025-09560-0.Peer-Reviewed Original ResearchConceptsIntroductionImmune checkpoint inhibitorsTherapy initiationPatient-reported outcomesGeneralized Estimating EquationsSignificant cognitive impairmentICI-treated patientsAnti-cancer immunityClinically significant cognitive impairmentCognitive functionCognitive impairmentTreatment-related cognitive impairmentPhysical functionCheckpoint inhibitorsMild to severe symptomsImpaired physical functionRisk patientsImmune dysregulationConcurrent symptomsInflammatory biomarkersPatient characteristicsSymptom scoresCancer therapyCognitive function scoresT-scoreTherapy[Association between physical activity and cognitive impairment in older adults aged 65 years and above in longevity areas of China].
Xu H, Wu Y, Chen C, Meng X, Chen J, Zhang Z, Zhong Z, Yang J, Fu X, Chen S, Chen Y, Li Z, Ye L, Shi X, Lyu Y. [Association between physical activity and cognitive impairment in older adults aged 65 years and above in longevity areas of China]. Chinese Journal Of Epidemiology 2025, 46: 753-760. PMID: 40494781, DOI: 10.3760/cma.j.cn112338-20250124-00060.Peer-Reviewed Original ResearchConceptsLevels of physical activityPhysical activityOlder adultsCognitive impairmentIntensity levels of physical activityIntensity of physical activityPhysical Activity ScaleChronic disease historyWork-related activitiesMultifactorial logistic regression modelsLogistic regression modelsMini-MentalBiomarkers Cohort StudyChinese versionActivity ScaleActive leisureCohort studyLongevity areasDemographic characteristicsHealthy agingDisease historyHousehold activitiesRegression modelsCognitive functionNegative associationCombining transcranial direct current stimulation with music therapy improves cognitive function in schizophrenia: study protocol for a randomized, double-blind, sham-controlled clinical trial
Wei Y, He S, Luo P, Su H, Chen Y, Qin S, Zhang Z, Liu R, Wei D, Wang J, Wang F, Wang C. Combining transcranial direct current stimulation with music therapy improves cognitive function in schizophrenia: study protocol for a randomized, double-blind, sham-controlled clinical trial. Frontiers In Psychiatry 2025, 16: 1543789. PMID: 40417274, PMCID: PMC12100747, DOI: 10.3389/fpsyt.2025.1543789.Peer-Reviewed Original ResearchMusic therapyQuality of lifeTranscranial direct current stimulationCognitive impairmentCognitive functionMT groupProtocol registration numberSham-controlled clinical trialSecond Affiliated Hospital of Xinxiang Medical UniversityEnhance cognitive functionResearch Ethics CommitteeChinese classical musicPrimary outcome measureDirect current stimulationSham-controlled trialActive transcranial direct current stimulationCombined interventionSham transcranial direct current stimulationOutcome measuresClassical musicSecondary outcomesEfficacy of transcranial direct current stimulationStudy protocolRegistration numberSocial functioningPsychological Distress and Cognitive Function in Women: Exploring Potential Mediation by Use of Opiates, Sleep Aids, or Minor Tranquilizers
Sampson L, Lawn R, Murchland A, Liu J, Marquez C, Scoglio A, Jha S, Sumner J, Roberts A, Kang J, Chibnik L, Koenen K, Kubzansky L. Psychological Distress and Cognitive Function in Women: Exploring Potential Mediation by Use of Opiates, Sleep Aids, or Minor Tranquilizers. Journal Of Women's Health 2025 PMID: 40336460, DOI: 10.1089/jwh.2024.0991.Peer-Reviewed Original ResearchPosttraumatic stress disorderCognitive functionMedication useMinor tranquilizersMeasures of posttraumatic stress disorderNurses' Health Study IIAssociated with lower cognitive functionCogstate Brief BatterySleep aidsEvidence of mediationLower cognitive functionLearning/working memoryBrief batteryStress disorderPsychomotor speed/attentionAssociated with useDistress scoresHigh distressMediation analysisPsychological distressLinear regression modelsPotential mediatorsSelf-ReportAssessed associationsDepressionSingle-cell elderly blood–CSF atlas implicates peripherally influenced immune dysregulation in normal pressure hydrocephalus
Duy P, Kiziltug E, Greenberg A, Mehta N, Hao L, Fortes C, Mullany S, Fan B, Manichaikul A, Teich A, Chan D, Alper S, Hyman B, Arnold S, McKhann G, Frosch M, Kahle K. Single-cell elderly blood–CSF atlas implicates peripherally influenced immune dysregulation in normal pressure hydrocephalus. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2412159122. PMID: 40324076, PMCID: PMC12087963, DOI: 10.1073/pnas.2412159122.Peer-Reviewed Original ResearchConceptsIdiopathic normal pressure hydrocephalusNormal pressure hydrocephalusImmune dysregulationPeripheral bloodPressure hydrocephalusIdiopathic normal pressure hydrocephalus patientsProinflammatory alterationsVentricular CSFSingle-cell transcriptomicsINPH patientsCell populationsPatientsNeuroglial cellsCSFBloodHydrocephalusBaseline cognitive functionCognitive functionDysregulationMonocytes511. Associations of Cognitive Functions With EEG-Based Event-Related Potentials and Oscillations in Individuals at Clinical High-Risk for Psychosis: A Canonical Correlation Analysis of NAPLS2 Data
Hua J, Roach B, Hamilton H, Bachman P, Belger A, Carrion R, Duncan E, Johannesen J, Light G, Niznikiewicz M, Shapiro D, Woodberry K, Addington J, Bearden C, Cadenhead K, Cornblatt B, Perkins D, Stone W, Tsuang M, Walker E, Woods S, Cannon T, Mathalon D. 511. Associations of Cognitive Functions With EEG-Based Event-Related Potentials and Oscillations in Individuals at Clinical High-Risk for Psychosis: A Canonical Correlation Analysis of NAPLS2 Data. Biological Psychiatry 2025, 97: s308. DOI: 10.1016/j.biopsych.2025.02.750.Peer-Reviewed Original ResearchMultimorbidity patterns and cognitive change among Mexican older adults: findings from the Mexican Health and Aging Study
Bishop N, Botoseneanu A, Newsom J, Allore H, Nagel C, Markwardt S, Samper-Ternent R, Quiñones A. Multimorbidity patterns and cognitive change among Mexican older adults: findings from the Mexican Health and Aging Study. Journal Of Global Ageing 2025, 2: 65-97. DOI: 10.1332/29767202y2024d000000019.Peer-Reviewed Original ResearchMexican Health and Aging StudyHealth and Aging StudyMultimorbidity patternsMexican adultsChronic conditionsOlder adultsIncreasing burden of chronic conditionsDepressive symptomsBurden of chronic conditionsCo-occurring chronic conditionsCognitive declineCognitive functionAssociated with lower cognitive functionOlder Mexican adultsMexican Older AdultsRisk of cognitive declineAging StudyLower cognitive functionCognitive changesManagement of diabetesMultimorbidityIncreasing burdenCognitive trajectoriesLatent growth modelingOlder adulthoodImpact of Fatigue on Subjective and Objective Cognitive Functions in Persons with Post-COVID-19 Condition
Le G, Kwan A, Guo Z, Dev D, Wong S, Badulescu S, Ceban F, Teopiz K, Johnson D, Gill H, Di Vincenzo J, Meshkat S, Rhee T, Ho R, Phan L, Rosenblat J, Mansur R, Subramaniapillai M, McIntyre R. Impact of Fatigue on Subjective and Objective Cognitive Functions in Persons with Post-COVID-19 Condition. Clinical Nursing Research 2025, 34: 143-152. PMID: 40231351, DOI: 10.1177/10547738251329412.Peer-Reviewed Original ResearchConceptsDigit Symbol Substitution TestFatigue Severity ScaleTMT-A/BCognitive deficitsAssociated with cognitive deficitsTrail Making Test Part APost-COVID-19 conditionNeurobiological substratesDigit SymbolObjective cognitionSubstitution TestCognitive functionCognitionSeverity ScalePart AImpact of fatigueDeficitsPersonsMultiple lines of evidenceSecondary analysisGeneral populationLines of evidenceDebilitating conditionEffects of fatigueGeneralized linear modelDLG2 rs11607886 polymorphism associated with schizophrenia and precuneus functional changes
Zhu H, Wu Z, Wang J, Zhang E, Zhang S, Yang Y, Li W, Shi H, Yang G, Lv L, Zhang Y. DLG2 rs11607886 polymorphism associated with schizophrenia and precuneus functional changes. Schizophrenia Research 2025, 280: 50-58. PMID: 40220608, DOI: 10.1016/j.schres.2025.04.004.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingSZ patientsPrecuneus gyrusRight middle temporal gyrusHealthy controlsMiddle temporal gyrusIncreased risk of SZSevere mental disordersRisk of SZPathogenesis of SZAssociated with SZClinical symptom assessmentSignificant main effectLeft precuneus gyrusTemporal gyrusBrain regionsMental disordersSchizophreniaCognitive functionBrain functionSZ susceptibilityMain effectGyrusMagnetic resonance imagingSingle nucleotide polymorphismsUnraveling the Neural Landscape of Mental Disorders using Double Functional Independent Primitives (dFIPs)
Soleimani N, Iraji A, Pearlson G, Preda A, Calhoun V. Unraveling the Neural Landscape of Mental Disorders using Double Functional Independent Primitives (dFIPs). Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2025 PMID: 40222638, DOI: 10.1016/j.bpsc.2025.03.015.Peer-Reviewed Original ResearchAutism spectrum disorderFunctional network connectivityBipolar disorderPsychiatric conditionsMental disordersMental illnessResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingConnectivity patternsBrain network alterationsFunctional connectivity patternsNeurobiological underpinningsDepressive disorderEmotion regulationNeural signaturesPsychiatric diagnosisConnectivity alterationsBrain regionsSpectrum disorderCognitive functionNeural landscapeCerebellar connectivitySocial behaviorNetwork alterationsSchizophreniaSubjective and Objective Measures of Cognitive Function are Correlated in Persons with Post-COVID-19 Condition: A Secondary Analysis of a Randomized Controlled Trial (P1-10.009)
Lakhani M, Kwan A, Teopiz K, Nijjar C, Meshkat S, Badulescu S, Man R, Rhee T, Gill H, McIntyre R. Subjective and Objective Measures of Cognitive Function are Correlated in Persons with Post-COVID-19 Condition: A Secondary Analysis of a Randomized Controlled Trial (P1-10.009). Neurology 2025, 104 DOI: 10.1212/wnl.0000000000209090.Peer-Reviewed Original ResearchCOVID-19 Pandemic–Related Exposures and Cognitive Function in Middle-Aged Women
Wang S, Menor A, Chibnik L, Kang J, Vyas C, Blacker D, Kubzansky L, Koenen K, Roberts A. COVID-19 Pandemic–Related Exposures and Cognitive Function in Middle-Aged Women. JAMA Network Open 2025, 8: e255532. PMID: 40244583, PMCID: PMC12006873, DOI: 10.1001/jamanetworkopen.2025.5532.Peer-Reviewed Original ResearchConceptsMiddle-aged womenCognitive AssessmentStudy of registered nursesNurses' Health Study IICognitive functionCohort study analyzed dataCOVID-19 pandemicAssociated with cognitive functionCognitive declineCogstate Brief BatteryPost-COVID-19 conditionAssociated with cognitive declineAssociated with risk factorsStudy analyzed dataPandemic-related eventsComposite cognitive scoreCognitive test batteryReduced cognitive functionMain OutcomesEducation levelTest practice effectsCohort studyCOVID-19Brief batteryStudy IIAssociations Between Internalized HIV Stigma and Cognitive Function Among Older Women With HIV
Vu T, Wise J, Jones D, Wingood G, Diaz M, Chandran A, Cohen M, Weiser S, Spence A, Wilson T, Norcini-Pala A, Sharma A, Rubin L, Turan B, Turan J, Monin J. Associations Between Internalized HIV Stigma and Cognitive Function Among Older Women With HIV. The Journals Of Gerontology Series B 2025, 80: gbaf058. PMID: 40123355, PMCID: PMC12067073, DOI: 10.1093/geronb/gbaf058.Peer-Reviewed Original ResearchConceptsInternalized HIV stigmaHIV stigmaAssociated with poorer global cognitive functionCognitive functionHIV Stigma ScalePoorer global cognitive functionStigma reduction interventionsAnnual incomeBenefit cognitive functionDomain-specific scoresFine motor functionGlobal cognitive scoreNonprescription drug useGlobal cognitive functionWomen's Interagency HIV StudyStigma ScaleMental healthReduction interventionsDepressive symptomsLinear regression modelsOlder womenWomen ageStigmaCognitive AssessmentAlcohol useGrowth‐Associated Protein 43 Levels in the Cerebrospinal Fluid Correspond to the Cerebral Blood Flow Alterations in Alzheimer's Dementia Continuum: An Original Study
Songhori N, Goushky M, Khaleghi M, Mojerloo M, Sadeghi M, Mozafar M, Aghdam Z, Ghajar M, Kianifar Y, Karimzadeh F, Khosravi F, Mayeli M. Growth‐Associated Protein 43 Levels in the Cerebrospinal Fluid Correspond to the Cerebral Blood Flow Alterations in Alzheimer's Dementia Continuum: An Original Study. Health Science Reports 2025, 8: e70534. PMID: 40078900, PMCID: PMC11896815, DOI: 10.1002/hsr2.70534.Peer-Reviewed Original ResearchMild cognitive impairmentComposite scoreAlzheimer's Disease Neuroimaging InitiativeMini Mental State ExaminationExecutive function composite scoreMental State ExaminationCognitive impairmentIndependent t-testDiagnostic groupsDementia continuumMultiple linear regression analysisState ExaminationAlzheimer's diseaseAPOE-e4Cognitive statusLinear regression analysisCognitive composite scoreComparison of continuous variablesCognitive scoresConfounding factorsCN individualsCerebrospinal fluid biomarkersSignificant positive correlationCognitive functionMann-Whitney testReduced removal of waste products from energy metabolism takes center stage in human brain aging
Mangia S, DiNuzzo M, Ponticorvo S, Dienel G, Behar K, Benveniste H, Hyder F, Giove F, Herculano-Houzel S, Petroff O, Eberly L, Filip P, Michaeli S, Rothman D. Reduced removal of waste products from energy metabolism takes center stage in human brain aging. Scientific Reports 2025, 15: 8127. PMID: 40057554, PMCID: PMC11890754, DOI: 10.1038/s41598-025-90342-3.Peer-Reviewed Original ResearchBrain connectivity correlates of the impact of a digital intervention for individuals with subjective cognitive decline on depression and IL-18
Catalogna M, Somerville Y, Saporta N, Nathansohn-Levi B, Shelly S, Edry L, Zagoory-Sharon O, Feldman R, Amedi A. Brain connectivity correlates of the impact of a digital intervention for individuals with subjective cognitive decline on depression and IL-18. Scientific Reports 2025, 15: 6863. PMID: 40011544, PMCID: PMC11865443, DOI: 10.1038/s41598-025-91457-3.Peer-Reviewed Original ResearchConceptsBrain connectivityCognitive declineResting-state functional connectivityEffect sizeCognitive behavioral therapyLate-life depressionSelf-reported depressionMedium effect sizeDigital interventionsInterventions targeting mental healthMood regulationBehavioral therapyDepressive symptomsDecreased connectivityPost-intervention changesFunctional connectivityTwo-week interventionCognitive functionSpatial cognitionDepression scoresBrain healthBehavioral outcomesBrain functionPsychological techniquesPsychological healthDeep learning to quantify the pace of brain aging in relation to neurocognitive changes
Yin C, Imms P, Chowdhury N, Chaudhari N, Ping H, Wang H, Bogdan P, Irimia A, Weiner M, Aisen P, Petersen R, Jack C, Jagust W, Landau S, Rivera-Mindt M, Okonkwo O, Shaw L, Lee E, Toga A, Beckett L, Harvey D, Green R, Saykin A, Nho K, Perrin R, Tosun D, Sachdev P, Green R, Drake E, Montine T, Conti C, Weiner M, Nosheny R, Truran Sacrey D, Fockler J, Miller M, Conti C, Kwang W, Jin C, Diaz A, Ashford M, Flenniken D, Kormos A, Petersen R, Aisen P, Rafii M, Raman R, Jimenez G, Donohue M, Salazar J, Fidell A, Boatwright V, Robison J, Zimmerman C, Cabrera Y, Walter S, Clanton T, Shaffer E, Webb C, Hergesheimer L, Smith S, Ogwang S, Adegoke O, Mahboubi P, Pizzola J, Jenkins C, Beckett L, Harvey D, Donohue M, Saito N, Diaz A, Hussen K, Okonkwo O, Rivera-Mindt M, Amaza H, Thao M, Parkins S, Ayo O, Glittenberg M, Hoang I, Germano K, Strong J, Weisensel T, Magana F, Thomas L, Guzman V, Ajayi A, Di Benedetto J, Talavera S, Jack C, Felmlee J, Fox N, Thompson P, DeCarli C, Forghanian-Arani A, Borowski B, Reyes C, Hedberg C, Ward C, Schwarz C, Reyes D, Gunter J, Moore-Weiss J, Kantarci K, Matoush L, Senjem M, Vemuri P, Reid R, Malone I, Thomopoulos S, Nir T, Jahanshad N, Knaack A, Fletcher E, Harvey D, Tosun-Turgut D, Rossi Chen S, Choe M, Crawford K, Yushkevich P, Das S, Jagust W, Landau S, Koeppe R, Rabinovici G, Villemagne V, LoPresti B, Perrin R, Morris J, Franklin E, Bernhardt H, Cairns N, Taylor-Reinwald L, Shaw L, Lee E, Lee V, Korecka M, Brylska M, Wan Y, Trojanowki J, Toga A, Crawford K, Neu S, Saykin A, Nho K, Foroud T, Jo T, Risacher S, Craft H, Apostolova L, Nudelman K, Faber K, Potter Z, Lacy K, Kaddurah-Daouk R, Shen L, Karlawish J, Erickson C, Grill J, Largent E, Harkins K, Weiner M, Thal L, Kachaturian Z, Frank R, Snyder P, Buckholtz N, Hsiao J, Ryan L, Molchan S, Khachaturian Z, Carrillo M, Potter W, Barnes L, Bernard M, González H, Ho C, Hsiao J, Jackson J, Masliah E, Masterman D, Okonkwo O, Perrin R, Ryan L, Silverberg N, Silbert L, Kaye J, White S, Pierce A, Thomas A, Clay T, Schwartz D, Devereux G, Taylor J, Ryan J, Nguyen M, DeCapo M, Shang Y, Schneider L, Munoz C, Ferman D, Conant C, Martin K, Oleary K, Pawluczyk S, Trejo E, Dagerman K, Teodoro L, Becerra M, Fairooz M, Garrison S, Boudreau J, Avila Y, Brewer J, Jacobson A, Gama A, Kim C, Little E, Frascino J, Ferng N, Trujillo S, Heidebrink J, Koeppe R, MacDonald S, Malyarenko D, Ziolkowski J, O’Connor J, Robert N, Lowe S, Rogers V, Petersen R, Hackenmiller B, Boeve B, Albers C, Kreuger C, Jones D, Knopman D, Botha H, Magnuson J, Graff-Radford J, Crawley K, Schumacher M, McKinzie S, Smith S, Helland T, Lowe V, Ramanan V, Pavlik V, Faircloth J, Bishop J, Nath J, Chaudhary M, Kataki M, Yu M, Pacini N, Barker R, Brooks R, Aggarwal R, Honig L, Stern Y, Mintz A, Cordona J, Hernandez M, Long J, Arnold A, Groves A, Middleton A, Vogler B, McCurry C, Mayo C, Raji C, Amtashar F, Klemp H, Elmore H, Ruszkiewicz J, Kusuran J, Stewart J, Horenkamp J, Greeson J, Wever K, Vo K, Larkin K, Rao L, Schoolcraft L, Gallagher L, Paczynski M, McMillan M, Holt M, Gagliano N, Henson R, LaBarge R, Swarm R, Munie S, Cepeda S, Winterton S, Hegedus S, Wilson T, Harte T, Bonacorsi Z, Geldmacher D, Watkins A, Barger B, Smelser B, Bates C, Stover C, McKinley E, Ikner G, Hendrix H, Cooper H, Mahaffey J, Booth Robbins L, Brown Ashley L, Natelson-Love M, Carter P, Solomon V, Grossman H, Groome A, Ardolino A, Kaplan A, Sheppard F, Burgos-Rivera G, Garcia-Camilo G, Lim J, Neugroschl J, Jackson K, Evans K, Soleimani L, Sano M, Ghesani N, Binder S, Apuango X, Sood A, Troutman A, Blanchard K, Richards A, Nelson G, Hendrickson K, Yurko E, Plenge J, Rufo V, Shah R, Duara R, Lynch B, Chirinos C, Dittrich C, Campbell D, Mejia D, Perez G, Colvee H, Gonzalez J, Gondrez J, Knaack J, Acevedo M, Cereijo M, Greig-Custo M, Villar M, Wishnia M, Detling S, Barker W, Albert M, Moghekar A, Rodzon B, Demsky C, Pontone G, Pekar J, Farrington L, Pomper M, Johnson N, Alo T, Sadowski M, Ulysse A, Masurkar A, Marti B, Mossa D, Geesey E, Petrocca E, Schulze E, Wong J, Boonsiri J, Kenowsky S, Martinez T, Briglall V, Doraiswamy P, Nwosu A, Adhikari A, Hellegers C, Petrella J, James O, Wong T, Hawk T, Vaishnavi S, McCoubrey H, Nasrallah I, Rovere R, Maneval J, Robinson E, Rivera F, Uffelman J, Combs M, O’Donnell P, Manning S, King R, Nieto A, Glueck A, Mandal A, Swain A, Gamble B, Meacham B, Forenback D, Ross D, Cheatham E, Hartman E, Cornell G, Harp J, Ashe L, Goins L, Watts L, Yazell M, Mandal P, Buckler R, Vincent S, Rudd T, Lopez O, Malia A, Chiado C, Zik C, Ruszkiewicz J, Savage K, Fenice L, Oakley M, Tacey P, Berman S, Bowser S, Hegedus S, Saganis X, Porsteinsson A, Mathewson A, Widman A, Holvey B, Clark E, Morales E, Young I, Ruszkiewicz J, Hopkins K, Martin K, Kowalski N, Hunt R, Calzavara R, Kurvach R, D’Ambrosio S, Thai G, Vides B, Lieb B, McAdams-Ortiz C, Toso C, Mares I, Moorlach K, Liu L, Corona M, Nguyen M, Tallakson M, McDonnell M, Rangel M, Basheer N, Place P, Romero R, Tam S, Nguyen T, Thomas A, Frolov A, Khera A, Browning A, Kelley B, Dawson C, Mathews D, Most E, Phillips E, Nguyen L, Nunez M, Miller M, Jones M, Martinez N, Logan R, McColl R, Pham S, Fox T, Moore T, Levey A, Brown A, Kippels A, Ellison A, Lyons C, Hales C, Parry C, Williams C, McCorkle E, Harris G, Rose H, Jooma I, Al-Amin J, Lah J, Webster J, Swiniarski J, Chapman L, Donnelly L, Mariotti L, Locke M, Vaughn P, Penn R, Carpentier S, Yeboah S, Basadre S, Malakauskas S, Lyron S, Villinger T, Burney T, Burns J, Abusalim A, Dahlgren A, Montero A, Arthur A, Dooly H, Kreszyn K, Berner K, Gillen L, Scanlan M, Madison M, Mathis N, Switzer P, Townley R, Fikru S, Sullivan S, Wright E, Beigi M, Daley A, Ko A, Luong B, Nyborg G, Morales J, Durbin K, Garcia L, Parand L, Macias L, Monserratt L, Farchi M, Wu P, Hernandez R, Rodriguez T, Graff-Radford N, Marolt A, Thomas A, Aloszka D, Moncayo E, Westerhold E, Day G, Chrestensen K, Imhansiemhonehi M, McKinzie S, Stephens S, Grant S, Brosch J, Perkins A, Saunders A, Kovac D, Polson H, Mwaura I, Mejia K, Britt K, King K, Nichols K, Lawrence K, Rankin L, Farlow M, Wiesenauer P, Bryant R, Herring S, Lynch S, Wilson S, Day T, Korst W, van Dyck C, Mecca A, Miller A, Brennan A, Khan A, Ruan A, Gunnoud C, Mendonca C, Raynes-Goldfinger D, Salardini E, Hidalgo E, Cooper E, Singh E, Murphy E, May J, Stanhope J, Lam J, Waszak J, Nelsen K, Sacaza K, Hasbani M, Donahue M, Chen M, Barcelos N, Eigenberger P, Bonomi R, O’Dell R, Jefferson S, Khasnavis S, Smilowitz S, DeStefano S, Good S, Camarro T, Clayton V, Cavrel Y, Lu Y, Chertkow H, Bergman H, Hosein C, Black S, Kapadia A, Bhan A, Lam B, Scott C, Gabriel G, Bray J, Zotovic L, Gutierrez M, Masellis M, Farshadi M, Gui M, Mitchell M, Taylor R, Endre R, Taghi-Zada Z, Hsiung R, English C, Kim E, Yau E, Tong H, Barlow L, Jennings L, Assaly M, Nunes P, Marian T, Kertesz A, Rogers J, Trost D, Wint D, Bernick C, Munic D, Grant I, Korkoyah A, Raja A, Lapins A, Ryan C, Pejic J, Basham K, Lukose L, Haddad L, Quinlan L, 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Deep learning to quantify the pace of brain aging in relation to neurocognitive changes. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2413442122. PMID: 39993207, PMCID: PMC11912385, DOI: 10.1073/pnas.2413442122.Peer-Reviewed Original ResearchConceptsCN adultsBrain agingNeuroanatomical agingLongitudinal modelAdverse cognitive changesChronological ageAlzheimer's diseaseNeurocognitive agingCognitive changesNeurocognitive changesCognitive functionNeurocognitive statusAssociated with changesAge trendsLongitudinal MRIAdultsBrainQuantify DNA methylationAD risk assessmentBlood-brain barrier
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