2025
2′-Fucosyllactose mitigates cognitive deficits in Alzheimer models: targeting amyloid pathology, oxidative stress, and synaptic plasticity
Munni Y, Tran K, Jeon S, Hwang M, Yoon J, Song Y, Oh T, Gum S, Yang I. 2′-Fucosyllactose mitigates cognitive deficits in Alzheimer models: targeting amyloid pathology, oxidative stress, and synaptic plasticity. Frontiers In Pharmacology 2025, 16: 1598030. DOI: 10.3389/fphar.2025.1598030.Peer-Reviewed Original ResearchPrimary hippocampal neuronsY-maze testWater mazeY-mazeCognitive performanceSynaptic vesicle protein 2Synaptic vesicle recyclingMouse model of ADAlzheimer's diseaseHuman milk oligosaccharidesRelevant to ADDisorder complexitySynaptic plasticityCytokine levels in vivoMouse modelModel of ADOxidative stressAD-related cognitive declineMorris water mazeInterleukin (IL)-6 levelsTumor necrosis factor (TNF)-aBrain-derived neurotrophic factorShortened escape latencyVesicle recyclingPostsynaptic density protein 95Network-wide aberrancies in neuronal activity during working memory in a large cohort of patients with mood disorders: associations with cognitive impairment and functional disability
Damgaard V, Schandorff J, Macoveanu J, Sankar A, Zarp J, Fisher P, Jørgensen M, Kessing L, Knudsen G, Frokjaer V, Miskowiak K. Network-wide aberrancies in neuronal activity during working memory in a large cohort of patients with mood disorders: associations with cognitive impairment and functional disability. Molecular Psychiatry 2025, 1-9. PMID: 40527901, DOI: 10.1038/s41380-025-03078-x.Peer-Reviewed Original ResearchCognitive control networkFunctional magnetic resonance imagingMood disordersCognitive performanceHypo-activityCross-sectional functional magnetic resonance imagingWorking memory n-back taskCognitive impairmentHyper-activityRight middle frontal gyrusLeft dorsolateral prefrontal cortexDaily functioningHealthy controlsDorsolateral prefrontal cortexFrontal medial cortexN-back taskMiddle frontal gyrusAssociated with cognitive impairmentAssociated with cognitionComprehensive neurocognitive testingAssessment of daily functionCognitive controlDMN abnormalitiesPrefrontal cortexFrontal gyrusPredicting cognitive functioning in early psychosis: factors supporting and limiting generalizability of connectome-based models
O’Neill A, Pax M, Parent J, Sepulcre J, Camprodon J, Noble S, Roffman J, Eryilmaz H. Predicting cognitive functioning in early psychosis: factors supporting and limiting generalizability of connectome-based models. NPP—Digital Psychiatry And Neuroscience 2025, 3: 11. PMID: 40475845, PMCID: PMC12133584, DOI: 10.1038/s44277-025-00032-1.Peer-Reviewed Original ResearchConnectome-based predictive modelingEarly psychosisCognitive functionGoal of precision psychiatryPredictors of cognitive functionPrediction of cognitive functionPredicting cognitive performancePredicting cognitive functionModels of cognitionConnectome-based modelsPersonalized treatment developmentBrain connectivity patternsImpact functional outcomesHuman Connectome ProjectFluid cognitionPsychotic disordersSomatomotor networkCognitive abilitiesCognitive performancePrecision psychiatryVirtual lesion analysisTreatment developmentPsychosisCognitive outcomesCognitive impairmentSex differences in the confounders influencing the relationships linking socioeconomic factors and cognitive performance with family history of Alzheimer's disease and related dementias
He J, Cabrera‐Mendoza B, Friligkou E, Mecca A, van Dyck C, Pathak G, Polimanti R. Sex differences in the confounders influencing the relationships linking socioeconomic factors and cognitive performance with family history of Alzheimer's disease and related dementias. Alzheimer's & Dementia 2025, 21: e70215. PMID: 40421744, PMCID: PMC12107445, DOI: 10.1002/alz.70215.Peer-Reviewed Original ResearchConceptsSocioeconomic factorsFamily historySocioeconomic statusFamily history of Alzheimer's diseaseAssociation of socioeconomic factorsHistory of Alzheimer's diseaseUs Research ProgramCognitive performanceHigher socioeconomic statusSex-specific associationsAlzheimer's Disease AssessmentSex differencesUK BiobankADRDAlzheimer's diseaseGenetically informed analysesDementiaSample sizeSexGenetic analysisAlzheimerLimited informationStatusConfoundingBiobankDissecting causal relationships between cortical morphology and neuropsychiatric disorders: a bidirectional Mendelian randomization study
Lin B, Li Y, Goula A, Chang X, Grasby K, Medland S, Andreassen O, Rutten B, Guloksuz S, van der Meer D, Luykx J. Dissecting causal relationships between cortical morphology and neuropsychiatric disorders: a bidirectional Mendelian randomization study. Nature Mental Health 2025, 3: 613-625. DOI: 10.1038/s44220-025-00397-4.Peer-Reviewed Original ResearchMean cortical thicknessCognitive performanceCortical morphologySchizophrenia riskBrain cortical surface areaEffects of cognitive performanceCortical surface areaImproving brain healthCortical morphological measuresNeuropsychiatric disordersNeuropsychiatric phenotypesBidirectional associationsBrain healthSchizophreniaNeuropsychiatric traitsCortical thicknessGlobal mean cortical thicknessSmoking initiationPositive causal effectTemporal thicknessInvestigate causal linksCausal effectsBrainCausal linkIntervention studiesElevated serum leucine levels are associated with cognitive impairment and reduced gray matter and cerebral volume across the Alzheimer’s disease continuum
Nasiri H, Azargoonjahromi A, Nouri Z, Azimi S, Zand H, Shourideh A, Heydari S, Mahmoudvand B, Barabadi S, Samadpour N, Mohamadhosseini A, Khodadadi A, Shakeri S, Mayeli M, Initiative F. Elevated serum leucine levels are associated with cognitive impairment and reduced gray matter and cerebral volume across the Alzheimer’s disease continuum. Neuroscience 2025, 577: 47-53. PMID: 40348165, DOI: 10.1016/j.neuroscience.2025.05.013.Peer-Reviewed Original ResearchConceptsCognitive performanceBrain volumeMediation analysisAlzheimer's Disease Assessment Scale-cognitive subscaleReduced gray matterGray matter volumeStructural brain volumesAssociated with cognitive impairmentAlzheimer's diseaseGray matterMagnetic resonance imagingPoor cognitive outcomesAlzheimer's disease continuumMatter volumeT1-weighted magnetic resonance imagingBrain structuresCognitive outcomesCerebral volumeCognitive impairmentCognitive declineBrain atrophyAD continuumBrainSerum leucine levelsAD pathologyCerebral perfusion differences in the visual cortex and fusiform subregions across the psychosis spectrum
Sritharan J, Zeng V, Petr J, Mutsaerts H, Hoang D, Bolo N, Ivleva E, Dai W, Gershon E, Keedy S, Parker D, Trotti R, McDowell J, Clementz B, Tamminga C, Pearlson G, Keshavan M, Lizano P. Cerebral perfusion differences in the visual cortex and fusiform subregions across the psychosis spectrum. Frontiers In Psychiatry 2025, 16: 1566184. PMID: 40365009, PMCID: PMC12069394, DOI: 10.3389/fpsyt.2025.1566184.Peer-Reviewed Original ResearchPsychosis spectrum disordersFusiform gyrusSchizoaffective disorderPseudo-continuous arterial spin-labeling scansCerebral blood flowOccipital lobeOverall cognitive performanceArterial spin labeling scansGray matter cerebral blood flowPsychosis spectrumBipolar disorderCognitive measuresCognitive performancePsychosisSpectrum disorderDiagnostic groupsPerfusion differencesVisual processingCognitive impairmentVisual hallucinationsCytoarchitectonic subregionsPerfusion alterationsLabeling scansSchizophreniaHealthy controlsCultural variables influence performance on the MATRICS Consensus Cognitive Battery among people at clinical high risk for psychosis
Guest R, Aberizk K, Addington J, Bearden C, Cadenhead K, Cannon T, Cornblatt B, Keshavan M, Mathalon D, Perkins D, Stone W, Woods S, Walker E. Cultural variables influence performance on the MATRICS Consensus Cognitive Battery among people at clinical high risk for psychosis. Schizophrenia Research 2025, 280: 60-68. PMID: 40250131, PMCID: PMC12169887, DOI: 10.1016/j.schres.2025.04.019.Peer-Reviewed Original ResearchConceptsMATRICS Consensus Cognitive BatteryConsensus Cognitive BatteryClinical high riskCognitive batteryCHR-PHopkins Verbal Learning Test-RevisedNorth American Prodrome Longitudinal StudyEnglish speakersHealthy controlsLetter-Number SpanPsychosis-Risk SyndromesMultigroup structural equation modelingInfluence cognitive performanceCultural variablesNative English speakersSample of peopleLetter-NumberNeuropsychological measuresVariables influencing performanceTest-RevisedCognitive performanceStructural equation modelingAnimal namesDiagnostic groupsCanadian sampleRepresenting brain-behavior associations by retaining high-motion minoritized youth
Ramduny J, Uddin L, Vanderwal T, Feczko E, Fair D, Kelly C, Baskin-Sommers A. Representing brain-behavior associations by retaining high-motion minoritized youth. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2025 PMID: 39921132, DOI: 10.1016/j.bpsc.2025.01.014.Peer-Reviewed Original ResearchBrain-behavior associationsFunctional MRIAdolescent Brain Cognitive Development<sup>SM<Effect sizeHispanic youthInternalizing psychopathologyCognitive performanceParticipant sexFunctional connectivityFMRI dataMinoritized individualsWhite youthHead motionMinoritized youthYouthSources of noisePsychopathologyDiverse populationsRacial/ethnic groupsAssociationPartial Spearman rank correlationsAdolescentsDisproportionate numberProfile of non-invasive physical health indicators associated with cognitive performance in Chinese older adults: evidence from the China Health and Retirement Longitudinal Study
Wei X, Li C, Liu D, Chen J, Ju Y, Liu J, Liu B, Zhang Y. Profile of non-invasive physical health indicators associated with cognitive performance in Chinese older adults: evidence from the China Health and Retirement Longitudinal Study. BMC Public Health 2025, 25: 420. PMID: 39894807, PMCID: PMC11789399, DOI: 10.1186/s12889-025-21479-z.Peer-Reviewed Original ResearchConceptsPhysical health indicatorsHealth indicatorsMild cognitive impairmentOlder adultsChina HealthCognitive performanceRight grip strengthChinese older adultsScreening of cognitive declineCognitive domainsLongitudinal cohort designCognitive performance domainsSubgroup analysisDomains of cognitive performancePhysical functionBackgroundExisting studiesGrip strengthCohort designLinear regression modelsMultiple linear regression modelStandardised interviewMethodsThe present studyResultsPulmonary functionSex-specific factorsGeneral cognitionCerebrospinal Fluid Biomarkers and Cognition in Alzheimer Disease and Frontotemporal Dementia in a Memory Clinic Setting
Cayir S, Sadabad F, Mecca A, Matuskey D, Fesharaki-Zadeh A. Cerebrospinal Fluid Biomarkers and Cognition in Alzheimer Disease and Frontotemporal Dementia in a Memory Clinic Setting. Alzheimer Disease & Associated Disorders 2025, 39: 22-27. PMID: 40397510, DOI: 10.1097/wad.0000000000000656.Peer-Reviewed Original ResearchMoCA scoresMemory clinic settingHospital memory clinicCognitive performanceMontreal Cognitive AssessmentFrontotemporal dementiaAlzheimer's diseaseCognitive test scoresP-tauMemory clinicElectronic records of patientsRetrospective cohort studyT-tauCohort studyCognitive AssessmentElectronic recordsMoCACerebrospinal fluidRecords of patientsIndex scoreTau-related pathologyClinical settingDementiaConcentrations of T-tauScores
2024
Cognitive performance and differentiation of B-SNIP psychosis Biotypes: Algorithmic Diagnostics for Efficient Prescription of Treatments (ADEPT) - 2
Clementz B, Chattopadhyay I, Hill S, McDowell J, Keedy S, Parker D, Trotti R, Ivleva E, Keshavan M, Gershon E, Pearlson G, Tamminga C, Gibbons R. Cognitive performance and differentiation of B-SNIP psychosis Biotypes: Algorithmic Diagnostics for Efficient Prescription of Treatments (ADEPT) - 2. Biomarkers In Neuropsychiatry 2024, 12: 100117. PMID: 40353045, PMCID: PMC12061035, DOI: 10.1016/j.bionps.2024.100117.Peer-Reviewed Original ResearchCognitive measuresCognitive performanceStop signal reaction timeCorrect response latencyClinical assessmentWRAT ReadingVerbal memoryPsychophysiological measuresBiomarker panelResponse latencySymbolic codeTreatment investigationsDigital sequencesReaction timeItemsPrescription of treatmentClinical trialsDiagnostic algorithmWRATPsychosisDSMNeuroimaging Correlates of the NIH-Toolbox-Driven Cognitive Metrics in Children
Acosta-Rodriguez H, Yuan C, Bobba P, Stephan A, Zeevi T, Malhotra A, Tran A, Kaltenhauser S, Payabvash S. Neuroimaging Correlates of the NIH-Toolbox-Driven Cognitive Metrics in Children. Journal Of Integrative Neuroscience 2024, 23: 217. PMID: 39735971, PMCID: PMC11851640, DOI: 10.31083/j.jin2312217.Peer-Reviewed Original ResearchConceptsCognitive composite scoreAdolescent Brain Cognitive DevelopmentFluid cognition composite scoresStructural magnetic resonance imagingComposite scoreDiffusion tensor imagingNeuroimaging correlatesCognitive functionRs-fMRINational Institutes of Health (NIH) Toolbox Cognition BatteryCognitive scoresMicrostructural integrityResting-state functional connectivityCrystallized cognition composite scoreCortical surface areaTotal cognitive scoreWM microstructural integrityCognitive batteryCrystallized cognitionNeuroanatomical correlatesWhite matterCognitive performanceNeuroimaging metricsFunctional connectivityNeuroimaging dataEffects of gene dosage on cognitive ability: A function-based association study across brain and non-brain processes
Huguet G, Renne T, Poulain C, Dubuc A, Kumar K, Kazem S, Engchuan W, Shanta O, Douard E, Proulx C, Jean-Louis M, Saci Z, Mollon J, Schultz L, Knowles E, Cox S, Porteous D, Davies G, Redmond P, Harris S, Schumann G, Dumas G, Labbe A, Pausova Z, Paus T, Scherer S, Sebat J, Almasy L, Glahn D, Jacquemont S. Effects of gene dosage on cognitive ability: A function-based association study across brain and non-brain processes. Cell Genomics 2024, 4: 100721. PMID: 39667348, PMCID: PMC11701252, DOI: 10.1016/j.xgen.2024.100721.Peer-Reviewed Original ResearchConceptsCopy-number variantsGenome-wide association studiesAssociation studiesCognitive abilitiesBiological processesEffect of gene dosageNeurodevelopmental disordersAssociated with cognitionHigher cognitive performanceGene dosageGene setsAssociated with higher cognitive performanceCognitive performanceGenesCell typesEffect sizeCognitionDeletionDuplicationDisordersNon-brain tissuesMedical comorbiditiesAbilityVariantsBrainMultimodal predictive modeling: Scalable imaging informed approaches to predict future brain health
Ajith M, Spence J, Chapman S, Calhoun V. Multimodal predictive modeling: Scalable imaging informed approaches to predict future brain health. Journal Of Neuroscience Methods 2024, 414: 110322. PMID: 39608579, PMCID: PMC11687617, DOI: 10.1016/j.jneumeth.2024.110322.Peer-Reviewed Original ResearchStatic functional network connectivityHealth constructsNeuroimaging dataBrain healthResting-state functional magnetic resonance imagingFunctional magnetic resonance imagingSupport vector regressionFunctional network connectivityRandom forestCognitive performanceAssessment-onlyRs-fMRINeural patternsBehavioral outcomesBehavioral dataDiverse data sourcesNeural connectionsPsychological stateTraining stageMagnetic resonance imagingLongitudinal changesNetwork connectivityBrainPerformance evaluationVector regressionLong-term cognitive effects of menopausal hormone therapy: Findings from the KEEPS Continuation Study
Gleason C, Dowling N, Kara F, James T, Salazar H, Simo C, Harman S, Manson J, Hammers D, Naftolin F, Pal L, Miller V, Cedars M, Lobo R, Malek-Ahmadi M, Kantarci K. Long-term cognitive effects of menopausal hormone therapy: Findings from the KEEPS Continuation Study. PLOS Medicine 2024, 21: e1004435. PMID: 39570992, PMCID: PMC11581397, DOI: 10.1371/journal.pmed.1004435.Peer-Reviewed Original ResearchConceptsOral conjugated equine estrogenLatent growth modelingLong-term cognitive effectsCognitive factor scoresCognitive benefitsCognitive performanceFactor scoresBaseline cognitionFollow-upClinical trialsEarly postmenopauseIn-person research visitsYears of follow-upRandomized to placeboMenopausal hormone therapyGlobal cognitive scoreNeuroimaging effectsCognitive measuresCognitive harmLongitudinal cohort studyCognitive changesCognitive slopesCognitive dataTest batteryCognitive functionA Method for Multimodal IVA Fusion Within a MISA Unified Model Reveals Markers of Age, Sex, Cognition, and Schizophrenia in Large Neuroimaging Studies
Silva R, Damaraju E, Li X, Kochunov P, Ford J, Mathalon D, Turner J, van Erp T, Adali T, Calhoun V. A Method for Multimodal IVA Fusion Within a MISA Unified Model Reveals Markers of Age, Sex, Cognition, and Schizophrenia in Large Neuroimaging Studies. Human Brain Mapping 2024, 45: e70037. PMID: 39560198, PMCID: PMC11574741, DOI: 10.1002/hbm.70037.Peer-Reviewed Original ResearchConceptsMultimodal neuroimaging datasetSchizophrenia patientsNeuroimaging studiesCognitive performanceGroup differencesSchizophreniaSex effectsNeuroimaging datasetsMagnetic resonance imagingCognitionAge-associated declineControl subjectsMarkers of agingResonance imagingNon-imaging variablesSubject profilesSexNeuroimagingUK Biobank datasetAdolescent brain maturation associated with environmental factors: a multivariate analysis
Ray B, Jensen D, Suresh P, Thapaliya B, Sapkota R, Farahdel B, Fu Z, Chen J, Calhoun V, Liu J. Adolescent brain maturation associated with environmental factors: a multivariate analysis. Frontiers In Neuroimaging 2024, 3: 1390409. PMID: 39629197, PMCID: PMC11613425, DOI: 10.3389/fnimg.2024.1390409.Peer-Reviewed Original ResearchLeft medial orbitofrontal cortexReduced gray matter densityMedial orbitofrontal cortexMiddle temporal gyrusGray matter densityIncreased functional connectivityIncrease cognitive performanceSusceptible to environmental influencesBilateral occipital regionsDelayed brain maturationIncreased cortical thicknessOrbitofrontal cortexAdolescent brainHuman adolescentsTemporal gyrusBrain characteristicsCognitive performanceBrain regionsBrain age estimationBrain metricsFunctional connectivityBrain agingBrain maturationBrain variationBrain modalitiesInhibition of brain glutamate carboxypeptidase II (GCPII) to enhance cognitive function
Wiseman R, Bigos K, Arnsten A, Slusher B. Inhibition of brain glutamate carboxypeptidase II (GCPII) to enhance cognitive function. Advances In Pharmacology 2024, 102: 27-63. PMID: 39929583, PMCID: PMC12120972, DOI: 10.1016/bs.apha.2024.10.018.Peer-Reviewed Original ResearchN-acetylaspartyl glutamateGlutamate carboxypeptidase IICognitive deficitsCognitive functionDorsolateral prefrontal cortex of primatesPrefrontal cortex of primatesHigher order cognitive processesDorsolateral prefrontal cortexMetabotropic glutamate receptor 3Inhibition of glutamate carboxypeptidase IIImprove cognitive deficitsEnhance cognitive functionImprove cognitive performanceEnzyme glutamate carboxypeptidase IIGlutamate receptor 3Executive functionCortex of primatesMGlu3 receptorsCarboxypeptidase IICognitive performanceCognitive processesPersistent neuronal firingClinical populationsNeuronal firingClinical workEffect of Esketamine Nasal Spray on Cognition in Patients With Treatment-Resistant Depression: Results From Four Phase 3 Studies
Morrison R, Singh J, Daly E, Fedgchin M, Ochs-Ross R, Karcher K, Lane R, Cooper K, Sanacora G, Maruff P, Drevets W. Effect of Esketamine Nasal Spray on Cognition in Patients With Treatment-Resistant Depression: Results From Four Phase 3 Studies. The International Journal Of Neuropsychopharmacology 2024, 27: pyae046. PMID: 39514643, PMCID: PMC11561565, DOI: 10.1093/ijnp/pyae046.Peer-Reviewed Original ResearchEsketamine nasal sprayTreatment-resistant depressionLong-term maintenance treatmentMADRS scoreOral antidepressantHopkins Verbal Learning Test-RevisedMaintenance treatmentCognitive test batteryEffects of esketamineGroup mean performanceFollow-up assessmentMild to moderate impairmentDepression severityTest-RevisedCogState batteryCognitive performancePsychomotor functionTest batteryCognitive testsCognitionEsketamineNasal sprayEffect sizeDepressionEffects of short-term
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