2025
Combining transcranial direct current stimulation with music therapy improves cognitive function in schizophrenia: study protocol for a randomized, double-blind, sham-controlled clinical trial
Wei Y, He S, Luo P, Su H, Chen Y, Qin S, Zhang Z, Liu R, Wei D, Wang J, Wang F, Wang C. Combining transcranial direct current stimulation with music therapy improves cognitive function in schizophrenia: study protocol for a randomized, double-blind, sham-controlled clinical trial. Frontiers In Psychiatry 2025, 16: 1543789. PMID: 40417274, PMCID: PMC12100747, DOI: 10.3389/fpsyt.2025.1543789.Peer-Reviewed Original ResearchMusic therapyQuality of lifeTranscranial direct current stimulationCognitive impairmentCognitive functionMT groupProtocol registration numberSham-controlled clinical trialSecond Affiliated Hospital of Xinxiang Medical UniversityEnhance cognitive functionResearch Ethics CommitteeChinese classical musicPrimary outcome measureDirect current stimulationSham-controlled trialActive transcranial direct current stimulationCombined interventionSham transcranial direct current stimulationOutcome measuresClassical musicSecondary outcomesEfficacy of transcranial direct current stimulationStudy protocolRegistration numberSocial functioningModulation of dopaminergic transmission and brain activity by frontotemporal tDCS: A multimodal PET-MR imaging study
Fonteneau C, Merida I, Redoute J, Haesebaert F, Lancelot S, Costes N, Mondino M, Brunelin J. Modulation of dopaminergic transmission and brain activity by frontotemporal tDCS: A multimodal PET-MR imaging study. Brain Stimulation 2025, 18: 1065-1073. PMID: 40340023, DOI: 10.1016/j.brs.2025.05.006.Peer-Reviewed Original ResearchTranscranial direct current stimulationPositron emission tomographyArterial spin labelingMagnetic resonance imagingWhite matter microstructural integrityModulation of dopaminergic transmissionParallel-group studyNo significant effects of tDCSOptimization of therapeutic strategiesNon-displaceable binding potentialEffects of transcranial direct current stimulationCerebral blood flowNeurophysiological mechanismsDiffusion weighted imagingMicrostructural integrityPET-MR imagingActive transcranial direct current stimulationDopaminergic transmissionDouble-blindSimultaneous positron emission tomographyDopamine releaseDopamine transmissionClinical benefitDirect current stimulationDopamine system
2024
Cognitive Remediation in Patients With Bipolar Disorder: A Randomized Trial by Sequential tDCS and Navigated rTMS Targeting the Primary Visual Cortex
Zhou H, Wang M, Xu T, Zhang X, Zhao X, Tang L, Zhao P, Wang D, Lai J, Wang F, Zhang S, Hu S. Cognitive Remediation in Patients With Bipolar Disorder: A Randomized Trial by Sequential tDCS and Navigated rTMS Targeting the Primary Visual Cortex. CNS Neuroscience & Therapeutics 2024, 30: e70179. PMID: 39703101, PMCID: PMC11659637, DOI: 10.1111/cns.70179.Peer-Reviewed Original ResearchConceptsRepetitive transcranial magnetic stimulationNeuronavigated repetitive transcranial magnetic stimulationTranscranial direct current stimulationBipolar disorderNavigated repetitive transcranial magnetic stimulationNon-invasive brain stimulationDepressive symptomsBD patientsRating ScaleYoung Mania Rating ScaleHamilton Depression Rating ScaleCognitive impairmentTHINC-integrated toolMania Rating ScaleDepression Rating ScaleTranscranial direct current stimulation treatmentImprove cognitive impairmentVisual cortexTHINC-itCognitive remediationDepressive episodeTranscranial magnetic stimulationNeurocognitive effectsNeurocognitive functionDirect current stimulationTranscranial Direct Current Stimulation Combined With Repetitive Transcranial Magnetic Stimulation for Depression
Zhou D, Li X, Wei S, Yu C, Wang D, Li Y, Li J, Liu J, Li S, Zhuang W, Li Y, Luo R, Liu Z, Liu J, Xu Y, Fan J, Zhu G, Xu W, Tang Y, Cho R, Kosten T, Zhang X. Transcranial Direct Current Stimulation Combined With Repetitive Transcranial Magnetic Stimulation for Depression. JAMA Network Open 2024, 7: e2444306. PMID: 39535797, PMCID: PMC11561687, DOI: 10.1001/jamanetworkopen.2024.44306.Peer-Reviewed Original ResearchConceptsSham repetitive transcranial magnetic stimulationActive repetitive transcranial magnetic stimulationSham transcranial direct current stimulationRepetitive transcranial magnetic stimulationActive transcranial direct current stimulationTranscranial direct current stimulationTranscranial magnetic stimulationPrimary outcomeIntention-to-treat approachRTMS interventionSham-controlled randomized clinical trialRepetitive transcranial magnetic stimulation sessionsDirect current stimulationMagnetic stimulationSafety of repetitive transcranial magnetic stimulationDepressive disorderMain OutcomesRandomized clinical trialsTotal scoreCurrent stimulationTranscranial direct current stimulation sessionsDorsolateral prefrontal cortexBaseline to week 2Hamilton Depression Rating ScaleRating ScaleCognitive enhancing effect of rTMS combined with tDCS in patients with major depressive disorder: a double-blind, randomized, sham-controlled study
Li X, Liu J, Wei S, Yu C, Wang D, Li Y, Li J, Zhuang W, Luo R, Li Y, Liu Z, Su Y, Liu J, Xu Y, Fan J, Zhu G, Xu W, Tang Y, Yan H, Cho R, Kosten T, Zhou D, Zhang X. Cognitive enhancing effect of rTMS combined with tDCS in patients with major depressive disorder: a double-blind, randomized, sham-controlled study. BMC Medicine 2024, 22: 253. PMID: 38902735, PMCID: PMC11188255, DOI: 10.1186/s12916-024-03443-7.Peer-Reviewed Original ResearchConceptsRBANS total scoreRepetitive transcranial magnetic stimulationTranscranial direct current stimulationMDD patientsTotal scoreHDRS-24Transcranial direct current stimulation groupDepressive disorderImmediate memoryDepressive symptomsCognitive dysfunctionHamilton Depression Rating ScaleTreatment of cognitive dysfunctionDepressed response ratesDepression Rating ScaleCognitive enhancing effectsTreating cognitive dysfunctionImprove neurocognitive impairmentsActive rTMS groupDouble-blindSafety of repetitive transcranial magnetic stimulationTranscranial direct current stimulation treatmentMDD inpatientsRepeatable BatterySessions of treatmentClinical neurophysiology in the treatment of movement disorders: IFCN handbook chapter
Lefaucheur J, Moro E, Shirota Y, Ugawa Y, Grippe T, Chen R, Benninger D, Jabbari B, Attaripour S, Hallett M, Paulus W. Clinical neurophysiology in the treatment of movement disorders: IFCN handbook chapter. Clinical Neurophysiology 2024, 164: 57-99. PMID: 38852434, PMCID: PMC11418354, DOI: 10.1016/j.clinph.2024.05.007.Peer-Reviewed Original ResearchTranscranial alternating current stimulationTranscranial direct current stimulationLow-intensity transcranial electrical stimulationRepetitive transcranial magnetic stimulationSpinal cord stimulationCurrent stimulationMovement disordersTreated with botulinum toxin injectionsPulse generatorTranscranial electrical stimulationBotulinum toxin injectionIdentification of musclesShort-term clinical impactDirect current stimulationDeep brain stimulationAt-home useTherapeutic neuromodulationChronic diseasesTranscranial applicationTranscranial magnetic stimulationSurgical implantation of electrodesTreatment of movement disordersFUS stimulationAxial signsNeuromodulation techniquesIncreases in functional connectivity between the default mode network and sensorimotor network correlate with symptomatic improvement after transcranial direct current stimulation for obsessive-compulsive disorder
Echevarria M, Batistuzzo M, Silva R, Brunoni A, Sato J, Miguel E, Hoexter M, Shavitt R. Increases in functional connectivity between the default mode network and sensorimotor network correlate with symptomatic improvement after transcranial direct current stimulation for obsessive-compulsive disorder. Journal Of Affective Disorders 2024, 355: 175-183. PMID: 38548207, DOI: 10.1016/j.jad.2024.03.141.Peer-Reviewed Original ResearchTranscranial direct current stimulationObsessive-compulsive disorderDirect current stimulationCurrent stimulationActive transcranial direct current stimulationSensorimotor networkOCD symptom dimensionsTreatment-resistant obsessive-compulsive disorderNeurobiological mechanisms of actionObsessive-compulsive disorder pathophysiologyWhole-brain connectivity analysisDaily tDCS sessionsSymptom improvementResting-state functional MRITDCS sessionsNon-invasive neuromodulation interventionsBrain stimulation interventionsFunctional connectivity changesAssociated with connectivityLeft deltoidSymptom dimensionsNeurobiological mechanismsLeft precuneusMode networkPre/postcentral gyri
2023
A systematic review and meta-analysis of neuromodulation therapies for substance use disorders
Mehta D, Praecht A, Ward H, Sanches M, Sorkhou M, Tang V, Steele V, Hanlon C, George T. A systematic review and meta-analysis of neuromodulation therapies for substance use disorders. Neuropsychopharmacology 2023, 49: 649-680. PMID: 38086901, PMCID: PMC10876556, DOI: 10.1038/s41386-023-01776-0.Peer-Reviewed Original ResearchRepetitive transcranial magnetic stimulationTranscranial direct current stimulationSubstance use disordersDeep brain stimulationDorsolateral prefrontal cortexUse disordersEffects of rTMSTreatment of SUDsSubstance useLong-term outcomesLeft dorsolateral prefrontal cortexTranscranial magnetic stimulationSystematic literature searchDirect current stimulationEffect sizeSubstance use outcomesAddiction neurocircuitryUncontrolled studiesDBS studiesNeuromodulation therapiesMagnetic stimulationPsychosocial treatmentsBrain stimulationTreatment durationAdministration protocolFrontopolar multifocal transcranial direct current stimulation reduces conditioned fear reactivity during extinction training: A pilot randomized controlled trial
Adams T, Kelmendi B, George J, Forte J, Hubert T, Wild H, Rippey C, Pittenger C. Frontopolar multifocal transcranial direct current stimulation reduces conditioned fear reactivity during extinction training: A pilot randomized controlled trial. Neurobiology Of Learning And Memory 2023, 205: 107825. PMID: 37699439, PMCID: PMC10872945, DOI: 10.1016/j.nlm.2023.107825.Peer-Reviewed Original ResearchConceptsTranscranial direct current stimulationSkin conductance responsesExtinction trainingDirect current stimulationExtinction learningCurrent stimulationReturn of fearFear extinction paradigmInhibition of fearFear extinction learningExposure-based therapyTreatment of anxietyFear inhibitionThreat cuesSafety learningExtinction paradigmFear reactivityFear processingConductance responsesExtinction trialsFunctional connectivityElectrodermal activityMixed ANOVARelated disordersAnxiety
2022
Neuromodulation treatments of problematic use of the Internet
Xu L, Geng X, Zhang J, Guo X, Potenza M, Zhang J. Neuromodulation treatments of problematic use of the Internet. Current Opinion In Behavioral Sciences 2022, 48: 101215. DOI: 10.1016/j.cobeha.2022.101215.Peer-Reviewed Original ResearchProblematic useBrain circuitsTranscranial direct current stimulationDorsolateral prefrontal cortexDirect current stimulationRepetitive transcranial magnetic stimulationExecutive controlNegative emotionsStimulus contextTranscranial magnetic stimulationAddictive behaviorsPrefrontal cortexCurrent stimulationAddiction severityBrain regionsMagnetic stimulationNeuromodulation treatmentsInvasive stimulationEmotionsCausal relationshipCravingFunctioningRigorous experimentsAddictionCortextDCS induced GABA change is associated with the simulated electric field in M1, an effect mediated by grey matter volume in the MRS voxel
Nandi T, Puonti O, Clarke W, Nettekoven C, Barron H, Kolasinski J, Hanayik T, Hinson E, Berrington A, Bachtiar V, Johnstone A, Winkler A, Thielscher A, Johansen-Berg H, Stagg C. tDCS induced GABA change is associated with the simulated electric field in M1, an effect mediated by grey matter volume in the MRS voxel. Brain Stimulation 2022, 15: 1153-1162. PMID: 35988862, PMCID: PMC7613675, DOI: 10.1016/j.brs.2022.07.049.Peer-Reviewed Original Research
2021
The effect of transcranial direct current stimulation (tDCS) combined with cognitive training on EEG spectral power in adolescent boys with ADHD: A double-blind, randomized, sham-controlled trial
Westwood SJ, Bozhilova N, Criaud M, Lam SL, Lukito S, Wallace-Hanlon S, Kowalczyk OS, Kostara A, Mathew J, Wexler BE, Kadosh RC, Asherson P, Rubia K. The effect of transcranial direct current stimulation (tDCS) combined with cognitive training on EEG spectral power in adolescent boys with ADHD: A double-blind, randomized, sham-controlled trial. IBRO Neuroscience Reports 2021, 12: 55-64. PMID: 35746969, PMCID: PMC9210460, DOI: 10.1016/j.ibneur.2021.12.005.Peer-Reviewed Original ResearchAttention-deficit/hyperactivity disorderTranscranial direct current stimulationRight inferior frontal cortexCognitive trainingDirect current stimulationChildren/adolescentsTask performanceCurrent stimulationAnodal transcranial direct current stimulationInferior frontal cortexCognitive measuresCognitive effectsHyperactivity disorderEEG spectral powerNeural effectsSham-controlled studyAdolescent boysGroup differencesSpectral powerQEEG measuresFrontal cortexAdolescentsComprehensive measureParticipantsTrainingTranscranial direct current stimulation targeting the medial prefrontal cortex modulates functional connectivity and enhances safety learning in obsessive‐compulsive disorder: Results from two pilot studies
Adams TG, Cisler JM, Kelmendi B, George JR, Kichuk SA, Averill CL, Anticevic A, Abdallah CG, Pittenger C. Transcranial direct current stimulation targeting the medial prefrontal cortex modulates functional connectivity and enhances safety learning in obsessive‐compulsive disorder: Results from two pilot studies. Depression And Anxiety 2021, 39: 37-48. PMID: 34464485, PMCID: PMC8732293, DOI: 10.1002/da.23212.Peer-Reviewed Original ResearchConceptsTranscranial direct current stimulationMedial prefrontal cortexDefault mode networkObsessive-compulsive disorderDirect current stimulationFunctional connectivityCurrent stimulationSham transcranial direct current stimulationResting-state functional magnetic resonanceSafety learningActive transcranial direct current stimulationEffects of tDCSMainstay of treatmentCommunity volunteersExposure-based psychotherapySuperior frontal gyrusFunctional magnetic resonanceBasal gangliaClinical trialsExposure-based therapyVivo exposureSalience networkSubjective emotional distressAnterior insulaPrefrontal cortexParsing the antidepressant effects of non-invasive brain stimulation and pharmacotherapy: A symptom clustering approach on ELECT-TDCS
Goerigk S, Padberg F, Chekroud A, Kambeitz J, Bühner M, Brunoni A. Parsing the antidepressant effects of non-invasive brain stimulation and pharmacotherapy: A symptom clustering approach on ELECT-TDCS. Brain Stimulation 2021, 14: 906-912. PMID: 34048940, DOI: 10.1016/j.brs.2021.05.008.Peer-Reviewed Original ResearchConceptsTranscranial direct current stimulationNon-invasive brain stimulationDepressive symptomsBrain stimulationEfficacy of tDCSCore depressive symptomsLinear mixed regression modelsDepressive symptom clustersConsiderable inter-individual variabilityDirect current stimulationEscitalopram 20Antidepressant effectsAntidepressant efficacyInter-individual variabilityAtypical symptomsDepressed patientsMixed regression modelsInsomnia symptomsTDCS sessionsPharmacotherapyEscitalopramSymptomsPlaceboSymptom clustersCurrent stimulationEfficacy and safety of transcranial direct current stimulation as an add-on treatment for obsessive-compulsive disorder: a randomized, sham-controlled trial
Silva R, Brunoni A, Goerigk S, Batistuzzo M, Costa D, Diniz J, Padberg F, D’Urso G, Miguel E, Shavitt R. Efficacy and safety of transcranial direct current stimulation as an add-on treatment for obsessive-compulsive disorder: a randomized, sham-controlled trial. Neuropsychopharmacology 2021, 46: 1028-1034. PMID: 33452434, PMCID: PMC8115679, DOI: 10.1038/s41386-020-00928-w.Peer-Reviewed Original ResearchConceptsTreatment-resistant obsessive-compulsive disorderTranscranial direct current stimulationSupplementary motor areaBaseline Y-BOCS scoresActive transcranial direct current stimulationObsessive-compulsive disorderY-BOCS scoresDirect current stimulationAdverse eventsWeek 12Efficacy of tDCSCurrent stimulationCathodal transcranial direct current stimulationSham-controlled trialMild adverse eventsClinical Global ImpressionSham-controlled studyBetween-group differencesSymptoms of depressionSecondary outcomesPrimary outcomeImprovement subscaleGlobal ImpressionNeuromodulation therapiesTreatment resistance
2020
Precision non-implantable neuromodulation therapies: a perspective for the depressed brain
Borrione L, Bellini H, Razza L, Avila A, Baeken C, Brem A, Busatto G, Carvalho A, Chekroud A, Daskalakis Z, Deng Z, Downar J, Gattaz W, Loo C, Lotufo P, da Graça M. Martin M, McClintock S, O’Shea J, Padberg F, Passos I, Salum G, Vanderhasselt M, Fraguas R, Benseñor I, Valiengo L, Brunoni A. Precision non-implantable neuromodulation therapies: a perspective for the depressed brain. Brazilian Journal Of Psychiatry 2020, 42: 403-419. PMID: 32187319, PMCID: PMC7430385, DOI: 10.1590/1516-4446-2019-0741.Peer-Reviewed Original ResearchConceptsMajor depressive disorderSide effectsCurrent first-line treatmentMultiple medication trialsMagnetic seizure therapyFirst-line treatmentCognitive side effectsTranscranial direct current stimulationTranscranial magnetic stimulationDirect current stimulationCognitive behavioral therapyCost-effectiveness analysisClinical respondersSeizure therapyElectroconvulsive therapyMedication trialsPathophysiological mechanismsClinical trialsDepressed patientsDepressive disorderDepressed brainMagnetic stimulationNeuromodulation techniquesCurrent stimulationTherapyEfficacy and Safety of Transcranial Direct Current Stimulation as a Treatment for Obsessive-Compulsive Disorder: A Randomized, Sham-Controlled Trial
Silva R, Brunoni A, Goerigk S, Batistuzzo M, Costa D, Diniz J, Padberg F, D'Urso G, Miguel E, Shavitt R. Efficacy and Safety of Transcranial Direct Current Stimulation as a Treatment for Obsessive-Compulsive Disorder: A Randomized, Sham-Controlled Trial. Biological Psychiatry 2020, 87: s127. DOI: 10.1016/j.biopsych.2020.02.342.Peer-Reviewed Original ResearchTranscranial direct current stimulationDirect current stimulationCurrent stimulationCompulsive disorderSham
2019
Transcranial direct current stimulation for Obsessive-Compulsive Disorder: patient selection and perspectives
da Silva R, Brunoni A, Miguel E, Shavitt R. Transcranial direct current stimulation for Obsessive-Compulsive Disorder: patient selection and perspectives. Neuropsychiatric Disease And Treatment 2019, 15: 2663-2669. PMID: 31571882, PMCID: PMC6754675, DOI: 10.2147/ndt.s184839.Peer-Reviewed Original ResearchTranscranial direct current stimulationDirect current stimulationSevere obsessive-compulsive disorderObsessive-compulsive disorderCurrent stimulationPrevious conventional treatmentSafe tolerability profileFirst treatment optionImprovement of OCDModalities of treatmentNon-invasive neuromodulation techniqueAlternative treatment modalityPubMed/MEDLINETime of assessmentTolerability profileClinical characteristicsClinical presentationPatient selectionPsychiatric comorbidityPharmacological treatmentTreatment optionsTreatment modalitiesClinical severityNeuromodulation techniquesConventional treatmentTranscranial direct current stimulation in obsessive-compulsive disorder: an update in electric field modeling and investigations for optimal electrode montage
da Silva R, Batistuzzo M, Shavitt R, Miguel E, Stern E, Mezger E, Padberg F, D’Urso G, Brunoni A. Transcranial direct current stimulation in obsessive-compulsive disorder: an update in electric field modeling and investigations for optimal electrode montage. Expert Review Of Neurotherapeutics 2019, 19: 1025-1035. PMID: 31244347, DOI: 10.1080/14737175.2019.1637257.Peer-Reviewed Original ResearchMindfulness‐Based Relapse Prevention and Transcranial Direct Current Stimulation to Reduce Heavy Drinking: A Double‐Blind Sham‐Controlled Randomized Trial
Witkiewitz K, Stein ER, Votaw VR, Wilson AD, Roos CR, Gallegos SJ, Clark VP, Claus ED. Mindfulness‐Based Relapse Prevention and Transcranial Direct Current Stimulation to Reduce Heavy Drinking: A Double‐Blind Sham‐Controlled Randomized Trial. Alcohol Clinical And Experimental Research 2019, 43: 1296-1307. PMID: 30977904, PMCID: PMC6551269, DOI: 10.1111/acer.14053.Peer-Reviewed Original ResearchConceptsMindfulness-based relapse preventionAlcohol cue reactivityAlcohol use disorderDirect current stimulationCue reactivitySham-controlled randomized trialHeavy drinking daysStop-signal reaction time taskRelapse preventionCurrent stimulationRight inferior frontal gyrusSelf-reported cravingInferior frontal gyrusReaction time taskTranscranial direct current stimulationPercent heavy drinking daysDrinking daysCurrent studyCue taskResponse inhibitionTime taskFrontal gyrusNeurobiological dysfunctionAnodal tDCSGroup treatment
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