2025
Neuroimaging Data Informed Mood and Psychosis Diagnosis Using an Ensemble Deep Multimodal Framework
Rokham H, Falakshahi H, Pearlson G, Calhoun V. Neuroimaging Data Informed Mood and Psychosis Diagnosis Using an Ensemble Deep Multimodal Framework. Human Brain Mapping 2025, 46: e70347. PMID: 40927869, PMCID: PMC12421244, DOI: 10.1002/hbm.70347.Peer-Reviewed Original ResearchConceptsBrain-based markersNeuroimaging dataMental illnessStructural neuroimaging dataSelf-report assessmentsMultimodal neuroimaging dataAbsence of biological dataPsychiatric groupsPsychosis diagnosisNosological categoriesNeurobiological informationNeurobiological insightsStructural MRIDiagnostic categoriesDiagnostic classificationBrain patternsNeuroimagingPsychosisMoodBrain imaging featuresIllnessLabeled categoriesHomogeneous categoriesBrainCategorizationSex differences in outcomes of first episode psychosis: results from an early intervention service
Domenicano I, Onofrio A, Citton M, Vecchioni L, De Donatis D, Bertelli R, Emanuelli F, Grassi L, Ferrara M. Sex differences in outcomes of first episode psychosis: results from an early intervention service. Frontiers In Behavioral Neuroscience 2025, 19: 1642460. PMID: 40989499, PMCID: PMC12450961, DOI: 10.3389/fnbeh.2025.1642460.Peer-Reviewed Original ResearchFirst-episode psychosisEarly intervention servicesSex differencesRates of cannabis useIntervention servicesAbsence of intellectual disabilityNon-affective psychosisPsychotic disordersEpisode psychosisCannabis useIntellectual disabilityOrganic psychosisPsychosisAlcohol misuseFollow-upProgram admissionOutcomes of patientsClinical trajectoryLong-term prognosisClinical perspectiveLong follow-upMonths follow-upMeasures analysisSex-based differencesMixed effects modelsImpact of puberty timing, status and oestradiol on psychotic experiences in the context of exposomic and genomic vulnerability to schizophrenia in female adolescents: longitudinal ABCD study.
Pries L, Prachason T, Arias-Magnasco A, Lin B, Rutten B, Guloksuz S. Impact of puberty timing, status and oestradiol on psychotic experiences in the context of exposomic and genomic vulnerability to schizophrenia in female adolescents: longitudinal ABCD study. The British Journal Of Psychiatry 2025, 1-8. PMID: 40899184, DOI: 10.1192/bjp.2025.36.Peer-Reviewed Original ResearchPsychotic experiencesPRS-SCZES-SCZAssociated with greater likelihoodAdolescent Brain Cognitive Development StudyAssociation of psychotic experiencesDevelopment of psychosisCognitive Development StudyFemale adolescentsPuberty statusNo significant interactionGreater likelihoodPubertal Development ScaleMental health outcomesAnnual follow-up assessmentsFollow-up assessmentAbsence of interactive effectsPsychosis scalesPolygenic risk scoresABCD studySchizophreniaOestradiol concentrationsFemale participantsDevelopment ScalePsychosisNeurobiology of Behavioral and Psychological Symptoms of Dementia A Focus on Agitation/Aggression, Apathy, and Psychosis
Tampi R, Joshi P, Zdanys K. Neurobiology of Behavioral and Psychological Symptoms of Dementia A Focus on Agitation/Aggression, Apathy, and Psychosis. Advances In Psychiatry And Behavioral Health 2025, 5: 129-137. DOI: 10.1016/j.ypsc.2025.01.002.Peer-Reviewed Original ResearchPredictors and Moderators of Long-Term Outcome of Persons at Clinical High Risk for Psychosis: Methods and Preliminary Data
Cadenhead K, Kennedy L, Mirzakhanian H, Addington J, Bearden C, Cannon T, Carrión R, Keshavan M, Mathalon D, Perkins D, Stone W, Walker E, Woods S. Predictors and Moderators of Long-Term Outcome of Persons at Clinical High Risk for Psychosis: Methods and Preliminary Data. Schizophrenia Bulletin 2025, sbaf133. PMID: 40856400, DOI: 10.1093/schbul/sbaf133.Peer-Reviewed Original ResearchClinical high riskClinical high-risk criteriaLong-term outcomesNorth American Prodrome Longitudinal Study sitesClinical high-risk participantsRates of affective disordersHigh riskLife courseNon-converter groupHigh-risk youthAssessment of individualsPsychosis statesAffective disordersPsychosocial functioningPsychosisTrajectory of diagnosisLonger-term outcomesClinical/functional outcomesLong-term assessmentGeneral populationBaseline dataParticipantsPreliminary dataEarly dataPersonsThe BAsic NeuroCognitive Continuum (BANCC): Delineation of dimensional and categorical features for etiological and treatment investigations of idiopathic psychosis
Warren H, Parker D, Trotti R, Zeng V, Meda S, Lencer R, Sprenger A, Hill S, Brown J, Doss I, Dumas E, Ivleva E, Pearlson G, Keshavan M, Keedy S, Gershon E, del Re E, Tamminga C, McDowell J, Gibbons R, Clementz B. The BAsic NeuroCognitive Continuum (BANCC): Delineation of dimensional and categorical features for etiological and treatment investigations of idiopathic psychosis. Psychiatry And Clinical Neurosciences 2025 PMID: 40855769, DOI: 10.1111/pcn.13887.Peer-Reviewed Original ResearchCognitive performanceBrief assessmentBrief Assessment of CognitionFirst-degree biological relativesWide Range Achievement TestStructural brain scansAssessment of cognitionTreatment investigationsResting state fMRIBrain function measuresSmooth pursuit eye movementsNeuro-cognitive dysfunctionPattern of relationshipsPsychosis pathophysiologyPsychosis probandsPursuit eye movementsIdiopathic psychosisNeuroanatomical measuresPsychosisAchievement testBiological relativesStop signalEye movementsCognitionFreeSurfer parcellationIdentifying individuals at clinical high risk for psychosis using a battery of tasks sensitive to symptom mechanisms
Williams T, Gold J, Waltz J, Schiffman J, Ellman L, Strauss G, Walker E, Woods S, Powers A, Kenney J, Pappu M, Corlett P, Tran T, Silverstein S, Zinbarg R, Mittal V. Identifying individuals at clinical high risk for psychosis using a battery of tasks sensitive to symptom mechanisms. Translational Psychiatry 2025, 15: 311. PMID: 40849429, PMCID: PMC12375010, DOI: 10.1038/s41398-025-03539-5.Peer-Reviewed Original ResearchConceptsCHR-P individualsClinical high riskCHR-PClinical InterviewComputerized assessmentAssessment of psychosis riskStructured Clinical InterviewRisk calculator scoresNeurocognitive mechanismsPsychosis symptomsPsychosis riskBehavioral tasksUnique predictorsMental disordersTask batteryPsychosisTask variablesComparison groupHealthy controlsRisk severityUpdate beliefsTaskMultinomial logistic regressionConsortium studyIndividualsPrediction of antipsychotic medication inception in antipsychotic-naive youth at clinical high risk for psychosis
Mukhtar H, Zhou D, Farina E, Saxena A, Cahill J, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshwan M, Mathalon D, Perkins D, Stone W, Cho Y, Powers A, Walker E, Woods S. Prediction of antipsychotic medication inception in antipsychotic-naive youth at clinical high risk for psychosis. Psychological Medicine 2025, 55: e241. PMID: 40842369, PMCID: PMC12404330, DOI: 10.1017/s0033291725101372.BooksClinical high riskCHR-PLifetime historyAugmentation of antidepressant treatmentComorbid major depressionAP useAntidepressant treatmentPositive symptomsMajor depressionAP medicationNAPLS-2Independent predictorsCHR-P.High riskBaseline clinical variablesPsychosisBaseline predictorsClinical variablesParticipantsBaseline characteristicsUnivariate analysisLogistic regression modelsObservational cohortMultivariate analysisAP initiationDifferentiating biomarker features and familial characteristics of B-SNIP psychosis Biotypes
Parker D, Trotti R, McDowell J, Keedy S, Keshavan M, Pearlson G, Gershon E, Ivleva E, Huang L, Sauer K, Hill S, Sweeney J, Tamminga C, Clementz B. Differentiating biomarker features and familial characteristics of B-SNIP psychosis Biotypes. Translational Psychiatry 2025, 15: 281. PMID: 40813865, PMCID: PMC12354876, DOI: 10.1038/s41398-025-03501-5.Peer-Reviewed Original ResearchConceptsFirst-degree relativesIdiopathic psychosisGeneral cognitionNon-psychotic first-degree relativesFirst-degree biological relativesFirst-degreeBipolar-Schizophrenia NetworkIntrinsic brain activityIntrinsic neural activityFamily characteristicsPsychosis probandsPsychosis subgroupsERP magnitudeEEG/ERP measuresCognitive performancePsychosisBrain activityDiagnostic assignmentBiotype-1Biotype-2Neural activityBiotype-3Biological relativesHealthy participantsHealthy individualsThe Future of Perceptual Dysregulation in Psychiatric Nosology
Powers A, Khalsa S. The Future of Perceptual Dysregulation in Psychiatric Nosology. Current Topics In Behavioral Neurosciences 2025, 1-16. PMID: 40794380, DOI: 10.1007/7854_2025_596.Peer-Reviewed Original ResearchPerceptual DysregulationPsychiatric nosologyPsychiatric symptomsMedical illnessTrauma-related disordersDiverse symptom presentationsBrain-body interactionsFunctional neurological disorderInteroceptive systemPsychiatric conditionsSymptom presentationInferential processesSensory inferenceTestable modelSensory inputNosologyNeurological illnessIllnessDisordersSymptomsDysregulationComputational neuroscienceInternal stateNeurological disordersPsychosisVictimization and engagement with the legal system among individuals at clinical high risk (CHR) for psychosis
Du A, Kennedy L, Addington J, Bearden C, Cannon T, Carrion R, Keshavan M, Mathalon D, Perkins D, Stone W, Walker E, Woods S, Cadenhead K. Victimization and engagement with the legal system among individuals at clinical high risk (CHR) for psychosis. Schizophrenia Research 2025, 284: 7-15. PMID: 40737766, DOI: 10.1016/j.schres.2025.07.015.Peer-Reviewed Original ResearchLegal systemLegal historyPerpetrators of crimesVictims of crimeHistory of victimizationClinical high-risk youthClinical high riskHistorical risk factorsReport victimizationLegal issuesVictimsCrimeComorbid mental illnessMental illnessYouthClinical high-risk participantsPsychotic illnessLife risk factorsPsychosis symptomsPerpetratorsViolencePsychosisHealthy controlsStudy-3EngagementThe moderating role of lifetime social engagement on the relationship between C-reactive protein and negative symptoms among young adults at clinical high risk for psychosis
Goldsmith D, Yuan Q, Addington J, Bearden C, Cadenhead K, Cannon T, Carrión R, Keshavan M, Mathalon D, Perkins D, Stone W, Tsuang M, Woods S, Walker E, Ku B. The moderating role of lifetime social engagement on the relationship between C-reactive protein and negative symptoms among young adults at clinical high risk for psychosis. Brain Behavior And Immunity 2025, 129: 890-897. PMID: 40730261, PMCID: PMC12360851, DOI: 10.1016/j.bbi.2025.07.023.Peer-Reviewed Original ResearchConceptsScale of Psychosis-risk SymptomsNegative symptomsCHR-P groupClinical high riskCHR-PC-reactive proteinAssociated with negative symptomsNorth American Prodrome Longitudinal StudySocial engagementDevelopment of negative symptomsPsychosis-risk symptomsSimple slope analysesCHR-P individualsYoung adultsHealthy controlsCHR-P subjectsLevels of social engagementSocial engagement levelsEarly developmental periodDepressive symptomsSimple slopesHC subjectsPsychosisHigh riskC-reactive protein valuesMultisensory overweighting of perceptual priors relates to positive symptoms in individuals at clinical high risk of psychosis
Pokorny V, Ellman L, Strauss G, Walker E, Woods S, Powers A, Corlett P, Silverstein S, Waltz J, Gold J, Schiffman J, Mittal V. Multisensory overweighting of perceptual priors relates to positive symptoms in individuals at clinical high risk of psychosis. Journal Of Vision 2025, 25: 2130. DOI: 10.1167/jov.25.9.2130.Peer-Reviewed Original ResearchMentalizing Across the Psychosis Continuum in Adolescence and Young Adulthood: A Systematic Review and Narrative Synthesis
Salaminios G, Hazlitt A, Fonagy P, Debbané M, Nolte T. Mentalizing Across the Psychosis Continuum in Adolescence and Young Adulthood: A Systematic Review and Narrative Synthesis. Schizophrenia Bulletin 2025, sbaf095. PMID: 40635557, DOI: 10.1093/schbul/sbaf095.Peer-Reviewed Original ResearchPsychosis continuumMental difficultiesPsychosis expressionCHR-PYoung adulthoodAdult samplesDiagnosis of psychotic disorderCHR-P samplesClinical-high riskYoung adult samplePsychosis samplePsychotic disordersPsychosis prodromeEpisode psychosisCommunity samplePsychotic manifestationsPsychosisMental dysfunctionIntervention targetsEarly courseMentalMental impairmentYoung adultsSynthesis of findingsAdolescentsUtilization of a psychosis consultation service: Early lessons from a statewide initiative
Tayfur S, Yoviene Sykes L, Tek C, Srihari V. Utilization of a psychosis consultation service: Early lessons from a statewide initiative. Schizophrenia Research 2025, 282: 198-202. PMID: 40614351, PMCID: PMC12276959, DOI: 10.1016/j.schres.2025.06.019.Peer-Reviewed Original ResearchConceptsRecent-onset psychosisEarly psychosis interventionContinuing carePsychosis programPsychosis interventionPsychosisCare of young peoplePsychosis careTransitions of careConsultation serviceLearning health systemFamily support strategiesClinical issuesSpecialty careLearning CollaborativeHealthcare leadersHealth systemOut-of-stateStatewide initiativeFamily engagementTeam meetingsSupport strategiesSpecial treatmentCareEarly lessonsCognitive subtypes in youth at clinical high risk for psychosis
Yassin W, Green J, Keshavan M, del Re E, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Mathalon D, Perkins D, Walker E, Woods S, Stone W. Cognitive subtypes in youth at clinical high risk for psychosis. Psychiatry And Clinical Neurosciences 2025 PMID: 40600477, DOI: 10.1111/pcn.13861.Peer-Reviewed Original ResearchClinical high riskCognitive subtypesWorking memoryClinical high-risk groupWorking memory domainsConversion statusPsychotic disordersCognitive clustersVerbal abilityCHR patientsCognitive measuresMemory domainCognitive domainsNAPLS-2Cognitive trajectoriesPsychosisImpairment groupIntact groupHealthy controlsFunction trajectoriesIntervention strategiesBaseline differencesMemoryHigh riskMonths of follow-upTreatment approaches and efficacy in psychedelic-induced psychosis: A systematic review
Sulstarova A, Scheuerlein L, Monari S, Seragnoli F, Gabriel T, Preller K, Böge K, Sentissi O, Kaiser S, Solmi M, Kirschner M, Sabé M. Treatment approaches and efficacy in psychedelic-induced psychosis: A systematic review. Asian Journal Of Psychiatry 2025, 110: 104604. PMID: 40614615, DOI: 10.1016/j.ajp.2025.104604.Peer-Reviewed Original ResearchConceptsFirst-generation antipsychoticsSecond-generation antipsychoticsElectroconvulsive therapySchizophrenia spectrum disordersRisk of psychosisSecond-generation agentsCase seriesCase reportFollow-upBipolar disorderAntipsychoticsMinority of usersPsychosisSpectrum disorderAverage patient agePrimary substanceFollow-up dataSystematic reviewInterpretation of findingsComprehensive follow-upTreatment approachesSecond-generationPatient ageProspective studyTreatment optionsClinical predictors of readmission to psychiatric inpatient care: A 20-year follow up study of former adolescent inpatients
Leppanen J, Kieseppä V, Eskelinen S, Säynäjäkangas V, Rutten B, Gülöksüz S, Halt A, Riipinen P, Díaz-Caneja C, Kelleher I. Clinical predictors of readmission to psychiatric inpatient care: A 20-year follow up study of former adolescent inpatients. Psychiatry Research 2025, 351: 116606. PMID: 40578224, DOI: 10.1016/j.psychres.2025.116606.Peer-Reviewed Original ResearchConceptsPsychosis symptomsTransdiagnostic markerPsychiatric inpatientsSeverity of psychosis symptomsSeverity of depressive symptomsAdolescent psychiatric inpatientsSchizophrenia spectrum diagnosisObsessive-compulsive disorderSeverity of depressionPsychiatric inpatient careMarkers of illness severityDuration of readmissionsAdolescent inpatientsSpectrum diagnosisConduct disorderPsychiatric diagnosisDepressive symptomsEating DisordersPsychosisSubstance useInpatient admissionsIllness severityClinical predictorsCumulative durationInpatientsPredicting cognitive functioning in early psychosis: factors supporting and limiting generalizability of connectome-based models
O’Neill A, Pax M, Parent J, Sepulcre J, Camprodon J, Noble S, Roffman J, Eryilmaz H. Predicting cognitive functioning in early psychosis: factors supporting and limiting generalizability of connectome-based models. NPP—Digital Psychiatry And Neuroscience 2025, 3: 11. PMID: 40475845, PMCID: PMC12133584, DOI: 10.1038/s44277-025-00032-1.Peer-Reviewed Original ResearchConnectome-based predictive modelingEarly psychosisCognitive functionGoal of precision psychiatryPredictors of cognitive functionPrediction of cognitive functionPredicting cognitive performancePredicting cognitive functionModels of cognitionConnectome-based modelsPersonalized treatment developmentBrain connectivity patternsImpact functional outcomesHuman Connectome ProjectFluid cognitionPsychotic disordersSomatomotor networkCognitive abilitiesCognitive performancePrecision psychiatryVirtual lesion analysisTreatment developmentPsychosisCognitive outcomesCognitive impairmentBrain Age Disparities in Psychosis Across DSM Diagnoses and B-SNIP Biotypes
Promet L, Meda S, Alliey-Rodriguez N, Clementz B, Gershon E, Hill S, Ivleva E, Keedy S, Keshavan M, McDowell J, Parker D, Tamminga C, Pearlson G. Brain Age Disparities in Psychosis Across DSM Diagnoses and B-SNIP Biotypes. Schizophrenia Bulletin 2025, sbaf022. PMID: 40448350, DOI: 10.1093/schbul/sbaf022.Peer-Reviewed Original ResearchBrain age gapBipolar-Schizophrenia NetworkDSM diagnosesBrain agingPRS-SZComorbid disordersNon-psychotic first-degree relativesHealthy controlsAssociated with symptom severityPsychotic bipolar disorderSubtypes of psychosisStructural T1-weighted imagesBrain structural differencesPsychotropic medication useSchizoaffective disorderPsychosis probandsPsychotic disordersBipolar disorderPolygenic risk scoresSymptom severityFirst-degree relativesPsychosisAge gapDSMIntermediate phenotypes
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