2025
Predicting cognitive functioning in early psychosis: factors supporting and limiting generalizability of connectome-based models
O’Neill A, Pax M, Parent J, Sepulcre J, Camprodon J, Noble S, Roffman J, Eryilmaz H. Predicting cognitive functioning in early psychosis: factors supporting and limiting generalizability of connectome-based models. NPP—Digital Psychiatry And Neuroscience 2025, 3: 11. PMID: 40475845, PMCID: PMC12133584, DOI: 10.1038/s44277-025-00032-1.Peer-Reviewed Original ResearchConnectome-based predictive modelingEarly psychosisCognitive functionGoal of precision psychiatryPredictors of cognitive functionPrediction of cognitive functionPredicting cognitive performancePredicting cognitive functionModels of cognitionConnectome-based modelsPersonalized treatment developmentBrain connectivity patternsImpact functional outcomesHuman Connectome ProjectFluid cognitionPsychotic disordersSomatomotor networkCognitive abilitiesCognitive performancePrecision psychiatryVirtual lesion analysisTreatment developmentPsychosisCognitive outcomesCognitive impairmentEnhancing Coordinated Specialty Care Through Early Detection: Impact of Reduced Duration of Untreated Psychosis
Hazan H, Ferrara M, Zhou B, Li F, Imetovski S, Sykes L, Pollard J, Cahill J, Gibbs-Dean T, Corbera S, Karmani S, Riley S, Tayfur S, Tek C, Keshavan M, Srihari V. Enhancing Coordinated Specialty Care Through Early Detection: Impact of Reduced Duration of Untreated Psychosis. Schizophrenia Bulletin 2025, sbaf044. PMID: 40339151, DOI: 10.1093/schbul/sbaf044.Peer-Reviewed Original ResearchDuration of untreated psychosisFirst-episode psychosisCoordinated Specialty CareUntreated psychosisMediation analysisShorter duration of untreated psychosisFirst-episode psychosis patientsEarly interventionEarly psychosisBenefits of early interventionPsychosisGAFFunctional outcomesGlobal assessmentEarly detection campaignsSpecialty careIntake processRecovery outcomesSpecial treatmentQuality of lifeStreamlining referralsFunctional recoveryScoresPatientsInterventionTrajectories of positive symptoms and suicidality in individuals at clinical high risk for psychosis
Deng W, MacNutt C, Addington J, Bearden C, Cadenhead K, Carrión R, Keshavan M, Mathalon D, Perkins D, Stone W, Walker E, Woods S, Cannon T. Trajectories of positive symptoms and suicidality in individuals at clinical high risk for psychosis. Journal Of Affective Disorders 2025, 384: 208-213. PMID: 40334865, DOI: 10.1016/j.jad.2025.05.023.Peer-Reviewed Original ResearchConceptsPositive symptomsClinical high riskSuicidal ideationCHR-PMeasures of suicidal ideationEarly stages of psychosisPersistence of suicidal ideationSeverity of depressive symptomsPositive symptom severityAssessment timepointsCHR-P participantsEmergence of suicidalityStages of psychosisCHR-P populationTargeted suicide prevention strategiesPsychotic disordersEarly psychosisSuicide prevention strategiesDepressive symptomsSymptom severityPsychosisIdeationDelusionsSuicideHallucinationsInsight and Its Trajectory: Predicting the Risk of Psychiatric Hospitalizations Among First-Episode Psychosis During the First Year of Coordinated Specialty Care
Hazan H, Ferrara M, Gibbs-Dean T, Tayfur S, Corbera S, Karmani S, Song Z, Li F, Vlachos I, Selakovic M, Tek C, Srihari V. Insight and Its Trajectory: Predicting the Risk of Psychiatric Hospitalizations Among First-Episode Psychosis During the First Year of Coordinated Specialty Care. Schizophrenia Bulletin 2025, sbaf019. PMID: 40227145, DOI: 10.1093/schbul/sbaf019.Peer-Reviewed Original ResearchCoordinated Specialty CareFirst-episode psychosisBaseline insightRisk of psychiatric hospitalizationFirst-episodeEarly psychosisInsight groupLength of stayPsychiatric hospitalSpecialty carePsychosisLongitudinal trajectoriesGreater reductionsHospital outcomesHigh-low-highPredicting clinical improvementHospital dataModifiable factorsMonths pre-ParticipantsHospitalization riskClinical improvementRecovery trajectoriesReduce hospitalizationsBaselineForging a learning health system for early psychosis: Insights from the academic community EPINET
Vohs J, Cahill J, Taylor S, Heckers S, Weiss A, Chaudhry S, Silverstein S, Tso I, Breitborde N, Vinson A, Lapidos A, Visco A, Satchivi A, Gaunnac M, Breier A, Srihari V. Forging a learning health system for early psychosis: Insights from the academic community EPINET. Schizophrenia Research 2025, 278: 109-118. PMID: 40147210, PMCID: PMC12011207, DOI: 10.1016/j.schres.2025.03.020.Peer-Reviewed Original ResearchConceptsLearning healthcare systemEarly Psychosis Intervention NetworkQuality improvementClinical workflowLearning health systemProvision of intervention servicesQuality improvement effortsCulture of continuous learningIntervention NetworkHealth systemDisease trajectoryInterventional careHealthcare systemPractice-based researchImprovement effortsEvidence-basedClinical sitesIntervention servicesSocietal costsSteering CommitteeFirst-episode psychosisImplementation lessonsEarly psychosisEngaging stakeholdersSix-month intervalsThe STEP Learning Collaborative: A statewide Learning Healthcare System (LHS) for first episode psychosis
Yoviene Sykes L, Levine N, Tayfur S, Gibbs-Dean T, Hazan H, Imetovski S, James J, Karmani S, Mathis W, Markovich P, Purushothaman D, Riley S, Tek C, Veillette C, Cahill J, Giard J, Marracino A, Barrette K, Bozak S, Gregory F, McDermott G, Srihari V. The STEP Learning Collaborative: A statewide Learning Healthcare System (LHS) for first episode psychosis. Schizophrenia Research 2025, 278: 96-108. PMID: 40132282, PMCID: PMC11981821, DOI: 10.1016/j.schres.2025.03.029.Peer-Reviewed Original ResearchConceptsLearning healthcare systemLearning CollaborativeHealthcare systemSchizophrenia spectrum disordersPopulation health outcomesLearning health systemSystems of careCare modelHigh-quality treatmentStage of illnessHealth outcomesHealth systemWorkforce developmentDuration of untreated psychosisStatewide systemEarly stages of illnessEarly psychosisWorkforce readinessStrengthening integrationPolicy advocacyLeverage informaticsCareEpisode psychosisStakeholder engagementUntreated psychosisDeep multimodal representations and classification of first-episode psychosis via live face processing
Singh R, Zhang Y, Bhaskar D, Srihari V, Tek C, Zhang X, Noah J, Krishnaswamy S, Hirsch J. Deep multimodal representations and classification of first-episode psychosis via live face processing. Frontiers In Psychiatry 2025, 16: 1518762. PMID: 40134976, PMCID: PMC11934110, DOI: 10.3389/fpsyt.2025.1518762.Peer-Reviewed Original ResearchFirst-episode psychosisPositive and Negative Syndrome ScaleFunctional Near-Infrared SpectroscopyGlobal Assessment of FunctioningEarly psychosisNeural correlates of social cognitionFirst-episode psychosis individualsNegative Syndrome ScaleBehavior recordsAssessment of functioningSevere psychiatric disordersSyndrome ScaleFace processingPsychosis symptomsNeural underpinningsSocial cognitionNeural correlatesPsychiatric disordersBrain activitySocial difficultiesNeurophysiological dysfunctionPsychosisNeural characteristicsMultimodal representationsAcquisition paradigmEmergence and dynamics of delusions and hallucinations across stages in early psychosis
Mourgues-Codern C, Benrimoh D, Gandhi J, Farina E, Vin R, Zamorano T, Parekh D, Malla A, Joober R, Lepage M, Iyer S, Addington J, Bearden C, Cadenhead K, Cornblatt B, Keshavan M, Stone W, Mathalon D, Perkins D, Walker E, Cannon T, Woods S, Shah J, Powers A. Emergence and dynamics of delusions and hallucinations across stages in early psychosis. Biological Psychiatry 2025 PMID: 40020853, DOI: 10.1016/j.biopsych.2025.02.891.Peer-Reviewed Original ResearchFirst-episode psychosis patientsSymptom patternsNorth American Prodrome Longitudinal StudyPositive symptoms of psychosisSymptoms of psychosisCHR-P samplesEarly intervention programsPositive symptomsDelusional ideationPsychosis patientsEarly psychosisCHR-PNeural mechanismsDelusionsHallucination onsetHallucinationsPsychosisBaseline assessmentLongitudinal studyIntervention programsSymptomsTime courseParticipantsIdeationOnset
2024
Robust Brain Correlates of Cognitive Performance in Psychosis and Its Prodrome
Ward H, Beermann A, Xie J, Yildiz G, Felix K, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Seidman L, Stone W, Tsuang M, Walker E, Woods S, Coleman M, Bouix S, Holt D, Öngür D, Breier A, Shenton M, Heckers S, Halko M, Lewandowski K, Brady R. Robust Brain Correlates of Cognitive Performance in Psychosis and Its Prodrome. Biological Psychiatry 2024, 97: 139-147. PMID: 39032726, PMCID: PMC11634655, DOI: 10.1016/j.biopsych.2024.07.012.Peer-Reviewed Original ResearchAuditory continuous performance taskConnectome-wide association studiesEarly psychosisCognitive performanceNorth American Prodrome Longitudinal Study 2At-risk individualsCorrelates of cognitive performanceBrain-cognition relationshipsBrain-phenotype relationshipsBrain-behavior associationsContinuous performance taskEarly-course psychosisLongitudinal Study 2Resting-state fMRIProspective study of individualsHuman Connectome ProjectPsychosis onsetStudy of individualsPsychosisStudy 2Performance tasksNeurocognitive impairmentCognitive instrumentsHealthy participantsRobust associationsA whole-brain neuromark resting-state fMRI analysis of first-episode and early psychosis: Evidence of aberrant cortical-subcortical-cerebellar functional circuitry
Jensen K, Calhoun V, Fu Z, Yang K, Faria A, Ishizuka K, Sawa A, Andrés-Camazón P, Coffman B, Seebold D, Turner J, Salisbury D, Iraji A. A whole-brain neuromark resting-state fMRI analysis of first-episode and early psychosis: Evidence of aberrant cortical-subcortical-cerebellar functional circuitry. NeuroImage Clinical 2024, 41: 103584. PMID: 38422833, PMCID: PMC10944191, DOI: 10.1016/j.nicl.2024.103584.Peer-Reviewed Original ResearchConceptsFunctional network connectivityFirst-episodeEarly psychosisAberrant functional network connectivityResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingCorrelates of psychosisResting-state fMRI analysisWhole-brain approachPsychiatric disordersPsychiatric illnessSubcortical regionsCerebellar regionsFMRI analysisPsychosisControl participantsCognitive functionRs-fMRICerebellar connectivityMulti-site datasetFunctional circuitryMagnetic resonance imagingCircuitryResonance imagingProminent pattern
2023
A Brainwide Risk Score for Psychiatric Disorder Evaluated in a Large Adolescent Population Reveals Increased Divergence Among Higher-Risk Groups Relative to Control Participants
Yan W, Pearlson G, Fu Z, Li X, Iraji A, Chen J, Sui J, Volkow N, Calhoun V. A Brainwide Risk Score for Psychiatric Disorder Evaluated in a Large Adolescent Population Reveals Increased Divergence Among Higher-Risk Groups Relative to Control Participants. Biological Psychiatry 2023, 95: 699-708. PMID: 37769983, PMCID: PMC10942727, DOI: 10.1016/j.biopsych.2023.09.017.Peer-Reviewed Original ResearchFunctional network connectivityHealthy control individualsPsychiatric disordersRisk scoreEarly psychosisPsychiatric riskControl individualsStudy participantsHigh-risk groupMajor depressive disorderHigh-risk patternsPsychiatric risk assessmentCognitive Development StudyUnaffected adolescentsAdolescent Brain Cognitive Development (ABCD) studyLarge adolescent populationDepressive disorderHigh riskPsychosis scoresBipolar disorderPotential biomarkersEarly screeningPsychiatric vulnerabilityAdolescent populationDisordersAberrant Hierarchical Prediction Errors Are Associated With Transition to Psychosis: A Computational Single-Trial Analysis of the Mismatch Negativity
Hauke D, Charlton C, Schmidt A, Griffiths J, Woods S, Ford J, Srihari V, Roth V, Diaconescu A, Mathalon D. Aberrant Hierarchical Prediction Errors Are Associated With Transition to Psychosis: A Computational Single-Trial Analysis of the Mismatch Negativity. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2023, 8: 1176-1185. PMID: 37536567, DOI: 10.1016/j.bpsc.2023.07.011.Peer-Reviewed Original ResearchConceptsPrecision-weighted prediction errorsHealthy control participantsCourse of schizophreniaCHR-P individualsLower-level precision-weighted prediction errorsControl participantsLow-level sensoryPredictive coding accountMismatch negativity paradigmHierarchical Gaussian FilterPrediction errorEarly psychosisSingle-trial analysisClinical high riskDouble deviantsMismatch negativityComputational mechanismsElectroencephalography amplitudeFuture psychosisComputational modelSchizophreniaPsychosisIndividualsParticipantsSensor spaceCharacterization of the extracellular free water signal in schizophrenia using multi-site diffusion MRI harmonization
Cetin-Karayumak S, Lyall A, Di Biase M, Seitz-Holland J, Zhang F, Kelly S, Elad D, Pearlson G, Tamminga C, Sweeney J, Clementz B, Schretlen D, Stegmayer K, Walther S, Lee J, Crow T, James A, Voineskos A, Buchanan R, Szeszko P, Malhotra A, Keshavan M, Shenton M, Rathi Y, Pasternak O, Kubicki M. Characterization of the extracellular free water signal in schizophrenia using multi-site diffusion MRI harmonization. Molecular Psychiatry 2023, 28: 2030-2038. PMID: 37095352, PMCID: PMC11146151, DOI: 10.1038/s41380-023-02068-1.Peer-Reviewed Original ResearchDuration of illnessIllness stageHealthy controlsWhole brain white matterDifferent illness stagesFree-water imagingSchizophrenia spectrum disordersYounger patientsBrain white matterExtracellular free waterProlonged illnessEarly psychosisDiffusion magnetic resonanceWhite matterDemographic dataIllnessSchizophreniaSmall effect sizesShort durationTime courseAgeEffect sizeSignificant global increaseInternational sitesDisorders
2022
Illness Phase as a Key Assessment and Intervention Window for Psychosis
Kohler C, Wolf D, Abi-Dargham A, Anticevic A, Cho Y, Fonteneau C, Gil R, Girgis R, Gray D, Grinband J, Javitch J, Kantrowitz J, Krystal J, Lieberman J, Murray J, Ranganathan M, Santamauro N, Van Snellenberg J, Tamayo Z, Group T, D'Souza D, Srihari V, Gueorguieva R, Patel P, Forselius-Bielen K, Lu J, Butler A, Fram G, Afriyie-Agyemang Y, Selloni A, Cadavid L, Gomez-Luna S, Gupta A, Radhakrishnan R, Rashid A, Aker R, Abrahim P, Nia A, Surti T, Kegeles L, Carlson M, Goldberg T, Gangwisch J, Benedict E, Govil P, Brazis S, Mayer M, de la Garrigue N, Fallon N, Baumvoll T, Abeykoon S, Perlman G, Bobchin K, Elliott M, Schmidt L, Rush S, Port A, Heffernan Z, Laney N, Kantor J, Hohing T, Gur R, Gur R, Calkins M. Illness Phase as a Key Assessment and Intervention Window for Psychosis. Biological Psychiatry Global Open Science 2022, 3: 340-350. PMID: 37519466, PMCID: PMC10382701, DOI: 10.1016/j.bpsgos.2022.05.009.Peer-Reviewed Original ResearchIllness phasePotential critical windowsPhase-specific biomarkersDopaminergic abnormalitiesFunctional outcomeSpecialty careSymptom assessmentIllness stageChronic illnessClinical assessmentIllness trajectoryNeurophysiological biomarkersFunctional abnormalitiesClinical careEarly psychosisMemory dysfunctionPsychotic disordersTreatment targetsAllostatic adaptationIntervention windowClinical programsBrain developmentCritical windowDysfunctionIllnessEarly intervention service systems for youth mental health: integrating pluripotentiality, clinical staging, and transdiagnostic lessons from early psychosis
Shah J, Jones N, van Os J, McGorry P, Gülöksüz S. Early intervention service systems for youth mental health: integrating pluripotentiality, clinical staging, and transdiagnostic lessons from early psychosis. The Lancet Psychiatry 2022, 9: 413-422. PMID: 35430004, DOI: 10.1016/s2215-0366(21)00467-3.Peer-Reviewed Original ResearchConceptsRisk mental stateBroader mental health systemNon-psychotic disordersPerson-centred careMental health systemYouth mental healthClinical stagingEarly intervention service systemFirst episodeRelevance of outcomesEarly psychosisCenters of expertiseFrequent developmentDifferential riskClinical researchHealth systemPsychosisSpecific interventionsMental healthSyndromeMental statesDisordersTraditional diagnosisOutcomesClinic
2021
Computational Mechanism for the Effect of Psychosis Community Treatment: A Conceptual Review From Neurobiology to Social Interaction
Benrimoh D, Sheldon A, Sibarium E, Powers AR. Computational Mechanism for the Effect of Psychosis Community Treatment: A Conceptual Review From Neurobiology to Social Interaction. Frontiers In Psychiatry 2021, 12: 685390. PMID: 34385938, PMCID: PMC8353084, DOI: 10.3389/fpsyt.2021.685390.Peer-Reviewed Original ResearchComputational modelAssertive community treatmentProcessing-based accountExperience of psychosisEvidence-based clinical interventionsCommunity treatmentPrevious computational modelsCognitive resourcesPositive psychotic symptomsComputational underpinningsComputational mechanismsSocial interactionStrong social elementSensory informationPositive symptomsConceptual reviewClinical interventionsEarly psychosisSocial elementsCandidate mechanismPsychotic symptomsNeurobiologyPsychosisConceptual paperMultiple levelsImplementing organicity investigations in early psychosis: Spreading expertise
Kurukgy J, Bourgin J, Benoit J, Guessoum S, Benoit L. Implementing organicity investigations in early psychosis: Spreading expertise. PLOS ONE 2021, 16: e0252610. PMID: 34111172, PMCID: PMC8191881, DOI: 10.1371/journal.pone.0252610.Peer-Reviewed Original ResearchMorphometric Attention and Language Brain Correlates in Early Psychosis With Cannabis Use and Polygenic Risk Score: A BSNIP Study
Reed A, Zeng V, Alliey-Rodriguez N, Tamminga C, Clementz B, Pearlson G, Sweeney J, Gershon E, Keshavan M, del Re E. Morphometric Attention and Language Brain Correlates in Early Psychosis With Cannabis Use and Polygenic Risk Score: A BSNIP Study. Biological Psychiatry 2021, 89: s242-s243. DOI: 10.1016/j.biopsych.2021.02.608.Peer-Reviewed Original ResearchTreatment decision‐making needs among emerging adults with early psychosis
Thomas E, Suarez J, Lucksted A, Siminoff L, Hurford I, Dixon L, O'Connell M, Salzer M. Treatment decision‐making needs among emerging adults with early psychosis. Early Intervention In Psychiatry 2021, 16: 78-90. PMID: 33599089, PMCID: PMC9116145, DOI: 10.1111/eip.13134.Peer-Reviewed Original ResearchConceptsTreatment decision-making needsEarly psychosisDecision-making needsTreatment decision-making experiencesEIP programMental health servicesDecision-making facilitatorsThematic analysis approachDecision-making experiencesHealth servicesOptimization of interventionsPsychiatric medicationsService disengagementSemistructured interviewsSocial supportEmerging AdultsPsychosisService engagementQualitative studyNVivo 12 PlusTreatment goalsLack internal resourcesSocial factorsAdultsTreatment decisions
2020
Estimated Proportions and Characteristics of National Survey Respondents Reporting New Diagnoses of Schizophrenia or Other Psychoses in the Past Year as Compared With Prior Years.
Bommersbach T, Rhee TG, Stefanovics E, Rosenheck R. Estimated Proportions and Characteristics of National Survey Respondents Reporting New Diagnoses of Schizophrenia or Other Psychoses in the Past Year as Compared With Prior Years. The Journal Of Nervous And Mental Disease 2020, 209: 65-70. PMID: 33141782, DOI: 10.1097/nmd.0000000000001259.Peer-Reviewed Original ResearchConceptsSubstance use disordersUse disordersEarly psychosisPast-year substance use disorderInfrequency of casesFirst-time diagnosisFirst-episode psychosisPopulation-based estimatesNational Epidemiologic SurveyAlcohol use disorderRelated Conditions-IIINational survey respondentsMean ageEpidemiologic dataGeneral populationNew diagnosisEpidemiologic SurveyOlder populationPrevious yearPsychosisSchizophreniaPast yearDiagnosisDisordersSimilar elevations
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