2025
Single-cell elderly blood–CSF atlas implicates peripherally influenced immune dysregulation in normal pressure hydrocephalus
Duy P, Kiziltug E, Greenberg A, Mehta N, Hao L, Fortes C, Mullany S, Fan B, Manichaikul A, Teich A, Chan D, Alper S, Hyman B, Arnold S, McKhann G, Frosch M, Kahle K. Single-cell elderly blood–CSF atlas implicates peripherally influenced immune dysregulation in normal pressure hydrocephalus. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2412159122. PMID: 40324076, PMCID: PMC12087963, DOI: 10.1073/pnas.2412159122.Peer-Reviewed Original ResearchConceptsIdiopathic normal pressure hydrocephalusNormal pressure hydrocephalusImmune dysregulationPeripheral bloodPressure hydrocephalusIdiopathic normal pressure hydrocephalus patientsProinflammatory alterationsVentricular CSFSingle-cell transcriptomicsINPH patientsCell populationsPatientsNeuroglial cellsCSFBloodHydrocephalusBaseline cognitive functionCognitive functionDysregulationMonocytesUnbiased CSF Proteomics in Patients With Idiopathic Normal Pressure Hydrocephalus to Identify Molecular Signatures and Candidate Biomarkers
de Geus M, Wu C, Dodge H, Leslie S, Wang W, Lam T, Kahle K, Chan D, Kivisäkk P, Nairn A, Arnold S, Carlyle B. Unbiased CSF Proteomics in Patients With Idiopathic Normal Pressure Hydrocephalus to Identify Molecular Signatures and Candidate Biomarkers. Neurology 2025, 104: e213375. PMID: 39951680, PMCID: PMC11837848, DOI: 10.1212/wnl.0000000000213375.Peer-Reviewed Original ResearchConceptsNeuronal pentraxin receptorIdiopathic normal pressure hydrocephalusTranscriptome dataAlzheimer's diseaseDifferential expression of proteinsGene ontology analysisDifferential expression analysisGene Set Enrichment AnalysisDownregulation of proteinsDifferentially expressed proteinsNormal pressure hydrocephalusBiological process enrichmentExpression of proteinsPotential disease biomarkersOntology analysisProteomic analysis of CSFPathophysiology of idiopathic normal pressure hydrocephalusProteomic analysisProteomic studiesProcess of immune responseEnrichment analysisExpression analysisPressure hydrocephalusDifferential expressionDiagnosis of idiopathic normal pressure hydrocephalus
2024
Machine learning on unbiased proteomics of cerebrospinal fluid uncovers differential molecular signatures of Alzheimer’s disease and Normal Pressure Hydrocephalus
de Geus M, Wu C, Dodge H, Leslie S, Wang W, Lam T, Nairn A, Kivisäkk P, Arnold S, Carlyle B. Machine learning on unbiased proteomics of cerebrospinal fluid uncovers differential molecular signatures of Alzheimer’s disease and Normal Pressure Hydrocephalus. Alzheimer's & Dementia 2024, 20: e091783. PMCID: PMC11714358, DOI: 10.1002/alz.091783.Peer-Reviewed Original ResearchGene Set Enrichment AnalysisAlzheimer's diseaseSignatures of Alzheimer's diseasePathology of ADMolecular signaturesPathways related to glycolysisNormal pressure hydrocephalusImmune response pathwaysGene setsResponse pathwaysData-independent acquisition mass spectrometryMolecular-level investigationsEnrichment analysisProteomic investigationsCerebrospinal fluidMetabolic processesProteome quantificationProteinGenetics and molecular pathophysiology of normal pressure hydrocephalus.
Mehta N, Maury E, Buller Z, Duy P, Fortes C, Alper S, Erson-Omay E, Kahle K. Genetics and molecular pathophysiology of normal pressure hydrocephalus. Journal Of Neurosurgery 2024, 142: 346-352. PMID: 39178477, DOI: 10.3171/2024.5.jns24980.Peer-Reviewed Original ResearchIdiopathic normal pressure hydrocephalusNormal pressure hydrocephalusPathophysiology of idiopathic normal pressure hydrocephalusIntegrative genetic analysisPressure hydrocephalusPathophysiology of normal pressure hydrocephalusGenomic studiesGenetic analysisGenetic insightsUrinary incontinenceSurgical interventionCerebral ventricleClinical studiesFamilial casesMolecular pathophysiologyCSF dynamicsDisease pathogenesisNeuroinflammatory processesCerebral pressureHydrocephalusGeneticsCognitive impairmentBiomechanical instability of the brain–CSF interface in hydrocephalus
Duy P, Mehta N, Kahle K. Biomechanical instability of the brain–CSF interface in hydrocephalus. Brain 2024, 147: 3274-3285. PMID: 38798141, PMCID: PMC11449143, DOI: 10.1093/brain/awae155.Peer-Reviewed Original ResearchBrain-CSF interfaceBrain parenchymaPost-hemorrhagic hydrocephalusLow intracranial pressureAbnormal biomechanical propertiesNormal pressure hydrocephalusPost-infectiousCongenital hydrocephalusImpaired neurodevelopmentCommunicating hydrocephalusCSF homeostasisBiomechanical instabilityHydrocephalusIntracranial pressureAnimal studiesPressure hydrocephalusArachnoid granulationsPrimary derangementBrain surgeryStudy of hydrocephalusAge groupsCSF reabsorptionVentriculomegalyVentricleSecondary enlargementThe eShunt® System: A Novel Minimally Invasive CSF Shunting System for the Treatment of Idiopathic Normal Pressure Hydrocephalus (P10-4.014)
Lylyk P, Matouk C, Siddiqui A, Riina H, Lylyk I, Bleise C, Scrivano E, Lylyk P, Antonios J, Beneduce B, Levy E, Heilman C, Malek A. The eShunt® System: A Novel Minimally Invasive CSF Shunting System for the Treatment of Idiopathic Normal Pressure Hydrocephalus (P10-4.014). Neurology 2024, 102 DOI: 10.1212/wnl.0000000000206181.Peer-Reviewed Original Research157 Minimally Invasive Treatment of Idiopathic Normal Pressure Hydrocephalus Using the Endovascular eShunt Implant
Lylyk P, Matouk C, Siddiqui A, Lylyk I, Bleise C, Scrivano E, Lylyk N, Antonios J, Beneduce B, Levy E, Heilman C, Malek A. 157 Minimally Invasive Treatment of Idiopathic Normal Pressure Hydrocephalus Using the Endovascular eShunt Implant. Neurosurgery 2024, 70: 36-37. DOI: 10.1227/neu.0000000000002809_157.Peer-Reviewed Original ResearchNeurogenic Bladder Symptom ScoreComposite outcome scoreNormal pressure hydrocephalusIdiopathic normal pressure hydrocephalusOutcome scoresVentriculo-peritoneal shunt surgeryTimed Up &Treatment of idiopathic normal pressure hydrocephalusPressure hydrocephalusTreat communicating hydrocephalusFavorable risk profileFunctional outcome scoresMinimally invasive treatmentFollow-up dataMontreal Cognitive AssessmentCompared to baselineGait improvementFollow-up phaseShunt surgeryUrinary continenceCSF shuntingUrinary incontinenceElderly patientsPre-treatment scoresFollow-upUtility of cortical tissue analysis in normal pressure hydrocephalus
Greenberg A, Mekbib K, Mehta N, Kiziltug E, Duy P, Smith H, Junkkari A, Leinonen V, Hyman B, Chan D, Curry W, Arnold S, Barker F, Frosch M, Kahle K. Utility of cortical tissue analysis in normal pressure hydrocephalus. Cerebral Cortex 2024, 34: bhae001. PMID: 38275188, PMCID: PMC10839843, DOI: 10.1093/cercor/bhae001.Peer-Reviewed Original ResearchConceptsIdiopathic normal pressure hydrocephalus patientsNormal pressure hydrocephalus patientsCerebrospinal fluid shuntsNormal pressure hydrocephalusIdiopathic normal pressure hydrocephalusHydrocephalus patientsPressure hydrocephalusOriginal patient cohortCortical pathologyRisks of treatmentPrognostic adjunctClinical improvementTissue analysisNegative pathologyShunt outcomeClinical outcomesPatient cohortUnfavorable outcomePooled analysisSystematic reviewOriginal cohortPooled statisticsLiving patientsConfounding diagnosesPatients
2023
P117/179 Treatment of normal pressure hydrocephalus using the eShunt endovascular transvenous implant
Pedro L, Matouk C, Siddiqui A, Lylyk I, Bleise C, Scrivano E, Lylyk P, Joseph A, Brandon B, Elad L, Heilman C, Malek A. P117/179 Treatment of normal pressure hydrocephalus using the eShunt endovascular transvenous implant. 2023, a59.3-a60. DOI: 10.1136/jnis-2023-esmint.146.Peer-Reviewed Original ResearchTreatment of normal pressure hydrocephalusNormal pressure hydrocephalusTransvenous implantationPressure hydrocephalusO-039 Preliminary results of the cerevasc eShunt implant in the treatment of normal pressure hydrocephalus
Lylyk P, Matouk C, Siddiqui A, Lylyk I, Bleise C, Scrivano E, Lylyk N, Antonios J, Beneduce B, Levy E, Heilman C, Malek A. O-039 Preliminary results of the cerevasc eShunt implant in the treatment of normal pressure hydrocephalus. 2023, a31-a32. DOI: 10.1136/jnis-2023-snis.39.Peer-Reviewed Original ResearchIn Reply to the Letter to Editor Regarding "Hospital Frailty Risk Score Predicts Adverse Events and Readmission Following Ventriculoperitoneal Shunt Surgery for Normal Pressure Hydrocephalus"
Koo A, Elsamadicy A, Matouk C. In Reply to the Letter to Editor Regarding "Hospital Frailty Risk Score Predicts Adverse Events and Readmission Following Ventriculoperitoneal Shunt Surgery for Normal Pressure Hydrocephalus". World Neurosurgery 2023, 169: 124. PMID: 36585096, DOI: 10.1016/j.wneu.2022.11.023.Peer-Reviewed Original Research
2022
Hospital Frailty Risk Score Predicts Adverse Events and Readmission Following a Ventriculoperitoneal Shunt Surgery for Normal Pressure Hydrocephalus
Koo AB, Elsamadicy AA, Renedo D, Sarkozy M, Reeves BC, Barrows MM, Hengartner A, Havlik J, Sandhu MRS, Antonios JP, Malhotra A, Matouk CC. Hospital Frailty Risk Score Predicts Adverse Events and Readmission Following a Ventriculoperitoneal Shunt Surgery for Normal Pressure Hydrocephalus. World Neurosurgery 2022, 170: e9-e20. PMID: 35970293, DOI: 10.1016/j.wneu.2022.08.037.Peer-Reviewed Original ResearchConceptsHospital Frailty Risk ScoreFrailty Risk ScoreVP shunt surgeryVentriculoperitoneal shunt surgeryAdverse eventsShunt surgeryIndependent predictorsNPH patientsRisk scoreHealth care resource utilizationMultivariate logistic regression analysisNormal pressure hydrocephalus patientsRetrospective cohort studyNationwide Readmissions DatabaseNormal pressure hydrocephalusLogistic regression analysisRegression analysisMultivariate regression analysisUnplanned readmissionCohort studyHospital readmissionPressure hydrocephalusAdmission costsReadmissionHydrocephalus patients513 Surveilling Cerebrospinal Fluid Protein Biomarkers in Brain Metastasis
Cheok S, Arnal-Estape A, Wei W, Nguyen D, Chiang V. 513 Surveilling Cerebrospinal Fluid Protein Biomarkers in Brain Metastasis. Neurosurgery 2022, 68: 129-129. DOI: 10.1227/neu.0000000000001880_513.Peer-Reviewed Original ResearchBrain metastasesCerebrospinal fluidIntraparenchymal diseaseCentral nervous system pathologyCerebrospinal fluid (CSF) protein biomarkersIntraparenchymal brain metastasesManagement of patientsNormal pressure hydrocephalusNervous system pathologyCurrent diagnostic standardNon-malignant samplesWarrants further explorationCSF profilePressure hydrocephalusRadiation necrosisLung cancerSimilar pathogenesisBrain parenchymaInflammatory diseasesIntracranial diseaseBreast cancerClinical dataCSF leakTreatment responsePatients
2021
Patient Risk Factors Associated With 30- and 90-Day Readmission After Ventriculoperitoneal Shunt Placement for Idiopathic Normal Pressure Hydrocephalus in Elderly Patients: A Nationwide Readmission Study
Koo AB, Elsamadicy AA, Lin IH, David WB, Reeves BC, Santarosa C, Cord B, Malhotra A, Kahle KT, Matouk CC. Patient Risk Factors Associated With 30- and 90-Day Readmission After Ventriculoperitoneal Shunt Placement for Idiopathic Normal Pressure Hydrocephalus in Elderly Patients: A Nationwide Readmission Study. World Neurosurgery 2021, 152: e23-e31. PMID: 33862298, DOI: 10.1016/j.wneu.2021.04.010.Peer-Reviewed Original ResearchConceptsIdiopathic normal pressure hydrocephalusVP shunt surgeryShunt surgeryElderly patientsNormal pressure hydrocephalusPressure hydrocephalusNationwide Readmissions DatabaseVentriculoperitoneal shunt surgeryPatient risk factorsVentriculoperitoneal shunt placementQuality of careMultivariate regression analysisIndex admissionUnplanned readmissionReadmission ratesRenal failureMechanical complicationsPostoperative infectionShunt placementNinth RevisionFemale sexRisk factorsSubdural hemorrhageClinical ModificationReadmissionThe Utility of Imaging Parameters in Predicting Long-Term Clinical Improvement After Shunt Surgery in Patients with Idiopathic Normal Pressure Hydrocephalus
Subramanian HE, Fadel SA, Matouk CC, Zohrabian VM, Mahajan A. The Utility of Imaging Parameters in Predicting Long-Term Clinical Improvement After Shunt Surgery in Patients with Idiopathic Normal Pressure Hydrocephalus. World Neurosurgery 2021, 149: e1-e10. PMID: 33662608, DOI: 10.1016/j.wneu.2021.02.108.Peer-Reviewed Original ResearchConceptsIdiopathic normal pressure hydrocephalusShunt surgeryNormal pressure hydrocephalusEvans indexCognitive improvementShunt placementPressure hydrocephalusImaging featuresLong-term patient-reported outcomesLong-term clinical improvementTelephone interviewsPreoperative imaging parametersVentriculoperitoneal shunt surgeryCerebrospinal fluid drainagePatient-reported outcomesLong-term outcomesLong-term cognitive improvementMagnetic resonance imagingImaging parametersClinical improvementGait improvementMedian durationClinical outcomesShunt candidatesFluid drainageTumor DNA Mutations From Intraparenchymal Brain Metastases Are Detectable in CSF
Cheok SK, Narayan A, Arnal-Estape A, Gettinger S, Goldberg SB, Kluger HM, Nguyen D, Patel A, Chiang V. Tumor DNA Mutations From Intraparenchymal Brain Metastases Are Detectable in CSF. JCO Precision Oncology 2021, 5: 163-172. PMID: 34250381, PMCID: PMC8232069, DOI: 10.1200/po.20.00292.Peer-Reviewed Original ResearchConceptsIntraparenchymal brain metastasesBrain metastasesCell-free DNAExtracranial tumorsBrain metastasis tissuesProgressive brain metastasesThird of patientsNormal pressure hydrocephalusTumor DNA mutationsPrimary cancer typeAnalysis of CSFSamples of CSFLeptomeningeal diseaseEffective surrogate markerBrain biopsyPressure hydrocephalusLumbar punctureSurrogate markerCancer-associated genesMetastasis tissuesPatientsMetastasisDiscordant responsesRenal cellsGenomic profiling
2020
Patient Risk Factors Associated with 30- and 90- Day Readmission after Ventriculoperitoneal Shunt Placement for Idiopathic Normal Pressure Hydrocephalus in Elderly Patients
Koo A, Elsamadicy A, Lin I, David W, Reeves B, Santarosa C, Cord B, Malhotra A, Kahle K, Matouk C. Patient Risk Factors Associated with 30- and 90- Day Readmission after Ventriculoperitoneal Shunt Placement for Idiopathic Normal Pressure Hydrocephalus in Elderly Patients. Neurosurgery 2020, 67 DOI: 10.1093/neuros/nyaa447_202.Peer-Reviewed Original ResearchFully Automated Segmentation of Head CT Neuroanatomy Using Deep Learning
Cai J, Akkus Z, Philbrick K, Boonrod A, Hoodeshenas S, Weston A, Rouzrokh P, Conte G, Zeinoddini A, Vogelsang D, Huang Q, Erickson B. Fully Automated Segmentation of Head CT Neuroanatomy Using Deep Learning. Radiology Artificial Intelligence 2020, 2: e190183. PMID: 33937839, PMCID: PMC8082409, DOI: 10.1148/ryai.2020190183.Peer-Reviewed Original ResearchIdiopathic normal pressure hydrocephalusHead CT scanCT scanIntracranial structuresNoncontrast head CT scansNormal pressure hydrocephalusRetrospective studyVentricular enlargementInterobserver variabilityInternal capsulePressure hydrocephalusAutomated SegmentationStatistical significanceDice coefficientNormal volumeScanningHydrocephalusPatients35. EVALUATING CSF CIRCULATING TUMOR DNA IN INTRAPARENCHYMAL BRAIN METASTASIS
Cheok S, Narayan A, Arnal-Estape A, Patel A, Nguyen D, Chiang V. 35. EVALUATING CSF CIRCULATING TUMOR DNA IN INTRAPARENCHYMAL BRAIN METASTASIS. Neuro-Oncology Advances 2020, 2: ii6-ii6. PMCID: PMC7401400, DOI: 10.1093/noajnl/vdaa073.023.Peer-Reviewed Original ResearchIntraparenchymal brain metastasesBrain metastasis tissuesNormal pressure hydrocephalusBrain metastasesCerebrospinal fluidLeptomeningeal diseaseCell-free DNACSF ctDNAMetastasis tissuesTumor DNASamples of CSFStudy 12 patientsPrimary cancer typeAnalysis of CSFIntraparenchymal diseaseFurther therapySystemic metastasesPlasma ctDNASixteen patientsIntraparenchymal tumorsPressure hydrocephalusColorectal cancerLumbar punctureDetection of novelCancer-associated genes
2019
Idiopathic Normal Pressure Hydrocephalus With Stuttering: Report of Two Cases and Review of the Literature
Mathew P, Chiu L, Lee C, Carroll R, Johnson MD. Idiopathic Normal Pressure Hydrocephalus With Stuttering: Report of Two Cases and Review of the Literature. World Neurosurgery 2019, 135: 176-179. PMID: 31805405, PMCID: PMC8424911, DOI: 10.1016/j.wneu.2019.11.152.Peer-Reviewed Original ResearchConceptsIdiopathic normal pressure hydrocephalusNormal pressure hydrocephalusCSF drainageGait difficultyPressure hydrocephalusCognitive impairmentVentriculoperitoneal shunt placementLumbar CSF drainageVP shunt revisionCases of patientsGait apraxiaUrinary incontinenceVP shuntShunt placementShunt revisionCerebral ventricleLumbar punctureDrainage proceduresSelect circumstancesMotor apraxiaNeurological disordersIncontinenceSymptomsPatientsHydrocephalus
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