2025
Comparison of behavioral outcomes following cranial vault remodeling versus strip craniectomy for non-syndromic sagittal craniosynostosis
Parikh N, Hu K, Lewis K, Kauke-Navarro M, Allam O, Goss J, Ihnat J, Persing J, Golinko M, Alperovich M. Comparison of behavioral outcomes following cranial vault remodeling versus strip craniectomy for non-syndromic sagittal craniosynostosis. Child's Nervous System 2025, 41: 248. PMID: 40719882, DOI: 10.1007/s00381-025-06900-7.Peer-Reviewed Original ResearchConceptsBehavior Rating InventoryNon-syndromic sagittal craniosynostosisExecutive functionElevated scoresCranial vault remodelingSocial Responsiveness Scale-2nd editionChild Behavior ChecklistT-score distributionT-scoreStrip craniectomyBehavior ChecklistBehavior problemsPeer relationsVault remodelingSurgical techniqueBehavioral outcomesSagittal craniosynostosisBehavioral developmentBehavioral risk profilesBehavioral differencesEmotional/behavioral regulationInfluence of surgical techniquePatients aged 6T-score categoriesAged 6Supervised brain node and network construction under voxel-level functional imaging
Xu W, Wang S, Gao S, Tian X, Tan C, Shen X, Luo W, Constable T, Li T, Zhao Y. Supervised brain node and network construction under voxel-level functional imaging. Imaging Neuroscience 2025, 3: imag.a.56. PMID: 40800928, PMCID: PMC12319940, DOI: 10.1162/imag.a.56.Peer-Reviewed Original ResearchAdolescent Brain Cognitive DevelopmentHuman Connectome ProjectResting-stateFunctional time-coursesBrain functional architectureBrain nodesConnectome ProjectCognitive tasksBrain regionsBrain parcellationFMRI dataBrain connectivityParcellation schemesBehavioral outcomesCognitive developmentConnectivity matrixFunctional architectureDownstream prediction tasksNode partitionBrainFunctional imagingBrain atlasesPrediction taskTwo-step processTime courseLongitudinal effects of language skills and maternal depression symptoms on problem behaviours in preschool children
Qi C, Van Horn M, Bulotsky-Shearer R, Futterer J, Davis A, Zieher A, Carta J. Longitudinal effects of language skills and maternal depression symptoms on problem behaviours in preschool children. Early Child Development And Care 2025, 195: 724-743. DOI: 10.1080/03004430.2025.2527136.Peer-Reviewed Original ResearchMaternal depressive symptomsChildren's language skillsDepressive symptomsProblem behaviorsLanguage skillsPreschool Language Scale-5Preschool childrenChild Behavior ChecklistExpressive language skillsEpidemiologic Studies Depression ScalePositive behavioral outcomesBehavior ChecklistHead Start programmeBehavioral outcomesScale-5Depression ScaleBehavioral healthLongitudinal effectsModerating RolePreschoolIntervention programmeSymptomsStart programmeComprehensive preventionChildrenTraining in Psychodynamic Psychotherapy
Lafont E, Sheppe A, Malberg N, Rice T. Training in Psychodynamic Psychotherapy. Child And Adolescent Psychiatric Clinics Of North America 2025, 34: 493-509. PMID: 40516958, DOI: 10.1016/j.chc.2025.03.002.Peer-Reviewed Original ResearchConceptsPsychodynamic psychotherapy trainingTransference-Focused PsychotherapyPsychodynamic psychotherapy treatmentPsychodynamic psychotherapyPsychotherapy trainingPsychotherapy treatmentImprove behavioral outcomesPsychotherapyContemporary psychiatryBehavioral outcomesPsychiatric trainingEvidence-based approachChildrenPsychopharmacologyPsychodynamicsPsychiatryResidency training requirementsMentalAdolescentsTrainingShort-termTraining requirementsPersonal interestsSupervisorsThe Police Opioid Seizure Temporal Risk (POSTeR) model of increased exposure to fatal overdose
Del Pozo B, Green T, Godvin M, Ray B. The Police Opioid Seizure Temporal Risk (POSTeR) model of increased exposure to fatal overdose. International Journal Of Drug Policy 2025, 139: 104789. PMID: 40157153, PMCID: PMC12045107, DOI: 10.1016/j.drugpo.2025.104789.Peer-Reviewed Original ResearchConceptsRisk of fatal overdoseAcute opioid withdrawal symptomsOpioid withdrawal symptomsPrevalence of illicit drugsFatal overdoseIllicit opioidsOutcomes of opioid use disorderOpioid use disorderWithdrawal symptomsUse disorderReduced aversionOpioid dependenceSubstance useBehavioral outcomesPsychological outcomesReduce opioid toleranceIllicit substancesPoliceLocal levelCausal modelPolice seizuresIllicit drugsDrug seizuresQualitative accountsOpioid toleranceBrain connectivity correlates of the impact of a digital intervention for individuals with subjective cognitive decline on depression and IL-18
Catalogna M, Somerville Y, Saporta N, Nathansohn-Levi B, Shelly S, Edry L, Zagoory-Sharon O, Feldman R, Amedi A. Brain connectivity correlates of the impact of a digital intervention for individuals with subjective cognitive decline on depression and IL-18. Scientific Reports 2025, 15: 6863. PMID: 40011544, PMCID: PMC11865443, DOI: 10.1038/s41598-025-91457-3.Peer-Reviewed Original ResearchConceptsBrain connectivityCognitive declineResting-state functional connectivityEffect sizeCognitive behavioral therapyLate-life depressionSelf-reported depressionMedium effect sizeDigital interventionsInterventions targeting mental healthMood regulationBehavioral therapyDepressive symptomsDecreased connectivityPost-intervention changesFunctional connectivityTwo-week interventionCognitive functionSpatial cognitionDepression scoresBrain healthBehavioral outcomesBrain functionPsychological techniquesPsychological health
2024
Multimodal predictive modeling: Scalable imaging informed approaches to predict future brain health
Ajith M, Spence J, Chapman S, Calhoun V. Multimodal predictive modeling: Scalable imaging informed approaches to predict future brain health. Journal Of Neuroscience Methods 2024, 414: 110322. PMID: 39608579, PMCID: PMC11687617, DOI: 10.1016/j.jneumeth.2024.110322.Peer-Reviewed Original ResearchStatic functional network connectivityHealth constructsNeuroimaging dataBrain healthResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingSupport vector regressionFunctional network connectivityRandom forestCognitive performanceAssessment-onlyRs-fMRINeural patternsBehavioral outcomesBehavioral dataDiverse data sourcesNeural connectionsPsychological stateTraining stageMagnetic resonance imagingLongitudinal changesNetwork connectivityBrainPerformance evaluationVector regressionBrain age prediction and deviations from normative trajectories in the neonatal connectome
Sun H, Mehta S, Khaitova M, Cheng B, Hao X, Spann M, Scheinost D. Brain age prediction and deviations from normative trajectories in the neonatal connectome. Nature Communications 2024, 15: 10251. PMID: 39592647, PMCID: PMC11599754, DOI: 10.1038/s41467-024-54657-5.Peer-Reviewed Original ResearchConceptsPostmenstrual agePerinatal periodBrain age predictionFunctional connectomeMonths of postnatal lifeMonths of lifePreterm infantsNormative trajectoryConnectome-based predictive modelingThird trimesterPerinatal exposureBrain age gapPostnatal lifeResting-state fMRIInfantsHuman Connectome ProjectNeonatal connectomeDevelopmental trajectoriesBrainBehavioral outcomesNormative dataMonthsConnectome ProjectDTI dataConnectomeAN INTEGRATIVE NETWORK-BASED MEDIATION MODEL (NMM) TO ESTIMATE MULTIPLE GENETIC EFFECTS ON OUTCOMES MEDIATED BY FUNCTIONAL CONNECTIVITY.
Dai W, Zhang H. AN INTEGRATIVE NETWORK-BASED MEDIATION MODEL (NMM) TO ESTIMATE MULTIPLE GENETIC EFFECTS ON OUTCOMES MEDIATED BY FUNCTIONAL CONNECTIVITY. The Annals Of Applied Statistics 2024, 18: 2277-2294. PMID: 39640845, PMCID: PMC11616023, DOI: 10.1214/24-aoas1880.Peer-Reviewed Original ResearchGenetic variantsFunctional connectivityEffects of multiple genetic variantsMediation modelBehavioral outcomesEffects of genetic variantsMultiple genetic variantsCumulative genetic effectsFluid intelligenceUnivariate mediatorImpact of geneticsCognitive behaviorVisual networkGenetic effectsNeural circuitsNetwork mediatorsFunctional networksYoung adultsVariantsEarly-life maturation of the somatosensory cortex: sensory experience and beyond
Nwabudike I, Che A. Early-life maturation of the somatosensory cortex: sensory experience and beyond. Frontiers In Neural Circuits 2024, 18: 1430783. PMID: 39040685, PMCID: PMC11260818, DOI: 10.3389/fncir.2024.1430783.Peer-Reviewed Original ResearchConceptsEarly life experiencesAtypical sensory perceptionLife experiencesPostnatal sensory experienceSensory experienceBehavioral outcomesNeurodevelopmental disordersCortex developmentSubstance exposureSensory circuitsSomatosensory cortexSocial isolationPhysiological changesConcurrent factorsSensory perceptionRadiographic severity is associated with worse executive function in metopic craniosynostosis
Almeida M, Alper D, Barrero C, Parikh N, Hauc S, Moscarelli J, Golinko M, Persing J, Swanson J, Alperovich M. Radiographic severity is associated with worse executive function in metopic craniosynostosis. Child's Nervous System 2024, 40: 3971-3982. PMID: 38904768, DOI: 10.1007/s00381-024-06493-7.Peer-Reviewed Original ResearchSeverity of metopic synostosisExecutive functionConners-3Neurocognitive testsBehavior Rating Inventory of Executive Function-2Endocranial bifrontal angleAssociated with worse executive functionSocial Responsiveness Scale-2Behavior Rating InventoryImpact executive functioningWorse executive functionChild Behavior ChecklistMetopic synostosisBRIEF-2Behavior ChecklistSchool ageBehavioral assessmentBehavioral difficultiesScale-2Subscale scoresAssociated with worse scoresBehavioral outcomesPhenotypic severitySociodemographic riskPre-operative CT imagesBrain-state mediated modulation of inter-laminar dependencies in visual cortex
Das A, Sheffield A, Nandy A, Jadi M. Brain-state mediated modulation of inter-laminar dependencies in visual cortex. Nature Communications 2024, 15: 5105. PMID: 38877026, PMCID: PMC11178935, DOI: 10.1038/s41467-024-49144-w.Peer-Reviewed Original ResearchConceptsBrain state fluctuationsUnique dependenceSpatial attentionBehavioral outcomesState fluctuationsDeployment of spatial attentionDeployment of attentionBehaviorally relevant objectsComputational goalCluttered environmentsVisual cortexObject recognitionExcitatory populationHierarchical computationVisual area V4Internal fluctuationsDependenceRelevant objectsModulation patternsTask demandsEnhance information transferCortical networksNeural activityInformation transferArea V4The role of genetics on behavioral outcomes in nonsyndromic sagittal synostosis.
Alper D, Almeida M, Hu K, Yang J, Timberlake A, Shah J, Persing J, Alperovich M. The role of genetics on behavioral outcomes in nonsyndromic sagittal synostosis. Journal Of Neurosurgery Pediatrics 2024, 34: 234-245. PMID: 38875721, DOI: 10.3171/2024.4.peds23510.Peer-Reviewed Original ResearchBehavioral outcomesNonsyndromic sagittal synostosisSocial Responsiveness Scale-2nd editionBehavior Rating InventoryAttention-deficit/hyperactivity disorderSagittal synostosisPly geneRelative to controlsExecutive functionAttention-deficit/hyperactivityExternalizing behaviorsExternalizing problemsLoss of functionBehavior problemsASD domainAssociated with worse scoresOutcomes of patientsRule-breakingParents of children aged 6Treating sagittal synostosisOlder ageAssociation of mutationsBehavior scoresSociodemographic factorsPly groupsComparison of emotional and behavioral regulation between metopic and sagittal synostosis
Almeida M, Alper D, Parikh N, De Baun H, Kammien A, Persing J, Alperovich M. Comparison of emotional and behavioral regulation between metopic and sagittal synostosis. Child's Nervous System 2024, 40: 2789-2799. PMID: 38691155, DOI: 10.1007/s00381-024-06387-8.Peer-Reviewed Original ResearchIntelligence quotientBehavior Rating Inventory of Executive Function-2Wechsler Abbreviated Scale of IntelligenceSocial Responsiveness Scale-2Behavior Rating InventoryWechsler Abbreviated ScaleExecutive function subscalesChild Behavior ChecklistExecutive function scoresScale of IntelligenceWASI-IIBRIEF-2Conners-3Executive functionExternalizing behaviorsBehavior ChecklistBehavioral regulationProblems subscaleSchool ageBehavioral assessmentBehavioral difficultiesScale-2Behavioral outcomesRule-breakingBehavioral differencesBehavioral discrimination and olfactory bulb encoding of odor plume intermittency
Gumaste A, Baker K, Izydorczak M, True A, Vasan G, Crimaldi J, Verhagen J. Behavioral discrimination and olfactory bulb encoding of odor plume intermittency. ELife 2024, 13: e85303. PMID: 38441541, PMCID: PMC11001298, DOI: 10.7554/elife.85303.Peer-Reviewed Original ResearchDiscrimination taskOdor-guided navigationOdor sourceTrained miceNeural representationNeural responsesTask performanceBehavioral outcomesBehavioral discriminationOlfactory bulbBehavioral parametersOdor landscapeOdorTaskOlfactory searchSniffingCuesNavigational cuesMiceBulbEncodingAnimalsDiscriminationAirborne plumeNavigation
2023
Responsive Neurostimulation for People With Drug-Resistant Epilepsy and Autism Spectrum Disorder
Fields M, Marsh C, Eka O, Johnson E, Marcuse L, Kwon C, Young J, LaVega-Talbott M, Kurukumbi M, Von Allmen G, Zempel J, Friedman D, Jette N, Singh A, Yoo J, Blank L, Panov F, Ghatan S. Responsive Neurostimulation for People With Drug-Resistant Epilepsy and Autism Spectrum Disorder. Journal Of Clinical Neurophysiology 2023, 41: 64-71. PMID: 35512185, PMCID: PMC10756699, DOI: 10.1097/wnp.0000000000000939.Peer-Reviewed Original ResearchConceptsDrug-resistant epilepsySuper respondersSeizure reductionPromising surgical optionResponsive neurostimulator systemRNS SystemAutism spectrum disorderSurgical candidatesSurgical evaluationSurgical optionsMulticenter studySpectrum disorderGeneral populationResponsive neurostimulationPatientsResponse rateSmall cohortEpilepsyNeurostimulator systemHigh rateRespondersDescriptive statisticsSystem placementBehavioral outcomesDisordersMaternal adverse childhood experiences on child growth and development in rural Pakistan: An observational cohort study
Chung E, Scherer E, LeMasters K, Bates L, Hagaman A, Staley B, Zalla L, Sikander S, Maselko J. Maternal adverse childhood experiences on child growth and development in rural Pakistan: An observational cohort study. PLOS Global Public Health 2023, 3: e0001669. PMID: 37878564, PMCID: PMC10599588, DOI: 10.1371/journal.pgph.0001669.Peer-Reviewed Original ResearchReceptive language developmentAdverse childhood experiencesMaternal adverse childhood experiencesLanguage developmentChild outcomesFine motorChildhood experiencesLevel of adversityMother-child dyadsCognitive developmentSocioemotional developmentSocioemotional problemsEmotional neglectEmotional abuseBehavioral outcomesToddler DevelopmentBehavioral developmentDifficulties QuestionnaireBayley ScalesPhysical abuseSocioemotionalChild growthIntergenerational transmissionNull relationshipAdapted versionComparison of Emotional and Behavioral Regulation Between Metopic and Sagittal Synostosis
Almeida M, Alper D, Parikh N, Debaum H, Kammien A, Persing J, Alperovich M. Comparison of Emotional and Behavioral Regulation Between Metopic and Sagittal Synostosis. 2023 DOI: 10.21203/rs.3.rs-3423777/v1.Peer-Reviewed Original ResearchSocial Responsiveness Scale-2More difficultyBehavior Rating InventorySchool ageWechsler Abbreviated ScaleExecutive function scoresExecutive function subscalesExecutive Function-2Child Behavior ChecklistIntelligence quotient (IQ) testingBRIEF-2Executive functionRating InventoryAbbreviated ScaleConners 3Behavioral difficultiesBehavioral regulationProblems subscaleBehavior ChecklistBehavioral outcomesScale-2Behavioral assessmentMore childrenOverall difficultyBehavioral differencesTranscriptional signatures of heroin intake and relapse throughout the brain reward circuitry in male mice
Browne C, Futamura R, Minier-Toribio A, Hicks E, Ramakrishnan A, Martínez-Rivera F, Estill M, Godino A, Parise E, Torres-Berrío A, Cunningham A, Hamilton P, Walker D, Huckins L, Hurd Y, Shen L, Nestler E. Transcriptional signatures of heroin intake and relapse throughout the brain reward circuitry in male mice. Science Advances 2023, 9: eadg8558. PMID: 37294757, PMCID: PMC10256172, DOI: 10.1126/sciadv.adg8558.Peer-Reviewed Original ResearchConceptsOpioid use disorderHeroin intakeContext-induced drug-seekingBrain reward circuitryHeroin self-administrationRNA-seqDrug seekingReward circuitryGenome-wide association study dataSelf-AdministrationHeroin exposureDrug-takingIntegration of RNA-seq dataUse disorderPatterns of transcriptional regulationRNA-seq dataBehavioral outcomesMale miceMolecular changesTranscriptional regulationRegion-SpecificGene candidatesRNA sequencingHeroinBioinformatics analysisProblematic use of the internet among adolescents: A four-wave longitudinal study of trajectories, predictors and outcomes
Geng X, Zhang J, Liu Y, Xu L, Han Y, Potenza M, Zhang J. Problematic use of the internet among adolescents: A four-wave longitudinal study of trajectories, predictors and outcomes. Journal Of Behavioral Addictions 2023, 12: 435-447. PMID: 37294627, PMCID: PMC10316164, DOI: 10.1556/2006.2023.00021.Peer-Reviewed Original ResearchConceptsDevelopmental trajectoriesAcademic functioningIndividual differencesFour-wave longitudinal studyProblematic developmental trajectoriesInter-parental conflictProblematic useDifferent developmental trajectoriesPoor academic functioningMental health difficultiesEffective intervention programsDevelopmental patternsFamily predictorsFamilial predictorsBehavioral outcomesLatent class growth modelsHealth difficultiesInterpersonal relationshipsChildhood maltreatmentAdverse correlatesIntervention programsModerate increasingMental healthAdolescentsLow decreasing
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply