2025
Growth‐Associated Protein 43 Levels in the Cerebrospinal Fluid Correspond to the Cerebral Blood Flow Alterations in Alzheimer's Dementia Continuum: An Original Study
Songhori N, Goushky M, Khaleghi M, Mojerloo M, Sadeghi M, Mozafar M, Aghdam Z, Ghajar M, Kianifar Y, Karimzadeh F, Khosravi F, Mayeli M. Growth‐Associated Protein 43 Levels in the Cerebrospinal Fluid Correspond to the Cerebral Blood Flow Alterations in Alzheimer's Dementia Continuum: An Original Study. Health Science Reports 2025, 8: e70534. PMID: 40078900, PMCID: PMC11896815, DOI: 10.1002/hsr2.70534.Peer-Reviewed Original ResearchMild cognitive impairmentComposite scoreAlzheimer's Disease Neuroimaging InitiativeMini Mental State ExaminationExecutive function composite scoreMental State ExaminationCognitive impairmentIndependent t-testDiagnostic groupsDementia continuumMultiple linear regression analysisState ExaminationAlzheimer's diseaseAPOE-e4Cognitive statusLinear regression analysisCognitive composite scoreComparison of continuous variablesCognitive scoresConfounding factorsCN individualsCerebrospinal fluid biomarkersSignificant positive correlationCognitive functionMann-Whitney test
2023
Reductions in synaptic marker SV2A in early-course Schizophrenia
Yoon J, Zhang Z, Mormino E, Davidzon G, Minzenberg M, Ballon J, Kalinowski A, Hardy K, Naganawa M, Carson R, Khalighi M, Park J, Levinson D, Chin F. Reductions in synaptic marker SV2A in early-course Schizophrenia. Journal Of Psychiatric Research 2023, 161: 213-217. PMID: 36934603, DOI: 10.1016/j.jpsychires.2023.02.026.Peer-Reviewed Original ResearchConceptsChronic patientsSynaptic pruningStage of illnessEarly course patientsEarly course schizophreniaSeverity of delusionsWidespread reductionMajor disease mechanismsSynaptic deficitsSynaptic markersSynaptic eliminationPET scansFormal onsetBrain regionsSignificant positive correlationPatientsSchizophrenia studiesSchizophreniaDisease mechanismsCognitive performanceIllnessEarly phaseSpecific bindingPresent studyPositive correlation
2022
Scale-Free Functional Brain Networks Exhibit Increased Connectivity, Are More Integrated and Less Segregated in Patients with Parkinson’s Disease following Dopaminergic Treatment
Stylianou O, Kaposzta Z, Czoch A, Stefanovski L, Yabluchanskiy A, Racz F, Ritter P, Eke A, Mukli P. Scale-Free Functional Brain Networks Exhibit Increased Connectivity, Are More Integrated and Less Segregated in Patients with Parkinson’s Disease following Dopaminergic Treatment. Fractal And Fractional 2022, 6: 737. PMID: 38106971, PMCID: PMC10723163, DOI: 10.3390/fractalfract6120737.Peer-Reviewed Original ResearchHealthy control individualsMini-Mental State ExaminationDopaminergic treatmentParkinson's diseaseFunctional connectivityMental State ExaminationStandard therapyPD patientsPD populationHC groupState ExaminationFunctional brain networksControl individualsPharmacological studiesSignificant positive correlationDiseaseBrain networksPatientsCognitive performanceAdult Reading TestPositive correlationTreatmentLong-term memoryTherapyTop-down sensory prediction in the infant brain at 6 months is correlated with language development at 12 and 18 months
Wang S, Zhang X, Hong T, Tzeng OJL, Aslin R. Top-down sensory prediction in the infant brain at 6 months is correlated with language development at 12 and 18 months. Brain And Language 2022, 230: 105129. PMID: 35576737, PMCID: PMC11956832, DOI: 10.1016/j.bandl.2022.105129.Peer-Reviewed Original ResearchConceptsMacArthur-Bates Communicative Development InventoriesLanguage developmentSensory predictionsVocabulary scoresVocabulary developmentVisual stimuliOccipital cortex activationCommunicative Development InventoryInfant language developmentExpressive vocabulary scoresInfants' vocabulary developmentNeural levelUnexpected omissionAuditory stimuliDevelopment InventoryNeural responsesCortex activationInfant brainNeural signalsPrevious researchStimuliSignificant positive correlationRobust supportMonthsScores
2021
Household Food Expenditure Share During Pregnancy: Evidence From Rural Sri Lanka
Gunarathne S, Wickramasinghe N, Agampodi T, Prasanna I, Agampodi S. Household Food Expenditure Share During Pregnancy: Evidence From Rural Sri Lanka. Current Developments In Nutrition 2021, 5: 753. PMCID: PMC8181375, DOI: 10.1093/cdn/nzab046_050.Peer-Reviewed Original ResearchPregnant womenHousehold food expenditureMean monthly household incomeRural pregnant womenIncome quintileSelf-administered questionnaireMonthly household incomeHousehold incomeProspective cohortPregnancy cohortMean ageHighest quintilePositive correlationTrimesterPregnancyRural Sri LankaSignificant positive correlationWeak positive correlationQuintileMeasures ANOVAOne-way ANOVASignificant differencesCohortPregabalin Treatment does not Affect Amyloid Pathology in 5XFAD Mice
Sadleir K, Popovoic J, Zhu W, Reidel C, Do H, Silverman R, Vassar R. Pregabalin Treatment does not Affect Amyloid Pathology in 5XFAD Mice. Current Alzheimer Research 2021, 18: 283-297. PMID: 34259145, PMCID: PMC9527523, DOI: 10.2174/1567205018666210713125333.Peer-Reviewed Original ResearchConceptsVoltagegated calcium channelsPlacebo-treated miceNeuropathic painPregabalin treatmentStatistically significant positive correlationCalcium channelsCalcium influxAb levelsDecreased markersPregabalinSignificant positive correlationCerebral concentrationsEffective treatmentAmyloid depositsCausative roleDystrophyCalcium dysregulationMiceNeuritic dystrophyProgression of amyloid pathologyPathologyImmunofluorescence imagingNeuronal processesPlaqueTreatment
2020
Association Between Entrustable Professional Activities and Milestones Evaluations: Real-time Assessments Correlate With Semiannual Reviews
Albright JB, Meier AH, Ruangvoravat L, VanderMeer TJ. Association Between Entrustable Professional Activities and Milestones Evaluations: Real-time Assessments Correlate With Semiannual Reviews. Journal Of Surgical Education 2020, 77: e220-e228. PMID: 32747323, DOI: 10.1016/j.jsurg.2020.07.027.Peer-Reviewed Original ResearchConceptsSignificant positive correlationSUNY Upstate Medical UniversityMilestone scoresGall bladder diseaseUniversity-based hospitalEntrustable professional activitiesSurgical residentsUpstate Medical UniversityPositive correlationGeneral surgery residentsBiannual evaluationBladder diseaseMedical UniversityACGME milestonesSpearman rank correlationPilot studySurgery residentsMilestone evaluationsSignificant correlationSurgeryEPA evaluationScoresAmerican BoardResident progressionSemiannual reviewsImpact of socioeconomic status on psychological functioning in survivorship following breast cancer and reconstruction
Le NK, Gabrick KS, Chouairi F, Mets EJ, Avraham T, Alperovich M. Impact of socioeconomic status on psychological functioning in survivorship following breast cancer and reconstruction. The Breast Journal 2020, 26: 1695-1701. PMID: 32337778, DOI: 10.1111/tbj.13849.Peer-Reviewed Original ResearchConceptsPatients' socioeconomic statusQuality of lifeBreast reconstructionBreast cancerSocioeconomic statusCancer treatmentPatient-reported outcome measuresSingle academic centerInitial cancer treatmentBreast cancer treatmentPopulation health risk factorsHealth risk factorsLow socioeconomic statusHigher socioeconomic statusStudy time periodBaseline comorbiditiesCancer stageRisk factorsOutcome measuresAnalysis of covariancePatient experienceAcademic centersPatientsSignificant positive correlationSatisfaction domains
2018
Temporal and spatial associations between influenza and asthma hospitalisations in New York City from 2002 to 2012: a longitudinal ecological study
Trinh P, Jung TH, Keene D, Demmer RT, Perzanowski M, Lovasi G. Temporal and spatial associations between influenza and asthma hospitalisations in New York City from 2002 to 2012: a longitudinal ecological study. BMJ Open 2018, 8: e020362. PMID: 30269061, PMCID: PMC6169763, DOI: 10.1136/bmjopen-2017-020362.Peer-Reviewed Original ResearchConceptsInfluenza hospitalisationsAsthma hospitalisationsExcess riskLongitudinal ecological studyAge groupsClinical Modification diagnosis codesSignificant positive correlationInfluenza prevention strategiesSignificant correlationDifferent age groupsNinth RevisionDiagnosis codesPrimary diagnosisAdults 18HospitalisationStatewide PlanningPositive correlationInternational ClassificationIndividuals 18Prevention strategiesRisk percentageAdult populationOverall populationAsthmaInfluenza
2017
Complexity of macrophage migration inhibitory factor (MIF) and other angiogenic biomarkers profiling in pulmonary arterial hypertension
Marshall JD, Sauler M, Tonelli A, Rao Y, Bucala R, Lee PJ, Fares WH. Complexity of macrophage migration inhibitory factor (MIF) and other angiogenic biomarkers profiling in pulmonary arterial hypertension. Pulmonary Circulation 2017, 7: 730-733. PMID: 28714356, PMCID: PMC5841895, DOI: 10.1177/2045893217724141.Peer-Reviewed Original ResearchMacrophage migration inhibitory factorMigration inhibitory factorInhibitory factorPulmonary arterial hypertension patientsPulmonary arterial hypertensionArterial hypertension patientsArterial hypertensionHypertension patientsAngiogenic biomarkersAngiogenic factorsSignificant positive correlationBiomarkersPositive correlationRegulation roleHypertensionPatientsFactorsPathobiology
2016
Population Pharmacokinetics and Pharmacodynamics of Lumefantrine in Young Ugandan Children Treated With Artemether-Lumefantrine for Uncomplicated Malaria
Tchaparian E, Sambol NC, Arinaitwe E, McCormack SA, Bigira V, Wanzira H, Muhindo M, Creek DJ, Sukumar N, Blessborn D, Tappero JW, Kakuru A, Bergqvist Y, Aweeka FT, Parikh S. Population Pharmacokinetics and Pharmacodynamics of Lumefantrine in Young Ugandan Children Treated With Artemether-Lumefantrine for Uncomplicated Malaria. The Journal Of Infectious Diseases 2016, 214: 1243-1251. PMID: 27471317, PMCID: PMC5034953, DOI: 10.1093/infdis/jiw338.Peer-Reviewed Original ResearchConceptsArtemether-lumefantrineRecurrent parasitemiaLumefantrine exposurePopulation pharmacokineticsUgandan childrenYoung Ugandan childrenPlasmodium falciparum malariaDay 7 concentrationsAge 6 monthsFirst-order absorptionWhole blood concentrationsYoung childrenUncomplicated malariaFalciparum malariaBlood concentrationsTreatment outcomesLumefantrine concentrationsSignificant positive correlationParasitemiaOlder childrenPharmacokineticsLumefantrineMalariaExposure levelsOpen modelDiabetes knowledge and self-efficacy among rural women in Gujarat, India
Mehta NV, Trivedi M, Maldonado LE, Saxena D, Humphries DL. Diabetes knowledge and self-efficacy among rural women in Gujarat, India. Rural And Remote Health 2016, 16: 3629. PMID: 26976745, DOI: 10.22605/rrh3629.Peer-Reviewed Original ResearchConceptsMean knowledge scoreDiabetes knowledgeParticipants' mean knowledge scoreEmpowerment Scale-Short FormEducational interventionRural womenAwareness of diabetesCross-sectional studyCause of diabetesMichigan Diabetes ResearchType II diabetesHealth Belief ModelMedian self-efficacy scoresDiabetic womenCase of womenPositive correlationSelf-efficacy scoresDiabetesII diabetesKnowledge scoreScale-Short FormSignificant positive correlationMean percentageDiabetes researchLow levels
2015
Tumor-associated Neutrophils and Malignant Progression in Intraductal Papillary Mucinous Neoplasms
Sadot E, Basturk O, Klimstra D, Gönen M, Lokshin A, Gian R, D’Angelica M, DeMatteo R, Kingham T, Jarnagin W, Allen P. Tumor-associated Neutrophils and Malignant Progression in Intraductal Papillary Mucinous Neoplasms. Annals Of Surgery 2015, 262: 1102-1107. PMID: 25563865, PMCID: PMC4643387, DOI: 10.1097/sla.0000000000001044.Peer-Reviewed Original ResearchConceptsIntraductal papillary mucinous neoplasmTumor-associated neutrophilsGrade of dysplasiaPapillary mucinous neoplasmSurrogate markerMalignant progressionMucinous neoplasmsIdentification of high-risk diseaseResected intraductal papillary mucinous neoplasmsHigher grades of dysplasiaIPMN progressionLow/intermediate-grade dysplasiaAssociated with malignant progressionAssociated with high gradeHigh-risk diseaseHigh-grade dysplasiaHigh gradeInvasive carcinomaLow/intermediate-gradeParenchymal inflammationInflammatory markersInflammatory mediatorsDysplasiaSignificant positive correlationLow riskPatterns in Leptospira Shedding in Norway Rats (Rattus norvegicus) from Brazilian Slum Communities at High Risk of Disease Transmission
Costa F, Wunder EA, De Oliveira D, Bisht V, Rodrigues G, Reis MG, Ko AI, Begon M, Childs JE. Patterns in Leptospira Shedding in Norway Rats (Rattus norvegicus) from Brazilian Slum Communities at High Risk of Disease Transmission. PLOS Neglected Tropical Diseases 2015, 9: e0003819. PMID: 26047009, PMCID: PMC4457861, DOI: 10.1371/journal.pntd.0003819.Peer-Reviewed Original ResearchConceptsLeptospiral loadHuman infectionsNorway ratsEssential epidemiological informationAge of ratsSpirochetal loadPositive kidneysLeptospiral carriageMAT titersHigh riskLeptospiral infectionEpidemiological informationSignificant positive correlationUrine samplesRatsInfectionMultivariate modelingUrineDisease transmissionKidneyRiskGenome equivalentsSlum communitiesRat populationsLeptospires
2013
Evaluation of liver fibrosis and hepatic venous pressure gradient with MR elastography in a novel swine model of cirrhosis
Huang SY, Abdelsalam ME, Harmoush S, Ensor JE, Chetta JA, Hwang KP, Stafford RJ, Madoff DC, Avritscher R. Evaluation of liver fibrosis and hepatic venous pressure gradient with MR elastography in a novel swine model of cirrhosis. Journal Of Magnetic Resonance Imaging 2013, 39: 590-597. PMID: 24532376, DOI: 10.1002/jmri.24189.Peer-Reviewed Original ResearchConceptsHepatic venous pressure gradientVenous pressure gradientLiver stiffnessLiver fibrosisSwine modelExperimental animalsMR elastographyHigher liver stiffnessMean fibrosis scoreNovel swine modelReliable noninvasive techniquePositive correlationLiver cirrhosisTransarterial embolizationFibrosis scoreCirrhosisFibrosisExperimental swineSignificant positive correlationNoninvasive technique
2012
A left cerebellar pathway mediates language in prematurely-born young adults
Constable RT, Vohr BR, Scheinost D, Benjamin JR, Fulbright RK, Lacadie C, Schneider KC, Katz KH, Zhang H, Papademetris X, Ment LR. A left cerebellar pathway mediates language in prematurely-born young adults. NeuroImage 2012, 64: 371-378. PMID: 22982585, PMCID: PMC3508203, DOI: 10.1016/j.neuroimage.2012.09.008.Peer-Reviewed Original ResearchConceptsPT subjectsTerm controlsInferior frontal gyrusFunctional MRIFunctional connectivityResting-state functional MRIYoung adultsCognitive outcomesSeed-based connectivity analysisAge 20 yearsSeed-based analysisAlternative neural pathwaysControl young adultsPreterm subjectsCerebellar connectivityNeural pathwaysCerebellar pathwaysIndex scoreNineteen ptsGray matterMaternal educationQuadrangular lobuleDevelopmental delayPT brainSignificant positive correlationSerum levels of soluble CD25 as a marker for hepatocellular carcinoma
CABRERA R, FITIAN A, ARARAT M, XU Y, BRUSKO T, WASSERFALL C, ATKINSON M, LIU C, NELSON D. Serum levels of soluble CD25 as a marker for hepatocellular carcinoma. Oncology Letters 2012, 4: 840-846. PMID: 23205111, PMCID: PMC3506698, DOI: 10.3892/ol.2012.826.Peer-Reviewed Original ResearchSerum levelsEarly hepatocellular carcinomaHepatocellular carcinomaHCC presenceSoluble CD25Pg/Levels of sCD25Healthy control subjectsNovel predictive markerAdvanced cirrhosisPresent study studyAdvanced fibrosisTumor burdenTumor stageControl subjectsHCC patientsPredictive markerImmune factorsGlobal unmet needLarge cohortSCD25PatientsSmall seriesUnmet needSignificant positive correlationIntestinal and plasma VEGF levels in cirrhosis: the role of portal pressure
Huang H, Haq O, Utsumi T, Sethasine S, Abraldes JG, Groszmann RJ, Iwakiri Y. Intestinal and plasma VEGF levels in cirrhosis: the role of portal pressure. Journal Of Cellular And Molecular Medicine 2012, 16: 1125-1133. PMID: 21801303, PMCID: PMC3213314, DOI: 10.1111/j.1582-4934.2011.01399.x.Peer-Reviewed Original ResearchConceptsPlasma VEGF levelsPortal pressureVEGF levelsPortal hypertensionIntestinal VEGFDevelopment of cirrhosisFibrosis/cirrhosisAge-matched controlsGroups of ratsEnd of exposureCirrhosisRatsSignificant positive correlationWeeksHypertensionVEGFInhalationPositive correlationDifferent stagesCarbon tetrachlorideLevelsPathologyControl
2010
Sex Differences in Striatal Dopamine Release in Young Adults After Oral Alcohol Challenge: A Positron Emission Tomography Imaging Study With [11C]Raclopride
Urban NB, Kegeles LS, Slifstein M, Xu X, Martinez D, Sakr E, Castillo F, Moadel T, O'Malley SS, Krystal JH, Abi-Dargham A. Sex Differences in Striatal Dopamine Release in Young Adults After Oral Alcohol Challenge: A Positron Emission Tomography Imaging Study With [11C]Raclopride. Biological Psychiatry 2010, 68: 689-696. PMID: 20678752, PMCID: PMC2949533, DOI: 10.1016/j.biopsych.2010.06.005.Peer-Reviewed Original ResearchConceptsDopamine releaseStriatal subregionsAlcohol-induced dopamine releasePositron emission tomography scanAlcohol challengeStriatal dopamine releaseEmission tomography scanMaximum alcohol consumptionOral alcohol challengePositron emission tomographySex differencesAlcohol administrationYoung social drinkersTomography scanAbility of alcoholOral alcoholRewarding effectsMixed model analysisAlcohol consumptionAbuse liabilitySeparate daysSignificant negative correlationEmission tomographyVentral striatumSignificant positive correlation
2009
Dopamine and Serotonin Transporter Availability During Acute Alcohol Withdrawal: Effects of Comorbid Tobacco Smoking
Cosgrove KP, Krantzler E, Frohlich EB, Stiklus S, Pittman B, Tamagnan GD, Baldwin RM, Bois F, Seibyl JP, Krystal JH, O'Malley SS, Staley JK. Dopamine and Serotonin Transporter Availability During Acute Alcohol Withdrawal: Effects of Comorbid Tobacco Smoking. Neuropsychopharmacology 2009, 34: 2218-2226. PMID: 19440191, PMCID: PMC4457331, DOI: 10.1038/npp.2009.49.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcohol DrinkingBrainBrain MappingCase-Control StudiesCocaineDopamine Plasma Membrane Transport ProteinsFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedProtein BindingRadiopharmaceuticalsSerotonin Plasma Membrane Transport ProteinsSmokingStatistics as TopicSubstance Withdrawal SyndromeTomography, Emission-Computed, Single-PhotonYoung AdultConceptsDA transporter availabilityTobacco smokingSerotonin transporter availabilityTransporter availabilityAlcohol drinkersAcute withdrawalAlcohol drinkingLast drinkCIT single photon emissionAcute alcohol withdrawalHeavy alcohol drinkingSingle photon emissionEffects of alcoholControl smokersAlcohol withdrawalSynaptic markersNeuroadaptive changesNonsmokersSmokersSmokingTotal groupBrainstemSignificant positive correlationFirst weekPrevious month
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