2025
Predicting cognitive functioning in early psychosis: factors supporting and limiting generalizability of connectome-based models
O’Neill A, Pax M, Parent J, Sepulcre J, Camprodon J, Noble S, Roffman J, Eryilmaz H. Predicting cognitive functioning in early psychosis: factors supporting and limiting generalizability of connectome-based models. NPP—Digital Psychiatry And Neuroscience 2025, 3: 11. PMID: 40475845, PMCID: PMC12133584, DOI: 10.1038/s44277-025-00032-1.Peer-Reviewed Original ResearchConnectome-based predictive modelingEarly psychosisCognitive functionGoal of precision psychiatryPredictors of cognitive functionPrediction of cognitive functionPredicting cognitive performancePredicting cognitive functionModels of cognitionConnectome-based modelsPersonalized treatment developmentBrain connectivity patternsImpact functional outcomesHuman Connectome ProjectFluid cognitionPsychotic disordersSomatomotor networkCognitive abilitiesCognitive performancePrecision psychiatryVirtual lesion analysisTreatment developmentPsychosisCognitive outcomesCognitive impairment
2024
Generalizable and replicable brain-based predictions of cognitive functioning across common psychiatric illness
Chopra S, Dhamala E, Lawhead C, Ricard J, Orchard E, An L, Chen P, Wulan N, Kumar P, Rubenstein A, Moses J, Chen L, Levi P, Holmes A, Aquino K, Fornito A, Harpaz-Rotem I, Germine L, Baker J, Yeo B, Holmes A. Generalizable and replicable brain-based predictions of cognitive functioning across common psychiatric illness. Science Advances 2024, 10: eadn1862. PMID: 39504381, PMCID: PMC11540040, DOI: 10.1126/sciadv.adn1862.Peer-Reviewed Original ResearchConceptsPrediction of cognitionCognitive functionPrediction of cognitive functionFunctional neuroimaging dataTransdiagnostic sampleComputational psychiatryPsychiatric illnessNeuroimaging dataCognitive impairmentCognitionPopulation-level datasetsPsychiatryAssociated with poor outcomesUK BiobankImpairmentBrainIllnessSymptomsPrediction studiesParticipantsPoor outcomeClinical studiesSamples
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